Loredana Maria Toma (Himiniuc) - Academia.edu (original) (raw)

Papers by Loredana Maria Toma (Himiniuc)

The Medical-Surgical Journal, Mar 29, 2019

MATERNAL-FETAL ATTACHMENT - UPDATE ON THE ROLE OF THREE DIMENSIONAL, FOUR-DIMENSIONAL AND HD LIVE... more MATERNAL-FETAL ATTACHMENT - UPDATE ON THE ROLE OF THREE DIMENSIONAL, FOUR-DIMENSIONAL AND HD LIVE ULTRASOUND (Abstract): The continuous improvement in obstetrics imagery during the last few decades has contributed in the refining of the prenatal diagnosis but also to enhance the maternal fetal bonding. Two-dimensional (2D) ultrasound images have a positive influence on the attitude of expectant parents toward the pregnancy by enhancing the parental-fetal bond and reducing anxiety in parents. The introduction of three-dimensional (3D) ultrasonography (US) created the opportunity of having a non-invasive technique with easily understood images of the fetus. HD Live technology is a novel US technique that improves the quality of the 3D/4D images. HD Live uses an adjustable light source and software that calculates the propagation of light through surface structures in relation to the direction of light. The HD Live photos are more impressive than the classic 3D pictures, and parents usually request photos. Three-dimensional HD Live enables detailed observation of the fetal external anatomy beginning with the first trimester and doesn’t increase significantly the examination time. HD Live may play a role in strengthening this relationship between parents and their future child.

Gels, May 17, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

The Medical-Surgical Journal, Sep 30, 2020

Aim: Bleeding complications happen more frequently in pregnant females who carry mechanical heart... more Aim: Bleeding complications happen more frequently in pregnant females who carry mechanical heart valves (MHVs) compared with biological prosthesis valves (BPVs). The main objective for these patients represents a rigorous and individual monitoring of the anticoagulant treatment in order to minimalize the rate of complications that may appear. We present from “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology from Iasi, the case of a 30-year-old pregnant woman with dichorionic-diamniotic twin pregnancy, barrier of MHV, who suffered postoperative bleeding complication under guidelines recommended doses of anticoagulant. The hematoma that developed five days after the caesarian section need it surgical intervention for hemostasis correction. Conclusions: The incidence of bleeding complications is higher during pregnancy and postpartum in MHV carriers. Thrombosis or hemorrhage usually occur when the monitoring of anticoagulation is improper or when the treatment must be interrupted for different reasons.

The Medical-Surgical Journal, Mar 31, 2020

The prevalence of infertility is raising nowadays, affecting 15% of couples in their reproductive... more The prevalence of infertility is raising nowadays, affecting 15% of couples in their reproductive age. It has significant medical, social, and financial implications. It is estimated that 2-3% of all births in developed countries are the result of IVF procedures. The demand for assisted reproduction techniques is constantly increasing, and there is a continuous need to develop more efficient and less harmful protocols. Materials and methods: The descriptive, retrospective analytical study was performed on a group of 657 pregnant women with infertility treatment followed before pregnancy, who gave birth in the Department of Obstetrics-Gynecology of “Cuza-Voda” Hospital in Iasi, between 2010 and 2018. Results: No comorbidity was noted as a good predictor in the determinism of low birth weight, which led to the conclusion that infertility treatments do not independently influence the prognosis of birth weight in girls in our study group (AUC<0.600). Conclusions: The expected outcome of infertility treatments is highly dependent on the effectiveness of controlled ovarian stimulation, a routine procedure prior to IVF, and the results obtained must be constantly analyzed in order to be improved for the benefit of patients.

Journal of Immunology Research

Cervical cancer represents a major health problem among females due to its increased mortality ra... more Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, th...

