Li Castillo - Academia.edu (original) (raw)
Papers by Li Castillo
Clinical Pharmacology & Therapeutics, 2006
BACKGROUNDIn swine therapeutics, antibiotics are distributed mostly through feed offered for ad l... more BACKGROUNDIn swine therapeutics, antibiotics are distributed mostly through feed offered for ad libitum consumption. Our goal is to quantify the impact of individual feed intake of swine on antibiotics exposure.In swine therapeutics, antibiotics are distributed mostly through feed offered for ad libitum consumption. Our goal is to quantify the impact of individual feed intake of swine on antibiotics exposure.METHODSWe develop a computerized ad libitum individual feed intake model that considers the two reported scenarios. To assess the exposure variations of in-feed chlortetracycline (CTC), we include this model as input function into a pharmacokinetic (PK) model. The model is validated with three data sets collected in a research pigsty. Each set has 36 pigs randomly split in three pens by a weight stratification receiving 0, 500 or 1000 ppm of CTC for 11 days. An electronic feeder records the individual feed intake data. Blood and fecal samples are also taken.We develop a computerized ad libitum individual feed intake model that considers the two reported scenarios. To assess the exposure variations of in-feed chlortetracycline (CTC), we include this model as input function into a pharmacokinetic (PK) model. The model is validated with three data sets collected in a research pigsty. Each set has 36 pigs randomly split in three pens by a weight stratification receiving 0, 500 or 1000 ppm of CTC for 11 days. An electronic feeder records the individual feed intake data. Blood and fecal samples are also taken.RESULTSOur analysis shows that each feeding strategy influences the mean or the fluctuations in CTC plasma concentrations. Exposure to CTC decreases with growth stage and therapy duration. Hence, dosing regimens should be devised based on the MIC of the targeted pathogen, the animal's growth stage and adjusted depending on dosing duration.Our analysis shows that each feeding strategy influences the mean or the fluctuations in CTC plasma concentrations. Exposure to CTC decreases with growth stage and therapy duration. Hence, dosing regimens should be devised based on the MIC of the targeted pathogen, the animal's growth stage and adjusted depending on dosing duration.CONCLUSIONSOur model will assist veterinarians in the design of in-feed dosing regimens, contribute to the health and welfare of animals and reduce the costs of experiments. This method can be generalized and incorporated into medical practice, particularly to make projections of patient non-adherence to drugs, to explain treatment failure and to guide practitioners in adjusting the dosing regimen.Clinical Pharmacology & Therapeutics (2005) 79, P57–P57; doi: 10.1016/j.clpt.2005.12.207Our model will assist veterinarians in the design of in-feed dosing regimens, contribute to the health and welfare of animals and reduce the costs of experiments. This method can be generalized and incorporated into medical practice, particularly to make projections of patient non-adherence to drugs, to explain treatment failure and to guide practitioners in adjusting the dosing regimen.Clinical Pharmacology & Therapeutics (2005) 79, P57–P57; doi: 10.1016/j.clpt.2005.12.207
Fuel and Energy Abstracts, 2011
A measurement of the cross-section for ϒ(1S) → µ + µ − production in proton-proton collisions at ... more A measurement of the cross-section for ϒ(1S) → µ + µ − production in proton-proton collisions at centre of mass energy of 7 TeV is presented. The cross-section is measured as a function of the ϒ(1S) transverse momentum in two bins of rapidity, |y ϒ(1S) | < 1.2 and 1.2 < |y ϒ(1S) | < 2.4. The measurement requires that both muons have transverse momentum p µ T > 4 GeV and pseudorapidity |η µ | < 2.5 in order to reduce theoretical uncertainties on the acceptance, which depend on the poorly known polarization. The results are based on an integrated luminosity of 1.13 pb −1 , collected with the ATLAS detector at the Large Hadron Collider. The cross-section measurement is compared to theoretical predictions: it agrees to within a factor of two with a prediction based on the NRQCD model including colour-singlet and colour-octet matrix elements as implemented in PYTHIA while it disagrees by up to a factor of ten with the next-to-leading order prediction based on the colour-singlet-model.
