Larisa Balykova - Academia.edu (original) (raw)

Papers by Larisa Balykova

The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of t... more The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of the most relevant at the monent. The leading cause of perinatal morbidity and mortality continue to remain hypoxic-ischemic brain damage the fetus and newborn. Ischemic-hypoxic damage of the central nervous system (CNS) is the most dangerous and prognostic significance. They often fatal and takes a leading role in the future of children and maladjustment of severe disabling diseases. Introduction of innovative medical technologies in health care practice greatly enhances the study of the causes of many diseases and abnormalities in newborns and helps to clarify the etiology, pathogenetic mechanisms, clinical and morphological structure, as well as typical for different gestational age localization of brain damage. It is shown that the generalized disorder of lipid metabolism with the development membranodestruktive processes is closely correlated with the severity of hypoxic-ischemic lesi...

The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same ... more The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, like the intestinal microbiota, it is involved in modulating the immune response to infectious agents in the host organism. A causal relationship between the composition of the respiratory microbiota and the likelihood of development and the severity of COVID-19 may be hypothesized. We analyze biomaterial from nasopharyngeal smears from 336 patients with a confirmed diagnosis of COVID-19, selected during the first and second waves of the epidemic in Russia. Sequences from a similar study conducted in Spain were also included in the analysis. We investigated associations between disease severity and microbiota at the level of microbial community (community types) and individual microbes (differentially represented species). To search for associations, we performed multivariate analysis, taking into account comorbidities, type of community and lineage of the virus. We found that two ...

Pharmacy & Pharmacology

The aim of the study is to assess the efficacy and safety of the Favipiravir (Areplivir) drug, co... more The aim of the study is to assess the efficacy and safety of the Favipiravir (Areplivir) drug, compared to the standard etiotropic therapy in the patients hospitalized with COVID-19.Material and methods. The research was conducted as a part of an open, randomized, multicenter comparative study of the efficacy and safety of Areplivir, 200 mg film-coated tablets (“PROMOMED RUS” LLC, Russia), in the patients hospitalized with COVID-19. The dosing regimen of Favipiravir was 1600 mg twice a day on the 1st day and 600 mg twice a day on days 2–14. Thirty nine patients were enrolled into the study with a laboratory-established diagnosis of a new type of Coronavirus infection caused by SARS-CoV-2 (confirmed) of moderate severity, with pneumonia. The group of comparison (22 patients) received standard etiotropic therapy, prescribed in accordance with the current version of the temporary guidelines for the diagnosis and treatment of COVID-19, represented mainly by Hydroxychloroquine with the d...

Russian Pediatric Journal

This article presents the view expressed in contemporary scientific literature on the evolution o... more This article presents the view expressed in contemporary scientific literature on the evolution of definitions, diagnostic approaches and risk stratification for suddenly occurred life-threatening conditions accompanied by cardiorespiratory disorders in children of the first year of life. The term “brief resolved unexplained event (BRUE)” has replaced the terms “apparent life-threatening event” and “aborted sudden infant death syndrome”. The provided information is derived from clinical guidelines of the American Academy of Pediatrics and the Italian Society of Pediatrics dealing with the above clinical conditions. The authors’ view is focused on the life-threatening situations and risk stratification for adverse outcome. The criteria for classifying infants’ condition as a low risk of life-threatening condition following the occurred event are provided. The authors’ collective invites the national pediatric community for a discussion on the issue of a life-threatening nature of BRU...

Science and Innovations in Medicine

The article presents a review of literature data on the long QT syndrome (LQTS), focusing on the ... more The article presents a review of literature data on the long QT syndrome (LQTS), focusing on the role of secondary factors in the development of this disorder. In particular, it describes in detail pseudohypoparathyroidism a rare genetically and clinically heterogeneous condition characterized by resistance to parathyroid hormone, often manifested by arrhythmogenic syncope and seizures. A specific clinical case illustrates the necessity to exclude the endocrine and electrolyte abnormalities in syncopal conditions associated with the QT interval prolongation.

Russian Pediatric Journal

Background. This review article surveys literature data on the methods of timely diagnosis and tr... more Background. This review article surveys literature data on the methods of timely diagnosis and treatment of congenital cytomegalovirus infection (CMVI) in newborn infants. In recent years CMVI has become a subject of numerous global-scale studies. Such increased interest in CMVI is due to the fact that the consequences of congenital CMVI have a social impact. Description of clinical case. A clinical case of congenital manifest cytomegalovirus infection is described. The infant was diagnosed with CMVI on the 10th day of life. Complex therapy was prescribed in accordance with the protocol of management of congenital CMVI which led to positive dynamics. Conclusion. By today, an algorithm for detection and treatment of CMVI which brings positive results has been worked out. However, it is essential to keep in mind the long-term sequelae of CMVI and devote close attention to dispensary follow-up of such patients.

