Dylan Lederman - Academia.edu (original) (raw)
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Papers by Dylan Lederman
Mathematics, 2022
Parameter estimation from observable or experimental data is a crucial stage in any modeling stud... more Parameter estimation from observable or experimental data is a crucial stage in any modeling study. Identifiability refers to one’s ability to uniquely estimate the model parameters from the available data. Structural unidentifiability in dynamic models, the opposite of identifiability, is associated with the notion of degeneracy where multiple parameter sets produce the same pattern. Therefore, the inverse function of determining the model parameters from the data is not well defined. Degeneracy is not only a mathematical property of models, but it has also been reported in biological experiments. Classical studies on structural unidentifiability focused on the notion that one can at most identify combinations of unidentifiable model parameters. We have identified a different type of structural degeneracy/unidentifiability present in a family of models, which we refer to as the Lambda-Omega (Λ-Ω) models. These are an extension of the classical lambda-omega (λ-ω) models that have be...
Mathematics, 2022
Parameter estimation from observable or experimental data is a crucial stage in any modeling stud... more Parameter estimation from observable or experimental data is a crucial stage in any modeling study. Identifiability refers to one’s ability to uniquely estimate the model parameters from the available data. Structural unidentifiability in dynamic models, the opposite of identifiability, is associated with the notion of degeneracy where multiple parameter sets produce the same pattern. Therefore, the inverse function of determining the model parameters from the data is not well defined. Degeneracy is not only a mathematical property of models, but it has also been reported in biological experiments. Classical studies on structural unidentifiability focused on the notion that one can at most identify combinations of unidentifiable model parameters. We have identified a different type of structural degeneracy/unidentifiability present in a family of models, which we refer to as the Lambda-Omega (Λ-Ω) models. These are an extension of the classical lambda-omega (λ-ω) models that have be...