Experimental and Therapeutic Medicine

A major myomectomy-associated problem is excessive blood loss. The aim of the present study was t... more A major myomectomy-associated problem is excessive blood loss. The aim of the present study was to evaluate the effect of glypressin on blood loss during laparoscopic myomectomy (LM) in women with uterine myomas. A total of 188 women scheduled for LM for uterine myomas were divided into two groups. The one group of women (n=64) received a 5-ml intramyometrial injection of glypressin 0.2 mg/ml (glypressin group; group 1). The other group of women (n=124) (group 2) had an LM performed without any other method to reduce blood loss. The decrease in postoperative hemoglobin (Hb), hematocrit (Ht), morbidity and duration of hospital stay were assessed. The results revealed that Hb and Ht (as it was presumed) exhibited similar changes in our study. Statistically significant differences (P<0.05) were obtained between the two groups in terms of Hb and Ht; after LM both Hb and Ht were decreased. In conclusion, the impact of glypressin administration in hemorrhage control in uterine leiomyomas may establish new future perspectives, regarding its administration in gynecological hemorrhagic pathologies.

Polymers, Apr 30, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

The Medical-Surgical Journal, Dec 23, 2020

Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects wit... more Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient`s comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a conservation multifractal law of probability density followed by validation of the model. Moreover, because nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are widely used in endometriosis as painkillers for dysmenorrhea management or Asherman syndrome for reducing the endometrial inflammation, some implications of our model for drug delivery systems applied in the field of gy...

The electrocardiogram is one of the first test directing reperfusion therapy for patients with ac... more The electrocardiogram is one of the first test directing reperfusion therapy for patients with acute myocardial infarction, depending on the presence or absence of ST-segment elevation. The presence of left or right bundle branch block on an electrocardiogram is frequently encountered in our clinical practice and their hemodynamic implications are increasingly being studied. However, the presence of left bundle block is usually associated with a more reserved prognosis compared to normal intraventricular conduction. In the same time, the presence of right bundle branch block is often considered benign in the absence of a cardiac pathology. Also, left bundle branch block has historically prevented accurate recognition of acute myocardial infarction. This may lead to a poor allocation of reperfusion therapy and secondary to a suboptimal patient outcome. Over the past 20 years, the management guidelines for these patients have shifted from one extreme to the other, considering the limi...

Osseous metaplasia of the endometrium represents a disorder of the uterus characterized by the pr... more Osseous metaplasia of the endometrium represents a disorder of the uterus characterized by the presence of mature or immature bone in the uterine cavity. In most of the cases infertility or menorrhagia can be present, although sometimes this condition can be asymptomatic. Endovaginal ultrasound and particularly three-dimensional ultrasound are very important diagnostic tools. Hysteroscopic removal of the bony fragments helps in treating both infertility and menorrhagia. We present a case of 28 years-old women with osseous metaplasia and uterine synechia. Three-dimensional ultrasound was useful for the diagnosis and both affections were solved by hysteroscopic approach

Journal of Personalized Medicine

Placental morbid adherence is a known risk factor for postpartum hemorrhage. The incidence of abn... more Placental morbid adherence is a known risk factor for postpartum hemorrhage. The incidence of abnormal placental attachment has been increasing over the past few decades, mainly due to rising rates of cesarean deliveries, advanced maternal age, and the use of assisted reproductive technologies. Cesarean section is a significant risk factor for placenta increta, as it disrupts the normal architecture of the uterine wall, making it more difficult for the placenta to detach after delivery. We present the case of a woman who underwent a cesarean section at 28 weeks due to anterior placenta previa, accompanied by hemorrhage and rupture of membranes. Following the delivery, she experienced normal postoperative bleeding and was discharged home after five days. However, six weeks later, she presented with heavy bleeding, leading to the decision to perform a total hysterectomy. The levels of HCG were found to be low. The pathological examination of the specimens confirmed a diagnosis of plac...

