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Papers by Leyla Djansugurova

Research paper thumbnail of Genome-wide study of Almaty region people for a long time living in areas of pesticide contamination

Bio web of conferences/BIO web of conferences, 2024

Research paper thumbnail of Advanced median-based genetic similarity analysis in Kazakh Tazy dogs: A novel approach for breed conformity assessment

bioRxiv (Cold Spring Harbor Laboratory), Mar 20, 2024

Research paper thumbnail of The Effect of Granulometry of Carbonaceous Materials and Application Rates on the Availability of Soil-Bound Dichlorodiphenyltrichloroethane (DDT) and Its Metabolites

Journal of xenobiotics, Feb 11, 2024

Research paper thumbnail of Association between Glutathione S-Transferase M1 and T1 Polymorphisms and Colorectal Cancer Risk in Patients from Kazakhstan

Clinical Laboratory, 2015

ABSTRACT

Research paper thumbnail of Microbial Load as Ecotoxicological Assessment of Heavy Metals Presence in Soil Samples from the Kazakhstan Part of the Caspian Sea

Eurasian Chemico-Technological Journal

Soil as a natural resource and a powerful regulator of matter flow, plays crucial role in providi... more Soil as a natural resource and a powerful regulator of matter flow, plays crucial role in providing habitat for proper structuring and functioning soil microbial communities. Under the influence of unregulated industrial activities with social-economic co-development, soil and water involved a whole range of changes leading to soil erosion-degradation and pollution of aquatic ecosystems. One of the most promising techniques for determining the total effect of exposure to heavy metals on environmental media is bio-indication (bio-testing), which is based on rapid, robust and cost-effective methods. Acquaintance, with the microbial background of soil is essential to assess the degree of soil pollution with heavy metals. In this study, an eco-toxicological assessment using microbial community characteristics on heavy metals in soil samples from the urban ecosystems of the Kazakhstan part of the Caspian Sea (Atyrau and Mangystau regions) has been discussed. According to the results of t...

Research paper thumbnail of Analysis of the association of APC, MLH1 and RASSF1A genes methylation with the risk of colorectal cancer

Journal of Cancer Science & Therapy, Feb 4, 2017

Research paper thumbnail of MtDNA CONTROL REGIONS ANALYSIS AT ETHNIC KAZAKHS

SERIES OF BIOLOGICAL AND MEDICAL, Oct 15, 2018

Research paper thumbnail of G39179T DNMT3B Gene Variants in Relation to Colorectal Cancer Risk in Kazakhstan Population

Journal of Carcinogenesis & Mutagenesis, 2015

Research paper thumbnail of Screening the APC, MLH1, MSH2 and TP53 Mutations in Patients with Early Onset of Colorectal Cancer

Journal of Carcinogenesis & Mutagenesis, 2014

Research paper thumbnail of Nuclear Weapons Tests and Human Germline Mutation Rate

Research paper thumbnail of TP53 Arg72Pro and CCND1 A870G polymorphisms and esophageal cancer risk

Research paper thumbnail of Preferential Lectin Binding of Cancer Cells upon Sialic Acid Treatment Under Nutrient Deprivation

Applied Biochemistry and Biotechnology, 2013

Research paper thumbnail of The problem of POP pesticides in Kazakhstan and methods for their restoration using the new high-efficient phytoremediant Мiscanthus sinensis (on the example of the Talgar region)

Eurasian Journal of Ecology, 2019

Research paper thumbnail of Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides

Toxics

The long-term storage of unutilized pesticides raised new problems of long-term environmental con... more The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final s...

Research paper thumbnail of Homozygosity mapping in the Kazakh national dog breed Tazy

Research Square (Research Square), Apr 11, 2023

The identi cation of runs of homozygosity (ROH) is an informative approach to assessing the histo... more The identi cation of runs of homozygosity (ROH) is an informative approach to assessing the history and possible patterns of directional selection pressure. To our knowledge, the present study is the rst to provide an overview of the ROH pattern in the Kazakh national dog breed Tazy from a genome-wide perspective. A total of 1699 homozygous segments were identi ed in 39 Tazy dogs. The ROH consisted mainly of shorter segments (1-2 Mb), which accounted for approximately 67% of the total ROH. The estimated inbreeding coe cients of the ROH ranged from 0.028 to 0.058 with a mean of 0.057. Five hot genomic regions were identi ed on chromosomes 18, 22, and 25 that overlapped with regions of hunting traits in other hunting breeds. Among the 12 candidate genes located in these regions, the gene CAB39L may be a candidate that affects running speed and endurance of the Tazy dog. Eight genes could belong to an evolutionarily conserved complex as they were clustered in a large protein network with strong linkages. The results may enable effective interventions when incorporated into conservation planning and selection of the Tazy breed.

