Laura Gimenez - Academia.edu (original) (raw)
Papers by Laura Gimenez
Tissue Antigens, 1999
CD1 molecules are able to present unusual antigens, lipids or glycolipids from mycobacterium cell... more CD1 molecules are able to present unusual antigens, lipids or glycolipids from mycobacterium cell walls to T lymphocytes. Previous studies have suggested that polymorphism of these genes is very limited, in contrast with classical major histocompatibility complex (MHC) antigen-presenting molecules. Our aim was to study possible allelic variations of exons 2 and 3, encoding for the alpha1 and alpha2 domains, respectively, of human CD1A, -B, -C and -D genes. We analyzed genomic samples of unrelated, healthy individuals from different ethnic background: 70 Caucasians from Europe, 33 Black Africans (13 from Tanzania and 20 Zulus), 19 Caucasians from the Sahara and 44 Asian individuals. We have found CD1A to be a biallelic locus with a common allele which was present in the majority of the individuals studied. The second allele differed from the common one by a single-point mutation, resulting in a change of Cys to Trp at position 52 in the alpha1 domain. This second allele was found in heterozygosis in 7 out of 70 Caucasians from Europe (allelic frequencies P=0.95 and q=0.05). In the Chinese population, we found the second allele present in heterozygosis in 19 from the 44 individuals studied, and we also found 6 homozygous individuals for the second allele (allelic frequencies P=0.64 and q=0.35). In addition, we detected a synonymous mutation (C to T transition) in codon 34 of CD1C exon 2 in 4 out of 20 Zulus and in 2 of the 13 Blacks from Tanzania.
Historical series of precipitation data can show characteristics like the trend, which represents... more Historical series of precipitation data can show characteristics like the trend, which represents the long-run movements in the series, and a seasonal pattern which repeats itself more o less every year. The structural time series models will capture these characteristics. They can be interpreted by regressions on time functions where the parameters changes over time. The main objective of the present work was to fit structural time series models to rainfall data in Galicia, northwest of Spain. This region comprises four provinces: Coruña, Lugo, Orense and Pontevedra. Climate oscillates from temperate humid Atlantic to Mediterranean. Rainfall regime is characterized by a strong seasonality with low values in summer months and large values in autumn and winter months. Yearly amounts of rain as well as rainfall differences between seasons increase from the Atlantic to the Mediterranean areas. Therefore, differences in rainfall regime induced by topography, distance to the coast and other factors are apparent between different zones within Galicia. For example the coastal area, the inland River valleys or the mountain systems show characteristic rainfall regimes. We analyzed rainfall data in 21 weather stations distributed over the four provinces of Galicia. The period analyzed was different in each station. The maximum length of the data series was thirty years and the minimum length was eight years. A structural time series models was adjusted to the data of each of the studied weather stations. The model was used to forecast monthly rainfall during 2008. The results showed that mean levels of monthly rainfall in each province of Galicia were as follows: 83.10 mm in Coruña, 65.37 mm in Lugo, 64.98 mm in Orense and 125.75 mm in Pontevedra. Models showed a trend without slope for all the stations and the seasonality was in all the cases a deterministic component. The agreement between predictions and measured values of rain during 2008 is discussed.
European Psychiatry, 2000
Psychotherapy and Psychosomatics, 2007
their unaffected sisters. Conclusions: Traits of childhood overeating were more common in bulimic... more their unaffected sisters. Conclusions: Traits of childhood overeating were more common in bulimic women compared to their unaffected siblings. Subjects with AN did not differ from their sisters on eating variables. The increased risk of BN due to childhood overweight suggests that prevention strategies for childhood obesity and overweight may therefore be applicable in BN.
Appetite, 2007
To examine whether there is an association between individual and family eating patterns during c... more To examine whether there is an association between individual and family eating patterns during childhood and the likelihood of developing an eating disorder (ED) later in life. The sample comprised 261 eating disorder patients [33.5% [N ¼ 88] anorexia nervosa (AN), 47.2% [N ¼ 123] with bulimia nervosa (BN) and 19.3% [N ¼ 50] with Eating Disorders Not Otherwise Specified (EDNOS)] and 160 healthy controls from the Province of Catalonia, Spain, who were matched for age and education. All patients were consecutively admitted to our Psychiatry Department and were diagnosed according to DSM-IV criteria. Participants completed the Early Eating Environmental Subscale of the Cross-Cultural (Environmental) Questionnaire (CCQ), a retrospective measure of childhood eating attitudes and behaviours. In the control group, also the General Health Questionnaire-28 (GHQ-28) was used. During childhood and early adolescence, the following main factors were identified to be linked to eating disorders: eating excessive sweets and snacks and consuming food specially prepared for the respondent. Conversely, regular breakfast consumption was negatively associated with an eating disorder. Compared to healthy controls, eating disorder patients report unfavourable eating patterns early in life, which in conjunction with an excessive importance given to food by the individual and the family may increase the likelihood for developing a subsequent eating disorder. r
To examine whether there is an association between individual and family eating patterns during c... more To examine whether there is an association between individual and family eating patterns during childhood and the likelihood of developing an eating disorder (ED) later in life. The sample comprised 261 eating disorder patients (33.5% (N ¼ 88) anorexia nervosa (AN), 47.2% (N ¼ 123) with bulimia nervosa (BN) and 19.3% (N ¼ 50) with Eating Disorders Not Otherwise Specified
Tissue Antigens, 1999
CD1 molecules are able to present unusual antigens, lipids or glycolipids from mycobacterium cell... more CD1 molecules are able to present unusual antigens, lipids or glycolipids from mycobacterium cell walls to T lymphocytes. Previous studies have suggested that polymorphism of these genes is very limited, in contrast with classical major histocompatibility complex (MHC) antigen-presenting molecules. Our aim was to study possible allelic variations of exons 2 and 3, encoding for the alpha1 and alpha2 domains, respectively, of human CD1A, -B, -C and -D genes. We analyzed genomic samples of unrelated, healthy individuals from different ethnic background: 70 Caucasians from Europe, 33 Black Africans (13 from Tanzania and 20 Zulus), 19 Caucasians from the Sahara and 44 Asian individuals. We have found CD1A to be a biallelic locus with a common allele which was present in the majority of the individuals studied. The second allele differed from the common one by a single-point mutation, resulting in a change of Cys to Trp at position 52 in the alpha1 domain. This second allele was found in heterozygosis in 7 out of 70 Caucasians from Europe (allelic frequencies P=0.95 and q=0.05). In the Chinese population, we found the second allele present in heterozygosis in 19 from the 44 individuals studied, and we also found 6 homozygous individuals for the second allele (allelic frequencies P=0.64 and q=0.35). In addition, we detected a synonymous mutation (C to T transition) in codon 34 of CD1C exon 2 in 4 out of 20 Zulus and in 2 of the 13 Blacks from Tanzania.
