Lara Lima - Academia.edu (original) (raw)

Papers by Lara Lima

Archives of Health

Este artigo objetivou analisar a qualificação do acolhimento das Equipes de Saúde Bucal no estado... more Este artigo objetivou analisar a qualificação do acolhimento das Equipes de Saúde Bucal no estado do Ceará. Trata-se de uma pesquisa de cunho quantitativo, utilizando-se de dados secundários coletados a partir do 3° ciclo de avaliação externa do Programa Nacional de Melhoria do Acesso e de Qualidade da Atenção Básica (PMAQ-AB) efetuado no primeiro semestre de 2019. Foram coletados os dados referentes ao acolhimento das equipes de saúde bucal, organizados no módulo VI da planilha: “Equipes Saúde Bucal Brasil” no período de agosto a outubro de 2020, sendo eles analisados por método de estatística descritiva. Os resultados mostram que aproximadamente 99% das equipes realizam o acolhimento no Ceará, uma avaliação positiva quanto ao uso do acolhimento como tecnologia leve que objetiva um atendimento humanizado. No entanto, evidenciou-se falhas quanto a sua plena execução, como se observa nos dados obtidos na Região de Sobral, que obteve 73% de positividade quanto ao preparo prévio para a...

TRANSPORTES

O espraiamento urbano é um fenômeno comum nas metrópoles brasileiras. A população de alta renda c... more O espraiamento urbano é um fenômeno comum nas metrópoles brasileiras. A população de alta renda conduz um processo de autossegregação socioespacial que, combinado à periferização de segmentos de baixa renda, tem contribuído para o agravamento da problemática das desigualdades na acessibilidade às atividades urbanas. Esta pesquisa exploratória buscou investigar os efeitos do espraiamento residencial urbano sobre os níveis de acessibilidade às oportunidades de emprego em Fortaleza, e como esses efeitos impactam de forma desigual os distintos grupos socioeconômicos. Para tanto, propôs-se uma representação conceitual dessa problemática e sua caracterização a partir da definição e territorialização de indicadores agregados de uso do solo e de acessibilidade aos postos de trabalho. Os resultados apontam processos de descentralização distintos por grupo de renda, com distribuições desiguais e não equânimes do acesso às oportunidades de empregos, configurando Fortaleza como uma produção de ...

BMC Medicine, 2022

Background Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essentia... more Background Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyuridine, to thymine and uracil. Biallelic TYMP variants are responsible for Mitochondrial NeuroGastroIntestinal Encephalomyopathy (MNGIE), an autosomal recessive disorder characterized in most patients by gastrointestinal and neurological symptoms, ultimately leading to death. Studies on the impact of TYMP variants in cellular systems with relevance to the organs affected in MNGIE are still scarce and the role of TP in adipose tissue remains unexplored. Methods Deep phenotyping was performed in three patients from two families carrying homozygous TYMP variants and presenting with lipoatrophic diabetes. The impact of the loss of TP expression was evaluated using a CRISPR-Cas9-mediated TP knockout (KO) strategy in human adipose stem cells (ASC), which can be differentia...

Journal of Algebra, 2021

We study parameter spaces of linear series on projective curves in the presence of unibranch sing... more We study parameter spaces of linear series on projective curves in the presence of unibranch singularities, i.e. cusps; and to do so, we stratify cusps according to value semigroup. We show that generalized Severi varieties of maps P 1 → P n with images of fixed degree and arithmetic genus are often reducible whenever n ≥ 3. We also prove that the Severi variety of degree-d maps with a hyperelliptic cusp of delta-invariant g d is of codimension at least (n − 1)g inside the space of degree-d holomorphic maps P 1 → P n ; and that for small g, the bound is exact, and the corresponding space of maps is the disjoint union of unirational strata. Finally, we conjecture a generalization for unicuspidal rational curves associated to an arbitrary value semigroup. Contents 20 3.2. Generic cusps with ramification (2m, 2m + 2,. .. , 2m + 2n − 2), n ≥ 3 26 References 29

Introducao: A contaminacao dos solos e das reservas de recursos hidricos e, ha muito tempo, uma g... more Introducao: A contaminacao dos solos e das reservas de recursos hidricos e, ha muito tempo, uma grande preocupacao da humanidade quando se trata da exploracao mineral, da producao industrial e dos servicos variados. O bario e um dos metais pesados com grande potencial para causar contaminacao ambiental, e a industria de petroleo e responsavel por uma boa parcela dos efluentes contaminados por bario. Objetivos: Neste contexto, o desenvolvimento de carvao ativo a partir da casca de laranja para a remocao de ions de Ba (2+) contribui para a pesquisa pela importância de tratar estes efluentes extremamente danosos ao meio ambiente e a saude humana e dando uma aplicacao a esse residuo que seria descartado. Na producao de um adsorvente e necessario caracterizar, testar a capacidade de adsorcao do material in natura, melhorar a sua capacidade de adsorcao e ampliar suas possibilidades de aplicacao. Metodologia: As modificacoes realizadas na casca da laranja foram: tratamento termico, tratame...