Research paper thumbnail of A genome-wide association study for different types allergic diseases

International Journal of Biology and Chemistry

Research paper thumbnail of RS2710102 Polymorphism of the CNTNAP2 Gene is Related to Autism Susceptibility in a Kazakhstani Population

International journal of biology and chemistry, Jun 1, 2022

CNTNAP2 Abst stereotypical behaviors. Genetically determined pathologies of neurodevelopment and ... more CNTNAP2 Abst stereotypical behaviors. Genetically determined pathologies of neurodevelopment and synaptic functioning are increas-CNTNAP2) gene encodes a protein, which plays an essential role in brain development. Genetic variations in the CNTNAP2 gene can perturb its functions, contributing to the genetic predisposition to ASDs. The study aimed to investigate an association of the CNTNAP2 rs2710102 with ASDs in a Kazakhstani population. The study involved patients diagnosed with ASDs and healthy controls of Kazakhstani origin. PCR-RFLP assay was used for the genotyping rs2710102 CNTNAP2 SNP. The distribution of the rs2710102 genotype was under the Hardy-Weinberg equilibrium in both cases and controls. C allele and 3

Research paper thumbnail of Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan

Disease Markers

The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader autis... more The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader autism phenotypes (BAP) offers a promising approach to the search for ASD candidate variants. Here, a total of 650,000 genetic markers were tested in four Kazakhstani multiplex families with ASD and BAP to obtain data on de novo mutations (DNMs), common, and rare inherited variants that may contribute to the genetic risk for developing autistic traits. The variants were analyzed in the context of gene networks and pathways. Several previously well-described enriched pathways were identified, including ion channel activity, regulation of synaptic function, and membrane depolarization. Perhaps these pathways are crucial not only for the development of ASD but also for ВАР. The results also point to several additional biological pathways (circadian entrainment, NCAM and BTN family interactions, and interaction between L1 and Ankyrins) and hub genes (CFTR, NOD2, PPP2R2B, and TTR). The obtained re...

Research paper thumbnail of Phytoremediation of Soil Contaminated by Organochlorine Pesticides and Toxic Trace Elements: Prospects and Limitations of Paulownia tomentosa

Toxics

Paulownia tomentosa (Thunb.) Steud is a drought-resistant, low-maintenance and fast-growing energ... more Paulownia tomentosa (Thunb.) Steud is a drought-resistant, low-maintenance and fast-growing energy crop that can withstand a wide range of climatic conditions, provides a high biomass yield (approximately 50 t DM ha−1 yr−1), and develops successfully in contaminated sites. In Kazakhstan, there are many historically contaminated sites polluted by a mixture of xenobiotics of organic and inorganic origin that need to be revitalised. Pilot-scale research evaluated the potential of P. tomentosa for the phytoremediation of soils historically contaminated with organochlorine pesticides (OCPs) and toxic trace elements (TTEs) to minimise their impact on the environment. Targeted soils from the obsolete pesticide stockpiles located in three villages of Talgar district, Almaty region, Kazakhstan, i.e., Amangeldy (soil A), Beskainar (soil B), and Kyzylkairat (soil K), were subjected to research. Twenty OCPs and eight TTEs (As, Cr, Co, Ni, Cu, Zn, Cd, and Pb) were detected in the soils. The phyt...

Research paper thumbnail of Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague

Proceedings of the National Academy of Sciences

Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks ... more Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks of plague and research using ancient DNA could demonstrate that it already affected human populations during the Neolithic. However, the pathogen’s genetic diversity, geographic spread, and transmission dynamics during this early period of Y. pestis evolution are largely unexplored. Here, we describe a set of ancient plague genomes up to 5,000 y old from across Eurasia. Our data demonstrate that two genetically distinct forms of Y. pestis evolved in parallel and were both distributed across vast geographic distances, potentially occupying different ecological niches. Interpreted within the archeological context, our results suggest that the spread of plague during this period was linked to increased human mobility and intensification of animal husbandry.

