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Papers by Lauren Barnes
Bulletin of the American Physical Society, 2020
The standard of care treatment for neovascular age-related macular degeneration, delivered as ocu... more The standard of care treatment for neovascular age-related macular degeneration, delivered as ocular injection, is based on anti-vascular endothelial growth factor (anti-VEGF). The course of treatment may need to be modified quickly for certain patients based on their response. Models that track both the concentration and the response to an anti-VEGF treatment are presented. The specific focus is to assess the existence of analytical solutions for the different types of models. Both an ODE-based model and a map-based model illustrate the dependence of the solution on various biological parameters and allow the measurement of patient-specific parameters from experimental data. A PDE-based model incorporates diffusive effects. The results are consistent with observed values, and could provide a framework for practitioners to understand the effect of the therapy on the progression of the disease in both responsive and non-responsive patients.
Lauren Barnes, Katelynn Huneycutt, Elita Lobo, Nick Mazzoleni, Jenna McDanold, Richard Moore, Apr... more Lauren Barnes, Katelynn Huneycutt, Elita Lobo, Nick Mazzoleni, Jenna McDanold, Richard Moore, Aprajita Singh, Jerome Troy, and Thomas Tu New Jersey Institute of Technology University of Maryland, Baltimore County University of Massachusetts, Amherst North Carolina State University Rochester Institute of Technology University of Texas, Dallas University of Delaware University of California, Los Angeles
Comptes Rendus. Mécanique, 2020
Bulletin of the American Physical Society, 2020
The standard of care treatment for neovascular age-related macular degeneration, delivered as ocu... more The standard of care treatment for neovascular age-related macular degeneration, delivered as ocular injection, is based on anti-vascular endothelial growth factor (anti-VEGF). The course of treatment may need to be modified quickly for certain patients based on their response. Models that track both the concentration and the response to an anti-VEGF treatment are presented. The specific focus is to assess the existence of analytical solutions for the different types of models. Both an ODE-based model and a map-based model illustrate the dependence of the solution on various biological parameters and allow the measurement of patient-specific parameters from experimental data. A PDE-based model incorporates diffusive effects. The results are consistent with observed values, and could provide a framework for practitioners to understand the effect of the therapy on the progression of the disease in both responsive and non-responsive patients.
Lauren Barnes, Katelynn Huneycutt, Elita Lobo, Nick Mazzoleni, Jenna McDanold, Richard Moore, Apr... more Lauren Barnes, Katelynn Huneycutt, Elita Lobo, Nick Mazzoleni, Jenna McDanold, Richard Moore, Aprajita Singh, Jerome Troy, and Thomas Tu New Jersey Institute of Technology University of Maryland, Baltimore County University of Massachusetts, Amherst North Carolina State University Rochester Institute of Technology University of Texas, Dallas University of Delaware University of California, Los Angeles
Comptes Rendus. Mécanique, 2020