Lara Gallo - Academia.edu (original) (raw)

Papers by Lara Gallo

Research paper thumbnail of Sub-endocardial and sub-epicardial measurement of myocardial blood flow using 13NH3 PET in man

Journal of Nuclear Cardiology, 2018

Background. This study examined whether measuring myocardial blood flow (MBF) in the sub-endocard... more Background. This study examined whether measuring myocardial blood flow (MBF) in the sub-endocardial (SEN) and sub-epicardial (SEP) layers of the left ventricular myocardium using 13 NH 3 positron emission tomography (PET) and an automated procedure gives reasonable results in patients with known or suspected coronary artery disease (CAD). Methods. Resting and stress 13 NH 3 dynamic PET were performed in 70 patients. Using ‡ 70% diameter stenosis in invasive coronary angiography (ICA) to identify significant CAD, we examined the diagnostic value of SEN-and SEP-MBF, and coronary flow reserve (CFR) vs. the corresponding conventional data averaged on the whole wall thickness. Results. ICA demonstrated 36 patients with significant CAD. Their global stress average [1

Research paper thumbnail of Automatic Exposure Control in Digital Mammography: Contrast-to-Noise Ratio Versus Average Glandular Dose

Lecture Notes in Computer Science, 2008

... Yaffe, MJ, Bloomquist, AK, Mawdsley, GE, Pisano, ED, Hendrick, RE, Fajardo, LL, Boone, JM, Ka... more ... Yaffe, MJ, Bloomquist, AK, Mawdsley, GE, Pisano, ED, Hendrick, RE, Fajardo, LL, Boone, JM, Kanal, K., Mahesh, M., Fleischman, RC, Och, J., Williams, MB, Beideck, DJ, Maidment, ADA: Quality control for digital mammography: part II rec-ommendations from the ACRIN DMIST ...

Research paper thumbnail of Impact of objective volumetric breast density estimates on mean glandular dose calculations in digital mammography

In this paper we review the activities of Air Tra c Control and Management (ATC/M) and expose sce... more In this paper we review the activities of Air Tra c Control and Management (ATC/M) and expose scenarios that illustrate current and future challenges in this domain. In particular we look at those challenges that can be tackled with the use of immersion. We introduce the concepts of an immersive Remote Tower and Collaborative Immersive Trajectory analysis. These make use of immersive technologies such as Head Mounted Displays (HMDs) or large, tiled displays to immerse users in their tasks, better supporting the management and analysis of the complex data produced in this domain.

Research paper thumbnail of Regadenoson vs Dypiridamole in the quantification of Myocardial Blood Flow. Initial Italian experience

The Journal of Nuclear Medicine, 2015

Research paper thumbnail of Sub-endocardial and sub-epicardial measurement of myocardial blood flow using 13NH3 PET in man

Journal of Nuclear Cardiology

BackgroundThis study examined whether measuring myocardial blood flow (MBF) in the sub-endocardia... more BackgroundThis study examined whether measuring myocardial blood flow (MBF) in the sub-endocardial (SEN) and sub-epicardial (SEP) layers of the left ventricular myocardium using 13NH3 positron emission tomography (PET) and an automated procedure gives reasonable results in patients with known or suspected coronary artery disease (CAD).MethodsResting and stress 13NH3 dynamic PET were performed in 70 patients. Using ≥ 70% diameter stenosis in invasive coronary angiography (ICA) to identify significant CAD, we examined the diagnostic value of SEN- and SEP-MBF, and coronary flow reserve (CFR) vs. the corresponding conventional data averaged on the whole wall thickness.ResultsICA demonstrated 36 patients with significant CAD. Their global stress average [1.61 (1.26, 1.87) mL·min−1·g−1], SEN [1.39 (1.2, 1.59) mL·min−1·g−1] and SEP [1.22 (0.96, 1.44) mL·min−1·g−1] MBF were significantly lower than in the 34 no-CAD patients: 2.05 (1.76, 2.52), 1.72 (1.53, 1.89) and 1.46 (1.23, 1.89) mL·min−1·g−1, respectively, all P < .005. In the 60 CAD vs. the 150 non-CAD territories, stress average MBF was 1.52 (1.10, 1.83) vs. 2.06 (1.69, 2.48) mL·min−1·g−1, SEN-MBF 1.33 (1.02, 1.58) vs. 1.66 (1.35, 1.93) mL·min−1·g−1, and SEP-MBF 1.07 (0.80, 1.29) vs. 1.40 (1.12, 1.69) mL·min−1·g−1, respectively, all P < .05. Using receiver operating characteristics analysis for the presence of significant CAD, the areas under the curve (AUC) were all significant (P < .0001 vs. AUC = 0.5) and similar: stress average MBF = 0.79, SEN-MBF = 0.75, and SEP-MBF = 0.73. AUC was 0.77 for the average CFR, 0.75 for SEN, and 0.70 for SEP CFR. The stress transmural perfusion gradient (TPG) AUC (0.51) was not significant. However, stress TPG was significantly lower in segments subtended by totally occluded arteries vs. those subtended by sub-total stenoses: 1.10 (0.86, 1.33) vs. 1.24 (0.98, 1.56), respectively, P < .005.ConclusionAutomatic assessment of SEN- and SEP-MBF (and CFR) using 13NH3 PET gives reasonable results that are in good agreement with the conventional average whole wall thickness data. Further studies are needed to examine the utility of layer measurements such as in patients with hibernating myocardium or microvascular disease.

