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Papers by Laxminarain Misra

Research paper thumbnail of ChemInform Abstract: 5-METHYLCOUMARIN DERIVATIVES FROM LYCOSERIS LATIFOLIA

Chemischer Informationsdienst, 1985

ChemInform Abstract Aus oberirdischen Teilen von Lycoseris latifolia wurden die Cumarin-Derivate ... more ChemInform Abstract Aus oberirdischen Teilen von Lycoseris latifolia wurden die Cumarin-Derivate (I)-(VI) (Diskussion der Biogenese) sowie die Verbindungen (VII) und (VIIIa)/(VIIIb) (nicht getrenntes Gemisch) isoliert und strukturell untersucht (NOE-Differenzspektroskopie). Die chemotaxonomische Bedeutung dieser Verbindungen wird kurz diskutiert.

Research paper thumbnail of In vitro withanolide production by Withania somnifera L. cultures

Zeitschrift fur Naturforschung. Section C, Biosciences

In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibit... more In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibited the potentiality to produce pharmacologically active withanolides. Multiple shoots cultures exhibited an increase in withanolide A accumulation compared to shoots of the mother plant. In vitro generated root cultures as well as callus and suspension cultures also produced withanolides albeit at lower levels.

Research paper thumbnail of High Concentration of Hepatoprotective Oleanolic Acid and its Derivatives in Lantana camara Roots*

Planta Medica, 1997

1. Planta Med. 1997 Dec;63(6):582. High concentration of hepatoprotective oleanolic acid and its ... more 1. Planta Med. 1997 Dec;63(6):582. High concentration of hepatoprotective oleanolic acid and its derivatives in Lantana camara roots. Misra LN, Dixit AK, Sharma RP. Phytochemical Technology Division, Central Institute of ...

Research paper thumbnail of New Sesquiterpene Lactone Type from Dugaldia hoopesii

Journal of Natural Products, 1984

Research paper thumbnail of Volatile Constituents of Dracocephalum nutans

Planta Medica, 1988

The essential oil of DRACOCEPHALUM NUTANS L. (Lamiaceae) has been investigated for the first time... more The essential oil of DRACOCEPHALUM NUTANS L. (Lamiaceae) has been investigated for the first time. The GC-MS analysis of the oil showed the presence of about 25 monoterpenoids including pinocamphone (56.4%), beta-pinene (12.7%), isopinocamphone (4.3%), alpha-phellandrene (4.6%), and isopinocampheol (3.7%).

Research paper thumbnail of Guaianolide α-arabinopyranosides from Helenium amarum

Phytochemistry

Abstract The aerial parts of Helenium amarum afforded, in addition to compounds reported previous... more Abstract The aerial parts of Helenium amarum afforded, in addition to compounds reported previously, several known sesquiterpene lactones as well as some new ones, two pseudoguaianolides and a complex mixture of guaianolide α-arabinopyranosides, which differed in the position of the double bond, the configuration at C-8 and the position of an acetate group in the sugar moiety. Furthermore seco-caryophyllenes and phenylpropane derivatives were isolated. The structures were elucidated by spectroscopic methods and few chemical transformations.

Research paper thumbnail of Isolation and Characterization of Steroids of Nutraceutical Value in Physalis minima

Preventive Nutrition and Food Science, 2006

Abstract (English) There is great demand of nutraceutical secondary metabolites in the world so a... more Abstract (English) There is great demand of nutraceutical secondary metabolites in the world so as to feed the population by improving agricultural production with new varieties of food crops but what is still more important is to add nutrition into the food. Physalis minima, ...

