Lakshminarayana Gopaliah - Academia.edu (original) (raw)

Uploads

Papers by Lakshminarayana Gopaliah

This article aims to review the available literature regarding the renal disease in corona virus ... more This article aims to review the available literature regarding the renal disease in corona virus disease 2019 (COVID 19), in the midst of ongoing pandemic. There is no available published data from India, regarding acute kidney injury (AKI) in COVID 19. There are only few studies are published from China, with a reported risk of AKI varying from 0.5 to 23 % and 0.8 to 9 % of them needed renal replacement therapy (RRT). There was higher risk of mortality in those with AKI needing RRT. Keywords: COVID 19, AKI.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopath... more Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopathological diagnosis promotes evidence-based practice in Nephrology. This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12.22%) and tubulointerstitial diseases (10%). The IgA nephropathy (IgAN) was the most common PGD and majority had mesangial hypercellularity (M1) (93.54%), tubular atrophy (T1 or T2 68.25%), and the most common pattern was M1, E0, S0, and T1, suggesting that patients of Indian subcontinent have aggressive disease type, unlike western literature. The focal segmental glomerulosclerosis (FSGS) was the second most common PGD and the majority were of not otherwise s...

Background: There is limited data regarding the prevalence of thyroid disorders in children and a... more Background: There is limited data regarding the prevalence of thyroid disorders in children and adolescents from India. Methods: All subjects aged 1-19 years, who underwent estimation of thyroid function tests (TFTs) at the EMS Memorial Cooperative Hospital and Research Centre, Perinthalmanna (2009-2013) were included in the study.Results: A total of 784 subjects (males-336, females-448), aged between 1-19 (Mean 11.12, SD-6.23) years, who underwent estimation of TFTs were studied. The prevalence rate of all thyroid function abnormalities was 9.18%. The thyroid function disorders were more common (10.89%) in adolescents (14-19 years) than children (1-13 years) (7.82%) and in females (12.05%) than males (5.36%) in both age groups. The prevalence rates of subclinical hypothyroidism (SCH), overt hypothyroidism (OH) and hyperthyroidism were 4.08%, 3.05% and 2.04% respectively. Conclusions: The thyroid function abnormalities are common in children and adolescents affecting about ~ 9% in s...

Indian Journal of Endocrinology and Metabolism, 2016

Background: Congenital hypothyroidism (CH) is most common preventable cause of mental retardation... more Background: Congenital hypothyroidism (CH) is most common preventable cause of mental retardation in children. Cord blood Thyroid Stimulating Hormone (CBTSH) level is an accepted screening tool for CH. Objectives: To study CBTSH profile in neonates born at tertiary care referral center and to analyze the influence of maternal and neonatal factors on their levels. Design: Cross retrospective sectional study. Methods: Study population included 979 neonates (males = 506 to females = 473). The CBTSH levels were estimated using electrochemiluminescence immunoassay on Cobas analyzer. Kit based cut-offs of TSH level were used for analysis. All neonates with abnormal CBSTH levels, were started on levothyroxine supplementation 10 μg/Kg/day and TSH levels were reassessed as per departmental protocol. Results: The mean CBTSH was 7.82 μIU/mL (Range 0.112 to 81.4, SD = 5.48). The mean CBTSH level was significantly higher in first order neonates, neonates delivered by assisted vaginal delivery an...

Innovative Journal of Medical and Health Science

Background: There is limited data regarding the prevalence of thyroid disorders in elderly from I... more Background: There is limited data regarding the prevalence of thyroid disorders in elderly from India. Methods: All subjects aged ≥ 60 years, who underwent estimation of thyroid function tests (TFTs) on their first visit to the hospital from 2009-2013 were included in the study. Results: A total of 1479 subjects (males-671, females-808), aged between 60-94 (Mean 69.02 SD: 7.21) years, were studied. Thyroid disorders were present in 13.99% of subjects. The prevalence rate of thyroid disorders was higher in females (14.73%) than males (13.11%) and in those aged ≥ 70 years [14.74%] than subjects in the age group of 60-69 years [13.57%]. Overt hypothyroidism (OH) was the commonest (5.81%) disorder followed by Subclinical hypothyroidism (SCH) in 5.54% subjects. Majority (90.69%) of cases OH were of primary hypothyroidism. The hyperthyroidism was prevalent in 1.76% followed by subclinical hyperthyroidism (SH) in 0.88% of subjects. All disorders were common in males than females; OH and hyperthyroidism were common in those aged ≥70 years and SCH and SH were common in age group of 60-69 years. Conclusions: The thyroid disorders are common in elderly subjects; affecting about ~ 14 % in study population. The OH was the commonest thyroid function disorder, followed by SCH, hyperthyroidism and SH with prevalence rates of 5.81, 5.54, 1.76 and 0.88% respectively; all were more common in females than males. The OH and hyperthyroidism showed an increasing trend with age; both in males and females.

