Lev Balashov - Academia.edu (original) (raw)
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Papers by Lev Balashov
Pediatr (Sankt-Peterburg), 2015
Kin substitutes present a heterogenous group of substances that aid in temporary or permanent cov... more Kin substitutes present a heterogenous group of substances that aid in temporary or permanent covering of wounds of various types. Although they can not replace surgical debridement or standard methods of treatment they proffer an alternative to standard methods of treatment whenever the latter are ineffective. Skin substitutes require less wound vascularization, they increase the wound’s cutaneous component, decrease or eliminate inhibitory factors, decrease inflammatory process and grant quick and safe wound closing. Mast cells besides regulating vascular reactions in trauma zone also boost immune, defensive and reparative processes in the wound. Stimulatory influence of mast cells upon fibrosis depend on activation of fibroblasts rather than direct collagen production by mast cells. Attention is focused at studies of autologous adult stem-cells’ stimulation in various organs and tissues as well as at intercellular matrix (ICM). ICM besides being cells’ fastening substrate also co...
Pediatrician (St. Petersburg), 2015
Periodic 3-hour daily exposition of white rats to hypoxic hypoxia (standard altitude 8250 m) for ... more Periodic 3-hour daily exposition of white rats to hypoxic hypoxia (standard altitude 8250 m) for 10 days have revealed males and females of both very young and extremely old age groups (“young” - 0,5 months old and “old” - 26 months old) to be more sensitive to chronic hypoxic hypoxia than mature middle-aged animals (“mature” - 3 months old). Their increased sensitivity was apparent in body mass dynamic changes, oxygen consumption, peripheral blood hemoglobin concentration, and red blood cells’ count and peroxidase activity. Parallel to these parameters hypophysis-adrenal system functional activity was assessed according to blood eosynophils’ amount, ascorbic acid adrenals’ concentration, hypophysis and adrenals relative masses changes and “resistance index”. Both male and female rats of “young” and “old” age groups demonstrated variability of different parameters however those characteristic of hypophysis-adrenals system functional activity were practically always involved. Granted...
Journal of Medicinal Food, 2009
Potentilla erecta, the tormentil, and its rhizome extracts have been known for a long time in tra... more Potentilla erecta, the tormentil, and its rhizome extracts have been known for a long time in traditional medicine as a remedy for the treatment of inflammations, wounds, and gastrointestinal disorders. Tormentil rhizomes have also been used as part of alcoholic beverages in Germany, the Ukraine, and Russia. Acute toxicity of an aqueous P. erecta rhizome extract was evaluated with a single dose administered by the intragastric route to rats and mice in dosages of 2.5 g/kg and 6.8 g/kg of body weight, respectively. Further, a single dose of this extract was applied intraperitoneally to rats and mice in dosages of 3.8 and 14.5 g/kg of body weight, respectively. After an observation period of 2 weeks after intragastric administration and 3 days following intraperitoneal administration, no mortality or any changes in appearance, behavior, or body weight occurred for both rats and mice in the high dosages mentioned. Macroscopic and microscopic studies of the internal organs of these rodents revealed no pathological changes. The data are in line with the long-time traditional use of P. erecta rhizome extracts and results from recent clinical trials in which no signs of any toxic effects have been known after the administration of a P. erecta rhizome extract for the treatment of ulcerative colitis in adults and rotavirus-induced diarrhea in children. Thus P. erecta rhizome extracts should be considered safe with respect to acute toxicity when applied to humans.
Pediatr (Sankt-Peterburg), 2015
Kin substitutes present a heterogenous group of substances that aid in temporary or permanent cov... more Kin substitutes present a heterogenous group of substances that aid in temporary or permanent covering of wounds of various types. Although they can not replace surgical debridement or standard methods of treatment they proffer an alternative to standard methods of treatment whenever the latter are ineffective. Skin substitutes require less wound vascularization, they increase the wound’s cutaneous component, decrease or eliminate inhibitory factors, decrease inflammatory process and grant quick and safe wound closing. Mast cells besides regulating vascular reactions in trauma zone also boost immune, defensive and reparative processes in the wound. Stimulatory influence of mast cells upon fibrosis depend on activation of fibroblasts rather than direct collagen production by mast cells. Attention is focused at studies of autologous adult stem-cells’ stimulation in various organs and tissues as well as at intercellular matrix (ICM). ICM besides being cells’ fastening substrate also co...
Pediatrician (St. Petersburg), 2015
Periodic 3-hour daily exposition of white rats to hypoxic hypoxia (standard altitude 8250 m) for ... more Periodic 3-hour daily exposition of white rats to hypoxic hypoxia (standard altitude 8250 m) for 10 days have revealed males and females of both very young and extremely old age groups (“young” - 0,5 months old and “old” - 26 months old) to be more sensitive to chronic hypoxic hypoxia than mature middle-aged animals (“mature” - 3 months old). Their increased sensitivity was apparent in body mass dynamic changes, oxygen consumption, peripheral blood hemoglobin concentration, and red blood cells’ count and peroxidase activity. Parallel to these parameters hypophysis-adrenal system functional activity was assessed according to blood eosynophils’ amount, ascorbic acid adrenals’ concentration, hypophysis and adrenals relative masses changes and “resistance index”. Both male and female rats of “young” and “old” age groups demonstrated variability of different parameters however those characteristic of hypophysis-adrenals system functional activity were practically always involved. Granted...
Journal of Medicinal Food, 2009
Potentilla erecta, the tormentil, and its rhizome extracts have been known for a long time in tra... more Potentilla erecta, the tormentil, and its rhizome extracts have been known for a long time in traditional medicine as a remedy for the treatment of inflammations, wounds, and gastrointestinal disorders. Tormentil rhizomes have also been used as part of alcoholic beverages in Germany, the Ukraine, and Russia. Acute toxicity of an aqueous P. erecta rhizome extract was evaluated with a single dose administered by the intragastric route to rats and mice in dosages of 2.5 g/kg and 6.8 g/kg of body weight, respectively. Further, a single dose of this extract was applied intraperitoneally to rats and mice in dosages of 3.8 and 14.5 g/kg of body weight, respectively. After an observation period of 2 weeks after intragastric administration and 3 days following intraperitoneal administration, no mortality or any changes in appearance, behavior, or body weight occurred for both rats and mice in the high dosages mentioned. Macroscopic and microscopic studies of the internal organs of these rodents revealed no pathological changes. The data are in line with the long-time traditional use of P. erecta rhizome extracts and results from recent clinical trials in which no signs of any toxic effects have been known after the administration of a P. erecta rhizome extract for the treatment of ulcerative colitis in adults and rotavirus-induced diarrhea in children. Thus P. erecta rhizome extracts should be considered safe with respect to acute toxicity when applied to humans.