Background Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It... more Background Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of this study was to evaluate the effectiveness of early etanercept+methotrexate (ETA+MTX) combination therapy versus step-up MTX monotherapy with ETA added in refractory disease. Methods A multi-centre, double-blind, randomized study in active polyarticular JIA patients treated with either ETA+MTX (n=35) or placebo+MTX (n=33) for up to 24 weeks, followed by a 24-week open-label phase. The efficacy endpoints included pedACR30 criteria improvement at week 12, inactive disease at week 24, and remission at week 48. Patients who failed to achieve the endpoints at week 12 or at week 24 escaped to open-label ETA+MTX. Safety was assessed at each visit. Results By intention-to-treat analysis, more patients in the ETA+MTX group reached the pedACR30 response at week 12 (33 (94.3%...

Mordovia University Bulletin

Введение. В последние годы в России остается актуальной проблема оценки состояния сердечно-сосуди... more Введение. В последние годы в России остается актуальной проблема оценки состояния сердечно-сосудистой системы у лиц, подверженных интенсивным физическим нагрузкам. Многогранность этой проблемы обусловлена неоднозначностью понимания механизмов формирования дезадаптационных механизмов патологической трансформации сердца атлетов, способных привести к внезапной смерти. Материалы и методы. Проведена экспериментально-клиническая оценка состояния миокарда. В экспериментальной части наблюдения выполнялись на модели интенсивного воздействия физической нагрузки на мышей. В клинической части работы лабораторно-инструментальными методами было обследовано 142 подростка, привлеченных к регулярным занятиям спортом. Результаты исследования. Установлено, что интенсивная физическая нагрузка приводила к развитию ультрастуктурных повреждений миокарда у экспериментальных животных, повышению уровня адреналина. Данные изменения коррелировали с выживаемостью животных в эксперименте. Клинические наблюдения указывали на стимулирование регулярными физическими нагрузками развития гипертрофии миокарда, вегетативных нарушений, а также биохимических сдвигов у лиц, подверженных регулярному воздействию спортивных нагрузок. Обсуждение и заключение. Было показано, что кроме гипертрофии миокарда и развития гемодинамических нарушений, в развитии дезадаптационных нарушений сердечно-сосудистой системы играют роль другие патофизиологические механизмы. Ключевые слова: сердце, физическая нагрузка, стресс, дезадаптация, сердечнососудистая система Для цитирования: Патогенетические аспекты формирования дезадаптационных изменений сердечно-сосудистой системы, опосредованных интенсивными физическими нагрузками / Л. А. Балыкова [и др.] // Вестник Мордовского универси

The guide will allow pediatricians to get information about the meaning of eponymous terms that t... more The guide will allow pediatricians to get information about the meaning of eponymous terms that they face in practice, educational and scientific activities, it contains 1212 eponymous symptoms, samples and reflexes, 752 symptom complexes, syndromes and diseases relevant to pediatric practice. The book consists of two parts, the first part includes the semiotics of pediatric diseases and presents their symptoms and signs. In the second part of the guide are syndromes and nosological units, which are systematized in alphabetical order. Their interpretation, historical information, data on epidemiology, etiology, pathogenesis and clinical picture of nosological units are given. From the standpoint of evidence-based medicine provides information on the diagnosis, treatment and prevention of these conditions, which may occur in the practice of a pediatrician. The guide is addressed to pediatricians, it is useful to researchers, teachers of higher medical school.

Current Pediatrics

Background. Implementation of mechanical circulatory support and heart transplantation technologi... more Background. Implementation of mechanical circulatory support and heart transplantation technologies in paediatric clinical practice is changing approaches of diagnostics and treatment of heart failure (HF) in children. The experience of carrying out such operations in Russian Federation is extremely limited until recently due to absence of legal mechanisms of people declaration of intention recording about postmortal use of organs for transplantation.Clinical Case Description. The rare clinical case of drug-refractory (cardiotonic agents and cardioverter defibrillator implantation) chronic cardiac failure caused by post-myocarditis dilated cardiomyopathy (DCM) which demanded heart transplantation. Postoperative course, specific and non-specific complications, diagnostics and correction approaches are described.Conclusion. In the absence of proper analysis of non-specific slight symptoms myocarditis can progress to DCM and be complicated by development of refractory HF. The only meth...

Polymers

This study looked into the synthesis and study of Dextrane Sulfate–Doxorubicin Nanoparticles (DS–... more This study looked into the synthesis and study of Dextrane Sulfate–Doxorubicin Nanoparticles (DS–Dox NP) that are sensitive to amylase and show anticoagulant properties. The particles were obtained by the method of solvent replacement. They had a size of 305 ± 58 nm, with a mass ratio of DS:Dox = 3.3:1. On heating to 37 °C, the release of Dox from the particles was equal to 24.2% of the drug contained. In the presence of amylase, this ratio had increased to 42.1%. The study of the biological activity of the particles included an assessment of the cytotoxicity and the effect on hemostasis and antitumor activity. In a study of cytotoxicity on the L929 cell culture, it was found that the synthesized particles had less toxicity, compared to free doxorubicin. However, in the presence of amylase, their cytotoxicity was higher than the traditional forms of the drug. In a study of the effect of DS–Dox NP on hemostasis, it was found that the particles had a heparin-like anticoagulant effect....