FREITAS, C. F. S.; LIMA, L. S. Cadastro territorial e SIG no processo de regularizacao fundiaria:... more FREITAS, C. F. S.; LIMA, L. S. Cadastro territorial e SIG no processo de regularizacao fundiaria: o caso da ZEIS do Planalto PICI em Fortaleza, Ceara. In: Simposio Brasileiro de Ciencias Geodesicas e Tecnologias da Geoinformacao, 4., 2012, Recife. Anais... Recife: Programa de Pos-Graduacao em Ciencias Geodesicas e Tecnologias da Geoinformacao do Departamento de Engenharia Cartografica da Universidade Federal de Pernambuco - UFPE, 2012.

European Journal of Clinical Nutrition, 2021

Background/Objectives Experimental and clinical studies have shown that vitamins A and E can inhi... more Background/Objectives Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients. Subjects/Methods We applied a cross-sectional study (2017–2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24‐hr dietary recalls. Results Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion ( p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension ( p = 0.013) and lymph node metastasis ( p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis. Conclusions A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients.

arXiv: Algebraic Geometry, 2020

This paper is the third in a series, in which we study singular rational curves in projective spa... more This paper is the third in a series, in which we study singular rational curves in projective space, deducing conditions on their parameterizations from the value semigroups of their singularities. Here we focus on rational curves with cusps whose semigroups are of hyperelliptic type. We prove that the variety of (parameterizations of) rational curves of sufficiently large fixed degree ddd in mathbbPn\mathbb{P}^nmathbbPn with a single hyperelliptic cusp of delta-invariant ggg is always of codimension at least (n−1)g(n-1)g(n−1)g inside the space of degree-$d$ holomorphic maps mathbbP1rightarrowmathbbPn\mathbb{P}^1 \rightarrow \mathbb{P}^nmathbbP1rightarrowmathbbPn; and that when ggg is small, this bound is exact and the corresponding space of maps is paved by unirational strata indexed by fixed ramification profiles. We also provide evidence for a conjectural generalization of this picture for rational curves with cusps of arbitrary value semigroup rmS{\rm S}rmS, and provide evidence for this conjecture whenever rmS{\rm S}rmS is a gamma\gammagamma-hyperelliptic semigroup ...

A expansao das areas urbanas pode levar a um espraiamento centro-periferia, fenomeno comum a maio... more A expansao das areas urbanas pode levar a um espraiamento centro-periferia, fenomeno comum a maioria das metropoles brasileiras. Nesse contexto, a populacao de alta renda vem sendo atraida por novas formas de habitats urbanos culminando num processo de autossegregacao socioespacial no territorio da cidade. Esse padrao acarreta em consequencias negativas para a cidade, com a expansao desmedida da mancha urbana comprometendo os niveis de acessibilidade as atividades de trabalho, estudo, dentre outras que a populacao deseja realizar. Esta pesquisa de mestrado tem como objetivo compreender o fenomeno do espraiamento urbano por autossegregacao e seu impacto na acessibilidade urbana de Fortaleza. Para isso, adotando uma abordagem interdisciplinar que considera a interacao dos subsistemas de uso do solo e de transportes, propoe-se a representacao, a caracterizacao e o diagnostico dessa problematica, a partir da definicao de indicadores capazes de representar os problemas e suas relacoes ca...