Historical series of precipitation data can show characteristics like the trend, which represents... more Historical series of precipitation data can show characteristics like the trend, which represents the long-run movements in the series, and a seasonal pattern which repeats itself more o less every year. The structural time series models will capture these characteristics. They can be interpreted by regressions on time functions where the parameters changes over time. The main objective of the present work was to fit structural time series models to rainfall data in Galicia, northwest of Spain. This region comprises four provinces: Coruña, Lugo, Orense and Pontevedra. Climate oscillates from temperate humid Atlantic to Mediterranean. Rainfall regime is characterized by a strong seasonality with low values in summer months and large values in autumn and winter months. Yearly amounts of rain as well as rainfall differences between seasons increase from the Atlantic to the Mediterranean areas. Therefore, differences in rainfall regime induced by topography, distance to the coast and other factors are apparent between different zones within Galicia. For example the coastal area, the inland River valleys or the mountain systems show characteristic rainfall regimes. We analyzed rainfall data in 21 weather stations distributed over the four provinces of Galicia. The period analyzed was different in each station. The maximum length of the data series was thirty years and the minimum length was eight years. A structural time series models was adjusted to the data of each of the studied weather stations. The model was used to forecast monthly rainfall during 2008. The results showed that mean levels of monthly rainfall in each province of Galicia were as follows: 83.10 mm in Coruña, 65.37 mm in Lugo, 64.98 mm in Orense and 125.75 mm in Pontevedra. Models showed a trend without slope for all the stations and the seasonality was in all the cases a deterministic component. The agreement between predictions and measured values of rain during 2008 is discussed.
European Psychiatry, 2000
Psychotherapy and Psychosomatics, 2007
their unaffected sisters. Conclusions: Traits of childhood overeating were more common in bulimic... more their unaffected sisters. Conclusions: Traits of childhood overeating were more common in bulimic women compared to their unaffected siblings. Subjects with AN did not differ from their sisters on eating variables. The increased risk of BN due to childhood overweight suggests that prevention strategies for childhood obesity and overweight may therefore be applicable in BN.
Appetite, 2007
To examine whether there is an association between individual and family eating patterns during c... more To examine whether there is an association between individual and family eating patterns during childhood and the likelihood of developing an eating disorder (ED) later in life. The sample comprised 261 eating disorder patients [33.5% [N ¼ 88] anorexia nervosa (AN), 47.2% [N ¼ 123] with bulimia nervosa (BN) and 19.3% [N ¼ 50] with Eating Disorders Not Otherwise Specified (EDNOS)] and 160 healthy controls from the Province of Catalonia, Spain, who were matched for age and education. All patients were consecutively admitted to our Psychiatry Department and were diagnosed according to DSM-IV criteria. Participants completed the Early Eating Environmental Subscale of the Cross-Cultural (Environmental) Questionnaire (CCQ), a retrospective measure of childhood eating attitudes and behaviours. In the control group, also the General Health Questionnaire-28 (GHQ-28) was used. During childhood and early adolescence, the following main factors were identified to be linked to eating disorders: eating excessive sweets and snacks and consuming food specially prepared for the respondent. Conversely, regular breakfast consumption was negatively associated with an eating disorder. Compared to healthy controls, eating disorder patients report unfavourable eating patterns early in life, which in conjunction with an excessive importance given to food by the individual and the family may increase the likelihood for developing a subsequent eating disorder. r
To examine whether there is an association between individual and family eating patterns during c... more To examine whether there is an association between individual and family eating patterns during childhood and the likelihood of developing an eating disorder (ED) later in life. The sample comprised 261 eating disorder patients (33.5% (N ¼ 88) anorexia nervosa (AN), 47.2% (N ¼ 123) with bulimia nervosa (BN) and 19.3% (N ¼ 50) with Eating Disorders Not Otherwise Specified