Mordovia University Bulletin

Аллахвердиев Сурхай Рагим оглы-академик Российской Академии Естествознания, профессор кафедры лес... more Аллахвердиев Сурхай Рагим оглы-академик Российской Академии Естествознания, профессор кафедры лесной индустрии, Бартынский государственный университет, профессор кафедры экологии и природопользования, ФГБОУ ВО «Московский педагогический государственный университет», доктор биологических наук, профессор (Бартын, Турция) Булгаков Алексей Григорьевич-профессор Института строительного дела, Дрезденский технический университет, доктор технических наук, профессор (Дрезден, Германия) Димитров Валерий Петрович-декан факультета приборостроения и технического регулирования, ФГБОУ ВО «Донской государственный технический университет», доктор технических наук, профессор, ORCID: 0000-0003-1439-1674 (Ростов-на-Дону, Россия) Ерофеев Владимир Трофимович-академик Российской академии архитектуры и строительных наук, декан архитектурно-строительного факультета, ФГБОУ ВО «МГУ им. Н. П. Огарёва», доктор технических наук, профессор (Саранск, Россия) Железникова Ольга Евгеньевна-директор Института электроники и светотехники, ФГБОУ ВО «МГУ им. Н. П. Огарёва», кандидат технических наук, доцент (Саранск, Россия) Игумнов Леонид Александрович-директор Научно-исследовательского института механики, заведующий кафедрой теоретической, компьютерной и экспериментальной механики, ФГАОУ ВО «Нижегородский государственный университет им. Н. И. Лобачевского», доктор физико-математических наук, профессор (Нижний Новгород, Россия) Кечемайкин Владимир Николаевич-директор Рузаевского института машиностроения, ФГБОУ ВО «МГУ им. Н. П. Огарёва», кандидат экономических наук (Саранск, Россия) Котин Александр Владимирович-заведующий кафедрой механизации переработки сельскохозяйственной продукции, ФГБОУ ВО «МГУ им. Н. П. Огарёва», доктор технических наук, профессор, ORCID: 0000-0003-0078-1866 (Саранск, Россия) Кусмарцев Федор Васильевич-декан физического факультета, Университет Лафборо, кандидат физико-математических наук (Лафборо, Великобритания) Маргулис Виктор Александрович-заведующий кафедрой теоретической физики, ФГБОУ ВО «МГУ им. Н. П. Огарёва», доктор физико-математических наук, профессор,

The Bulletin of Contemporary Clinical Medicine, 2013

Реферат. В статье приведено описание клинического случая миокардита у юного спортсмена, требовавш... more Реферат. В статье приведено описание клинического случая миокардита у юного спортсмена, требовавшего проведения дифференциального диагноза с крайней степенью специфических адаптационных изменений («спортивное сердце») и дезадаптационным ремоделированием («стрессорная кардиомиопатия»). Основными признаками, свидетельствовавшими в пользу миокардита, явились связанные с перенесенной вирусной инфекцией жалобы на усталость после нагрузки, нарушения реполяризации в сочетании с гипертрофией и дилатацией желудочков сердца с нарушением их функции, повышением уровня кардиоспецифических ферментов и титров антител к вирусу Эпштейна-Барр, миокарду и проводящей системе сердца, а также данные сцинтиграфии миокарда. Ключевые слова: миокардит, дети-спортсмены, спортивное сердце.

Mordovia University Bulletin, 2016

Введение. В последние годы в России отмечается тенденция к увеличению удельного веса недоношенных... more Введение. В последние годы в России отмечается тенденция к увеличению удельного веса недоношенных новорожденных, затянувшаяся постнатальная адаптация которых может быть связана с карнитиновой недостаточностью. Своевременная диагностика и коррекция карнитиновой недостаточности у недоношенных детей является возможным резервом предупреждения патологических состояний перинатального периода у данной категории пациентов. Материалы и методы. Клинико-лабораторными методами было обследовано 98 новорожденных детей. Результаты исследования. В ходе исследования было установлено, что у подавляющего числа новорожденных, вне зависимости от гестационного возраста и массы тела при рождении, в первые сутки жизни регистрируются нормальные значения общего карнитина и повышенное содержание свободного карнитина в периферической крови. Данные изменения наиболее характерны для глубоконедоношенных детей. Были выявлены статистически значимые различия в уровне общего и свободного карнитина в зависимости от пола новорожденных; установлена положительная корреляционная зависимость уровня общего карнитина от массы тела при рождении у глубоко недоношенных детей. Обсуждение и заключения. Было доказано, что введение L-карнитина в план выхаживания недоношенных детей способствует ускоренной прибавке в весе, достоверно сокращает продолжительность зондового кормления, снижает частоту развития анемии недоношенных и длительность неонатальной желтухи; показана способность Элькара корригировать функциональные нарушения сердечно-сосудистой системы у недоношенных детей. Ключевые слова: недоношенные дети, L-карнитин, синдром дезадаптации сердечно-сосудистой системы, карнитиновая недостаточность, Элькар Для цитирования: Оценка эффективности применения Элькара (L-карнитин) у недоношенных новорожденных / Л. А. Балыкова [и др.] // Вестник Мордовского уни