CONGRESSO BRASILEIRO CIÊNCIA E SOCIEDADE, 2019

As propostas metodológicas de ensino para crianças autistas tendem a variar conforme suas necessi... more As propostas metodológicas de ensino para crianças autistas tendem a variar conforme suas necessidades e grau de comprometimento, cada criança precisa de um atendimento diferenciado com metodologias apropriadas a suas necessidades (SANTOS et al, 2013). Apesar de ser um transtorno com diversos grupos de comprometimento do desenvolvimento neurológico, cada criança possui suas diferenças e a inclusão é um direito que todas têm para melhoria do aprendizado. Visto isso, surgiu o seguinte questionamento: Quais os problemas enfrentados pelos docentes na realização da inclusão de crianças com transtorno do espectro autista, em sala de aula? Tendo como objetivo geral descobrir e compreender através de estudos atuais as principais dificuldades encontradas pelos professores na realização da inclusão de crianças com transtorno do espectro autista em sala de aula. Os artigos foram coletados no banco de dados Scielo e PePSIC, possuindo como recorte temporal trabalhos entre os anos de 2009-2019. Sendo assim, o artigo discute quais as dificuldades e as estratégias de educação, que o professor pode desenvolver para que facilite a inclusão e o ensino dos alunos autistas, onde a falta de formação de profissionais capacitados, para isso devem serem aceitas pela turma e por toda sociedade e não apenas a inserção nas escolas regulares, devem ser aceitas em todos os níveis e em todos os lugares.

Biochimie, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

International Journal of Biological Macromolecules, 2020

Lectins are proteins capable of specific and reversible binding to mono-and/or oligosaccharides, ... more Lectins are proteins capable of specific and reversible binding to mono-and/or oligosaccharides, and within this group, Legume lectins are the most studied. However, most of these studies focus on the Papilionoideae subfamily, with Caesalpinioideae and Mimosoideae lectins being significantly less explored in the literature. The Mimosoideae subfamily consists of at least 79 genera and 3275 species, but, to date, only about 14 lectins have been purified, a fact which shows the lack of studies for this group. Based on their purification protocols, as well as physicochemical and structural properties, Mimosoideae lectins are very heterogeneous. Despite the few studies, a wide variety of biological activities have been tested, including, for example, inflammatory, anticancer, antibacterial, and antifungal. In this context, the present review aims to summarize the available data regarding the purification, physicochemical and structural properties, as well as biological activities, of lectins extracted from plants of the Mimosoideae subfamily in order to bring more insight to researchers interested in further exploring the potential of these molecules.

BMC Cancer, 2019

Background: Cancer is a genetic and epigenetic disease that involves inactivation of tumor suppre... more Background: Cancer is a genetic and epigenetic disease that involves inactivation of tumor suppressor genes and activation of proto-oncogenes. All-trans retinoic acid (ATRA) is an isomer of retinoic acid involved in the onset of differentiation and apoptosis of a number of normal and cancer cells, functioning as an anti-cancer agent in several neoplasms. Ectopic changes in the expression of certain microRNAs (miRNAs) occur in response to ATRA, leading to phenotypic alterations in neoplastic cell lines. Moreover, the modulation of miRNA patterns upon ATRA-treatment may represent an effective chemopreventive and anti-cancer therapy strategy. The present systematic review was performed to provide an overview of the modulation of ATRA-induced miRNA expression in different types of neoplastic cells and identify the efficacy of intervention factors (i.e., concentration and duration of treatment) and how they influence expression profiles of oncogenesis-targeting miRNAs. Methods: A systematic search was conducted according to the PRISMA statement via the US National Library of Medicine MEDLINE/PubMed bibliographic search engine. Results: The search identified 31 experimental studies involving human cell lines from nine different cancer types (neuroblastoma, acute myeloid leukemia, breast cancer, lung cancer, pancreatic cancer, glioma, glioblastoma, embryonal carcinoma, and colorectal cancer) treated with ATRA at concentrations ranging from 10 − 3 μmol/L to 10 2 μmol mol/L for 24 h to 21 days. Conclusion: The concentrations used and the duration of treatment of cancer cells with ATRA varied widely. The presence of ATRA in the culture medium of cancer cells was able to modulate the expression of more than 300 miRNAs, and inhibit invasive behavior and deregulated growth of cancer cells, resulting in total tumor remission in some cases. ATRA may thus be broadly effective for neoplasm treatment and prevention, although these studies may not accurately represent in vivo conditions. Additional studies are required to elucidate ATRA-induced miRNA modulation during neoplasm treatment.

European Journal of Organic Chemistry, 2018

A straightforward chemoenzymatic synthesis of luliconazole has been developed. The key step invol... more A straightforward chemoenzymatic synthesis of luliconazole has been developed. The key step involved the preparation of the enantiomerically pure β-halohydrin (1S)-2-chloro-1-(2,4dichlorophenyl)-1-ethanol through kinetic resolution of the corresponding racemic acetate, via hydrolytic approach, mediated by lipase from Thermomyces lanuginosus or Novozym 435 ®. This latter enzyme proved to be a robust biocatalyst in the kinetic resolution, leading to the (S)-β-halohydrin with high selectivity (e.e. > 99%, E > 200) in just 15 min, at 45 °C, and being reused for five-times with maintenance high values of both conversion and enantioselectivity. Subsequently, the (S)-β-halohydrin was subjected to a mesylation reaction and the mesylated derivative reacted with 1cyanomethylimidazole leading to luliconazole in 43% yield and enantiomeric excess > 99%.

