M Lappin - Academia.edu (original) (raw)

Papers by M Lappin

ABSTRACT Background/Question/Methods Determining mechanisms underlying the transmission of newly ... more ABSTRACT Background/Question/Methods Determining mechanisms underlying the transmission of newly recognized pathogens can be challenging, yet is fundamental to comprehend dynamics and, where appropriate, apply management. Transmission mechanisms for the newly recognized feline hemoplasma, ‘Candidatus Mycoplasma haemominutum’, have not been elucidated. Results/Conclusions We noted high incidence of this pathogen in bobcats, puma, and domestic cats in Colorado and California (3-77%, via PCR). We created a priori hypotheses/models of various transmission scenarios within and among domestic cats, pumas, and bobcats. Sources of hypothesized transmission included vector-borne, aggression and predation. Directionality in transmission (domestic to wild felids, wild to domestic and both directions) was also modeled. We then compared predictions from these models to incidence data, and identified optimal hypotheses by model selection. Results suggested transmission of ‘Candidatus M. haemominutum’ is vector-borne, transmitted within and among all species, and may also be transmitted by predation, but transmission by intraspecific aggression is unlikely. This approach may be useful to identify transmission mechanisms for other host-pathogen systems.

Acta Parasitologica, 2009

Prevalence of intestinal parasites in dogs and cats in Barcelona and surrounding areas was studie... more Prevalence of intestinal parasites in dogs and cats in Barcelona and surrounding areas was studied by analyzing 505 faecal samples of dogs and 50 of cats using a formol-ether diphasic method for helminths, a modified acid-fast technique for Cryptosporidium and other coccidian oocysts, and the Heindenhein technique for Giardia and Entamoeba trophozoites and cysts. Parasites were found in 26.9% of dogs and 34.0% of cats. Giardia duodenalis, Cryptosporidium sp., coccidian oocysts and Entamoeba sp. were detected in both dogs and cats. Taenia sp., Dipylidium caninum, Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis and Uncinaria sp. were also found in dogs but only Ancylostoma tubaeforme and Toxocara cati in cats. There was a significant relationship for G. duodenalis and Cryptosporidium sp. with seasonality and for G. duodenalis with geographical origin in dogs. Significant differences were also found for T. canis between stray and domestic dogs and for T. vulpi...

Physical Medicine and Rehabilitation Clinics of North America, 1998

Multiple sclerosis (MS) is a disease associated with neurologic disability such as central fatigu... more Multiple sclerosis (MS) is a disease associated with neurologic disability such as central fatigue, impaired bladder control, muscle weakness, sensory deficits, and impaired cognition. The cause of MS is unknown, but we have learned from histologic and radiologic studies that central nervous system damage occurs early in the progression of the disease. Recently, a histologic study has shown that widespread axonal damage occurs in MS along with demyelinati~n.~~ What is the possible connection between MS and bioelectromagnetic fields? In order for the nervous system to function properly, there are several structural, electrophysiologic, and chemical properties that need to be in place:

Journal of Inorganic and Nuclear Chemistry, 1970

Complexes of hexamethylenetetramine have been prepared with the halides of manganese (II), cobalt... more Complexes of hexamethylenetetramine have been prepared with the halides of manganese (II), cobalt(ll), nickel(I1) (except the iodide), zinc(lI), cadmium(ll) and iron(II) and copper(II) chlorides and also with the thiocyanates of cobalt(II), nickel(lI) and zinc(II). These complexes have been characterized by analysis, vibrational and electronic spectra and magnetic moments.

American Journal of Orthodontics, 1951

Chemical Geology: Isotope Geoscience section, 1985

... AND ORIGIN OF SOME NORWEGIAN ECLOGITES: A UPb ZIRCON AND REE STUDY DIETER GEBAUER', MICH... more ... AND ORIGIN OF SOME NORWEGIAN ECLOGITES: A UPb ZIRCON AND REE STUDY DIETER GEBAUER', MICHAEL A. LAPPINZ ... of Technology, 8092 Zurich (Switzerland) 'Department of Geology and Mineralogy, Marischal College, University of Aberdeen, Aberdeen, AB9 IAS ...