Fuel and Energy Abstracts, 2011
A measurement of the Z/γ⁎Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions ... more A measurement of the Z/γ⁎Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions at s=7 TeV is presented using Z/γ⁎→e+e−Z/γ⁎→e+e− and Z/γ⁎→μ+μ−Z/γ⁎→μ+μ− decays collected with the ATLAS detector in data sets with integrated luminosities of 35 pb−1 and 40 pb−1, respectively. The normalized differential cross sections are measured separately for electron and muon decay channels as well as for their combination up to pTZ of 350 GeV for invariant dilepton masses 66 GeV<mℓℓ<116 GeV66 GeV<mℓℓ<116 GeV. The measurement is compared to predictions of perturbative QCD and various event generators. The prediction of resummed QCD combined with fixed order perturbative QCD is found to be in good agreement with the data.
√ s = 7 TeV using final states with an electron or a muon and a hadronically decaying τ lepton
Vision Research, 2000
There are two visual components to gaze: head orientation and orientation of the eyes relative to... more There are two visual components to gaze: head orientation and orientation of the eyes relative to the head. This study explores the accuracy with which subjects can discriminate head orientation when the eyes are centered in the head. Discrimination thresholds averaged 1.9°of head rotation for base head orientations of 0°and 15°, but discrimination was markedly poorer around a 30°head orientation. Results were independent of spatial frequency and size over a 4-fold range. Neither negative contrast nor head inversion affected discrimination. Experiments dissociating the internal features from head outline revealed the presence of two main cues to discrimination: deviation of the head profile from bilateral symmetry, and deviation of nose orientation from vertical. Simulations show that model V4 units revealed in previous experiments with Glass patterns can extract the relevant head orientation information. The data are consistent with neurological data indicating a selective loss of face recognition in prosopagnosia with spared gaze discrimination.
Clinical Pharmacology & Therapeutics, 2006
BACKGROUNDIn swine therapeutics, antibiotics are distributed mostly through feed offered for ad l... more BACKGROUNDIn swine therapeutics, antibiotics are distributed mostly through feed offered for ad libitum consumption. Our goal is to quantify the impact of individual feed intake of swine on antibiotics exposure.In swine therapeutics, antibiotics are distributed mostly through feed offered for ad libitum consumption. Our goal is to quantify the impact of individual feed intake of swine on antibiotics exposure.METHODSWe develop a computerized ad libitum individual feed intake model that considers the two reported scenarios. To assess the exposure variations of in-feed chlortetracycline (CTC), we include this model as input function into a pharmacokinetic (PK) model. The model is validated with three data sets collected in a research pigsty. Each set has 36 pigs randomly split in three pens by a weight stratification receiving 0, 500 or 1000 ppm of CTC for 11 days. An electronic feeder records the individual feed intake data. Blood and fecal samples are also taken.We develop a computerized ad libitum individual feed intake model that considers the two reported scenarios. To assess the exposure variations of in-feed chlortetracycline (CTC), we include this model as input function into a pharmacokinetic (PK) model. The model is validated with three data sets collected in a research pigsty. Each set has 36 pigs randomly split in three pens by a weight stratification receiving 0, 500 or 1000 ppm of CTC for 11 days. An electronic feeder records the individual feed intake data. Blood and fecal samples are also taken.RESULTSOur analysis shows that each feeding strategy influences the mean or the fluctuations in CTC plasma concentrations. Exposure to CTC decreases with growth stage and therapy duration. Hence, dosing regimens should be devised based on the MIC of the targeted pathogen, the animal's growth stage and adjusted depending on dosing duration.Our analysis shows that each feeding strategy influences the mean or the fluctuations in CTC plasma concentrations. Exposure to CTC decreases with growth stage and therapy duration. Hence, dosing regimens