Lluís Cecchini - Academia.edu (original) (raw)

Papers by Lluís Cecchini

Transplantation Proceedings, 2006

Objectives. The objective of this study was to analyze the correlation between histological findi... more Objectives. The objective of this study was to analyze the correlation between histological findings in both transplanted kidneys from marginal donors. Methods. We retrospectively reviewed the histological information on 92 kidneys obtained between January 2001 and January 2004, corresponding to 46 marginal donors. Criteria for biopsy were age greater than 55 years, hypertension, diabetes, and proteinuria. Scores were established by the pathologist including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. The score for each lesion was classified as 0 if absent; 1 if Ͻ20%; 2 if Ͼ20% and Ͻ50%; and 3 if Ͼ50%. Finally, we defined an index of renal severity damage (RSD) in order to classify the kidneys for single transplantation (0), double transplantation (1), and unsuitable for transplantation (2). Results. Of the kidneys studied, 82.6% of both kidneys showed similar degrees of glomerulosclerosis (Ͻ20% in 71.7% and Ͼ20% in 10.9%), while 17.4% showed discrepancies (Ͼ vs Ͻ20%; P ϭ .008). On the other hand, RSD correlated in 82.6% of both kidneys (in 69.6% RSD ϭ 0; in 8.7% RSD ϭ 1; and in 4.3% RSD ϭ 2), while 17.4% showed discrepancies (P ϭ .001). In one case (2.2%), a great discrepancy was observed; one kidney was valid for single transplantation, and the other one not valid for any transplantation, single or double. Conclusions. This study demonstrated a correlation between the biopsy findings in both kidneys in 82.6% of marginal organ donors. However, in 17.4% of cases we observed discrepancies. The degree of glomerulosclerosis seemed to be a powerful parameter to define renal severity damage. According to these results we would recommend biopsy of both kidneys.

Clinical Nutrition ESPEN, 2016

European Urology Supplements, 2004

European Urology, 2003

Objective: To con®rm the very high male:female ratios previously observed among Spanish bladder c... more Objective: To con®rm the very high male:female ratios previously observed among Spanish bladder cancer patients and to assess gender differences in tumoral characteristics, diagnostic procedures, and treatment in a large series of consecutive bladder cancer patients. Patients and Methods: All newly diagnosed bladder cancer patients (n 615) in 17 Spanish hospitals, between 1997±2000, were included. Information was collected both through personal interviews to patients and from medical records using a structured form. Results: Seventy-six percent of tumours were super®cial. The male:female ratio was 6.7 and it was similar for super®cial and in®ltrating tumours. Women were older than men at the diagnosis of bladder cancer (68:2 AE 9:4 years versus 65:7 AE 9:7 years, p 0:01). Ten percent of super®cial tumours in women, versus 3% in men, were classi®ed as`o ther histological types'' (p 0:008). T1GIII tumours were more frequent among men (17% versus 7%, p 0:047). On the other hand, women were more likely to present with 0a-stage tumours (48.6% versus 35.5%, p 0:04), multiple tumours (50% versus 29%, trend test: 0.005), multi-centric tumours (54% versus 38%, p 0:019), and larger in®ltrating masses (5.2 cm versus 3.8 cm, p 0:03) than men. Among 0a-stage tumours, only 23% of women compared to 54% of men received transurethral resection (TUR) alone (p 0:002). Women were almost ®ve-fold more likely to receive additional therapies to TUR (p 0:004) after adjusting for age, geographical area, stage, tumoral size, nuclear grade, and multiplicity. Conclusion: The study con®rms the very high male:female ratio of bladder cancer in Spain. We found substantial differences in the pathological characteristics of tumours from men and women. There was a tendency for women to receive more frequently non-standard, more aggressive, therapy than men.

Circulation: Cardiovascular Quality and Outcomes, 2010

Background— Reduced heart rate variability (HRV), a measure of cardiac autonomic dysfunction, is ... more Background— Reduced heart rate variability (HRV), a measure of cardiac autonomic dysfunction, is a risk factor for coronary artery disease. Diet can influence HRV, but this association may be confounded by genetic and environmental factors. Methods and Results— We administered the Willett Food Frequency Questionnaire to 276 middle-aged male twins. We derived a score measuring the extent to which an individual's diet conformed to the Mediterranean diet following a published algorithm. The higher the score, the greater the similarity to the Mediterranean diet. All twins underwent 24-hour ambulatory ECG recording. Time and frequency domain measures of HRV were calculated. Mixed-effects regression was used to partition the association into between- and within-twin pair differences. After adjusting for energy intake, other nutritional factors, shared genes, and common environment, a 1-unit higher score was significantly associated with 3.9% to 13% higher time and frequency domain HRV...