Am J Ther, 2009

Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children,... more Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children, pharmaceuticals remain the cornerstone therapeutic option. Beyond conventional antiarrhythmic agents such as amiodarone, local anesthetics, tranquilizers, anticonvulsants, and neuroleptics exhibit antiarrhythmic properties. H(1)-histamine receptor blockers are widely used in treating allergies in children. Observational studies suggest efficacy of these agents for treating or preventing tachyarrhythmias, although prolongation of QT interval, and ventricular arrhythmias occur. We determined safety and efficacy of antihistamine, quifenadine, versus conventional amiodarone on cardiac rhythm in children with frequent premature beats (PB). One hundred and four patients (mean age 10.8 +/- 3.2 years) with ventricular (n = 65), supraventricular (n = 39) PB were randomized 1:1 to quifenadine (2 mg kg(-1) day(-1); n = 54), or amiodarone (9 mg kg(-1) day(-1), n = 50) arms. Both groups were treated for 2 weeks. All patients underwent 24-hour Holter monitoring 3 times: before at 14-28 days after randomization, and during the follow up at 2-3 months. The mean frequency of PB in quifenadine group was 562 +/- 61 per hour and 597 +/- 78 per hour in the amiodarone-treated children. Full antiarrhythmic efficacy (PB < 75% from baseline) has been achieved in 23/54 (43%) of quifenadine-treated patients, which was less than after amiodarone treatment (37/50, 74%, P = 0.02). Quifenadine was mostly beneficial in children with supraventricular PB and/or bradycardia than in those with ventricular PB; it was associated with a trend toward increased heart rate during day (88.5 +/- 8.4 beats/min) and night (67.3 +/- 6.2) compared with amiodarone (79.6 +/- 7.8 and 56.1 +/- 5.7 beats/min, respectively; P = 0.04). The incidence of side effects in quifenadine group (drowsiness and headache) was low (2%) in contrast to the alarming 40% risk associated with amiodarone therapy. Quifanidine exhibits antiarrhythmic activity in children with frequent PB, without significant QT prolongation, or sinus node depression. Although, H(1)-histamine receptor blocker is less potent than amiodarone, much better safety profile of quifenadine is advantageous, especially in children. Future large trials with proving novel antihistamines pleiotropy are warranted.

BioMed Research International, 2015

The present paper explores the role of erythrocytes in the pathogenesis of vascular diseases. The... more The present paper explores the role of erythrocytes in the pathogenesis of vascular diseases. The state of erythrocytes, their ionic composition and structure, and properties of erythrocytes hemoglobin were studied by using laser interference microscopy, Raman scattering spectroscopy, and capillary electrophoresis. In patients suffering from vascular disorders we identified statistically significant changes in the shape of erythrocytes, their ionic composition, and redistribution of hemoglobin throughout cells.

American Journal of Therapeutics, 2009

Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children,... more Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children, pharmaceuticals remain the cornerstone therapeutic option. Beyond conventional antiarrhythmic agents such as amiodarone, local anesthetics, tranquilizers, anticonvulsants, and neuroleptics exhibit antiarrhythmic properties. H(1)-histamine receptor blockers are widely used in treating allergies in children. Observational studies suggest efficacy of these agents for treating or preventing tachyarrhythmias, although prolongation of QT interval, and ventricular arrhythmias occur. We determined safety and efficacy of antihistamine, quifenadine, versus conventional amiodarone on cardiac rhythm in children with frequent premature beats (PB). One hundred and four patients (mean age 10.8 +/- 3.2 years) with ventricular (n = 65), supraventricular (n = 39) PB were randomized 1:1 to quifenadine (2 mg kg(-1) day(-1); n = 54), or amiodarone (9 mg kg(-1) day(-1), n = 50) arms. Both groups were treated for 2 weeks. All patients underwent 24-hour Holter monitoring 3 times: before at 14-28 days after randomization, and during the follow up at 2-3 months. The mean frequency of PB in quifenadine group was 562 +/- 61 per hour and 597 +/- 78 per hour in the amiodarone-treated children. Full antiarrhythmic efficacy (PB < 75% from baseline) has been achieved in 23/54 (43%) of quifenadine-treated patients, which was less than after amiodarone treatment (37/50, 74%, P = 0.02). Quifenadine was mostly beneficial in children with supraventricular PB and/or bradycardia than in those with ventricular PB; it was associated with a trend toward increased heart rate during day (88.5 +/- 8.4 beats/min) and night (67.3 +/- 6.2) compared with amiodarone (79.6 +/- 7.8 and 56.1 +/- 5.7 beats/min, respectively; P = 0.04). The incidence of side effects in quifenadine group (drowsiness and headache) was low (2%) in contrast to the alarming 40% risk associated with amiodarone therapy. Quifanidine exhibits antiarrhythmic activity in children with frequent PB, without significant QT prolongation, or sinus node depression. Although, H(1)-histamine receptor blocker is less potent than amiodarone, much better safety profile of quifenadine is advantageous, especially in children. Future large trials with proving novel antihistamines pleiotropy are warranted.