Aggressive angiomyxoma (AA) is a rare, benign and slowly growing mesenchymal tumor which affect w... more Aggressive angiomyxoma (AA) is a rare, benign and slowly growing mesenchymal tumor which affect women especially on the reproductive age. Because over 80% of cases are misdiagnosed and most of them are often confused with lipomas, the diagnosis is made by histological examination. We describe here a case of an 89-year-old female, at menopause, that presented with a large pedunculated angiomyxoma on the right upper of major labia. The vulvar AA diagnosed was made due to clinical-pathologic findings and histologic result after the local excision of the tumor. The patient was discharge 7 days after surgery and along of 7 months of follow-up no recurrence or metastasis were documented. In this case we showed the diagnosis, management and prediction for vulvar angiomyxoma in postmenopausal period, but further follow-up period is necessary for surveilling the recurrence, knowing that the tumor it may reappear in between 2 months and 12 years.

Symmetry

Two different operational procedures are proposed for evaluating and predicting the onset of epil... more Two different operational procedures are proposed for evaluating and predicting the onset of epileptic and eclamptic seizures. The first procedure analyzes the electrical activity of the brain (EEG signals) using nonlinear dynamic methods (the time variations of the standard deviation, the variance, the skewness and the kurtosis; the evolution in time of the spatial–temporal entropy; the variations of the Lyapunov coefficients, etc.). The second operational procedure reconstructs any type of EEG signal through harmonic mappings from the usual space to the hyperbolic one using the time homographic invariance of a multifractal-type Schrödinger equation in the framework of the scale relativity theory (i.e., in a multifractal paradigm of motions). More precisely, the explicit differential descriptions of the brain activity in the form of 2 × 2 matrices with real elements disclose, through the in-phase coherences at various scale resolutions (i.e., as scale transitions), the multitude of...

Experimental and Therapeutic Medicine

Taiwanese Journal of Obstetrics and Gynecology

Molecules

The aim of the study was to create a mathematical model useful for monitoring the release of bioa... more The aim of the study was to create a mathematical model useful for monitoring the release of bioactive aldehydes covalently bonded to the chitosan by reversible imine linkage, considered as a polymer–drug system. For this purpose, two hydrogels were prepared by the acid condensation reaction of chitosan with the antifungal 2-formyl-phenyl-boronic acid and their particularities; influencing the release of the antifungal aldehyde by shifting the imination equilibrium to the reagents was considered, i.e., the supramolecular nature of the hydrogels was highlighted by polarized light microscopy, while scanning electron microscopy showed their microporous morphology. Furthermore, the in vitro fungicidal activity was investigated on two fungal strains and the in vitro release curves of the antifungal aldehyde triggered by the pH stimulus were drawn. The theoretical model was developed starting from the hypothesis that the imine-chitosan system, both structurally and functionally, can be as...

Experimental and Therapeutic Medicine

The rupture of a subserosa variceal vein overlying a uterine myoma is a rare complication and a l... more The rupture of a subserosa variceal vein overlying a uterine myoma is a rare complication and a less common cause of gynecologic haemoperitoneum. The literature data are scarce regarding this condition and less than 100 cases have been reported (including those occurring during pregnancy). The present case is of a 48-year-old woman, with a history of asymptomatic uterine myoma, who was hospitalised for severe abdominal pain with sudden onset and signs of hypovolemic shock. The emergency conventional imaging exams confirmed the diagnosis of uterine myoma and haemoperitoneum, but did not reveal the source of bleeding. The cause of haemoperitoneum was detected by means of emergency laparotomy. In order to obtain quick hemostasis, in the settings of a rapid deteriorating hypovolemic shock, a supracervical hysterectomy was performed. The aim of the article is to raise awareness to gynecologists regarding this extremely rare life-threatening complication of the most common benign tumor of the uterus.

