León Ferder - Academia.edu (original) (raw)
Papers by León Ferder
Plastic and Reconstructive Surgery, 2008
Current Hypertension Reports
Hypertension, 2000
P183 Oxidative stress has been involved as a possible mechanism of tissue injury. The effect of E... more P183 Oxidative stress has been involved as a possible mechanism of tissue injury. The effect of E on OxS and tissue injury was studied in kidney and heart from streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley, were divided into: STZ (65 mg/kg, single i.p. dose); STZ+E (STZ and E, 20 mg E /L drinking water), and Control (C) (saline i.p. and tap water). At 6 mo. organs were studied by light microscopy. Glomerular (GML) and tubulointerstitial lesions (TIL) were graded by a semiquantitative score (0-4). Glycemia, creatinine clearance (CrCl) and proteinuria were determined. OxS was evaluated by determining total glutathione content (GSH), protein-associated sulfhydryls (SH) and 2-thiobarbituric reactive substances (TBARS, an indicator of lipid oxidation) in kidney and heart homogenates. In STZ rats E decreased proteinuria, GML and TIL,and increased CrCl. In kidney and heart, E attenuated OxS associated to STZ. Results suggest that, in addition to previously described mecha...
Hypertension, 2013
Background: Chronic kidney disease is highly prevalent and is associated with cardiovascular dise... more Background: Chronic kidney disease is highly prevalent and is associated with cardiovascular disease. Paricalcitol protects individuals from some of the renal and cardiovascular complications associated with kidney disease. However, its electrophysiological effect during myocardial ischemia-reperfusion is currently unknown. Aims: Using an obstructive nephropathy (ON) model, we plan to investigate the potential, structural, and functional changes of the heart that are linked to vitamin D deficiency. Methods: The ureters of adult rats (n = 10) were unilaterally obstructed. An inductor of the vitamin D receptor (VDR) was administered for 15 days (30ng/Kg/day, ip). We evaluated histological, molecular, and biochemical parameters, as well, cardiac electrophysiological activity with ischemia-reperfusion protocol. Results: we found changes in the action potential duration (APD) at 90% (* P<0.05 vs. C, +P<0.05 vs. O). The analysis revealed arrhythmias, ventricular tachycardia (VT), an...
Protein expression in SHRs cortex kidney. Representative blot of WT-1, VDR, Hsp70 and AT1 protein... more Protein expression in SHRs cortex kidney. Representative blot of WT-1, VDR, Hsp70 and AT1 protein expression in SHRs cortex kidney. Housekeeping gene β-actin protein expression is shown in the line here below. (TIF 26384 kb)
Insights in Clinical and Cellular Immunology, 2021
Current Protein & Peptide Science, 2020
Background: The neuroinflammatory process is associated with the pathogenesis of many cardiovascu... more Background: The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack of vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. Purpose of Review: This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central nervous system. Besides, the present article condenses the evidence supporting the link between vitamin D and the RAAS in hypertension and neuroinflammation. Highlights Standpoints: Vitamin D deficiency is highly prevalent in the world, and the rising prevalence of neuroinflammatory diseases and associated pathologies such as hypertension around the world...
The Journal of Steroid Biochemistry and Molecular Biology, 2020
Current Hypertension Reports, 2020
Current hypertension reports, Jan 9, 2018
Here, we review the known relations between hypertension and obesity to inflammation and postulat... more Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent. We will describe the multiple effects of melatonin on blood pressure, adiposity, body weight, and focus on mitochondrial-related anti-inflammatory and antioxidant protective effects. Hypertension and obesity are usually associated with systemic and tissular inflammation. The progressive affection of target-organs involves multiple mediators of inflammation, most of them redundant, which make anti-inflammatory strategies ineffective. Melatonin reduces blood pressure, body weight, and inflammation. The mechanisms of action of this ancient molecule of protection involve multiple levels of action, from subcellular to intercellular. Mitochondria is a key inflammatory element in vascular and adipose tissue and a potential pharmacological target. Melatonin protects against mitochondrial dysfunction. Melato...
Current Hypertension Reports, 2017
Current Hypertension Reports, 2015
Cardiovascular Research, 2011
American Journal of Hypertension, 2000
Cell Stress and Chaperones
Previous hypertension studies have shown that low levels of vitamin D are linked to elevated reni... more Previous hypertension studies have shown that low levels of vitamin D are linked to elevated renin-angiotensin system. The heat shock protein 70 regulates signaling pathways for cellular oxidative stress responses. Hsp70 has been shown to protect against Angiotensin II-induced hypertension and exert a cytoprotective effect. Here, we wanted to evaluate whether the vitamin D receptor (VDR) associated with Hsp70/AT1 expression may be involved in the mechanism by which paricalcitol provides renal protection in spontaneously hypertensive rats (SHRs). One-month-old female SHRs were treated for 4 months with vehicle, paricalcitol, enalapril, or a combination of both paricalcitol and enalapril. The following were determined: blood pressure; biochemical parameters; fibrosis; apoptosis; mitochondrial morphology; and VDR, AT1 receptor, and Hsp70 expression in the renal cortex. Blood pressure was markedly reduced by enalapril or the combination but not by paricalcitol alone. However, VDR activa...