Research paper thumbnail of Automatic Exposure Control in Digital Mammography: Contrast-to-Noise Ratio Versus Average Glandular Dose

Performance of Automatic Exposure control in several digital mammography systems (both CR and DR)... more Performance of Automatic Exposure control in several digital mammography systems (both CR and DR) were evaluated. The test procedure applied was that proposed by the European Guidelines, which requires measurement of contrast-to-noise ratio (CNR) produced by 0.2 mm Al superimposed on variable polymethyl-methacrylate (PMMA) thicknesses. PMMA layers were exposed by full automatic techniques and average glandular dose (AGD) determined. Results demonstrated that AGD values keep below the acceptable limits for all CR and DR systems at almost all equivalent breast thicknesses. CNR absolute values per each thickness can significantly vary, depending on characteristics of each type of equipment. The application of limits suggested by the European Guidelines for CNR variation with reference to 50 mm PMMA causes systematic failure for equivalent breast thickness above 50 mm; this may be due to the contradiction between the principles followed by the manufacturers to designed the AEC (signal c...

Research paper thumbnail of Sub-endocardial and sub-epicardial measurement of myocardial blood flow using 13NH3 PET in man

Journal of Nuclear Cardiology, 2018

Background. This study examined whether measuring myocardial blood flow (MBF) in the sub-endocard... more Background. This study examined whether measuring myocardial blood flow (MBF) in the sub-endocardial (SEN) and sub-epicardial (SEP) layers of the left ventricular myocardium using 13 NH 3 positron emission tomography (PET) and an automated procedure gives reasonable results in patients with known or suspected coronary artery disease (CAD). Methods. Resting and stress 13 NH 3 dynamic PET were performed in 70 patients. Using ‡ 70% diameter stenosis in invasive coronary angiography (ICA) to identify significant CAD, we examined the diagnostic value of SEN-and SEP-MBF, and coronary flow reserve (CFR) vs. the corresponding conventional data averaged on the whole wall thickness. Results. ICA demonstrated 36 patients with significant CAD. Their global stress average [1

Research paper thumbnail of Automatic Exposure Control in Digital Mammography: Contrast-to-Noise Ratio Versus Average Glandular Dose

Lecture Notes in Computer Science, 2008

... Yaffe, MJ, Bloomquist, AK, Mawdsley, GE, Pisano, ED, Hendrick, RE, Fajardo, LL, Boone, JM, Ka... more ... Yaffe, MJ, Bloomquist, AK, Mawdsley, GE, Pisano, ED, Hendrick, RE, Fajardo, LL, Boone, JM, Kanal, K., Mahesh, M., Fleischman, RC, Och, J., Williams, MB, Beideck, DJ, Maidment, ADA: Quality control for digital mammography: part II rec-ommendations from the ACRIN DMIST ...

Research paper thumbnail of Impact of objective volumetric breast density estimates on mean glandular dose calculations in digital mammography

In this paper we review the activities of Air Tra c Control and Management (ATC/M) and expose sce... more In this paper we review the activities of Air Tra c Control and Management (ATC/M) and expose scenarios that illustrate current and future challenges in this domain. In particular we look at those challenges that can be tackled with the use of immersion. We introduce the concepts of an immersive Remote Tower and Collaborative Immersive Trajectory analysis. These make use of immersive technologies such as Head Mounted Displays (HMDs) or large, tiled displays to immerse users in their tasks, better supporting the management and analysis of the complex data produced in this domain.