Clinics (Sao Paulo, Brazil), Jan 18, 2018

The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in... more The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.

Journal of Molecular Catalysis B: Enzymatic, 2016

A recombinant Candida antarctica lipase B expressed in Pichia pastoris (LIPB) was immobilized on ... more A recombinant Candida antarctica lipase B expressed in Pichia pastoris (LIPB) was immobilized on poreexpanded SBA-15 previously modified 3-amino-propyltriethoxysilane (APTES) and activated with two bifunctional reagents, glutaraldehyde (GA) or divinylsulfone (DVS), producing the biocatalysts: SBA-15-APTES-GA-LIPB and SBA-15-APTES-DVS-LIPB, respectively. After LIPB immobilization, both preparations were then modified with glutaraldehyde, producing the biocatalysts: SBA-15-APTES-GA-LIPB-GA, SBA-15-APTES-DVS-LIPB-DVS. Alternatively, LIPB was immobilized on SBA-15-APTES-DVS at pH 10.2 and the biocatalyst was named SBA-15-APTES-DVS-LIPB-pH10. The different biocatalysts were assayed to check the effect of the immobilization strategies on the stability and in the substrate specificity during the kinetic resolution of (R,S)-Phenylethyl acetate. The thermal stability of some new preparations were higher than LIPB adsorbed on SBA-15 (SBA-15-LIPB) and LIPB immobilized on Glyoxyl-agarose. High conversions in the enzymatic kinetic resolution were obtained (43-50%) for all biocatalysts studied. Regarding activity and stability, the SBA-15-APTES-DVS-LIPB-pH10 was the most successful strategy, since, in first cycle, the maximum conversion was obtained (50%), and the biocatalyst remained active and enantioselective even after five successive cycles.

Journal of Biosciences and Medicines, 2015

Pereskia aculeata Miller commonly known as "ora-pro-nobis" has been used extensively in folclore ... more Pereskia aculeata Miller commonly known as "ora-pro-nobis" has been used extensively in folclore medicine. Plant belongs to the family Cactacea and it is found in the Brazil (reaching Bahia and Rio Grande do Sul states). The purpose was to evaluate the effects of plant on biochemical and corporal profiles of Wistar rats. The 80 animals were divided randomly into 4 groups by sex (n = 10 females and 10 males per group) as follows: G1 group (water/rat food ad libitum); G2 group (drink A: commercial condensed milk, sugar and water/rat food ad libitum); G3 group (drink B: P. aculeata juice/rat food ad libitum); G4 group (drink C: commercial condensed milk, sugar and P. aculeate juice/rat food ad libitum). After 35 days their biochemical and corporal profiles were analyzed (cholesterol, glycemia, triglycerides, HDL-c, AST, ALT, Lee Index, weight and visceral fat). Intake of the plant caused no changes in the lipid profile of Wistar rats. However, intake in male rats of the same prevented the increase in triglycerides front of a hypercaloric diet. There were significant changes in glycemic index due to the high carbohydrate content of the plant. The plant was effective in reducing the levels of AST and ALT in male rats and ALT only in females. The use of the plant did not cause significant changes in the index of Lee but the Pereskia aculeata Miller may reduce visceral fat gain in female with a regular diet.