Problem-Based Feline Medicine, 2006

Journal of Veterinary Internal Medicine, 2008

Upper respiratory tract disease (URTD) of cats is caused by a number of pathogens, including Chla... more Upper respiratory tract disease (URTD) of cats is caused by a number of pathogens, including Chlamydophila felis and Mycoplasma spp. For effective treatment of both infections, doxycycline and enrofloxacin are recommended, but adverse effects limit their use in cats. That the fluoroquinolone pradofloxacin is effective against C. felis and Mycoplasma infection in cats with URTD or conjunctivitis. Thirty-nine cats with signs of URTD or conjunctivitis. Placebo-controlled, double-blind clinical trial. Cats were randomly entered into 1 of 2 treatment groups: treated PO with either 5 mg/kg pradofloxacin q24h or 5 mg/kg doxycycline q12h for 42 consecutive days. Changes in health status and clinical scores were evaluated. The presence of C. felis and Mycoplasma spp. was determined by quantitative polymerase chain reaction (PCR) and nested PCR of conjunctival swabs, respectively. At the beginning of the study, C. felis and Mycoplasma spp. were detected in 23 and 20 cats, respectively. Cats of both groups responded rapidly with a marked improvement in clinical signs within the 1st week. During treatment with either drug, C. felis DNA copy number declined quickly. Complete elimination of Mycoplasma spp. was achieved in both groups; however, whereas all cats receiving doxycycline eliminated C. felis, 4 cats treated with pradofloxacin remained PCR-positive. This study demonstrates that both pradofloxacin and doxycycline have good efficacy against C. felis and Mycoplasma spp., resulting in a marked improvement of clinical signs. However, C. felis DNA remained in some cats after treatment with pradofloxacin, suggesting that infection might not have been eliminated.

British Journal of Religious Education, 2003

and-conditions-of-access.pdf This article may be used for research, teaching and private study pu... more and-conditions-of-access.pdf This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material.

Veterinary Clinics of North America: Small Animal Practice, 2005

The most common protozoal agents infecting the gastrointestinal tract of cats are Giardia spp, Cr... more The most common protozoal agents infecting the gastrointestinal tract of cats are Giardia spp, Cryptosporidium spp, Cystoisospora spp, Sarcocystis spp, Besnoitia spp, Hammondia spp, Toxoplasma gondii, Entamoeba histolytica, and Tritrichomonas fetus [1-8]. Giardia spp are flagellates with trophozoite and cyst stages; T fetus is a flagellate that only produces trophozoites; Cystoisospora spp, Sarcocystis spp, Besnoitia spp, Hammondia spp, T gondii, and Cryptosporidium spp are coccidians that produce oocysts; and E histolytica is an amoeba with trophozoite and cyst stages. Balantidium coli is a ciliate that infects many warm-blooded vertebrates but has not been shown to infect cats [9]. Cystoisospora spp, Sarcocystis spp, Besnoitia spp, Hammondia spp, and T gondii only complete the intestinal cycle in one species. Some isolates of Cryptosporidium spp, Giardia spp, and E histolytica can infect multiple hosts and so can be zoonotic. The enteric phase of T gondii is blunted by immune responses to the organism; thus, enteric disease is selflimited. T gondii is most commonly associated with polysystemic illness [3]. Transmission and distribution Fecal oral transmission occurs with all the enteric protozoans. Cryptosporidium spp oocysts are immediately infectious when passed by the host; however, T gondii and Cystoisospora spp must sporulate outside the host to be infectious. Trophozoites and cysts of Giardia spp are potentially infectious; however, transmission occurs most frequently after ingestion of cysts, because trophozoites are generally killed by gastric secretions. Ingestion of the organism in the tissues of transport hosts can also result in infection by Cystoisospora spp, Besnoitia spp, Hammondia spp, and T gondii. Carnivorism can result in infection by Cryptosporidium spp, Giardia spp, and E histolytica if the organisms are present in the intestines of the prey species. Infections can

53rd EAEG Meeting, 1991

The results of many VSPs are disappointing because they have not been planned in detail, and proc... more The results of many VSPs are disappointing because they have not been planned in detail, and processing has not been optimised to achieve the prime objectives due to lack of communication between the specialists involved in planning, acquiring, processing and interpreting the data. In the case study reported here the close co-operation between interpreter, technical advisor and VSP processing geophysicist resulted in a carefully designed survey and an optimised processing sequence which fulfilled the planned objective and yielded further information.

