Levend Ozkan - Academia.edu (original) (raw)

Papers by Levend Ozkan

Open Journal of Urology, 2016

International Journal of Clinical and Experimental Medicine, 2014

To determine the efficacy of a new method called by us as “gross intra-operative evaluation (GIE)... more To determine the efficacy of a new method called by us as “gross intra-operative evaluation (GIE)” for the assessment of surgical margin (SM) status. A total of 26 consecutive patients operated with cT1a-b renal tumors at a single center were included in this study. After the excision, the tumors were uniformly divided into two halves in the longitudinal axis ex vivo. In this way, margins were exposed for GIE for the evaluation of the safety of SMs. Findings of GIE were compared with the permanent section analysis in terms of SM status. Mean patient age, tumor size and margin thickness was 59 (38-79), 3.1 (1.5-6) cm and 3.7 (0.1-12) mm, respectively. In all patients, GIE showed intact margins and none of the patients had positive SM in the final pathological examination. There was no evidence of local recurrence or distant metastasis with a mean follow-up of 25 (4-104) months. All patients are alive. GIE of resected specimen without FS analysis is a safe and effective method for the evaluation of SMs in partial nephrectomy patients.

JPMA. The Journal of the Pakistan Medical Association, 2016

Persistent lymphatic drainage is uncommon after most of the surgical operations. It is related wi... more Persistent lymphatic drainage is uncommon after most of the surgical operations. It is related with mechanical, nutritional and immunological problems as well as electrolyte imbalance and protein deficiency. It is most commonly seen in retroperitoneal surgeries including abdominal aortic surgery and retroperitoneal lymph node dissection. Conservative management is the first treatment choice and resolves the problem in most cases. However persistent high output drainage may not be resolved with conservative approach and surgical or invasive treatment may become necessary. Additionally, surgical management of persistent lymphatic drainage has not been sufficiently discussed in the literature. In this study, we present a case of persistent very high output lymphatic drainage after right radical nephrectomy which failed with conservative approach and was successfully treated with surgical management.

Turkiye Klinikleri Journal of Urology Special Topics, 2010

... Akut komp li ke ol ma yan sis tit eti yo lo ji sin de %70-95 sık lık la Esc he ric hi a co li... more ... Akut komp li ke ol ma yan sis tit eti yo lo ji sin de %70-95 sık lık la Esc he ric hi a co li (E. Co li) rol oy - nar.5,6 Di ğer et ken ler sta fi lo ko kus sap ro fi ti kus, kleb si el la, pro te us, en te ro kok lar ve grup B strep to - kok lar ola rak sı ra la na bi lir.6 ...

Journal of Sexual Medicine

Journal of Sexual Medicine

Idiopathic scrotal calcinosis (ISC) is characterised by the presence of multiple firm scrotal nod... more Idiopathic scrotal calcinosis (ISC) is characterised by the presence of multiple firm scrotal nodules of unknown or controversial etiology. It is a rare, yet benign, entity of the scrotal skin. However, it affects the quality of life of the patients. Here, we describe a case report of ISC in a 50 year-old male patient with a 20 year-history of symptoms. Despite the delayed diagnosis, patient was treated with surgical excision succesfully. No recurrence has been seen by the end of the 3 years of follow-up. We also reviewed the literature.

In this study, we investigated the protective effects of pentoxifylline on the testes of male rat... more In this study, we investigated the protective effects of pentoxifylline on the testes of male rats exposed to cigarette smoke. Twenty-seven male Wistar rats were divided into 3 equal groups: Group 1 – control group with only saline (0.9% NaCl) injection for 8 weeks, Group 2 – cigarette smoke + saline for 8 weeks, and Group 3 –cigarette smoke + pentoxifylline for 8 weeks. The rats were killed after 8 weeks; the testes were fixed in paraformaldehyde 4% solution and processed for histological study. Paraffin sections (5 m) were stained with hematoxylin and eosin. TUNEL method was used to identify apoptotic cells. Immunoreactivity was examined by light microscopy. For statistical analysis, each mean was compared using the Mann-Whitney U-Wilcoxon rank sum W-test and level of significance was taken as p<0.05. Our results showed that the mean number of atrophic seminiferous tubules and apoptotic cells was significantly increased in Group 2, compared to other groups (p<0.05). Degener...