Medicina

Background and Objectives: The most utilized approach for the embolization of uterine arteries is... more Background and Objectives: The most utilized approach for the embolization of uterine arteries is the transfemoral path. However, the transradial approach (TRA) has been gaining popularity among cardiologic interventions in the last years but only few studies have shown its applicability in uterine myoma treatment. The objective of this paper is to assess the feasibility, safety and efficacy of TRA when compared with the transbrachial, transulnar or transfemoral approach (TFA) for uterine arteries embolization (UAE). Materials and methods: A systematic review of the literature that analyzes the TRA for UAE it was carried out, in order to assess its safety and effectiveness. It was systematically searched the literature (Google Scholar, PubMed/MEDLINE, Cochrane Library and Embase) using the words “uterine artery embolization”/“uterine embolization” and “transradial”/“radial”. All the relevant papers published until March 2020 were retrieved and analyzed. Results: Ten studies were con...

Experimental and Therapeutic Medicine

The rapid development achieved over the last decades in volume rendering of ultrasound data, know... more The rapid development achieved over the last decades in volume rendering of ultrasound data, known as three-dimensional (3D) ultrasound technique, leads to new opportunities for refining the diagnosis in many gynaecologic conditions. The aim of the present study was to evaluate the advantages of 3D ultrasound over two-dimensional (2D) ultrasound in uterine pathology and to establish the optimal time point during the menstrual cycle to perform 3D ultrasound examination in order to achieve the maximum of useful information. A cross-sectional study on 200 patients who underwent gynaecologic 2D and 3D ultrasound examinations was performed. The addition of 3D examination to 2D ultrasound in uterine pathology provided the most useful information concerning: Congenital uterine anomalies, intrauterine devices (IUDs), adenomyosis, and submucous myomas. The findings showed that the 3D ultrasound scan is a useful tool in gynaecology, especially in cases with congenital uterine anomalies, myoma, and IUD. Although initially it was used for research purposes only, recent findings suggest its usefulness in routine ultrasound scan and the possibility of witnessing its introduction as a recommended examination procedure in the foreseeable future. Further research should be conducted in order to establish the sensitivity of 3D ultrasound in the detection of minor endometrial conditions, by correlating the imaging findings with the hysteroscopic results.

The Medical-Surgical Journal, Mar 29, 2019

MATERNAL-FETAL ATTACHMENT - UPDATE ON THE ROLE OF THREE DIMENSIONAL, FOUR-DIMENSIONAL AND HD LIVE... more MATERNAL-FETAL ATTACHMENT - UPDATE ON THE ROLE OF THREE DIMENSIONAL, FOUR-DIMENSIONAL AND HD LIVE ULTRASOUND (Abstract): The continuous improvement in obstetrics imagery during the last few decades has contributed in the refining of the prenatal diagnosis but also to enhance the maternal fetal bonding. Two-dimensional (2D) ultrasound images have a positive influence on the attitude of expectant parents toward the pregnancy by enhancing the parental-fetal bond and reducing anxiety in parents. The introduction of three-dimensional (3D) ultrasonography (US) created the opportunity of having a non-invasive technique with easily understood images of the fetus. HD Live technology is a novel US technique that improves the quality of the 3D/4D images. HD Live uses an adjustable light source and software that calculates the propagation of light through surface structures in relation to the direction of light. The HD Live photos are more impressive than the classic 3D pictures, and parents usually request photos. Three-dimensional HD Live enables detailed observation of the fetal external anatomy beginning with the first trimester and doesn’t increase significantly the examination time. HD Live may play a role in strengthening this relationship between parents and their future child.

Gels, May 17, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

The Medical-Surgical Journal, Sep 30, 2020

Aim: Bleeding complications happen more frequently in pregnant females who carry mechanical heart... more Aim: Bleeding complications happen more frequently in pregnant females who carry mechanical heart valves (MHVs) compared with biological prosthesis valves (BPVs). The main objective for these patients represents a rigorous and individual monitoring of the anticoagulant treatment in order to minimalize the rate of complications that may appear. We present from “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynecology from Iasi, the case of a 30-year-old pregnant woman with dichorionic-diamniotic twin pregnancy, barrier of MHV, who suffered postoperative bleeding complication under guidelines recommended doses of anticoagulant. The hematoma that developed five days after the caesarian section need it surgical intervention for hemostasis correction. Conclusions: The incidence of bleeding complications is higher during pregnancy and postpartum in MHV carriers. Thrombosis or hemorrhage usually occur when the monitoring of anticoagulation is improper or when the treatment must be interrupted for different reasons.