Journal of Integrative Nephrology and Andrology

... How to Cite. SONI, SS, GOWRISHANKAR, S., KISHAN, AG and RAMAN, A. (2006), Non diabetic renal ... more ... How to Cite. SONI, SS, GOWRISHANKAR, S., KISHAN, AG and RAMAN, A. (2006), Non diabetic renal disease in type 2 diabetes mellitus. ... A, Korula A, Jeyaseelan L, Shastry JC, Jacob CK. Nondiabetic renal disease in noninsulin-dependent diabetics in a south Indian Hospital. ...

International Journal of Medical Research and Review

Pediatric Review: International Journal of Pediatric Research

Background: There is limited data regarding the prevalence of thyroid disorders in children and a... more Background: There is limited data regarding the prevalence of thyroid disorders in children and adolescents from India. Methods: All subjects aged 1-19 years, who underwent estimation of thyroid function tests (TFTs) at the EMS Memorial Cooperative Hospital and Research Centre, Perinthalmanna (2009-2013) were included in the study. Results: A total of 784 subjects (males-336, females-448), aged between 1-19 (Mean 11.12, SD-6.23) years, who underwent estimation of TFTs were studied. The prevalence rate of all thyroid function abnormalities was 9.18%. The thyroid function disorders were more common (10.89%) in adolescents (14-19 years) than children (1-13 years) (7.82%) and in females (12.05%) than males (5.36%) in both age groups. The prevalence rates of subclinical hypothyroidism (SCH), overt hypothyroidism (OH) and hyperthyroidism were 4.08%, 3.05% and 2.04% respectively. Conclusions: The thyroid function abnormalities are common in children and adolescents affecting about ~ 9% in study population. The SCH was the commonest thyroid function disorder, followed by OH and hyperthyroidism with female: male ratios of 2.5:1, 2.43:1 and 7:1 respectively. Majority of cases OH were of primary hypothyroidism. The SCH and hyperthyroidism were more prevalent in the adolescents than children; however, OH was more common in children than adolescents.

IP innovative publication pvt ltd, 2020

This article aims to review the available literature regarding the renal disease in corona virus ... more This article aims to review the available literature regarding the renal disease in corona virus disease 2019 (COVID 19), in the midst of ongoing pandemic. There is no available published data from India, regarding acute kidney injury (AKI) in COVID 19. There are only few studies are published from China, with a reported risk of AKI varying from 0.5 to 23 % and 0.8 to 9 % of them needed renal replacement therapy (RRT). There was higher risk of mortality in those with AKI needing RRT.

This article aims to review the available literature regarding the renal disease in corona virus ... more This article aims to review the available literature regarding the renal disease in corona virus disease 2019 (COVID 19), in the midst of ongoing pandemic. There is no available published data from India, regarding acute kidney injury (AKI) in COVID 19. There are only few studies are published from China, with a reported risk of AKI varying from 0.5 to 23 % and 0.8 to 9 % of them needed renal replacement therapy (RRT). There was higher risk of mortality in those with AKI needing RRT. Keywords: COVID 19, AKI.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopath... more Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopathological diagnosis promotes evidence-based practice in Nephrology. This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12.22%) and tubulointerstitial diseases (10%). The IgA nephropathy (IgAN) was the most common PGD and majority had mesangial hypercellularity (M1) (93.54%), tubular atrophy (T1 or T2 68.25%), and the most common pattern was M1, E0, S0, and T1, suggesting that patients of Indian subcontinent have aggressive disease type, unlike western literature. The focal segmental glomerulosclerosis (FSGS) was the second most common PGD and the majority were of not otherwise s...

Background: There is limited data regarding the prevalence of thyroid disorders in children and a... more Background: There is limited data regarding the prevalence of thyroid disorders in children and adolescents from India. Methods: All subjects aged 1-19 years, who underwent estimation of thyroid function tests (TFTs) at the EMS Memorial Cooperative Hospital and Research Centre, Perinthalmanna (2009-2013) were included in the study.Results: A total of 784 subjects (males-336, females-448), aged between 1-19 (Mean 11.12, SD-6.23) years, who underwent estimation of TFTs were studied. The prevalence rate of all thyroid function abnormalities was 9.18%. The thyroid function disorders were more common (10.89%) in adolescents (14-19 years) than children (1-13 years) (7.82%) and in females (12.05%) than males (5.36%) in both age groups. The prevalence rates of subclinical hypothyroidism (SCH), overt hypothyroidism (OH) and hyperthyroidism were 4.08%, 3.05% and 2.04% respectively. Conclusions: The thyroid function abnormalities are common in children and adolescents affecting about ~ 9% in s...

