Louis Gotthelf - Academia.edu (original) (raw)

Papers by Louis Gotthelf

Research paper thumbnail of Diagnosis and Treatment of Otitis Media

Research paper thumbnail of Chapter 8 – Perpetuating Factors and Treatment of Otitis Externa

Research paper thumbnail of Diagnosis of otitis media in dogs

Identifying and treating otitis media in pets is a challenging situation for the veterinarian, a ... more Identifying and treating otitis media in pets is a challenging situation for the veterinarian, a frustrating event in the pet owner’s life, and a painful condition for the patient. When a veterinarian does not properly diagnose and treat otitis media, pet owners often seek second, third, and fourth opinions from neighbouring veterinary practices. The diagnosis of otitis media in dogs can be quite difficult to make for a number of reasons: ● Dogs have a long, angled, funnel-shaped external ear canal making examination difficult ● Many patients with otitis media have an intact tympanic membrane (TM) ● Most dogs with otitis media also have a chronic otitis externa with pathological changes to the ear canal, making examination of the TM impossible (Figure 1)

Research paper thumbnail of Laser Surgery Procedures of the Ear

We provide asymptotic theory for this identification approach under mild α-mixing conditions that... more We provide asymptotic theory for this identification approach under mild α-mixing conditions that cover a large class of uncorrelated, but possibly dependent innovation processes, including conditional heteroskedasticity. We prove consistency of a residual-based moving block bootstrap for inference on statistics such as impulse response functions and forecast error variance decompositions. Wild bootstraps are proven to be generally invalid for these statistics and their coverage rates can be badly and persistently mis-sized.

Research paper thumbnail of Clinical Suite: Otitis Externa

Research paper thumbnail of Factors that Predispose the Ear to Otitis Externa

Small Animal Ear Diseases, 2005

Research paper thumbnail of Comprar Small Animal Ear Diseases | Louis N. Gotthelf | 9780721677507 | Saunders

Http Www Libreriasaulamedica Com, 2000

Research paper thumbnail of Comprar Small Animal Ear Diseases | Louis N Gotthelf | 9780721601373 | Saunders

Http Www Libreriasaulamedica Com, 2005

Research paper thumbnail of Ototoxicity

Small Animal Ear Diseases, 2005

Research paper thumbnail of Inflammatory Polyps

Small Animal Ear Diseases, 2005

Research paper thumbnail of Healing of the Ruptured Eardrum

Small Animal Ear Diseases, 2005

Research paper thumbnail of Examination of the External Ear Canal

Small Animal Ear Diseases, 2005

The diagnostic category of atypia of undetermined significance/follicular lesion of undetermined ... more The diagnostic category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has proven to be heterogeneous in terms of usage and clinical outcome. Several factors have been noted in the literature to lead to AUS/FLUS diagnosis. In this study, we assessed the significance of various clinicopathologic factors that may influence AUS/FLUS diagnosis. A search of our laboratory information system was performed to identify all in-house thyroid fine-needle aspiration (FNA) cases performed under ultrasound (US) guidance and diagnosed as AUS/FLUS from 2008-2011. Data-points collected for this study included: patient demographic information, size of the thyroid nodule sampled, aspirator, pathologist rendering the final diagnosis, and applicable follow up. The case cohort included 348 cases diagnosed as AUS/FLUS in 87 males and 261 females (average age of 56 years). All FNAs were performed under ultrasound guidance; 171 (49%) nodules were aspirated by a team of endocrinologists and 177 (51%) by a team of radiologists. The nodule size was available in 328 cases (average size of 2.63 cm); 14 (4%) measured <1.0 cm, 217 (66%) were 1.1-3.0 cm and 97 (30%) were 3.1->4.1 cm. Five cytopathologists interpreted all thyroid FNA cases; the AUS/FLUS rate varied from 10.2% in 2009 to 8% in 2011. Of the 348 cases diagnosed as AUS/FLUS, 219 (63%) were interpreted by two and the remaining 129 (37%) by three cytopathologists. Follow-up was available in 260 (75%) cases; 187 (54%) had 1-3 repeat FNA procedures. Histologic follow-up was available in 139 (40%) cases with an overall malignancy rate of 32% (45 cases). The malignancy rate was highest (32%) in nodules measuring 2.1-3.0 cm. Based on this study cytopathologic interpretation is the most significant factor for the variable rate and follow-up of cases diagnosed as AUS/FLUS.

Research paper thumbnail of Failure of Epithelial Migration: Ceruminoliths

Small Animal Ear Diseases, 2005

Research paper thumbnail of Primary Causes of Ear Disease

Small Animal Ear Diseases, 2005

Research paper thumbnail of Diagnosis and Treatment of Otitis Media

Seminars in Hearing, 1995

Research paper thumbnail of Small Animal Ear Diseases: An Illustrated Guide

The Canadian Veterinary Journal, 2000

3. MacKinnon BM. Sea lice: A review. World Aquacult 1997; 28(3):5-10. 4. Johnson SC, Albright LJ.... more 3. MacKinnon BM. Sea lice: A review. World Aquacult 1997; 28(3):5-10. 4. Johnson SC, Albright LJ. The developmental stages of Lepeophtheirus salmonis (Kr0yer, 1837) (Copepoda: Caligidae). Can J Zool 199 1;69:929-950. 5. Roth M, Richards RH, Sommerville C. ...