European Urology Supplements, 2010

European Urology Supplements, 2010

European Urology Supplements, 2010

The Journal of Urology, 2015

European Urology Supplements, 2014

International journal of clinical and experimental medicine, 2014

To evaluate exclusion of prostate cancer (PCa) by using empiric antibiotic treatment for patients... more To evaluate exclusion of prostate cancer (PCa) by using empiric antibiotic treatment for patients with total prostate specific antigen (PSA) between 4-10 ng/ml. A hundred asymptomatic men with a PSA between 4-10 ng/ml and normal digital rectal examination (DRE) were enrolled in this randomized prospective study. The treatment group (n=50) was given 400 mg of ofloxacin daily for 4 weeks, whereas the control group (n=50) was followed without any treatment. At the end of the four weeks, repeat PSA were measured and all patients underwent transrectal ultrasound (TRUS) guided biopsy, regardless of the repeat PSA levels. Totally 22 patients (22%) had prostate cancer (9 in treatment group and 13 in control group). A significant PSA decrease was observed in the treatment group at repeat PSA measurements (p=0.001). The PSA drop was also significantly more in patients without PCa than with PCa (p=0.028). In patients whose repeat PSA after antibiotic treatment decreased below 4 ng/ml, 2 times ...

International journal of clinical and experimental medicine, 2014

To determine the efficacy of a new method called by us as "gross intra-operative evaluation ... more To determine the efficacy of a new method called by us as "gross intra-operative evaluation (GIE)" for the assessment of surgical margin (SM) status. A total of 26 consecutive patients operated with cT1a-b renal tumors at a single center were included in this study. After the excision, the tumors were uniformly divided into two halves in the longitudinal axis ex vivo. In this way, margins were exposed for GIE for the evaluation of the safety of SMs. Findings of GIE were compared with the permanent section analysis in terms of SM status. Mean patient age, tumor size and margin thickness was 59 (38-79), 3.1 (1.5-6) cm and 3.7 (0.1-12) mm, respectively. In all patients, GIE showed intact margins and none of the patients had positive SM in the final pathological examination. There was no evidence of local recurrence or distant metastasis with a mean follow-up of 25 (4-104) months. All patients are alive. GIE of resected specimen without FS analysis is a safe and effective meth...

Toxicology and industrial health, 2011

In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced d... more In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced damage in rat kidney tissues. Twenty-seven male Wistar rats were used in the study. Animals were divided into three equal groups as follows: Group 1: control group with only normal saline (NS; 0.9% NaCl) injection for 8 weeks; Group 2: cigarette smoking and NS injection for 8 weeks; and Group 3: cigarette smoking and PTX injection for 8 weeks. The rats were sacrificed after 8 weeks and their kidneys were excised for histopathological analysis. Serial paraffin sections (5 µm) of the kidneys were cut and stained with hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS). The terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) method was used to assess apoptosis. Glomerular diameters, glomerular cell number and proximal tubule cell numbers were compared between the groups. Our results showed that PTX treatment prevented negative effe...

Korean Journal of Urology, 2010

Purpose: The aim of this study was to evaluate the effect of asymptomatic urethral caruncle (UC) ... more Purpose: The aim of this study was to evaluate the effect of asymptomatic urethral caruncle (UC) on micturition in women suffering from urinary incontinence. Materials and Methods: A total of 232 patients participated in the study. UC was diagnosed in 50 of 232 patients with urinary incontinence during a physical examination in our clinic. All cases were divided into 2 groups: UC combined with urinary incontinence (group 1) and urinary incontinence only (group 2). Urodynamic evaluations were performed according to the International Continence Society standards. Results: Both groups were similar in terms of voiding diary, pad test and residual urine volume. Urodynamic studies revealed no significant difference between group 1 and 2 (infravesical obstruction: 6% vs. 4.4%; overactive detrusor: 44% vs. 42.9% respectively). The rates of severe IPSS (37.8% vs. 20.9%) and severe cystocele (20.9% vs. 13.8%) were numerically higher in group 1 with no statistically significant difference. Conclusions: Our results suggest that there is no effect of asymptomatic UC on lower urinary tract symptoms in women with urinary incontinence. Therefore, treating asymptomatic UC is unnecessary in these patients. However, during incontinence surgery, it is the surgeon's decision whether to treat asymptomatic UC.

International journal of clinical and experimental medicine, 2014

The Allium Bulbar Urethral Stent (BUS) is a fully covered, self-expandable, large caliber metal s... more The Allium Bulbar Urethral Stent (BUS) is a fully covered, self-expandable, large caliber metal stent specially designed for the treatment of bulbar urethra strictures. The stent is intended for a long term use for the purpose of opening the occluded urethral passage and to allow spontaneous urination. This study objective was to evaluate the clinical efficacy of temporary placement of the Allium BUS stent. This was a prospective study in 54 men with recurrent benign urethral stricture conducted during 2009 to 2012. All men underwent an internal urethrotomy or dilatation procedure followed by an endoscopic stent placement. Clinical success was achieved in 44 (81.4%) of the 54 patients. No patient reported discomfort at the stent site. 2 stents migrated distally. 1 stent was occluded. All stents were removed in a mean time of 8.8 (range 3-18) months following implantation. This experience with the Allium BUS for treating urethral strictures suggests that it is safe and reliable treat...