Research paper thumbnail of Process isolation of withaferin-A from plant materials and products therefrom

Research paper thumbnail of Composition of the essential oil of Cedrus deodara

Research paper thumbnail of Weitere Phloroglucin- und a-Pyron-Derivate aus Helichrysum -Arten

Research paper thumbnail of Schematic representation of metabolic pathway of tropane alkaloid biosynthesis. TR-I, Tropinone reductase I; TR-II, Tropinone reductase II

Research paper thumbnail of A pharmaceutical composition useful as an immunomodulating agent and a process for the preparation thereof

Research paper thumbnail of Alkaloidal constituents of seeds

Research paper thumbnail of Leaves of Solanaceae Plants Possess Full Metabolic Competence to Synthesize Tropane Alkaloids: Evidences from Withania

Medicinal plants are key resources to derive phytomolecule based leads for drug discovery and dev... more Medicinal plants are key resources to derive phytomolecule based leads for drug discovery and development. A number of Solanaceae plants have been described to possess medicinal properties such as members of the genus Withania, W. somnifera (Ashwagandha) and W. coagulans. Rejuvenating properties of these herbs are well documented and ascribed to the presence of a set of pharmacologically important compounds such as withanolides, withanamides and alkaloids. Tropane alkaloids (Hyoscyamine, Atropine, Scopolamine) are amongst the oldest known drugs. Tropinone reductases (TRs) are the branching enzymes in the tropane biosynthetic pathway belonging to the SDR family of proteins. These catalyze the conversion of tropinone into tropine or pseudotropine thereby bifurcating the pathway leading to synthesis of hyoscyamine, scopolamine and calystegines. Tropinone reductase genes were isolated and characterized from W. somnifera and W.coagulans. The recombinant enzymes exhibited characteristic c...

Research paper thumbnail of Seco-helenanolides from Dugaldia integrifolia

Phytochemistry, 1985

Abstract The aerial parts of Dugaldia integrifolia afforded, in addition to acetylhymenograndin, ... more Abstract The aerial parts of Dugaldia integrifolia afforded, in addition to acetylhymenograndin, floribundin, hymenoxon and isotelekin, three new seco -helenanolides and two derivatives of silphinene, one being isolated previously from Dugaldia hoopesii

Research paper thumbnail of 19β → 28-Lactonization of Pomonic Acid from Lantana camara roots

Zeitschrift für Naturforschung B, 2000

Lantana camara L. var. aculeata yielded a triterpenoid, pomonic acid (1). The acid-catalyzed lact... more Lantana camara L. var. aculeata yielded a triterpenoid, pomonic acid (1). The acid-catalyzed lactonization of this γ-hydroxy acid afforded a rearranged lactone 3, the structure of which was as­ signed by detailed 2D-NMR studies. A reaction mechanism involving a 1,3-butadiene intermediate is proposed.

Research paper thumbnail of New Withanolides from Fresh Berries of Withania somnifera

Zeitschrift für Naturforschung B, 2006

The chloroform extract of the fresh berries of Withania somnifera has been investigated to afford... more The chloroform extract of the fresh berries of Withania somnifera has been investigated to afford stigmasterol, its glucoside, withanone, 27-hydroxy withanolide A along with two new withanolides, namely, iso-withanone (1) and 6α,7α-epoxy-1α,3β ,5α-trihydroxy-witha-24-enolide (2). Compound 1 possesses an uncommon 17α-oriented side chain whereas compound 2 has 1α,3β - dihydroxy group which is a molecule of biogenetic significance for withasteroids.

Research paper thumbnail of n-Alkanes and α-Palmitin from Paspalum scrobiculatum Seeds

Zeitschrift für Naturforschung C, 2000

Hexane and methanol extracts of Paspalum scrobiculatum seeds have yielded several known fatty aci... more Hexane and methanol extracts of Paspalum scrobiculatum seeds have yielded several known fatty acids, sterols, unusual straight chain hydrocarbons which are well known for their insect pheromone activity along with the antitumour glyceride, α-palmitin.

Research paper thumbnail of Fatty Acids and Sterols from Cymbopogon martinii var. Motia Roots

Zeitschrift für Naturforschung C, 2000

The hexane and methanol extracts of the roots of Cymbopogon martinii var. motia have been investi... more The hexane and methanol extracts of the roots of Cymbopogon martinii var. motia have been investigated to afford mainly fatty acids and common sterols. A new hydroxy unsaturated fatty acid, namely, 16-hydroxypentacos- 14(z)-enoic acid, has also been isolated.