should be devised based on the MIC of the targeted pathogen, the animal's growth stage and adjusted depending on dosing duration.CONCLUSIONSOur model will assist veterinarians in the design of in-feed dosing regimens, contribute to the health and welfare of animals and reduce the costs of experiments. This method can be generalized and incorporated into medical practice, particularly to make projections of patient non-adherence to drugs, to explain treatment failure and to guide practitioners in adjusting the dosing regimen.Clinical Pharmacology & Therapeutics (2005) 79, P57–P57; doi: 10.1016/j.clpt.2005.12.207Our model will assist veterinarians in the design of in-feed dosing regimens, contribute to the health and welfare of animals and reduce the costs of experiments. This method can be generalized and incorporated into medical practice, particularly to make projections of patient non-adherence to drugs, to explain treatment failure and to guide practitioners in adjusting the dosing regimen.Clinical Pharmacology & Therapeutics (2005) 79, P57–P57; doi: 10.1016/j.clpt.2005.12.207
Fuel and Energy Abstracts, 2011
A measurement of the cross-section for ϒ(1S) → µ + µ − production in proton-proton collisions at ... more A measurement of the cross-section for ϒ(1S) → µ + µ − production in proton-proton collisions at centre of mass energy of 7 TeV is presented. The cross-section is measured as a function of the ϒ(1S) transverse momentum in two bins of rapidity, |y ϒ(1S) | < 1.2 and 1.2 < |y ϒ(1S) | < 2.4. The measurement requires that both muons have transverse momentum p µ T > 4 GeV and pseudorapidity |η µ | < 2.5 in order to reduce theoretical uncertainties on the acceptance, which depend on the poorly known polarization. The results are based on an integrated luminosity of 1.13 pb −1 , collected with the ATLAS detector at the Large Hadron Collider. The cross-section measurement is compared to theoretical predictions: it agrees to within a factor of two with a prediction based on the NRQCD model including colour-singlet and colour-octet matrix elements as implemented in PYTHIA while it disagrees by up to a factor of ten with the next-to-leading order prediction based on the colour-singlet-model.
Fuel and Energy Abstracts, 2011
A measurement of the Z/γ⁎Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions ... more A measurement of the Z/γ⁎Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions at s=7 TeV is presented using Z/γ⁎→e+e−Z/γ⁎→e+e− and Z/γ⁎→μ+μ−Z/γ⁎→μ+μ− decays collected with the ATLAS detector in data sets with integrated luminosities of 35 pb−1 and 40 pb−1, respectively. The normalized differential cross sections are measured separately for electron and muon decay channels as well as for their combination up to pTZ of 350 GeV for invariant dilepton masses 66 GeV<mℓℓ<116 GeV66 GeV<mℓℓ<116 GeV. The measurement is compared to predictions of perturbative QCD and various event generators. The prediction of resummed QCD combined with fixed order perturbative QCD is found to be in good agreement with the data.
√ s = 7 TeV using final states with an electron or a muon and a hadronically decaying τ lepton
Vision Research, 2000
There are two visual components to gaze: head orientation and orientation of the eyes relative to... more There are two visual components to gaze: head orientation and orientation of the eyes relative to the head. This study explores the accuracy with which subjects can discriminate head orientation when the eyes are centered in the head. Discrimination thresholds averaged 1.9°of head rotation for base head orientations of 0°and 15°, but discrimination was markedly poorer around a 30°head orientation. Results were independent of spatial frequency and size over a 4-fold range. Neither negative contrast nor head inversion affected discrimination. Experiments dissociating the internal features from head outline revealed the presence of two main cues to discrimination: deviation of the head profile from bilateral symmetry, and deviation of nose orientation from vertical. Simulations show that model V4 units revealed in previous experiments with Glass patterns can extract the relevant head orientation information. The data are consistent with neurological data indicating a selective loss of face recognition in prosopagnosia with spared gaze discrimination.