Research paper thumbnail of Regadenoson vs Dypiridamole in the quantification of Myocardial Blood Flow. Initial Italian experience

The Journal of Nuclear Medicine, 2015

Research paper thumbnail of Sub-endocardial and sub-epicardial measurement of myocardial blood flow using 13NH3 PET in man

Journal of Nuclear Cardiology

BackgroundThis study examined whether measuring myocardial blood flow (MBF) in the sub-endocardia... more BackgroundThis study examined whether measuring myocardial blood flow (MBF) in the sub-endocardial (SEN) and sub-epicardial (SEP) layers of the left ventricular myocardium using 13NH3 positron emission tomography (PET) and an automated procedure gives reasonable results in patients with known or suspected coronary artery disease (CAD).MethodsResting and stress 13NH3 dynamic PET were performed in 70 patients. Using ≥ 70% diameter stenosis in invasive coronary angiography (ICA) to identify significant CAD, we examined the diagnostic value of SEN- and SEP-MBF, and coronary flow reserve (CFR) vs. the corresponding conventional data averaged on the whole wall thickness.ResultsICA demonstrated 36 patients with significant CAD. Their global stress average [1.61 (1.26, 1.87) mL·min−1·g−1], SEN [1.39 (1.2, 1.59) mL·min−1·g−1] and SEP [1.22 (0.96, 1.44) mL·min−1·g−1] MBF were significantly lower than in the 34 no-CAD patients: 2.05 (1.76, 2.52), 1.72 (1.53, 1.89) and 1.46 (1.23, 1.89) mL·min−1·g−1, respectively, all P < .005. In the 60 CAD vs. the 150 non-CAD territories, stress average MBF was 1.52 (1.10, 1.83) vs. 2.06 (1.69, 2.48) mL·min−1·g−1, SEN-MBF 1.33 (1.02, 1.58) vs. 1.66 (1.35, 1.93) mL·min−1·g−1, and SEP-MBF 1.07 (0.80, 1.29) vs. 1.40 (1.12, 1.69) mL·min−1·g−1, respectively, all P < .05. Using receiver operating characteristics analysis for the presence of significant CAD, the areas under the curve (AUC) were all significant (P < .0001 vs. AUC = 0.5) and similar: stress average MBF = 0.79, SEN-MBF = 0.75, and SEP-MBF = 0.73. AUC was 0.77 for the average CFR, 0.75 for SEN, and 0.70 for SEP CFR. The stress transmural perfusion gradient (TPG) AUC (0.51) was not significant. However, stress TPG was significantly lower in segments subtended by totally occluded arteries vs. those subtended by sub-total stenoses: 1.10 (0.86, 1.33) vs. 1.24 (0.98, 1.56), respectively, P < .005.ConclusionAutomatic assessment of SEN- and SEP-MBF (and CFR) using 13NH3 PET gives reasonable results that are in good agreement with the conventional average whole wall thickness data. Further studies are needed to examine the utility of layer measurements such as in patients with hibernating myocardium or microvascular disease.

Research paper thumbnail of Automatic Exposure Control in Digital Mammography: Contrast-to-Noise Ratio Versus Average Glandular Dose

Performance of Automatic Exposure control in several digital mammography systems (both CR and DR)... more Performance of Automatic Exposure control in several digital mammography systems (both CR and DR) were evaluated. The test procedure applied was that proposed by the European Guidelines, which requires measurement of contrast-to-noise ratio (CNR) produced by 0.2 mm Al superimposed on variable polymethyl-methacrylate (PMMA) thicknesses. PMMA layers were exposed by full automatic techniques and average glandular dose (AGD) determined. Results demonstrated that AGD values keep below the acceptable limits for all CR and DR systems at almost all equivalent breast thicknesses. CNR absolute values per each thickness can significantly vary, depending on characteristics of each type of equipment. The application of limits suggested by the European Guidelines for CNR variation with reference to 50 mm PMMA causes systematic failure for equivalent breast thickness above 50 mm; this may be due to the contradiction between the principles followed by the manufacturers to designed the AEC (signal c...