Research paper thumbnail of Genome-wide study of Almaty region people for a long time living in areas of pesticide contamination

Bio web of conferences/BIO web of conferences, 2024

Research paper thumbnail of Advanced median-based genetic similarity analysis in Kazakh Tazy dogs: A novel approach for breed conformity assessment

bioRxiv (Cold Spring Harbor Laboratory), Mar 20, 2024

Research paper thumbnail of The Effect of Granulometry of Carbonaceous Materials and Application Rates on the Availability of Soil-Bound Dichlorodiphenyltrichloroethane (DDT) and Its Metabolites

Journal of xenobiotics, Feb 11, 2024

Research paper thumbnail of Association between Glutathione S-Transferase M1 and T1 Polymorphisms and Colorectal Cancer Risk in Patients from Kazakhstan

Clinical Laboratory, 2015

ABSTRACT

Research paper thumbnail of Microbial Load as Ecotoxicological Assessment of Heavy Metals Presence in Soil Samples from the Kazakhstan Part of the Caspian Sea

Eurasian Chemico-Technological Journal

Soil as a natural resource and a powerful regulator of matter flow, plays crucial role in providi... more Soil as a natural resource and a powerful regulator of matter flow, plays crucial role in providing habitat for proper structuring and functioning soil microbial communities. Under the influence of unregulated industrial activities with social-economic co-development, soil and water involved a whole range of changes leading to soil erosion-degradation and pollution of aquatic ecosystems. One of the most promising techniques for determining the total effect of exposure to heavy metals on environmental media is bio-indication (bio-testing), which is based on rapid, robust and cost-effective methods. Acquaintance, with the microbial background of soil is essential to assess the degree of soil pollution with heavy metals. In this study, an eco-toxicological assessment using microbial community characteristics on heavy metals in soil samples from the urban ecosystems of the Kazakhstan part of the Caspian Sea (Atyrau and Mangystau regions) has been discussed. According to the results of t...

Research paper thumbnail of Analysis of the association of APC, MLH1 and RASSF1A genes methylation with the risk of colorectal cancer

Journal of Cancer Science & Therapy, Feb 4, 2017

Research paper thumbnail of MtDNA CONTROL REGIONS ANALYSIS AT ETHNIC KAZAKHS

SERIES OF BIOLOGICAL AND MEDICAL, Oct 15, 2018

Research paper thumbnail of G39179T DNMT3B Gene Variants in Relation to Colorectal Cancer Risk in Kazakhstan Population

Journal of Carcinogenesis & Mutagenesis, 2015

Research paper thumbnail of Screening the APC, MLH1, MSH2 and TP53 Mutations in Patients with Early Onset of Colorectal Cancer

Journal of Carcinogenesis & Mutagenesis, 2014

Research paper thumbnail of Nuclear Weapons Tests and Human Germline Mutation Rate

Research paper thumbnail of TP53 Arg72Pro and CCND1 A870G polymorphisms and esophageal cancer risk

Research paper thumbnail of Preferential Lectin Binding of Cancer Cells upon Sialic Acid Treatment Under Nutrient Deprivation

Applied Biochemistry and Biotechnology, 2013

Research paper thumbnail of The problem of POP pesticides in Kazakhstan and methods for their restoration using the new high-efficient phytoremediant Мiscanthus sinensis (on the example of the Talgar region)

Eurasian Journal of Ecology, 2019

Research paper thumbnail of Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides

Toxics

The long-term storage of unutilized pesticides raised new problems of long-term environmental con... more The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final s...

Research paper thumbnail of Homozygosity mapping in the Kazakh national dog breed Tazy

Research Square (Research Square), Apr 11, 2023

The identi cation of runs of homozygosity (ROH) is an informative approach to assessing the histo... more The identi cation of runs of homozygosity (ROH) is an informative approach to assessing the history and possible patterns of directional selection pressure. To our knowledge, the present study is the rst to provide an overview of the ROH pattern in the Kazakh national dog breed Tazy from a genome-wide perspective. A total of 1699 homozygous segments were identi ed in 39 Tazy dogs. The ROH consisted mainly of shorter segments (1-2 Mb), which accounted for approximately 67% of the total ROH. The estimated inbreeding coe cients of the ROH ranged from 0.028 to 0.058 with a mean of 0.057. Five hot genomic regions were identi ed on chromosomes 18, 22, and 25 that overlapped with regions of hunting traits in other hunting breeds. Among the 12 candidate genes located in these regions, the gene CAB39L may be a candidate that affects running speed and endurance of the Tazy dog. Eight genes could belong to an evolutionarily conserved complex as they were clustered in a large protein network with strong linkages. The results may enable effective interventions when incorporated into conservation planning and selection of the Tazy breed.