The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of t... more The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of the most relevant at the monent. The leading cause of perinatal morbidity and mortality continue to remain hypoxic-ischemic brain damage the fetus and newborn. Ischemic-hypoxic damage of the central nervous system (CNS) is the most dangerous and prognostic significance. They often fatal and takes a leading role in the future of children and maladjustment of severe disabling diseases. Introduction of innovative medical technologies in health care practice greatly enhances the study of the causes of many diseases and abnormalities in newborns and helps to clarify the etiology, pathogenetic mechanisms, clinical and morphological structure, as well as typical for different gestational age localization of brain damage. It is shown that the generalized disorder of lipid metabolism with the development membranodestruktive processes is closely correlated with the severity of hypoxic-ischemic lesi...

The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same ... more The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, like the intestinal microbiota, it is involved in modulating the immune response to infectious agents in the host organism. A causal relationship between the composition of the respiratory microbiota and the likelihood of development and the severity of COVID-19 may be hypothesized. We analyze biomaterial from nasopharyngeal smears from 336 patients with a confirmed diagnosis of COVID-19, selected during the first and second waves of the epidemic in Russia. Sequences from a similar study conducted in Spain were also included in the analysis. We investigated associations between disease severity and microbiota at the level of microbial community (community types) and individual microbes (differentially represented species). To search for associations, we performed multivariate analysis, taking into account comorbidities, type of community and lineage of the virus. We found that two ...

Pharmacy & Pharmacology

The aim of the study is to assess the efficacy and safety of the Favipiravir (Areplivir) drug, co... more The aim of the study is to assess the efficacy and safety of the Favipiravir (Areplivir) drug, compared to the standard etiotropic therapy in the patients hospitalized with COVID-19.Material and methods. The research was conducted as a part of an open, randomized, multicenter comparative study of the efficacy and safety of Areplivir, 200 mg film-coated tablets (“PROMOMED RUS” LLC, Russia), in the patients hospitalized with COVID-19. The dosing regimen of Favipiravir was 1600 mg twice a day on the 1st day and 600 mg twice a day on days 2–14. Thirty nine patients were enrolled into the study with a laboratory-established diagnosis of a new type of Coronavirus infection caused by SARS-CoV-2 (confirmed) of moderate severity, with pneumonia. The group of comparison (22 patients) received standard etiotropic therapy, prescribed in accordance with the current version of the temporary guidelines for the diagnosis and treatment of COVID-19, represented mainly by Hydroxychloroquine with the d...

Russian Pediatric Journal

This article presents the view expressed in contemporary scientific literature on the evolution o... more This article presents the view expressed in contemporary scientific literature on the evolution of definitions, diagnostic approaches and risk stratification for suddenly occurred life-threatening conditions accompanied by cardiorespiratory disorders in children of the first year of life. The term “brief resolved unexplained event (BRUE)” has replaced the terms “apparent life-threatening event” and “aborted sudden infant death syndrome”. The provided information is derived from clinical guidelines of the American Academy of Pediatrics and the Italian Society of Pediatrics dealing with the above clinical conditions. The authors’ view is focused on the life-threatening situations and risk stratification for adverse outcome. The criteria for classifying infants’ condition as a low risk of life-threatening condition following the occurred event are provided. The authors’ collective invites the national pediatric community for a discussion on the issue of a life-threatening nature of BRU...

Science and Innovations in Medicine

The article presents a review of literature data on the long QT syndrome (LQTS), focusing on the ... more The article presents a review of literature data on the long QT syndrome (LQTS), focusing on the role of secondary factors in the development of this disorder. In particular, it describes in detail pseudohypoparathyroidism a rare genetically and clinically heterogeneous condition characterized by resistance to parathyroid hormone, often manifested by arrhythmogenic syncope and seizures. A specific clinical case illustrates the necessity to exclude the endocrine and electrolyte abnormalities in syncopal conditions associated with the QT interval prolongation.

Russian Pediatric Journal

Background. This review article surveys literature data on the methods of timely diagnosis and tr... more Background. This review article surveys literature data on the methods of timely diagnosis and treatment of congenital cytomegalovirus infection (CMVI) in newborn infants. In recent years CMVI has become a subject of numerous global-scale studies. Such increased interest in CMVI is due to the fact that the consequences of congenital CMVI have a social impact. Description of clinical case. A clinical case of congenital manifest cytomegalovirus infection is described. The infant was diagnosed with CMVI on the 10th day of life. Complex therapy was prescribed in accordance with the protocol of management of congenital CMVI which led to positive dynamics. Conclusion. By today, an algorithm for detection and treatment of CMVI which brings positive results has been worked out. However, it is essential to keep in mind the long-term sequelae of CMVI and devote close attention to dispensary follow-up of such patients.