Research paper thumbnail of Diagnosis and treatment of otitis media in dogs and cats

Veterinary Clinics of North America: Small Animal Practice, 2004

Research paper thumbnail of Diagnosis and Treatment of Otitis Media

Research paper thumbnail of Chapter 8 – Perpetuating Factors and Treatment of Otitis Externa

Research paper thumbnail of Diagnosis of otitis media in dogs

Identifying and treating otitis media in pets is a challenging situation for the veterinarian, a ... more Identifying and treating otitis media in pets is a challenging situation for the veterinarian, a frustrating event in the pet owner’s life, and a painful condition for the patient. When a veterinarian does not properly diagnose and treat otitis media, pet owners often seek second, third, and fourth opinions from neighbouring veterinary practices. The diagnosis of otitis media in dogs can be quite difficult to make for a number of reasons: ● Dogs have a long, angled, funnel-shaped external ear canal making examination difficult ● Many patients with otitis media have an intact tympanic membrane (TM) ● Most dogs with otitis media also have a chronic otitis externa with pathological changes to the ear canal, making examination of the TM impossible (Figure 1)

Research paper thumbnail of Laser Surgery Procedures of the Ear

We provide asymptotic theory for this identification approach under mild α-mixing conditions that... more We provide asymptotic theory for this identification approach under mild α-mixing conditions that cover a large class of uncorrelated, but possibly dependent innovation processes, including conditional heteroskedasticity. We prove consistency of a residual-based moving block bootstrap for inference on statistics such as impulse response functions and forecast error variance decompositions. Wild bootstraps are proven to be generally invalid for these statistics and their coverage rates can be badly and persistently mis-sized.

Research paper thumbnail of Clinical Suite: Otitis Externa

Research paper thumbnail of Factors that Predispose the Ear to Otitis Externa

Small Animal Ear Diseases, 2005

Research paper thumbnail of Comprar Small Animal Ear Diseases | Louis N. Gotthelf | 9780721677507 | Saunders

Http Www Libreriasaulamedica Com, 2000

Research paper thumbnail of Comprar Small Animal Ear Diseases | Louis N Gotthelf | 9780721601373 | Saunders

Http Www Libreriasaulamedica Com, 2005

Research paper thumbnail of Ototoxicity

Small Animal Ear Diseases, 2005

Research paper thumbnail of Inflammatory Polyps

Small Animal Ear Diseases, 2005

Research paper thumbnail of Healing of the Ruptured Eardrum

Small Animal Ear Diseases, 2005

Research paper thumbnail of Examination of the External Ear Canal

Small Animal Ear Diseases, 2005

The diagnostic category of atypia of undetermined significance/follicular lesion of undetermined ... more The diagnostic category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has proven to be heterogeneous in terms of usage and clinical outcome. Several factors have been noted in the literature to lead to AUS/FLUS diagnosis. In this study, we assessed the significance of various clinicopathologic factors that may influence AUS/FLUS diagnosis. A search of our laboratory information system was performed to identify all in-house thyroid fine-needle aspiration (FNA) cases performed under ultrasound (US) guidance and diagnosed as AUS/FLUS from 2008-2011. Data-points collected for this study included: patient demographic information, size of the thyroid nodule sampled, aspirator, pathologist rendering the final diagnosis, and applicable follow up. The case cohort included 348 cases diagnosed as AUS/FLUS in 87 males and 261 females (average age of 56 years). All FNAs were performed under ultrasound guidance; 171 (49%) nodules were aspirated by a team of endocrinologists and 177 (51%) by a team of radiologists. The nodule size was available in 328 cases (average size of 2.63 cm); 14 (4%) measured <1.0 cm, 217 (66%) were 1.1-3.0 cm and 97 (30%) were 3.1->4.1 cm. Five cytopathologists interpreted all thyroid FNA cases; the AUS/FLUS rate varied from 10.2% in 2009 to 8% in 2011. Of the 348 cases diagnosed as AUS/FLUS, 219 (63%) were interpreted by two and the remaining 129 (37%) by three cytopathologists. Follow-up was available in 260 (75%) cases; 187 (54%) had 1-3 repeat FNA procedures. Histologic follow-up was available in 139 (40%) cases with an overall malignancy rate of 32% (45 cases). The malignancy rate was highest (32%) in nodules measuring 2.1-3.0 cm. Based on this study cytopathologic interpretation is the most significant factor for the variable rate and follow-up of cases diagnosed as AUS/FLUS.

Research paper thumbnail of Failure of Epithelial Migration: Ceruminoliths

Small Animal Ear Diseases, 2005

Research paper thumbnail of Primary Causes of Ear Disease

Small Animal Ear Diseases, 2005

Research paper thumbnail of Diagnosis and Treatment of Otitis Media

Seminars in Hearing, 1995

Research paper thumbnail of Small Animal Ear Diseases: An Illustrated Guide

The Canadian Veterinary Journal, 2000

3. MacKinnon BM. Sea lice: A review. World Aquacult 1997; 28(3):5-10. 4. Johnson SC, Albright LJ.... more 3. MacKinnon BM. Sea lice: A review. World Aquacult 1997; 28(3):5-10. 4. Johnson SC, Albright LJ. The developmental stages of Lepeophtheirus salmonis (Kr0yer, 1837) (Copepoda: Caligidae). Can J Zool 199 1;69:929-950. 5. Roth M, Richards RH, Sommerville C. ...

Research paper thumbnail of Diagnosis and treatment of otitis media in dogs and cats

Veterinary Clinics of North America: Small Animal Practice, 2004