Research paper thumbnail of A genome-wide association study for different types allergic diseases

International Journal of Biology and Chemistry

Research paper thumbnail of RS2710102 Polymorphism of the CNTNAP2 Gene is Related to Autism Susceptibility in a Kazakhstani Population

International journal of biology and chemistry, Jun 1, 2022

CNTNAP2 Abst stereotypical behaviors. Genetically determined pathologies of neurodevelopment and ... more CNTNAP2 Abst stereotypical behaviors. Genetically determined pathologies of neurodevelopment and synaptic functioning are increas-CNTNAP2) gene encodes a protein, which plays an essential role in brain development. Genetic variations in the CNTNAP2 gene can perturb its functions, contributing to the genetic predisposition to ASDs. The study aimed to investigate an association of the CNTNAP2 rs2710102 with ASDs in a Kazakhstani population. The study involved patients diagnosed with ASDs and healthy controls of Kazakhstani origin. PCR-RFLP assay was used for the genotyping rs2710102 CNTNAP2 SNP. The distribution of the rs2710102 genotype was under the Hardy-Weinberg equilibrium in both cases and controls. C allele and 3

Research paper thumbnail of Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan

Disease Markers

The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader autis... more The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader autism phenotypes (BAP) offers a promising approach to the search for ASD candidate variants. Here, a total of 650,000 genetic markers were tested in four Kazakhstani multiplex families with ASD and BAP to obtain data on de novo mutations (DNMs), common, and rare inherited variants that may contribute to the genetic risk for developing autistic traits. The variants were analyzed in the context of gene networks and pathways. Several previously well-described enriched pathways were identified, including ion channel activity, regulation of synaptic function, and membrane depolarization. Perhaps these pathways are crucial not only for the development of ASD but also for ВАР. The results also point to several additional biological pathways (circadian entrainment, NCAM and BTN family interactions, and interaction between L1 and Ankyrins) and hub genes (CFTR, NOD2, PPP2R2B, and TTR). The obtained re...

Research paper thumbnail of Phytoremediation of Soil Contaminated by Organochlorine Pesticides and Toxic Trace Elements: Prospects and Limitations of Paulownia tomentosa

Toxics

Paulownia tomentosa (Thunb.) Steud is a drought-resistant, low-maintenance and fast-growing energ... more Paulownia tomentosa (Thunb.) Steud is a drought-resistant, low-maintenance and fast-growing energy crop that can withstand a wide range of climatic conditions, provides a high biomass yield (approximately 50 t DM ha−1 yr−1), and develops successfully in contaminated sites. In Kazakhstan, there are many historically contaminated sites polluted by a mixture of xenobiotics of organic and inorganic origin that need to be revitalised. Pilot-scale research evaluated the potential of P. tomentosa for the phytoremediation of soils historically contaminated with organochlorine pesticides (OCPs) and toxic trace elements (TTEs) to minimise their impact on the environment. Targeted soils from the obsolete pesticide stockpiles located in three villages of Talgar district, Almaty region, Kazakhstan, i.e., Amangeldy (soil A), Beskainar (soil B), and Kyzylkairat (soil K), were subjected to research. Twenty OCPs and eight TTEs (As, Cr, Co, Ni, Cu, Zn, Cd, and Pb) were detected in the soils. The phyt...

Research paper thumbnail of Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague

Proceedings of the National Academy of Sciences

Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks ... more Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks of plague and research using ancient DNA could demonstrate that it already affected human populations during the Neolithic. However, the pathogen’s genetic diversity, geographic spread, and transmission dynamics during this early period of Y. pestis evolution are largely unexplored. Here, we describe a set of ancient plague genomes up to 5,000 y old from across Eurasia. Our data demonstrate that two genetically distinct forms of Y. pestis evolved in parallel and were both distributed across vast geographic distances, potentially occupying different ecological niches. Interpreted within the archeological context, our results suggest that the spread of plague during this period was linked to increased human mobility and intensification of animal husbandry.