Indian Journal of Endocrinology and Metabolism, 2016

Background: Congenital hypothyroidism (CH) is most common preventable cause of mental retardation... more Background: Congenital hypothyroidism (CH) is most common preventable cause of mental retardation in children. Cord blood Thyroid Stimulating Hormone (CBTSH) level is an accepted screening tool for CH. Objectives: To study CBTSH profile in neonates born at tertiary care referral center and to analyze the influence of maternal and neonatal factors on their levels. Design: Cross retrospective sectional study. Methods: Study population included 979 neonates (males = 506 to females = 473). The CBTSH levels were estimated using electrochemiluminescence immunoassay on Cobas analyzer. Kit based cut-offs of TSH level were used for analysis. All neonates with abnormal CBSTH levels, were started on levothyroxine supplementation 10 μg/Kg/day and TSH levels were reassessed as per departmental protocol. Results: The mean CBTSH was 7.82 μIU/mL (Range 0.112 to 81.4, SD = 5.48). The mean CBTSH level was significantly higher in first order neonates, neonates delivered by assisted vaginal delivery an...

Innovative Journal of Medical and Health Science

Background: There is limited data regarding the prevalence of thyroid disorders in elderly from I... more Background: There is limited data regarding the prevalence of thyroid disorders in elderly from India. Methods: All subjects aged ≥ 60 years, who underwent estimation of thyroid function tests (TFTs) on their first visit to the hospital from 2009-2013 were included in the study. Results: A total of 1479 subjects (males-671, females-808), aged between 60-94 (Mean 69.02 SD: 7.21) years, were studied. Thyroid disorders were present in 13.99% of subjects. The prevalence rate of thyroid disorders was higher in females (14.73%) than males (13.11%) and in those aged ≥ 70 years [14.74%] than subjects in the age group of 60-69 years [13.57%]. Overt hypothyroidism (OH) was the commonest (5.81%) disorder followed by Subclinical hypothyroidism (SCH) in 5.54% subjects. Majority (90.69%) of cases OH were of primary hypothyroidism. The hyperthyroidism was prevalent in 1.76% followed by subclinical hyperthyroidism (SH) in 0.88% of subjects. All disorders were common in males than females; OH and hyperthyroidism were common in those aged ≥70 years and SCH and SH were common in age group of 60-69 years. Conclusions: The thyroid disorders are common in elderly subjects; affecting about ~ 14 % in study population. The OH was the commonest thyroid function disorder, followed by SCH, hyperthyroidism and SH with prevalence rates of 5.81, 5.54, 1.76 and 0.88% respectively; all were more common in females than males. The OH and hyperthyroidism showed an increasing trend with age; both in males and females.

Journal of Integrative Nephrology and Andrology

... How to Cite. SONI, SS, GOWRISHANKAR, S., KISHAN, AG and RAMAN, A. (2006), Non diabetic renal ... more ... How to Cite. SONI, SS, GOWRISHANKAR, S., KISHAN, AG and RAMAN, A. (2006), Non diabetic renal disease in type 2 diabetes mellitus. ... A, Korula A, Jeyaseelan L, Shastry JC, Jacob CK. Nondiabetic renal disease in noninsulin-dependent diabetics in a south Indian Hospital. ...

International Journal of Medical Research and Review

Pediatric Review: International Journal of Pediatric Research

Background: There is limited data regarding the prevalence of thyroid disorders in children and a... more Background: There is limited data regarding the prevalence of thyroid disorders in children and adolescents from India. Methods: All subjects aged 1-19 years, who underwent estimation of thyroid function tests (TFTs) at the EMS Memorial Cooperative Hospital and Research Centre, Perinthalmanna (2009-2013) were included in the study. Results: A total of 784 subjects (males-336, females-448), aged between 1-19 (Mean 11.12, SD-6.23) years, who underwent estimation of TFTs were studied. The prevalence rate of all thyroid function abnormalities was 9.18%. The thyroid function disorders were more common (10.89%) in adolescents (14-19 years) than children (1-13 years) (7.82%) and in females (12.05%) than males (5.36%) in both age groups. The prevalence rates of subclinical hypothyroidism (SCH), overt hypothyroidism (OH) and hyperthyroidism were 4.08%, 3.05% and 2.04% respectively. Conclusions: The thyroid function abnormalities are common in children and adolescents affecting about ~ 9% in study population. The SCH was the commonest thyroid function disorder, followed by OH and hyperthyroidism with female: male ratios of 2.5:1, 2.43:1 and 7:1 respectively. Majority of cases OH were of primary hypothyroidism. The SCH and hyperthyroidism were more prevalent in the adolescents than children; however, OH was more common in children than adolescents.

IP innovative publication pvt ltd, 2020

This article aims to review the available literature regarding the renal disease in corona virus ... more This article aims to review the available literature regarding the renal disease in corona virus disease 2019 (COVID 19), in the midst of ongoing pandemic. There is no available published data from India, regarding acute kidney injury (AKI) in COVID 19. There are only few studies are published from China, with a reported risk of AKI varying from 0.5 to 23 % and 0.8 to 9 % of them needed renal replacement therapy (RRT). There was higher risk of mortality in those with AKI needing RRT.