Lluvia López - Academia.edu (original) (raw)
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Universidad Pedagógica y Tecnológica de Colombia (UPTC)
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Papers by Lluvia López
Tetrahedron Letters, 2015
Several novel 2-(fluoroanilino)-3-(2,4-dinitroanilino) derivatives of 1,4-naphthoquinone have bee... more Several novel 2-(fluoroanilino)-3-(2,4-dinitroanilino) derivatives of 1,4-naphthoquinone have been synthesized in good to excellent yields. First, 2-chloro-3-(2,4-dinitroanilino)-1,4-naphthoquinone was prepared in two steps beginning with the reaction of 2,3-dichloro-1,4-naphthoquinone with aniline in the presence of a Lewis acid (CeCl 3 Á7H 2 O). The resulting 2-(anilino)-1,4-naphthoquinone was then nitrated. The strong electron withdrawing effect of the 2,4-dinitroanilino substituent on the naphthoquinone framework facilitated the displacement of the second chlorine atom by a variety of weakly nucleophilic fluoro-substituted anilines under reflux conditions. Ó 2015 Published by Elsevier Ltd.
Topics in Catalysis, 2008
A new and efficient protocol to prepare 2-(R-anilino)-1,4-naphthoquinones in quantitative yields ... more A new and efficient protocol to prepare 2-(R-anilino)-1,4-naphthoquinones in quantitative yields is presented. This synthesis occurs under mild conditions by reacting the corresponding aniline and 1,4-naphthoquinone in the presence of a bentonitic clay. The role of the clay is explained in terms of a reaction mechanism in which an activated complex is formed by the reaction of 1,4-naphthoquinone with Lewis acid sites of the clay. Based on the chemical composition of the clay, with Fe 3+ sites, the last step of the mechanism is proposed to involve an oxidationreduction reaction.
Journal of Fluorine Chemistry, 2011
Journal of Fluorine Chemistry, 2015
Tetrahedron Letters, 2015
Several novel 2-(fluoroanilino)-3-(2,4-dinitroanilino) derivatives of 1,4-naphthoquinone have bee... more Several novel 2-(fluoroanilino)-3-(2,4-dinitroanilino) derivatives of 1,4-naphthoquinone have been synthesized in good to excellent yields. First, 2-chloro-3-(2,4-dinitroanilino)-1,4-naphthoquinone was prepared in two steps beginning with the reaction of 2,3-dichloro-1,4-naphthoquinone with aniline in the presence of a Lewis acid (CeCl 3 Á7H 2 O). The resulting 2-(anilino)-1,4-naphthoquinone was then nitrated. The strong electron withdrawing effect of the 2,4-dinitroanilino substituent on the naphthoquinone framework facilitated the displacement of the second chlorine atom by a variety of weakly nucleophilic fluoro-substituted anilines under reflux conditions. Ó 2015 Published by Elsevier Ltd.
Topics in Catalysis, 2008
A new and efficient protocol to prepare 2-(R-anilino)-1,4-naphthoquinones in quantitative yields ... more A new and efficient protocol to prepare 2-(R-anilino)-1,4-naphthoquinones in quantitative yields is presented. This synthesis occurs under mild conditions by reacting the corresponding aniline and 1,4-naphthoquinone in the presence of a bentonitic clay. The role of the clay is explained in terms of a reaction mechanism in which an activated complex is formed by the reaction of 1,4-naphthoquinone with Lewis acid sites of the clay. Based on the chemical composition of the clay, with Fe 3+ sites, the last step of the mechanism is proposed to involve an oxidationreduction reaction.
Journal of Fluorine Chemistry, 2011
Journal of Fluorine Chemistry, 2015