Anais do 11º Congresso Brasileiro de Pesquisa e Desenvolvimento em Design, 2014

As questões apresentadas neste artigo se fundamentam em discussões realizadas pela equipe de prof... more As questões apresentadas neste artigo se fundamentam em discussões realizadas pela equipe de professores e alunos do curso de Design da Universidade Federal do Ceará durante o desenvolvimento de um sistema de comunicação para a cidade de Fortaleza. Conta-se com as possibilidades oferecidas pelas tecnologias digitais e de redes para a criação de sistemas de comunicação-sinalização, como legado da Copa 2014, a partir do uso dos recursos da realidade aumentada (RA). Tem como propósito explorar-em termos conceituais-uma tensão interpretativa que as tecnologias digitais podem promover nas formas de perceber e vivenciar os espaços urbanos, bem como-em termos de projeto-o desenvolvimento de interfaces gráficas que articulem uma noção de comunicação potencializada pelos mecanismos de trocas promovidos pela computação ubíqua a partir da articulação dos conceitos de estética da comunicação-tendo em vista o conceito de sublime tecnológico-e o pressuposto de uma cultura da presença , para refletir sobre métodos de projeto tendo em vista o pensamento da arte. Palavras-chave: método, projeto, interface, realidade aumentada. 1. INTRODUÇÃO Os dispositivos móveis são hoje artefatos dotados de recursos que possibilitam a conexão entre espaços físicos e virtuais, promovendo assim, formas de comunicação Blucher Design Proceedings

Northeast Brazilian Health Journal (Revista Piauiense de Saúde), 2013

Os problemas posturais relacionados a coluna vertebral na maioria das vezes tem sua origem na inf... more Os problemas posturais relacionados a coluna vertebral na maioria das vezes tem sua origem na infância, mais exatamente na fase escolar. Os especialistas recomendam a atividade fisica para correcao dos desvios posturais, sendo o ballet classico uma das principais atividades. Assim, o estudo teve como objetivo avaliar o perfil postural de escolares do sexo feminino, praticantes e nao praticantes de ballet classico do 6° ao 9° ano de uma escola particular de Timon - MA. Foram avaliadas 16 (dezesseis) escolares com media de 13,7±1,85 anos, praticantes de ballet classico (PB) e nao praticantes de ballet classico (NP), selecionadas por conveniencia. Essas foram avaliadas de acordo com o protocolo de Kendall (2007), no qual se utilizou um fio de prumo e um posturografo para a analise postural das participantes. As posturas encontradas no grupo total de escolares foram de 37,5% para postura normal, 12,5% cifose, 18,75% lordose, 6,25% escoliose, 18,75% cifose e lordose e 6,25% cifose, lordose e escoliose. Avaliadas separadamente, os grupos de praticantes e nao praticantes apresentaram 50% postura normal (PB), 25% (NP), ou seja, 75% da amostra de (NP), possuem algum problema postural. Ao analisar as posturas do grupo total, o percentual de escolares com postura normal difere das anormalidades p= 0,035, dentro do grupo (PB) e (NP), o primeiro mostrou p= 0,023 para diferencas posturais entre postura normal e anormalidades, enquanto o segundo nao foi encontrado diferenca. Na comparacao entre grupos (PB) e (NP), nao foram encontradas diferencas estatisticas entre as posturas apresentadas p= 0,123. A analise se deu por meio do teste de qui – quadrado teste- p<0,05 – SPSS 15.0 para Windows. Os resultados apontaram maior percentual de postura normal entre ambos os grupos, com uma prevalencia no grupo praticante de ballet. Indicando uma melhor postura nesse grupo, colocando a pratica do ballet classico, como opcao de atividade fisica para manutencao da postura corporal. A B S T R A C T The postural problems related to the spine most often have their origin in childhood more exactly on the school stage. Experts recommend physical activity for correcting postural deviations and classical ballet one of the main activities. Thus the study aimed to evaluate the postural profile of female students, practitioners and non-practitioners of classical ballet from the 6th to 9th grade from a private school of Timon - MA. We evaluated sixteen (16) students with an average of 13.7 ± 1.85 years practitioners of classical ballet (CP) and non-practicing classical ballet (NP) selected by convenience. These were evaluated according to the protocol Kendall (2007) which was used a plumb line and a posture meter for postural analysis of the participants. The postures found in the total group of students were 37.5% for normal posture, 12.5% kyphosis, lordosis 18.75%, 6.25% scoliosis, kyphosis and lordosis 18.75% and 6.25% kyphosis lordosis and scoliosis. Evaluated separately the groups of practitioners and non practitioners showed 50% normal posture (PB) 25% (NP), or 75% of the sample (NP) have a problem posture. By analyzing the postures of the total group, the percentage of students with normal posture abnormalities differs from p = 0.035, within group (PB) and (NP), the first showed p = 0.023 for differences between normal posture and postural abnormalities while second difference was not found. In the comparison between groups (PB) and (NP) there were no statistical differences between the positions presented p = 0.123. The analysis was done by the chi - square test, p <0.05 - SPSS 15.0 for Windows. The results showed a higher percentage of normal posture between both groups with a prevalence in the group practicing ballet. Indicating a better position in the group putting the practice of classical ballet as an option for physical activity to maintain body posture.