The Medical-Surgical Journal, Mar 31, 2020

The prevalence of infertility is raising nowadays, affecting 15% of couples in their reproductive... more The prevalence of infertility is raising nowadays, affecting 15% of couples in their reproductive age. It has significant medical, social, and financial implications. It is estimated that 2-3% of all births in developed countries are the result of IVF procedures. The demand for assisted reproduction techniques is constantly increasing, and there is a continuous need to develop more efficient and less harmful protocols. Materials and methods: The descriptive, retrospective analytical study was performed on a group of 657 pregnant women with infertility treatment followed before pregnancy, who gave birth in the Department of Obstetrics-Gynecology of “Cuza-Voda” Hospital in Iasi, between 2010 and 2018. Results: No comorbidity was noted as a good predictor in the determinism of low birth weight, which led to the conclusion that infertility treatments do not independently influence the prognosis of birth weight in girls in our study group (AUC<0.600). Conclusions: The expected outcome of infertility treatments is highly dependent on the effectiveness of controlled ovarian stimulation, a routine procedure prior to IVF, and the results obtained must be constantly analyzed in order to be improved for the benefit of patients.

Journal of Immunology Research

Cervical cancer represents a major health problem among females due to its increased mortality ra... more Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, th...

Experimental and Therapeutic Medicine

A major myomectomy-associated problem is excessive blood loss. The aim of the present study was t... more A major myomectomy-associated problem is excessive blood loss. The aim of the present study was to evaluate the effect of glypressin on blood loss during laparoscopic myomectomy (LM) in women with uterine myomas. A total of 188 women scheduled for LM for uterine myomas were divided into two groups. The one group of women (n=64) received a 5-ml intramyometrial injection of glypressin 0.2 mg/ml (glypressin group; group 1). The other group of women (n=124) (group 2) had an LM performed without any other method to reduce blood loss. The decrease in postoperative hemoglobin (Hb), hematocrit (Ht), morbidity and duration of hospital stay were assessed. The results revealed that Hb and Ht (as it was presumed) exhibited similar changes in our study. Statistically significant differences (P<0.05) were obtained between the two groups in terms of Hb and Ht; after LM both Hb and Ht were decreased. In conclusion, the impact of glypressin administration in hemorrhage control in uterine leiomyomas may establish new future perspectives, regarding its administration in gynecological hemorrhagic pathologies.

Polymers, Apr 30, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

The Medical-Surgical Journal, Dec 23, 2020

Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects wit... more Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient`s comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a conservation multifractal law of probability density followed by validation of the model. Moreover, because nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are widely used in endometriosis as painkillers for dysmenorrhea management or Asherman syndrome for reducing the endometrial inflammation, some implications of our model for drug delivery systems applied in the field of gy...

The electrocardiogram is one of the first test directing reperfusion therapy for patients with ac... more The electrocardiogram is one of the first test directing reperfusion therapy for patients with acute myocardial infarction, depending on the presence or absence of ST-segment elevation. The presence of left or right bundle branch block on an electrocardiogram is frequently encountered in our clinical practice and their hemodynamic implications are increasingly being studied. However, the presence of left bundle block is usually associated with a more reserved prognosis compared to normal intraventricular conduction. In the same time, the presence of right bundle branch block is often considered benign in the absence of a cardiac pathology. Also, left bundle branch block has historically prevented accurate recognition of acute myocardial infarction. This may lead to a poor allocation of reperfusion therapy and secondary to a suboptimal patient outcome. Over the past 20 years, the management guidelines for these patients have shifted from one extreme to the other, considering the limi...