BJU International, 2007

Osteoporosis was defined according to the International Society for Clinical Densitometry officia... more Osteoporosis was defined according to the International Society for Clinical Densitometry official position (2005). RESULTS A DCI of < 1000 mg, the National Institute of Health recommendation, was detected in 93% of the men, (93.5% under ADT and 91.5% after RP). Osteoporosis was identified in 49.2% (183) of the patients, 54.9% (146) under ADT and 34.9% (37) after RP. The mean DCI was 609.7 mg in men with osteoporosis and 682.8 mg in those without (P < 0.001); in men under ADT the mean DCI remained significantly lower in those with osteoporosis (615.5 vs 700.4 mg, P < 0.001). A multivariate analysis showed that DCI was an independent risk factor for osteoporosis, together with patient age, ADT and its duration. CONCLUSIONS DCI seems to be related to BMD; a low DCI was an independent risk factor for osteoporosis in men with prostate cancer. In the study population overall the DCI was inadequate. Urologists should recommend a DCI of > 1000 mg in patients with prostate cancer, especially in those under ADT.

European Urology Supplements, 2006

Additional file 1: Table S1. Characteristics of the study populations. Table S2. Replication of t... more Additional file 1: Table S1. Characteristics of the study populations. Table S2. Replication of the SNPs reported as associated with pancreatic cancer risk in European population and published in GWAS Catalog. Table S3. Validated variants (at the nominal p-value), in PanScan and PanC4 populations, among the top 20 SNPs identified in the PanGenEU GWAS study. Figure S1. Functional in-silico analysis strategy followed to identify novel genomic regions previously prioritized using the 1D, 2D and 3D approaches. Figure S2. GWAS Manhattan plot for the PanGenEU study. The x-axis is the genomic position of each variant and the y-axis is the −log10 p-value obtained in the 1D analysis. Figure S3. Q-Q plots for pancreatic cancer risk of the association results using the PanGenEU case-control study (S2a) and PanGenEU&EPICURO study populations (S2b). Figure S4. Scatterplot of the local Moran's index (LMI) obtained in the 2D approach and the –log10 p-value obtained in the GWAS analysis (1D app...

espanolLa cistectomia radical (CR) es un procedimiento con una elevada tasa de complicaciones. Lo... more espanolLa cistectomia radical (CR) es un procedimiento con una elevada tasa de complicaciones. Los protocolos de rehabilitacion multimodal (ERAS) optimizan al paciente para acelerar la recuperacion posquirurgica combinando estrategias pre, intra y posoperatorias. El objetivo principal de este estudio es dar a conocer el papel de la enfermera y remarcar su importancia dentro del equipo multidisciplinar. Para ello hemos elaborado una via clinica siguiendo los protocolos ERAS, donde se estandarizan los cuidados, marcando todas las actividades donde interviene enfermeria, tanto los enfocados al paciente como a la recogida de datos para la investigacion y mejora de nuestra funcion. Entre junio de 2015 y julio de 2016 se han realizado 14 CR incluidas en via clinica. Como conclusion, contar con el papel de la enfermeria es basico para el buen desarrollo e implantacion de un protocolo ERAS EnglishRadical Cystectomy (RC) is a highly complex procedure with multiple risks for complication. Enh...

ABSTRACTPancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors... more ABSTRACTPancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To-date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. Here, we complemented a classical new PC GWAS (1D) with spatial autocorrelation analysis (2D) and Hi-C maps (3D) to gain additional insight into the inherited basis of PC.In-silicofunctional analysis of public genomic information allowed prioritization of potentially relevant candidate variants. We replicated 17/40 previous PC-GWAS hits and identified novel variants with potential biological functions. The spatial autocorrelation approach prioritized low MAF variants not detected by GWAS. These were further expanded via 3D interactions to 54 target regions with high functional relevance. This multi-step strategy, combined with an in-depthin-silico functional analysis, offers a comprehensive approach to advance the study of PC genetic suscepti...

PROTEOMICS – Clinical Applications, 2019

Number of tables: 5 Number of figures: 2 CLINICAL RELEVANCE  This study is the first of its kin... more Number of tables: 5 Number of figures: 2 CLINICAL RELEVANCE  This study is the first of its kind to evaluate SPARC diagnostic and prognostic performance in urinary bladder cancer (UBC) in an amply sized population based sample.  While both primary and recurrent UBC cases had higher mean SPARC values, the low number of positive samples, renders the overall diagnostic performance insufficient for clinical implementation in primary and/or recurrent UBC  UBC patients undergoing disease monitoring and with positive SPARC findings were approximately twofold more likely to develop tumor progression and/or relapse. However, SPARC prognostic performance was apparently mediated by hematuria and thus ought to be interpreted with caution in clinical practice.