Background Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It... more Background Remission is the primary objective of treating juvenile idiopathic arthritis (JIA). It is still debatable whether early intensive treatment is superior in terms of earlier achievement of remission. The aim of this study was to evaluate the effectiveness of early etanercept+methotrexate (ETA+MTX) combination therapy versus step-up MTX monotherapy with ETA added in refractory disease. Methods A multi-centre, double-blind, randomized study in active polyarticular JIA patients treated with either ETA+MTX (n=35) or placebo+MTX (n=33) for up to 24 weeks, followed by a 24-week open-label phase. The efficacy endpoints included pedACR30 criteria improvement at week 12, inactive disease at week 24, and remission at week 48. Patients who failed to achieve the endpoints at week 12 or at week 24 escaped to open-label ETA+MTX. Safety was assessed at each visit. Results By intention-to-treat analysis, more patients in the ETA+MTX group reached the pedACR30 response at week 12 (33 (94.3%...

Mordovia University Bulletin

Введение. В последние годы в России остается актуальной проблема оценки состояния сердечно-сосуди... more Введение. В последние годы в России остается актуальной проблема оценки состояния сердечно-сосудистой системы у лиц, подверженных интенсивным физическим нагрузкам. Многогранность этой проблемы обусловлена неоднозначностью понимания механизмов формирования дезадаптационных механизмов патологической трансформации сердца атлетов, способных привести к внезапной смерти. Материалы и методы. Проведена экспериментально-клиническая оценка состояния миокарда. В экспериментальной части наблюдения выполнялись на модели интенсивного воздействия физической нагрузки на мышей. В клинической части работы лабораторно-инструментальными методами было обследовано 142 подростка, привлеченных к регулярным занятиям спортом. Результаты исследования. Установлено, что интенсивная физическая нагрузка приводила к развитию ультрастуктурных повреждений миокарда у экспериментальных животных, повышению уровня адреналина. Данные изменения коррелировали с выживаемостью животных в эксперименте. Клинические наблюдения указывали на стимулирование регулярными физическими нагрузками развития гипертрофии миокарда, вегетативных нарушений, а также биохимических сдвигов у лиц, подверженных регулярному воздействию спортивных нагрузок. Обсуждение и заключение. Было показано, что кроме гипертрофии миокарда и развития гемодинамических нарушений, в развитии дезадаптационных нарушений сердечно-сосудистой системы играют роль другие патофизиологические механизмы. Ключевые слова: сердце, физическая нагрузка, стресс, дезадаптация, сердечнососудистая система Для цитирования: Патогенетические аспекты формирования дезадаптационных изменений сердечно-сосудистой системы, опосредованных интенсивными физическими нагрузками / Л. А. Балыкова [и др.] // Вестник Мордовского универси

The guide will allow pediatricians to get information about the meaning of eponymous terms that t... more The guide will allow pediatricians to get information about the meaning of eponymous terms that they face in practice, educational and scientific activities, it contains 1212 eponymous symptoms, samples and reflexes, 752 symptom complexes, syndromes and diseases relevant to pediatric practice. The book consists of two parts, the first part includes the semiotics of pediatric diseases and presents their symptoms and signs. In the second part of the guide are syndromes and nosological units, which are systematized in alphabetical order. Their interpretation, historical information, data on epidemiology, etiology, pathogenesis and clinical picture of nosological units are given. From the standpoint of evidence-based medicine provides information on the diagnosis, treatment and prevention of these conditions, which may occur in the practice of a pediatrician. The guide is addressed to pediatricians, it is useful to researchers, teachers of higher medical school.

Current Pediatrics

Background. Implementation of mechanical circulatory support and heart transplantation technologi... more Background. Implementation of mechanical circulatory support and heart transplantation technologies in paediatric clinical practice is changing approaches of diagnostics and treatment of heart failure (HF) in children. The experience of carrying out such operations in Russian Federation is extremely limited until recently due to absence of legal mechanisms of people declaration of intention recording about postmortal use of organs for transplantation.Clinical Case Description. The rare clinical case of drug-refractory (cardiotonic agents and cardioverter defibrillator implantation) chronic cardiac failure caused by post-myocarditis dilated cardiomyopathy (DCM) which demanded heart transplantation. Postoperative course, specific and non-specific complications, diagnostics and correction approaches are described.Conclusion. In the absence of proper analysis of non-specific slight symptoms myocarditis can progress to DCM and be complicated by development of refractory HF. The only meth...

Polymers

This study looked into the synthesis and study of Dextrane Sulfate–Doxorubicin Nanoparticles (DS–... more This study looked into the synthesis and study of Dextrane Sulfate–Doxorubicin Nanoparticles (DS–Dox NP) that are sensitive to amylase and show anticoagulant properties. The particles were obtained by the method of solvent replacement. They had a size of 305 ± 58 nm, with a mass ratio of DS:Dox = 3.3:1. On heating to 37 °C, the release of Dox from the particles was equal to 24.2% of the drug contained. In the presence of amylase, this ratio had increased to 42.1%. The study of the biological activity of the particles included an assessment of the cytotoxicity and the effect on hemostasis and antitumor activity. In a study of cytotoxicity on the L929 cell culture, it was found that the synthesized particles had less toxicity, compared to free doxorubicin. However, in the presence of amylase, their cytotoxicity was higher than the traditional forms of the drug. In a study of the effect of DS–Dox NP on hemostasis, it was found that the particles had a heparin-like anticoagulant effect....