American Journal of Hypertension, 1997
Journal of cardiovascular pharmacology and therapeutics, Jan 12, 2014
Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial... more Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial vitamin D receptors (VDRs) are among the probable links between the 2 disorders. The vitamin D receptor activator paricalcitol protects against some renal and cardiovascular complications. However, the structural and electrophysiological effects of myocardial vitamin D receptor modification and its impact on the response to ischemia-reperfusion are currently unknown. This work attempted to determine whether obstructive nephropathy induced myocardial changes (in rats) linked to vitamin D receptor deficiency and to ventricular arrhythmias in Langendorff-perfused hearts. Unilateral ureteral-obstructed and Sham-operated rats were treated with either paricalcitol (30 ng/kg/d intraperitoneal) or vehicle for 15 days. In 5 hearts from each group, we found that obstructed rats showed a reduction in VDRs and an increase in angiotensin II type 1 receptor expression (messenger RNA and protein), suf...
Nephron, 1990
Ten patients (6 men, 4 women, age range 35-64 years) with glomerulopathies were studied. Diagnose... more Ten patients (6 men, 4 women, age range 35-64 years) with glomerulopathies were studied. Diagnoses were membranoproliferative glomerulonephritis (GN; n = 4), membranous GN (n = 3), focal and diffuse glomerulosclerosis (n = 2), and poststreptococcal GN (n = 1). These were confirmed by renal biopsy in 8 of the 10 patients. All patients had reduced function (creatinine clearance 15-55 ml/min); proteinuria ranged from 1.0 to 10.4 g/day. Three normotensive patients received enalapril 10 mg once daily. Seven hypertensives received enalapril 10-40 mg once daily to control blood pressure (BP). Concomitant diuretic therapy (furosemide/bumetanide) was administered to 6 patients. There were visits every 14 days for a mean of 15.9 months (range 9-26 months). Diet was monitored, and BP was significantly controlled in the hypertensive patients but not altered in the normotensives. Serum creatinine, blood urea nitrogen, creatinine clearance, and 24-hour urinary protein improved and did not deteriorate progressively. Serum potassium did not change significantly. No adverse clinical events were noted. Enalapril therapy may improve the prognosis for GN over time by maintaining glomerular filtration rate and decreasing proteinuria.
Plastic and Reconstructive Surgery, 2008
Current Hypertension Reports
Hypertension, 2000
P183 Oxidative stress has been involved as a possible mechanism of tissue injury. The effect of E... more P183 Oxidative stress has been involved as a possible mechanism of tissue injury. The effect of E on OxS and tissue injury was studied in kidney and heart from streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley, were divided into: STZ (65 mg/kg, single i.p. dose); STZ+E (STZ and E, 20 mg E /L drinking water), and Control (C) (saline i.p. and tap water). At 6 mo. organs were studied by light microscopy. Glomerular (GML) and tubulointerstitial lesions (TIL) were graded by a semiquantitative score (0-4). Glycemia, creatinine clearance (CrCl) and proteinuria were determined. OxS was evaluated by determining total glutathione content (GSH), protein-associated sulfhydryls (SH) and 2-thiobarbituric reactive substances (TBARS, an indicator of lipid oxidation) in kidney and heart homogenates. In STZ rats E decreased proteinuria, GML and TIL,and increased CrCl. In kidney and heart, E attenuated OxS associated to STZ. Results suggest that, in addition to previously described mecha...
Hypertension, 2013
Background: Chronic kidney disease is highly prevalent and is associated with cardiovascular dise... more Background: Chronic kidney disease is highly prevalent and is associated with cardiovascular disease. Paricalcitol protects individuals from some of the renal and cardiovascular complications associated with kidney disease. However, its electrophysiological effect during myocardial ischemia-reperfusion is currently unknown. Aims: Using an obstructive nephropathy (ON) model, we plan to investigate the potential, structural, and functional changes of the heart that are linked to vitamin D deficiency. Methods: The ureters of adult rats (n = 10) were unilaterally obstructed. An inductor of the vitamin D receptor (VDR) was administered for 15 days (30ng/Kg/day, ip). We evaluated histological, molecular, and biochemical parameters, as well, cardiac electrophysiological activity with ischemia-reperfusion protocol. Results: we found changes in the action potential duration (APD) at 90% (* P<0.05 vs. C, +P<0.05 vs. O). The analysis revealed arrhythmias, ventricular tachycardia (VT), an...