Open Journal of Urology, 2016

International Journal of Clinical and Experimental Medicine, 2014

To determine the efficacy of a new method called by us as “gross intra-operative evaluation (GIE)... more To determine the efficacy of a new method called by us as “gross intra-operative evaluation (GIE)” for the assessment of surgical margin (SM) status. A total of 26 consecutive patients operated with cT1a-b renal tumors at a single center were included in this study. After the excision, the tumors were uniformly divided into two halves in the longitudinal axis ex vivo. In this way, margins were exposed for GIE for the evaluation of the safety of SMs. Findings of GIE were compared with the permanent section analysis in terms of SM status. Mean patient age, tumor size and margin thickness was 59 (38-79), 3.1 (1.5-6) cm and 3.7 (0.1-12) mm, respectively. In all patients, GIE showed intact margins and none of the patients had positive SM in the final pathological examination. There was no evidence of local recurrence or distant metastasis with a mean follow-up of 25 (4-104) months. All patients are alive. GIE of resected specimen without FS analysis is a safe and effective method for the evaluation of SMs in partial nephrectomy patients.

JPMA. The Journal of the Pakistan Medical Association, 2016

Persistent lymphatic drainage is uncommon after most of the surgical operations. It is related wi... more Persistent lymphatic drainage is uncommon after most of the surgical operations. It is related with mechanical, nutritional and immunological problems as well as electrolyte imbalance and protein deficiency. It is most commonly seen in retroperitoneal surgeries including abdominal aortic surgery and retroperitoneal lymph node dissection. Conservative management is the first treatment choice and resolves the problem in most cases. However persistent high output drainage may not be resolved with conservative approach and surgical or invasive treatment may become necessary. Additionally, surgical management of persistent lymphatic drainage has not been sufficiently discussed in the literature. In this study, we present a case of persistent very high output lymphatic drainage after right radical nephrectomy which failed with conservative approach and was successfully treated with surgical management.

Turkiye Klinikleri Journal of Urology Special Topics, 2010

... Akut komp li ke ol ma yan sis tit eti yo lo ji sin de %70-95 sık lık la Esc he ric hi a co li... more ... Akut komp li ke ol ma yan sis tit eti yo lo ji sin de %70-95 sık lık la Esc he ric hi a co li (E. Co li) rol oy - nar.5,6 Di ğer et ken ler sta fi lo ko kus sap ro fi ti kus, kleb si el la, pro te us, en te ro kok lar ve grup B strep to - kok lar ola rak sı ra la na bi lir.6 ...

Journal of Sexual Medicine

Journal of Sexual Medicine

Idiopathic scrotal calcinosis (ISC) is characterised by the presence of multiple firm scrotal nod... more Idiopathic scrotal calcinosis (ISC) is characterised by the presence of multiple firm scrotal nodules of unknown or controversial etiology. It is a rare, yet benign, entity of the scrotal skin. However, it affects the quality of life of the patients. Here, we describe a case report of ISC in a 50 year-old male patient with a 20 year-history of symptoms. Despite the delayed diagnosis, patient was treated with surgical excision succesfully. No recurrence has been seen by the end of the 3 years of follow-up. We also reviewed the literature.

In this study, we investigated the protective effects of pentoxifylline on the testes of male rat... more In this study, we investigated the protective effects of pentoxifylline on the testes of male rats exposed to cigarette smoke. Twenty-seven male Wistar rats were divided into 3 equal groups: Group 1 – control group with only saline (0.9% NaCl) injection for 8 weeks, Group 2 – cigarette smoke + saline for 8 weeks, and Group 3 –cigarette smoke + pentoxifylline for 8 weeks. The rats were killed after 8 weeks; the testes were fixed in paraformaldehyde 4% solution and processed for histological study. Paraffin sections (5 m) were stained with hematoxylin and eosin. TUNEL method was used to identify apoptotic cells. Immunoreactivity was examined by light microscopy. For statistical analysis, each mean was compared using the Mann-Whitney U-Wilcoxon rank sum W-test and level of significance was taken as p<0.05. Our results showed that the mean number of atrophic seminiferous tubules and apoptotic cells was significantly increased in Group 2, compared to other groups (p<0.05). Degener...