The need for nurses and other healthcare practitioners to apply quality improvement methodology (... more The need for nurses and other healthcare practitioners to apply quality improvement methodology (QI methodology) within their everyday practice is becoming more prevalent in the NHS and is a key requirement of staff employed by Salford Royal NHS Foundation Trust. Aim/focus of the innovation A joint programme facilitated by Salford Royal NHS Foundation Trust and the University of Salford School of Nursing, Midwifery, Social Work & Social Sciences has been developed to develop undergraduate student nurses QI and leadership knowledge and skills. Methodology: Apply QI tools and techniques for the benefit of patient care; Work as a team to enhance quality and to measure the difference that they have made Develop their confidence in presenting the outcomes from their quality improvement; Support their development as a registered nurse through developing their leadership skills Structure of the Programme This programme adopts a blended teaching and learning approach. The programme is runni...

Journal of the Chemical Society C: Organic, 1968

Vapour-phase hydrogenation of perfluoro-(3,6-dihydro-2-methyl-2H-1,2-oxazine) in the presence of ... more Vapour-phase hydrogenation of perfluoro-(3,6-dihydro-2-methyl-2H-1,2-oxazine) in the presence of 1% palladium–alumina gave 4H,5H/-hexafluorotetrahydro-2-trifluoromethyl-1,2-oxazine and small amounts of 4H,4H,5H- and 4H,5H,5H-pentafluorotetrahydro-2-trifluoromethyl-1,2-oxazine. Dehydrofluorination of the 4H,5H-compound with aqueous potassium hydroxide gave an equimolar mixture of 4H- and 5H-pentafluoro-3,6-dihydro-2-trifluoromethyl-2H-1,2-oxazine. Hydrogenation of perfluorocyclopentene in the presence of 1% palladium–alumina gave 1H,2H/-octafluorocyclopentane and 1H,1H,2H-heptafluorocyclopentane. The 19F and 1H n.m.r. spectra of these hydrofluoro-compounds are discussed.

Chemischer Informationsdienst. Organische Chemie, 1971

Geological Society, London, Memoirs, 2003

The Guinevere Gas Field was discovered in January 1988 by the Mobil-operated well 48/17b-5. The f... more The Guinevere Gas Field was discovered in January 1988 by the Mobil-operated well 48/17b-5. The field lies in the UK Sector of the Southern North Sea and occupies Block 48/17b. The field is located within the footwall of the Dowsing Fault Zone on the western flank of the Sole Pit Basin. Guinevere is a compressional northwesterly-trending fault block that comprises Early Permian Leman Sandstone Formation (Rotliegend Group) reservoir, sourced from the Carboniferous below and sealed by Later Permian Zechstein evaporates above.The Guinevere Gas Field is estimated to contain 90 BCF of recoverable gas reserves and was brought on-stream in June 1993 using a single not-normally-manned minimum facilities platform. Field life is predicted to be 13 years. Gas and condensate are evacuated though the Lancelot Area Production System (LAPS) to the onshore Bacton gas terminal in East Anglia.

Geological Society, London, Memoirs, 2004

Three-dimensional (3D) seismic data have had a substantial impact on the successful exploration a... more Three-dimensional (3D) seismic data have had a substantial impact on the successful exploration and production of hydrocarbons. Although most commonly acquired by the oil and gas exploration industry, these data are starting to be used as a research tool in other Earth sciences disciplines. However despite some innovative new directions of academic investigation, most of the examples of how 3D seismic data have increased our understanding of the structure and stratigraphy of sedimentary basins come from the industry that acquired these data. The 3D seismic tool is also making significant inroads into other areas of Earth sciences, such as igneous and structural geology. However, there are pitfalls that parallel these advances: geoscientists need to be multidisciplined and true integrators, and at the same time have an ever-increasing knowledge of geophysical acquisition and processing. Notably the utility of the 3D seismic tool seems to have been overlooked by most of the academic c...

American journal of veterinary research, 1989

Four healthy cats were given clindamycin orally in daily doses of 25 or 50 mg/kg of body weight f... more Four healthy cats were given clindamycin orally in daily doses of 25 or 50 mg/kg of body weight for 6 weeks. Significant change in Factor-VII activity was not found, compared with pretreatment values. In 2 cats tested, toxin produced by Clostridium difficile was not detected in fecal samples obtained before treatment and at 6 weeks after treatment, suggesting that intestinal overgrowth by C difficile did not develop. Results of the study seemed to indicate that orally administered clindamycin does not measurably reduce synthesis of vitamin K-dependent clotting factors in healthy cats.