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Papers by Lindsay Beyger
Environmental toxicology and chemistry / SETAC, Jan 15, 2015
Understanding the environmental risks of pharmaceuticals and personal care products (PPCPs) has b... more Understanding the environmental risks of pharmaceuticals and personal care products (PPCPs) has become very important in the field of aquatic toxicology. Hydroxylpropyl-β-cyclodextrin (HPβCD) is an amphiphilic, toroidal shaped molecule with the ability to form non-covalent inclusion complexes with a variety of guest molecules. HPβCD can reduce volatility as well as improve the aqueous solubility of apolar guest compounds and is an emerging PPCP. As such, HPβCD is the active ingredient in Febreze, Procter & Gamble, and is extensively used as an excipient in the pharmaceutical industry. With the potential for entering the environment through wastewater treatment plant (WWTP) effluent, HPβCD poses an unknown risk to non-target aquatic biota. A 145-day chronic full life-cycle exposure using American flagfish (Jordanella floridae) was completed using flow-through nominal concentrations of 0 µg/L - control, 5 µg/L, 16 µg/L, 50 µg/L, 160 µg/L, 500 µg/L, and 1600 µg/L of HPβCD maintained vi...
Critical reviews in toxicology, Jan 6, 2015
Research in environmental toxicology involving pharmaceuticals and personal care products (PPCPs)... more Research in environmental toxicology involving pharmaceuticals and personal care products (PPCPs) has increased greatly over the last 10-15 years. Much research has been focused on the endocrine-disrupting potential of PPCPs, as they relate to negative population impacts of aquatic organisms. This review assesses the current data on the reported effects of PPCPs on fish reproduction with an emphasis on fecundity, a predictor of population effects. Studies of both individual PPCPs and PPCP mixtures are presented. As the majority of individual PPCP studies reviewed demonstrate negative effects on fish fecundity, we relate these findings to detected surface water concentrations of these compounds. Very few studies involving PPCP mixtures have been conducted; however, the need for these types of studies is warranted as fish are most likely exposed to mixtures of PPCPs in the wild. In addition, laboratory and field assessments of wastewater treatment plant (WWTP) effluents, a major sourc...
Ecotoxicology and Environmental Safety, 2012
Environmental toxicology and chemistry / SETAC, Jan 15, 2015
Understanding the environmental risks of pharmaceuticals and personal care products (PPCPs) has b... more Understanding the environmental risks of pharmaceuticals and personal care products (PPCPs) has become very important in the field of aquatic toxicology. Hydroxylpropyl-β-cyclodextrin (HPβCD) is an amphiphilic, toroidal shaped molecule with the ability to form non-covalent inclusion complexes with a variety of guest molecules. HPβCD can reduce volatility as well as improve the aqueous solubility of apolar guest compounds and is an emerging PPCP. As such, HPβCD is the active ingredient in Febreze, Procter & Gamble, and is extensively used as an excipient in the pharmaceutical industry. With the potential for entering the environment through wastewater treatment plant (WWTP) effluent, HPβCD poses an unknown risk to non-target aquatic biota. A 145-day chronic full life-cycle exposure using American flagfish (Jordanella floridae) was completed using flow-through nominal concentrations of 0 µg/L - control, 5 µg/L, 16 µg/L, 50 µg/L, 160 µg/L, 500 µg/L, and 1600 µg/L of HPβCD maintained vi...
Critical reviews in toxicology, Jan 6, 2015
Research in environmental toxicology involving pharmaceuticals and personal care products (PPCPs)... more Research in environmental toxicology involving pharmaceuticals and personal care products (PPCPs) has increased greatly over the last 10-15 years. Much research has been focused on the endocrine-disrupting potential of PPCPs, as they relate to negative population impacts of aquatic organisms. This review assesses the current data on the reported effects of PPCPs on fish reproduction with an emphasis on fecundity, a predictor of population effects. Studies of both individual PPCPs and PPCP mixtures are presented. As the majority of individual PPCP studies reviewed demonstrate negative effects on fish fecundity, we relate these findings to detected surface water concentrations of these compounds. Very few studies involving PPCP mixtures have been conducted; however, the need for these types of studies is warranted as fish are most likely exposed to mixtures of PPCPs in the wild. In addition, laboratory and field assessments of wastewater treatment plant (WWTP) effluents, a major sourc...
Ecotoxicology and Environmental Safety, 2012