Mordovia University Bulletin

Аллахвердиев Сурхай Рагим оглы-академик Российской Академии Естествознания, профессор кафедры лес... more Аллахвердиев Сурхай Рагим оглы-академик Российской Академии Естествознания, профессор кафедры лесной индустрии, Бартынский государственный университет, профессор кафедры экологии и природопользования, ФГБОУ ВО «Московский педагогический государственный университет», доктор биологических наук, профессор (Бартын, Турция) Булгаков Алексей Григорьевич-профессор Института строительного дела, Дрезденский технический университет, доктор технических наук, профессор (Дрезден, Германия) Димитров Валерий Петрович-декан факультета приборостроения и технического регулирования, ФГБОУ ВО «Донской государственный технический университет», доктор технических наук, профессор, ORCID: 0000-0003-1439-1674 (Ростов-на-Дону, Россия) Ерофеев Владимир Трофимович-академик Российской академии архитектуры и строительных наук, декан архитектурно-строительного факультета, ФГБОУ ВО «МГУ им. Н. П. Огарёва», доктор технических наук, профессор (Саранск, Россия) Железникова Ольга Евгеньевна-директор Института электроники и светотехники, ФГБОУ ВО «МГУ им. Н. П. Огарёва», кандидат технических наук, доцент (Саранск, Россия) Игумнов Леонид Александрович-директор Научно-исследовательского института механики, заведующий кафедрой теоретической, компьютерной и экспериментальной механики, ФГАОУ ВО «Нижегородский государственный университет им. Н. И. Лобачевского», доктор физико-математических наук, профессор (Нижний Новгород, Россия) Кечемайкин Владимир Николаевич-директор Рузаевского института машиностроения, ФГБОУ ВО «МГУ им. Н. П. Огарёва», кандидат экономических наук (Саранск, Россия) Котин Александр Владимирович-заведующий кафедрой механизации переработки сельскохозяйственной продукции, ФГБОУ ВО «МГУ им. Н. П. Огарёва», доктор технических наук, профессор, ORCID: 0000-0003-0078-1866 (Саранск, Россия) Кусмарцев Федор Васильевич-декан физического факультета, Университет Лафборо, кандидат физико-математических наук (Лафборо, Великобритания) Маргулис Виктор Александрович-заведующий кафедрой теоретической физики, ФГБОУ ВО «МГУ им. Н. П. Огарёва», доктор физико-математических наук, профессор,

The Bulletin of Contemporary Clinical Medicine, 2013

Реферат. В статье приведено описание клинического случая миокардита у юного спортсмена, требовавш... more Реферат. В статье приведено описание клинического случая миокардита у юного спортсмена, требовавшего проведения дифференциального диагноза с крайней степенью специфических адаптационных изменений («спортивное сердце») и дезадаптационным ремоделированием («стрессорная кардиомиопатия»). Основными признаками, свидетельствовавшими в пользу миокардита, явились связанные с перенесенной вирусной инфекцией жалобы на усталость после нагрузки, нарушения реполяризации в сочетании с гипертрофией и дилатацией желудочков сердца с нарушением их функции, повышением уровня кардиоспецифических ферментов и титров антител к вирусу Эпштейна-Барр, миокарду и проводящей системе сердца, а также данные сцинтиграфии миокарда. Ключевые слова: миокардит, дети-спортсмены, спортивное сердце.

Mordovia University Bulletin, 2016

Введение. В последние годы в России отмечается тенденция к увеличению удельного веса недоношенных... more Введение. В последние годы в России отмечается тенденция к увеличению удельного веса недоношенных новорожденных, затянувшаяся постнатальная адаптация которых может быть связана с карнитиновой недостаточностью. Своевременная диагностика и коррекция карнитиновой недостаточности у недоношенных детей является возможным резервом предупреждения патологических состояний перинатального периода у данной категории пациентов. Материалы и методы. Клинико-лабораторными методами было обследовано 98 новорожденных детей. Результаты исследования. В ходе исследования было установлено, что у подавляющего числа новорожденных, вне зависимости от гестационного возраста и массы тела при рождении, в первые сутки жизни регистрируются нормальные значения общего карнитина и повышенное содержание свободного карнитина в периферической крови. Данные изменения наиболее характерны для глубоконедоношенных детей. Были выявлены статистически значимые различия в уровне общего и свободного карнитина в зависимости от пола новорожденных; установлена положительная корреляционная зависимость уровня общего карнитина от массы тела при рождении у глубоко недоношенных детей. Обсуждение и заключения. Было доказано, что введение L-карнитина в план выхаживания недоношенных детей способствует ускоренной прибавке в весе, достоверно сокращает продолжительность зондового кормления, снижает частоту развития анемии недоношенных и длительность неонатальной желтухи; показана способность Элькара корригировать функциональные нарушения сердечно-сосудистой системы у недоношенных детей. Ключевые слова: недоношенные дети, L-карнитин, синдром дезадаптации сердечно-сосудистой системы, карнитиновая недостаточность, Элькар Для цитирования: Оценка эффективности применения Элькара (L-карнитин) у недоношенных новорожденных / Л. А. Балыкова [и др.] // Вестник Мордовского уни