Research paper thumbnail of Process for isolation of withaferin-A from plant materials and products therefrom

Research paper thumbnail of ChemInform Abstract: 5-METHYLCOUMARIN DERIVATIVES FROM LYCOSERIS LATIFOLIA

Chemischer Informationsdienst, 1985

ChemInform Abstract Aus oberirdischen Teilen von Lycoseris latifolia wurden die Cumarin-Derivate ... more ChemInform Abstract Aus oberirdischen Teilen von Lycoseris latifolia wurden die Cumarin-Derivate (I)-(VI) (Diskussion der Biogenese) sowie die Verbindungen (VII) und (VIIIa)/(VIIIb) (nicht getrenntes Gemisch) isoliert und strukturell untersucht (NOE-Differenzspektroskopie). Die chemotaxonomische Bedeutung dieser Verbindungen wird kurz diskutiert.

Research paper thumbnail of In vitro withanolide production by Withania somnifera L. cultures

Zeitschrift fur Naturforschung. Section C, Biosciences

In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibit... more In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibited the potentiality to produce pharmacologically active withanolides. Multiple shoots cultures exhibited an increase in withanolide A accumulation compared to shoots of the mother plant. In vitro generated root cultures as well as callus and suspension cultures also produced withanolides albeit at lower levels.

Research paper thumbnail of High Concentration of Hepatoprotective Oleanolic Acid and its Derivatives in Lantana camara Roots*

Planta Medica, 1997

1. Planta Med. 1997 Dec;63(6):582. High concentration of hepatoprotective oleanolic acid and its ... more 1. Planta Med. 1997 Dec;63(6):582. High concentration of hepatoprotective oleanolic acid and its derivatives in Lantana camara roots. Misra LN, Dixit AK, Sharma RP. Phytochemical Technology Division, Central Institute of ...

Research paper thumbnail of New Sesquiterpene Lactone Type from Dugaldia hoopesii

Journal of Natural Products, 1984

Research paper thumbnail of Volatile Constituents of Dracocephalum nutans

Planta Medica, 1988

The essential oil of DRACOCEPHALUM NUTANS L. (Lamiaceae) has been investigated for the first time... more The essential oil of DRACOCEPHALUM NUTANS L. (Lamiaceae) has been investigated for the first time. The GC-MS analysis of the oil showed the presence of about 25 monoterpenoids including pinocamphone (56.4%), beta-pinene (12.7%), isopinocamphone (4.3%), alpha-phellandrene (4.6%), and isopinocampheol (3.7%).

Research paper thumbnail of Guaianolide α-arabinopyranosides from Helenium amarum

Phytochemistry

Abstract The aerial parts of Helenium amarum afforded, in addition to compounds reported previous... more Abstract The aerial parts of Helenium amarum afforded, in addition to compounds reported previously, several known sesquiterpene lactones as well as some new ones, two pseudoguaianolides and a complex mixture of guaianolide α-arabinopyranosides, which differed in the position of the double bond, the configuration at C-8 and the position of an acetate group in the sugar moiety. Furthermore seco-caryophyllenes and phenylpropane derivatives were isolated. The structures were elucidated by spectroscopic methods and few chemical transformations.

Research paper thumbnail of Isolation and Characterization of Steroids of Nutraceutical Value in Physalis minima

Preventive Nutrition and Food Science, 2006

Abstract (English) There is great demand of nutraceutical secondary metabolites in the world so a... more Abstract (English) There is great demand of nutraceutical secondary metabolites in the world so as to feed the population by improving agricultural production with new varieties of food crops but what is still more important is to add nutrition into the food. Physalis minima, ...

