Libor Gabalec - Academia.edu (original) (raw)
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Papers by Libor Gabalec
Casopís lékar̆ů c̆eských, 2009
The assessment of the quality of life in chronic diseases has started to move from clinical studi... more The assessment of the quality of life in chronic diseases has started to move from clinical studies to practice. The main goal of the project was to assess the quality of life of Crohn's disease patients from two Czech centres by means of Czech versions of the general World Health Organization Quality of Life--BREF and specific Inflammatory Bowel Disease Questionnaire, to compare the quality of life of patients with an active disease and those in remission and to compare the quality of life with the general Czech population. 103 patients with Crohn's disease underwent a survey performed by means of two Czech versions of quality of life questionnaire. The dataset consisted of 53 men and 50 women; the average age of patients was 42 years. Increased activity was observed in 45 patients; 58 patients were in remission. By means of WHOQOL-BREF, we found the average global score of quality of life and satisfaction with health in our group to be 3.5 (Czech standard 3.8) and 2.8 (Cze...
Gastroenterology, 2009
from North Jutland and Aarhus counties, Denmark and 26,648 unexposed controls from the same count... more from North Jutland and Aarhus counties, Denmark and 26,648 unexposed controls from the same counties. Of these, 175 exposed patients with IBD before the infection, their 350 unexposed controls, and 80 unexposed individuals with IBD before the Salmonella/ Campylobacter infection were excluded. The final study cohort of 13,149 exposed and 26,218 unexposed individuals were followed for up to 15 years (mean 7.5 years). A firsttime diagnosis of IBD was reported in 107 exposed individuals (1.2%) and 74 unexposed individuals (0.5%) during follow-up. By Cox's proportional-hazards regression analysis the hazard rate ratio for IBD was 2.9 [95% CI 2.1-3.9] for the whole period and 1.9 [1.3-2.6] if the first year after Salmonella/Campylobacter infection was excluded. The increased risk in exposed subjects was observed throughout the observation period of 15 years. The increased risk was similar for Salmonella (n=6,464) and Campylobacter (n=6,685) and independent of age and gender of the patient. The increase in risk for a first-time diagnosis of Crohn's disease (n=47) and Ulcerative Colitis (n=134) was not significantly different. We conclude, that from a large, population-based cohort study with complete follow-up an increased risk of IBD was demonstrated in individuals notified in laboratory registries with an episode of Salmonella/Campylobacter gastroenteritis. This may have implications for the understanding of the pathogenesis of inflammatory bowel diseases, and it emphasizes the importance of food safety for disease prevention.
Alimentary Pharmacology and Therapeutics, 2006
Eudragit-L and ethylcellulose-coated mesalazine tablets are well tolerated and equally effective ... more Eudragit-L and ethylcellulose-coated mesalazine tablets are well tolerated and equally effective in achieving remission in mild-moderately active ulcerative colitis over 8 weeks.
The American Journal of Gastroenterology, 2015
Casopís lékar̆ů c̆eských, 2009
The assessment of the quality of life in chronic diseases has started to move from clinical studi... more The assessment of the quality of life in chronic diseases has started to move from clinical studies to practice. The main goal of the project was to assess the quality of life of Crohn's disease patients from two Czech centres by means of Czech versions of the general World Health Organization Quality of Life--BREF and specific Inflammatory Bowel Disease Questionnaire, to compare the quality of life of patients with an active disease and those in remission and to compare the quality of life with the general Czech population. 103 patients with Crohn's disease underwent a survey performed by means of two Czech versions of quality of life questionnaire. The dataset consisted of 53 men and 50 women; the average age of patients was 42 years. Increased activity was observed in 45 patients; 58 patients were in remission. By means of WHOQOL-BREF, we found the average global score of quality of life and satisfaction with health in our group to be 3.5 (Czech standard 3.8) and 2.8 (Cze...
Gastroenterology, 2009
from North Jutland and Aarhus counties, Denmark and 26,648 unexposed controls from the same count... more from North Jutland and Aarhus counties, Denmark and 26,648 unexposed controls from the same counties. Of these, 175 exposed patients with IBD before the infection, their 350 unexposed controls, and 80 unexposed individuals with IBD before the Salmonella/ Campylobacter infection were excluded. The final study cohort of 13,149 exposed and 26,218 unexposed individuals were followed for up to 15 years (mean 7.5 years). A firsttime diagnosis of IBD was reported in 107 exposed individuals (1.2%) and 74 unexposed individuals (0.5%) during follow-up. By Cox's proportional-hazards regression analysis the hazard rate ratio for IBD was 2.9 [95% CI 2.1-3.9] for the whole period and 1.9 [1.3-2.6] if the first year after Salmonella/Campylobacter infection was excluded. The increased risk in exposed subjects was observed throughout the observation period of 15 years. The increased risk was similar for Salmonella (n=6,464) and Campylobacter (n=6,685) and independent of age and gender of the patient. The increase in risk for a first-time diagnosis of Crohn's disease (n=47) and Ulcerative Colitis (n=134) was not significantly different. We conclude, that from a large, population-based cohort study with complete follow-up an increased risk of IBD was demonstrated in individuals notified in laboratory registries with an episode of Salmonella/Campylobacter gastroenteritis. This may have implications for the understanding of the pathogenesis of inflammatory bowel diseases, and it emphasizes the importance of food safety for disease prevention.
Alimentary Pharmacology and Therapeutics, 2006
Eudragit-L and ethylcellulose-coated mesalazine tablets are well tolerated and equally effective ... more Eudragit-L and ethylcellulose-coated mesalazine tablets are well tolerated and equally effective in achieving remission in mild-moderately active ulcerative colitis over 8 weeks.
The American Journal of Gastroenterology, 2015