Protein expression in SHRs cortex kidney. Representative blot of WT-1, VDR, Hsp70 and AT1 protein... more Protein expression in SHRs cortex kidney. Representative blot of WT-1, VDR, Hsp70 and AT1 protein expression in SHRs cortex kidney. Housekeeping gene β-actin protein expression is shown in the line here below. (TIF 26384 kb)
Insights in Clinical and Cellular Immunology, 2021
Current Protein & Peptide Science, 2020
Background: The neuroinflammatory process is associated with the pathogenesis of many cardiovascu... more Background: The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack of vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the essential mechanisms of blood pressure regulation. Purpose of Review: This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central nervous system. Besides, the present article condenses the evidence supporting the link between vitamin D and the RAAS in hypertension and neuroinflammation. Highlights Standpoints: Vitamin D deficiency is highly prevalent in the world, and the rising prevalence of neuroinflammatory diseases and associated pathologies such as hypertension around the world...
The Journal of Steroid Biochemistry and Molecular Biology, 2020
Current Hypertension Reports, 2020
Current hypertension reports, Jan 9, 2018
Here, we review the known relations between hypertension and obesity to inflammation and postulat... more Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent. We will describe the multiple effects of melatonin on blood pressure, adiposity, body weight, and focus on mitochondrial-related anti-inflammatory and antioxidant protective effects. Hypertension and obesity are usually associated with systemic and tissular inflammation. The progressive affection of target-organs involves multiple mediators of inflammation, most of them redundant, which make anti-inflammatory strategies ineffective. Melatonin reduces blood pressure, body weight, and inflammation. The mechanisms of action of this ancient molecule of protection involve multiple levels of action, from subcellular to intercellular. Mitochondria is a key inflammatory element in vascular and adipose tissue and a potential pharmacological target. Melatonin protects against mitochondrial dysfunction. Melato...
Current Hypertension Reports, 2017
Current Hypertension Reports, 2015
Cardiovascular Research, 2011
American Journal of Hypertension, 2000
Cell Stress and Chaperones
Previous hypertension studies have shown that low levels of vitamin D are linked to elevated reni... more Previous hypertension studies have shown that low levels of vitamin D are linked to elevated renin-angiotensin system. The heat shock protein 70 regulates signaling pathways for cellular oxidative stress responses. Hsp70 has been shown to protect against Angiotensin II-induced hypertension and exert a cytoprotective effect. Here, we wanted to evaluate whether the vitamin D receptor (VDR) associated with Hsp70/AT1 expression may be involved in the mechanism by which paricalcitol provides renal protection in spontaneously hypertensive rats (SHRs). One-month-old female SHRs were treated for 4 months with vehicle, paricalcitol, enalapril, or a combination of both paricalcitol and enalapril. The following were determined: blood pressure; biochemical parameters; fibrosis; apoptosis; mitochondrial morphology; and VDR, AT1 receptor, and Hsp70 expression in the renal cortex. Blood pressure was markedly reduced by enalapril or the combination but not by paricalcitol alone. However, VDR activa...
American Journal of Hypertension, 1997
Journal of cardiovascular pharmacology and therapeutics, Jan 12, 2014
Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial... more Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial vitamin D receptors (VDRs) are among the probable links between the 2 disorders. The vitamin D receptor activator paricalcitol protects against some renal and cardiovascular complications. However, the structural and electrophysiological effects of myocardial vitamin D receptor modification and its impact on the response to ischemia-reperfusion are currently unknown. This work attempted to determine whether obstructive nephropathy induced myocardial changes (in rats) linked to vitamin D receptor deficiency and to ventricular arrhythmias in Langendorff-perfused hearts. Unilateral ureteral-obstructed and Sham-operated rats were treated with either paricalcitol (30 ng/kg/d intraperitoneal) or vehicle for 15 days. In 5 hearts from each group, we found that obstructed rats showed a reduction in VDRs and an increase in angiotensin II type 1 receptor expression (messenger RNA and protein), suf...
Nephron, 1990
Ten patients (6 men, 4 women, age range 35-64 years) with glomerulopathies were studied. Diagnose... more Ten patients (6 men, 4 women, age range 35-64 years) with glomerulopathies were studied. Diagnoses were membranoproliferative glomerulonephritis (GN; n = 4), membranous GN (n = 3), focal and diffuse glomerulosclerosis (n = 2), and poststreptococcal GN (n = 1). These were confirmed by renal biopsy in 8 of the 10 patients. All patients had reduced function (creatinine clearance 15-55 ml/min); proteinuria ranged from 1.0 to 10.4 g/day. Three normotensive patients received enalapril 10 mg once daily. Seven hypertensives received enalapril 10-40 mg once daily to control blood pressure (BP). Concomitant diuretic therapy (furosemide/bumetanide) was administered to 6 patients. There were visits every 14 days for a mean of 15.9 months (range 9-26 months). Diet was monitored, and BP was significantly controlled in the hypertensive patients but not altered in the normotensives. Serum creatinine, blood urea nitrogen, creatinine clearance, and 24-hour urinary protein improved and did not deteriorate progressively. Serum potassium did not change significantly. No adverse clinical events were noted. Enalapril therapy may improve the prognosis for GN over time by maintaining glomerular filtration rate and decreasing proteinuria.