Prostate Cancer and Prostatic Diseases, 2004

Background: The development of laparoscopic radical prostatectomy (LRP) has been one of the surgi... more Background: The development of laparoscopic radical prostatectomy (LRP) has been one of the surgical advances in the treatment of localized prostate cancer. The procedure aims to combine the advantages of minimal access surgery with resection based on established oncological principles with cure rates and functional results that are at least comparable to open radical prostatectomy (ORP). Objectives: This review compares the advantages and disadvantages of the LRP to the ORP with regard to the real benefits to the patient. The impact on the urological practice was also addressed by the review. Methods: A comprehensive literature review of the published series/cases of both open and laparoscopic radical prostatectomy was performed. Results: LRP is a feasible and reproducible procedure for the treatment of localized prostate cancer. Although its technique is standardized, LRP is technically demanding and it takes longer time than ORP. Conclusion: The current published results of LRP show no advantages over that of the ORP. If long-term data shows better results in terms of functional and oncological outcomes, LRP may challenge or even replace the standard ORP in the treatment of localized prostate cancer.

Archivos españoles de urología, Jan 4, 2009

Resumen.-OBJETIVO: El esfínter urinario FlowSecure TM es una prótesis para la incontinencia urina... more Resumen.-OBJETIVO: El esfínter urinario FlowSecure TM es una prótesis para la incontinencia urinaria de esfuerzo que ha proporcionado unos excelentes resultados hasta el día de hoy. Si bien su colocación es sencilla, los urólogos acostumbrados a la colocación de otros tipos de prótesis pueden encontrar inconveniente el cambio a esta nueva técnica. Este artículo pretende demostrar que este nuevo esfínter se puede colocar de forma rápida y sencilla, así como discutir las diferencias respecto del modelo AMS-800 TM. MÉTODOS: A raíz de un paciente al que se colocó el esfínter urinario FlowSecure TM en nuestro centro se describe mediante dibujos la técnica de colocación y se apuntan ciertos consejos prácticos que hacen más fácil y rápida su colocación. RESULTADO: El tiempo quirúrgico fue de 90 minutos. El paciente presentó un postoperatorio correcto, retirándose la sonda vesical a las 24 horas y siendo dado de @ CORRESPONDENCE

Prostate Cancer and Prostatic Diseases, 2021

CONCLUSIONS: Our findings reinforce the need to include aggressiveness and susceptibility of PCa,... more CONCLUSIONS: Our findings reinforce the need to include aggressiveness and susceptibility of PCa, and T2DM treatments in the study of the relationship between both diseases.

The Prostate, 2021

Background: In the nonETS fusion of prostate cancer (PCa) pathway, SPOP mutations emerge as a dis... more Background: In the nonETS fusion of prostate cancer (PCa) pathway, SPOP mutations emerge as a distinct oncogenic driver subclass. Both SPOP downregulation and mutation can lead to SPOP target stabilization promoting dysregulation of key regulatory pathways. CHD1 gene is commonly deleted in PCa. CHD1 loss significantly co-occurs with SPOP mutations, resulting in a PCa subclass with increased AR transcriptional activity and with a specific epigenetic pattern. Methods: In this study, SPOP alterations at mutational and protein levels and CHD1 copy number alterations have been analyzed and correlated with ERG and PTEN protein expression and with the clinical pathological features of the patients. Results: SPOP protein loss has been detected in 42.9% of the cases, and it has been strongly associated with PTEN protein loss (p < .001). CHD1 gene loss has been detected in 24.5% and SPOP mutations in 5.9% of the cases. Loss of CHD1 has been strongly associated with SPOP mutations (p = .003) and has shown a trend to be associated with ERG wt cancers (p = .08). The loss of SPOP protein (p = .01) and the combination of PTEN and SPOP protein loss (p = .002) were both statistically more common in grade group 5 cancers, with a prevalence of 60% and 37.5%, respectively. Furthermore, SPOP loss/PTEN loss and SPOP wt/PTEN loss phenotypes were strongly associated with extraprostatic perineural infiltration (p = .007). Strong CHD1 loss was associated with a shorter time to PSA recurrence in the univariate (p = .04), and showed a trend to be associated with the PSA recurrence risk in the multivariate analysis (p = .058).

The Prostate, 2019

Background: ERG fusion-related prostate cancer (PrCa) is the most prevalent oncogenic driver subc... more Background: ERG fusion-related prostate cancer (PrCa) is the most prevalent oncogenic driver subclass. SPOP, FOXA1, and IDH1 mutations are other three main oncogenic driver subclasses in nonETS fusion PrCa. ERG protein levels seem to be increased in SPOP-mutated cases, and different studies reported that SPOP mutations and ERG fusions are mutually exclusive. The aim of this study has been to analyze the alterations in nonETS -oncogenic drivers in PrCa. Methods: SPOP, FOXA1, and IDH mutations were investigated by polymerase chain reaction (PCR) and Sanger direct sequencing. ERG, SPOP, and TMPRSS2-ERG messenger RNA expression was assessed by quantitative real-time PCR from complementary DNA, and the presence of the fusion was also analyzed by nonquantitative PCR. The clinical pathological features were retrieved from the charts of the 111 patients included in the study (MARBiobanc,