Osseous metaplasia of the endometrium represents a disorder of the uterus characterized by the pr... more Osseous metaplasia of the endometrium represents a disorder of the uterus characterized by the presence of mature or immature bone in the uterine cavity. In most of the cases infertility or menorrhagia can be present, although sometimes this condition can be asymptomatic. Endovaginal ultrasound and particularly three-dimensional ultrasound are very important diagnostic tools. Hysteroscopic removal of the bony fragments helps in treating both infertility and menorrhagia. We present a case of 28 years-old women with osseous metaplasia and uterine synechia. Three-dimensional ultrasound was useful for the diagnosis and both affections were solved by hysteroscopic approach

Journal of Personalized Medicine

Placental morbid adherence is a known risk factor for postpartum hemorrhage. The incidence of abn... more Placental morbid adherence is a known risk factor for postpartum hemorrhage. The incidence of abnormal placental attachment has been increasing over the past few decades, mainly due to rising rates of cesarean deliveries, advanced maternal age, and the use of assisted reproductive technologies. Cesarean section is a significant risk factor for placenta increta, as it disrupts the normal architecture of the uterine wall, making it more difficult for the placenta to detach after delivery. We present the case of a woman who underwent a cesarean section at 28 weeks due to anterior placenta previa, accompanied by hemorrhage and rupture of membranes. Following the delivery, she experienced normal postoperative bleeding and was discharged home after five days. However, six weeks later, she presented with heavy bleeding, leading to the decision to perform a total hysterectomy. The levels of HCG were found to be low. The pathological examination of the specimens confirmed a diagnosis of plac...

Aggressive angiomyxoma (AA) is a rare, benign and slowly growing mesenchymal tumor which affect w... more Aggressive angiomyxoma (AA) is a rare, benign and slowly growing mesenchymal tumor which affect women especially on the reproductive age. Because over 80% of cases are misdiagnosed and most of them are often confused with lipomas, the diagnosis is made by histological examination. We describe here a case of an 89-year-old female, at menopause, that presented with a large pedunculated angiomyxoma on the right upper of major labia. The vulvar AA diagnosed was made due to clinical-pathologic findings and histologic result after the local excision of the tumor. The patient was discharge 7 days after surgery and along of 7 months of follow-up no recurrence or metastasis were documented. In this case we showed the diagnosis, management and prediction for vulvar angiomyxoma in postmenopausal period, but further follow-up period is necessary for surveilling the recurrence, knowing that the tumor it may reappear in between 2 months and 12 years.

Symmetry

Two different operational procedures are proposed for evaluating and predicting the onset of epil... more Two different operational procedures are proposed for evaluating and predicting the onset of epileptic and eclamptic seizures. The first procedure analyzes the electrical activity of the brain (EEG signals) using nonlinear dynamic methods (the time variations of the standard deviation, the variance, the skewness and the kurtosis; the evolution in time of the spatial–temporal entropy; the variations of the Lyapunov coefficients, etc.). The second operational procedure reconstructs any type of EEG signal through harmonic mappings from the usual space to the hyperbolic one using the time homographic invariance of a multifractal-type Schrödinger equation in the framework of the scale relativity theory (i.e., in a multifractal paradigm of motions). More precisely, the explicit differential descriptions of the brain activity in the form of 2 × 2 matrices with real elements disclose, through the in-phase coherences at various scale resolutions (i.e., as scale transitions), the multitude of...