Am J Ther, 2009

Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children,... more Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children, pharmaceuticals remain the cornerstone therapeutic option. Beyond conventional antiarrhythmic agents such as amiodarone, local anesthetics, tranquilizers, anticonvulsants, and neuroleptics exhibit antiarrhythmic properties. H(1)-histamine receptor blockers are widely used in treating allergies in children. Observational studies suggest efficacy of these agents for treating or preventing tachyarrhythmias, although prolongation of QT interval, and ventricular arrhythmias occur. We determined safety and efficacy of antihistamine, quifenadine, versus conventional amiodarone on cardiac rhythm in children with frequent premature beats (PB). One hundred and four patients (mean age 10.8 +/- 3.2 years) with ventricular (n = 65), supraventricular (n = 39) PB were randomized 1:1 to quifenadine (2 mg kg(-1) day(-1); n = 54), or amiodarone (9 mg kg(-1) day(-1), n = 50) arms. Both groups were treated for 2 weeks. All patients underwent 24-hour Holter monitoring 3 times: before at 14-28 days after randomization, and during the follow up at 2-3 months. The mean frequency of PB in quifenadine group was 562 +/- 61 per hour and 597 +/- 78 per hour in the amiodarone-treated children. Full antiarrhythmic efficacy (PB < 75% from baseline) has been achieved in 23/54 (43%) of quifenadine-treated patients, which was less than after amiodarone treatment (37/50, 74%, P = 0.02). Quifenadine was mostly beneficial in children with supraventricular PB and/or bradycardia than in those with ventricular PB; it was associated with a trend toward increased heart rate during day (88.5 +/- 8.4 beats/min) and night (67.3 +/- 6.2) compared with amiodarone (79.6 +/- 7.8 and 56.1 +/- 5.7 beats/min, respectively; P = 0.04). The incidence of side effects in quifenadine group (drowsiness and headache) was low (2%) in contrast to the alarming 40% risk associated with amiodarone therapy. Quifanidine exhibits antiarrhythmic activity in children with frequent PB, without significant QT prolongation, or sinus node depression. Although, H(1)-histamine receptor blocker is less potent than amiodarone, much better safety profile of quifenadine is advantageous, especially in children. Future large trials with proving novel antihistamines pleiotropy are warranted.

BioMed Research International, 2015

The present paper explores the role of erythrocytes in the pathogenesis of vascular diseases. The... more The present paper explores the role of erythrocytes in the pathogenesis of vascular diseases. The state of erythrocytes, their ionic composition and structure, and properties of erythrocytes hemoglobin were studied by using laser interference microscopy, Raman scattering spectroscopy, and capillary electrophoresis. In patients suffering from vascular disorders we identified statistically significant changes in the shape of erythrocytes, their ionic composition, and redistribution of hemoglobin throughout cells.

American Journal of Therapeutics, 2009

Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children,... more Despite evolving success of mini-invasive techniques in treating cardiac arrhythmias in children, pharmaceuticals remain the cornerstone therapeutic option. Beyond conventional antiarrhythmic agents such as amiodarone, local anesthetics, tranquilizers, anticonvulsants, and neuroleptics exhibit antiarrhythmic properties. H(1)-histamine receptor blockers are widely used in treating allergies in children. Observational studies suggest efficacy of these agents for treating or preventing tachyarrhythmias, although prolongation of QT interval, and ventricular arrhythmias occur. We determined safety and efficacy of antihistamine, quifenadine, versus conventional amiodarone on cardiac rhythm in children with frequent premature beats (PB). One hundred and four patients (mean age 10.8 +/- 3.2 years) with ventricular (n = 65), supraventricular (n = 39) PB were randomized 1:1 to quifenadine (2 mg kg(-1) day(-1); n = 54), or amiodarone (9 mg kg(-1) day(-1), n = 50) arms. Both groups were treated for 2 weeks. All patients underwent 24-hour Holter monitoring 3 times: before at 14-28 days after randomization, and during the follow up at 2-3 months. The mean frequency of PB in quifenadine group was 562 +/- 61 per hour and 597 +/- 78 per hour in the amiodarone-treated children. Full antiarrhythmic efficacy (PB < 75% from baseline) has been achieved in 23/54 (43%) of quifenadine-treated patients, which was less than after amiodarone treatment (37/50, 74%, P = 0.02). Quifenadine was mostly beneficial in children with supraventricular PB and/or bradycardia than in those with ventricular PB; it was associated with a trend toward increased heart rate during day (88.5 +/- 8.4 beats/min) and night (67.3 +/- 6.2) compared with amiodarone (79.6 +/- 7.8 and 56.1 +/- 5.7 beats/min, respectively; P = 0.04). The incidence of side effects in quifenadine group (drowsiness and headache) was low (2%) in contrast to the alarming 40% risk associated with amiodarone therapy. Quifanidine exhibits antiarrhythmic activity in children with frequent PB, without significant QT prolongation, or sinus node depression. Although, H(1)-histamine receptor blocker is less potent than amiodarone, much better safety profile of quifenadine is advantageous, especially in children. Future large trials with proving novel antihistamines pleiotropy are warranted.