European Urology Supplements, 2010

European Urology Supplements, 2010

European Urology Supplements, 2010

The Journal of Urology, 2015

European Urology Supplements, 2014

International journal of clinical and experimental medicine, 2014

To evaluate exclusion of prostate cancer (PCa) by using empiric antibiotic treatment for patients... more To evaluate exclusion of prostate cancer (PCa) by using empiric antibiotic treatment for patients with total prostate specific antigen (PSA) between 4-10 ng/ml. A hundred asymptomatic men with a PSA between 4-10 ng/ml and normal digital rectal examination (DRE) were enrolled in this randomized prospective study. The treatment group (n=50) was given 400 mg of ofloxacin daily for 4 weeks, whereas the control group (n=50) was followed without any treatment. At the end of the four weeks, repeat PSA were measured and all patients underwent transrectal ultrasound (TRUS) guided biopsy, regardless of the repeat PSA levels. Totally 22 patients (22%) had prostate cancer (9 in treatment group and 13 in control group). A significant PSA decrease was observed in the treatment group at repeat PSA measurements (p=0.001). The PSA drop was also significantly more in patients without PCa than with PCa (p=0.028). In patients whose repeat PSA after antibiotic treatment decreased below 4 ng/ml, 2 times ...

International journal of clinical and experimental medicine, 2014

To determine the efficacy of a new method called by us as "gross intra-operative evaluation ... more To determine the efficacy of a new method called by us as "gross intra-operative evaluation (GIE)" for the assessment of surgical margin (SM) status. A total of 26 consecutive patients operated with cT1a-b renal tumors at a single center were included in this study. After the excision, the tumors were uniformly divided into two halves in the longitudinal axis ex vivo. In this way, margins were exposed for GIE for the evaluation of the safety of SMs. Findings of GIE were compared with the permanent section analysis in terms of SM status. Mean patient age, tumor size and margin thickness was 59 (38-79), 3.1 (1.5-6) cm and 3.7 (0.1-12) mm, respectively. In all patients, GIE showed intact margins and none of the patients had positive SM in the final pathological examination. There was no evidence of local recurrence or distant metastasis with a mean follow-up of 25 (4-104) months. All patients are alive. GIE of resected specimen without FS analysis is a safe and effective meth...

Toxicology and industrial health, 2011

In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced d... more In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced damage in rat kidney tissues. Twenty-seven male Wistar rats were used in the study. Animals were divided into three equal groups as follows: Group 1: control group with only normal saline (NS; 0.9% NaCl) injection for 8 weeks; Group 2: cigarette smoking and NS injection for 8 weeks; and Group 3: cigarette smoking and PTX injection for 8 weeks. The rats were sacrificed after 8 weeks and their kidneys were excised for histopathological analysis. Serial paraffin sections (5 µm) of the kidneys were cut and stained with hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS). The terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) method was used to assess apoptosis. Glomerular diameters, glomerular cell number and proximal tubule cell numbers were compared between the groups. Our results showed that PTX treatment prevented negative effe...

Korean Journal of Urology, 2010

Purpose: The aim of this study was to evaluate the effect of asymptomatic urethral caruncle (UC) ... more Purpose: The aim of this study was to evaluate the effect of asymptomatic urethral caruncle (UC) on micturition in women suffering from urinary incontinence. Materials and Methods: A total of 232 patients participated in the study. UC was diagnosed in 50 of 232 patients with urinary incontinence during a physical examination in our clinic. All cases were divided into 2 groups: UC combined with urinary incontinence (group 1) and urinary incontinence only (group 2). Urodynamic evaluations were performed according to the International Continence Society standards. Results: Both groups were similar in terms of voiding diary, pad test and residual urine volume. Urodynamic studies revealed no significant difference between group 1 and 2 (infravesical obstruction: 6% vs. 4.4%; overactive detrusor: 44% vs. 42.9% respectively). The rates of severe IPSS (37.8% vs. 20.9%) and severe cystocele (20.9% vs. 13.8%) were numerically higher in group 1 with no statistically significant difference. Conclusions: Our results suggest that there is no effect of asymptomatic UC on lower urinary tract symptoms in women with urinary incontinence. Therefore, treating asymptomatic UC is unnecessary in these patients. However, during incontinence surgery, it is the surgeon's decision whether to treat asymptomatic UC.

International journal of clinical and experimental medicine, 2014

The Allium Bulbar Urethral Stent (BUS) is a fully covered, self-expandable, large caliber metal s... more The Allium Bulbar Urethral Stent (BUS) is a fully covered, self-expandable, large caliber metal stent specially designed for the treatment of bulbar urethra strictures. The stent is intended for a long term use for the purpose of opening the occluded urethral passage and to allow spontaneous urination. This study objective was to evaluate the clinical efficacy of temporary placement of the Allium BUS stent. This was a prospective study in 54 men with recurrent benign urethral stricture conducted during 2009 to 2012. All men underwent an internal urethrotomy or dilatation procedure followed by an endoscopic stent placement. Clinical success was achieved in 44 (81.4%) of the 54 patients. No patient reported discomfort at the stent site. 2 stents migrated distally. 1 stent was occluded. All stents were removed in a mean time of 8.8 (range 3-18) months following implantation. This experience with the Allium BUS for treating urethral strictures suggests that it is safe and reliable treat...