Experimental and Therapeutic Medicine

Taiwanese Journal of Obstetrics and Gynecology

Molecules

The aim of the study was to create a mathematical model useful for monitoring the release of bioa... more The aim of the study was to create a mathematical model useful for monitoring the release of bioactive aldehydes covalently bonded to the chitosan by reversible imine linkage, considered as a polymer–drug system. For this purpose, two hydrogels were prepared by the acid condensation reaction of chitosan with the antifungal 2-formyl-phenyl-boronic acid and their particularities; influencing the release of the antifungal aldehyde by shifting the imination equilibrium to the reagents was considered, i.e., the supramolecular nature of the hydrogels was highlighted by polarized light microscopy, while scanning electron microscopy showed their microporous morphology. Furthermore, the in vitro fungicidal activity was investigated on two fungal strains and the in vitro release curves of the antifungal aldehyde triggered by the pH stimulus were drawn. The theoretical model was developed starting from the hypothesis that the imine-chitosan system, both structurally and functionally, can be as...

Experimental and Therapeutic Medicine

The rupture of a subserosa variceal vein overlying a uterine myoma is a rare complication and a l... more The rupture of a subserosa variceal vein overlying a uterine myoma is a rare complication and a less common cause of gynecologic haemoperitoneum. The literature data are scarce regarding this condition and less than 100 cases have been reported (including those occurring during pregnancy). The present case is of a 48-year-old woman, with a history of asymptomatic uterine myoma, who was hospitalised for severe abdominal pain with sudden onset and signs of hypovolemic shock. The emergency conventional imaging exams confirmed the diagnosis of uterine myoma and haemoperitoneum, but did not reveal the source of bleeding. The cause of haemoperitoneum was detected by means of emergency laparotomy. In order to obtain quick hemostasis, in the settings of a rapid deteriorating hypovolemic shock, a supracervical hysterectomy was performed. The aim of the article is to raise awareness to gynecologists regarding this extremely rare life-threatening complication of the most common benign tumor of the uterus.

Medicina

Background and Objectives: The most utilized approach for the embolization of uterine arteries is... more Background and Objectives: The most utilized approach for the embolization of uterine arteries is the transfemoral path. However, the transradial approach (TRA) has been gaining popularity among cardiologic interventions in the last years but only few studies have shown its applicability in uterine myoma treatment. The objective of this paper is to assess the feasibility, safety and efficacy of TRA when compared with the transbrachial, transulnar or transfemoral approach (TFA) for uterine arteries embolization (UAE). Materials and methods: A systematic review of the literature that analyzes the TRA for UAE it was carried out, in order to assess its safety and effectiveness. It was systematically searched the literature (Google Scholar, PubMed/MEDLINE, Cochrane Library and Embase) using the words “uterine artery embolization”/“uterine embolization” and “transradial”/“radial”. All the relevant papers published until March 2020 were retrieved and analyzed. Results: Ten studies were con...

Experimental and Therapeutic Medicine

The rapid development achieved over the last decades in volume rendering of ultrasound data, know... more The rapid development achieved over the last decades in volume rendering of ultrasound data, known as three-dimensional (3D) ultrasound technique, leads to new opportunities for refining the diagnosis in many gynaecologic conditions. The aim of the present study was to evaluate the advantages of 3D ultrasound over two-dimensional (2D) ultrasound in uterine pathology and to establish the optimal time point during the menstrual cycle to perform 3D ultrasound examination in order to achieve the maximum of useful information. A cross-sectional study on 200 patients who underwent gynaecologic 2D and 3D ultrasound examinations was performed. The addition of 3D examination to 2D ultrasound in uterine pathology provided the most useful information concerning: Congenital uterine anomalies, intrauterine devices (IUDs), adenomyosis, and submucous myomas. The findings showed that the 3D ultrasound scan is a useful tool in gynaecology, especially in cases with congenital uterine anomalies, myoma, and IUD. Although initially it was used for research purposes only, recent findings suggest its usefulness in routine ultrasound scan and the possibility of witnessing its introduction as a recommended examination procedure in the foreseeable future. Further research should be conducted in order to establish the sensitivity of 3D ultrasound in the detection of minor endometrial conditions, by correlating the imaging findings with the hysteroscopic results.