Research paper thumbnail of Process isolation of withaferin-A from plant materials and products therefrom

Research paper thumbnail of Composition of the essential oil of Cedrus deodara

Research paper thumbnail of Weitere Phloroglucin- und a-Pyron-Derivate aus Helichrysum -Arten

Research paper thumbnail of Schematic representation of metabolic pathway of tropane alkaloid biosynthesis. TR-I, Tropinone reductase I; TR-II, Tropinone reductase II

Research paper thumbnail of A pharmaceutical composition useful as an immunomodulating agent and a process for the preparation thereof

Research paper thumbnail of Alkaloidal constituents of seeds

Research paper thumbnail of Leaves of Solanaceae Plants Possess Full Metabolic Competence to Synthesize Tropane Alkaloids: Evidences from Withania

Medicinal plants are key resources to derive phytomolecule based leads for drug discovery and dev... more Medicinal plants are key resources to derive phytomolecule based leads for drug discovery and development. A number of Solanaceae plants have been described to possess medicinal properties such as members of the genus Withania, W. somnifera (Ashwagandha) and W. coagulans. Rejuvenating properties of these herbs are well documented and ascribed to the presence of a set of pharmacologically important compounds such as withanolides, withanamides and alkaloids. Tropane alkaloids (Hyoscyamine, Atropine, Scopolamine) are amongst the oldest known drugs. Tropinone reductases (TRs) are the branching enzymes in the tropane biosynthetic pathway belonging to the SDR family of proteins. These catalyze the conversion of tropinone into tropine or pseudotropine thereby bifurcating the pathway leading to synthesis of hyoscyamine, scopolamine and calystegines. Tropinone reductase genes were isolated and characterized from W. somnifera and W.coagulans. The recombinant enzymes exhibited characteristic c...

Research paper thumbnail of Seco-helenanolides from Dugaldia integrifolia

Phytochemistry, 1985

Abstract The aerial parts of Dugaldia integrifolia afforded, in addition to acetylhymenograndin, ... more Abstract The aerial parts of Dugaldia integrifolia afforded, in addition to acetylhymenograndin, floribundin, hymenoxon and isotelekin, three new seco -helenanolides and two derivatives of silphinene, one being isolated previously from Dugaldia hoopesii

Research paper thumbnail of 19β → 28-Lactonization of Pomonic Acid from Lantana camara roots

Zeitschrift für Naturforschung B, 2000

Lantana camara L. var. aculeata yielded a triterpenoid, pomonic acid (1). The acid-catalyzed lact... more Lantana camara L. var. aculeata yielded a triterpenoid, pomonic acid (1). The acid-catalyzed lactonization of this γ-hydroxy acid afforded a rearranged lactone 3, the structure of which was as­ signed by detailed 2D-NMR studies. A reaction mechanism involving a 1,3-butadiene intermediate is proposed.

Research paper thumbnail of New Withanolides from Fresh Berries of Withania somnifera

Zeitschrift für Naturforschung B, 2006

The chloroform extract of the fresh berries of Withania somnifera has been investigated to afford... more The chloroform extract of the fresh berries of Withania somnifera has been investigated to afford stigmasterol, its glucoside, withanone, 27-hydroxy withanolide A along with two new withanolides, namely, iso-withanone (1) and 6α,7α-epoxy-1α,3β ,5α-trihydroxy-witha-24-enolide (2). Compound 1 possesses an uncommon 17α-oriented side chain whereas compound 2 has 1α,3β - dihydroxy group which is a molecule of biogenetic significance for withasteroids.

Research paper thumbnail of n-Alkanes and α-Palmitin from Paspalum scrobiculatum Seeds

Zeitschrift für Naturforschung C, 2000

Hexane and methanol extracts of Paspalum scrobiculatum seeds have yielded several known fatty aci... more Hexane and methanol extracts of Paspalum scrobiculatum seeds have yielded several known fatty acids, sterols, unusual straight chain hydrocarbons which are well known for their insect pheromone activity along with the antitumour glyceride, α-palmitin.

Research paper thumbnail of Fatty Acids and Sterols from Cymbopogon martinii var. Motia Roots

Zeitschrift für Naturforschung C, 2000

The hexane and methanol extracts of the roots of Cymbopogon martinii var. motia have been investi... more The hexane and methanol extracts of the roots of Cymbopogon martinii var. motia have been investigated to afford mainly fatty acids and common sterols. A new hydroxy unsaturated fatty acid, namely, 16-hydroxypentacos- 14(z)-enoic acid, has also been isolated.

Research paper thumbnail of Process for isolation of withaferin-A from plant materials and products therefrom