Louis Roelandt - Academia.edu (original) (raw)

Papers by Louis Roelandt

Research paper thumbnail of Prévalence des troubles psychotraumatiques en France métropolitaine

Encephale-revue De Psychiatrie Clinique Biologique Et Therapeutique, 2008

G. Vaiva et al.

Research paper thumbnail of Nonfibrous Mineralogical Analysis of Bronchoalveolar Lavage Fluid from Blast-Furnace Workers

Archives of Environmental Health, 1995

Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We ... more Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant environment. In the current study, we further analyzed bronchoalveolar lavage fluid of steelworkers by measuring intramacrophagic trace-metal content and nonfibrous mineral particles, using the particle-induced x-ray emission method and electron microscopy, respectively. Forty-seven blast-furnace workers and 45 healthy white-collar workers volunteered for this study. Significantly increased levels of iron, titanium, zinc, and bromine were found in the steelworkers, and levels of lead, chromium, arsenic, and strontium tended to increase in the macrophages and bronchoalveolar lavage fluid of the steelworkers. Nonfibrous particles, including illite, kaolinite, talc, chlorite, amorphous silica, quartz, iron (compounds), and titanium hydroxide, were found in both groups, but the particle number per ml bronchoalveolar lavage fluid (particularly iron hydroxides and silicates) was more pronounced in blast-furnace workers. These elements and particles may act synergistically with other occupational carcinogens and cigarette smoke, the result of which may be an increased incidence of lung cancer in the ironsteel industry.

Research paper thumbnail of S.22.05 Trauma-related disorders and suicide in the French WHO study “Santé Mentale en Population Générale

European Neuropsychopharmacology, 2008

Research paper thumbnail of Correlation of location of acute myocardial infarct after noncardiac vascular surgery with preoperative dobutamine echocardiographic findings

American Journal of Cardiology, 2001

T he aim of this study was to assess the usefulness of preoperative dobutamine stress echocardiog... more T he aim of this study was to assess the usefulness of preoperative dobutamine stress echocardiography (DSE) for the identification of culprit coronary lesions in patients who died within 30 days of major vascular surgery and underwent autopsy.

Research paper thumbnail of Role of Dobutamine Stress Echocardiography for Preoperative Cardiac Risk Assessment Before Major Vascular Surgery: A Diagnostic Tool Comes of Age

Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques, 2000

Background: Cardiac complications are a major cause for perioperative mortality and morbidity Als... more Background: Cardiac complications are a major cause for perioperative mortality and morbidity Also, the presence and severity of underlying coronary artery disease (CAD) determine long-ten prognosis after successful surgery. Aim: This overview evaluates the additional value ofdobutamir, stress echocardiography (DSE) to common clinical cardiac risk factors and other noninvasii cardiac imaging modalities for perioperative and late cardiac prognosis. Results: DSE provides tl attending physician with preoperative prognostic information for perioperative and long-ten prognosis for cardiac events. It also enables the selection of high risk patients for evaluation i cardiac risk reduction therapies. Conclusions: DSE is a useful tool for preoperative cardiac ris evaluation in addition to common clinical cardiac risk factors. (ECHOCARDIOGRAPHY, Vo ume 17, January 2000)

Research paper thumbnail of Why do patients with ischemic cardiomyopathy and a substantial amount of viable myocardium not always recover in function after revascularization

Journal of Thoracic and Cardiovascular Surgery, 2004

Why do patients with ischemic cardiomyopathy and a substantial amount of Objective: In patients w... more Why do patients with ischemic cardiomyopathy and a substantial amount of Objective: In patients with ischemic cardiomyopathy and a substantial amount of dysfunctional but viable myocardium, myocardial revascularization may improve left ventricular ejection fraction. The aim of this study was to evaluate why not all patients with a substantial amount of viable tissue recover in function after revascularization.

Research paper thumbnail of Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

Cancer Cell, 2007

Activation of NF-kB has been noted in many tumor types, however only rarely has this been linked ... more Activation of NF-kB has been noted in many tumor types, however only rarely has this been linked to an underlying genetic mutation. An integrated analysis of high-density oligonucleotide array CGH and gene expression profiling data from 155 multiple myeloma samples identified a promiscuous array of abnormalities contributing to the dysregulation of NF-kB in approximately 20% of patients. We report mutations in ten genes causing the inactivation of TRAF2, TRAF3, CYLD, cIAP1/cIAP2, and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK that result primarily in constitutive activation of the non-canonical NF-kB pathway, with the single most common abnormality being inactivation of TRAF3. These results highlight the critical importance of the NF-kB pathway in the pathogenesis of multiple myeloma.

Research paper thumbnail of Irish cardiac society

Irish Journal of Medical Science, 1992

Patients were eligible if they presented within 24 hours of suspected acute myocardial infarction... more Patients were eligible if they presented within 24 hours of suspected acute myocardial infarction with no clear indications for, or contraindications to, the study treatments (although planned use of a few days of intravenous or oral nitrates was permitted). About 40% were within 6 hours of pain onset. 75% had ST elevation, 25% were aged 70% 15% had heart failure, and 2% had systolic blood pressure < 100 ramHg Patients were randomly allocated in a 2 x 2 x 2 factorial design between one month of oral captopril (6.25 mg initial dose, 12.5 rag 2 hours later, 25 mg 10-12 hours later and then 50 mg twice daily) versus placebo, one month of oral controlled-release isosorbide mouonitrate (lmdur: 30 mg initial dose, 30 mg 10-12 hours later and then 60 nag each morning) versus placebo, and 24 hours of intravenous magnesium sulphate (8 raraol initial bolus over 15 minutes followed by 72 mmcl)'versus open control. About 75% received fibrinolytic and almost all antiplatelet therapy.

Research paper thumbnail of Towards an Integrated Model of Weathering, Climate, and Biospheric Processes

Reviews in Mineralogy & Geochemistry, 2009

Research paper thumbnail of Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction

American Journal of Cardiology, 2004

Contractile function in patients with ischemic left ventricular (LV) dysfunction may improve afte... more Contractile function in patients with ischemic left ventricular (LV) dysfunction may improve after myocardial revascularization. Currently, the incidence of contractile function recovery after revascularization in these patients is unclear. The aim of this study was to assess the incidence of function improvement after myocardial revascularization in patients with ischemic LV dysfunction. A total of 258 consecutive patients (aged 59 +/- 12 years) with severely depressed LV ejection fractions (EFs) due to chronic coronary artery disease and heart failure symptoms were studied. All patients underwent radionuclide ventriculography and 2-dimensional echocardiography at rest before and 3 to 6 months after revascularization. At baseline, 1,330 segments (32%) were normal and 2,775 segments (68%) were dysfunctional. Improvement after revascularization occurred in 736 of the 2,775 dysfunctional segments (27%). Overall, LVEF improved from 29 +/- 7 to 32 +/- 9 (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001). A clinically significant improvement of LVEF (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/=5% postrevascularization) was present in 101 patients (39%). Improvement of LVEF after revascularization was frequently observed in patients with a more severely impaired baseline LVEF. At least 3 segments with improvement of function were needed for an improvement of LVEF of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/=5%.

Research paper thumbnail of Prévalence des troubles psychotraumatiques en France métropolitaine

Encephale-revue De Psychiatrie Clinique Biologique Et Therapeutique, 2008

G. Vaiva et al.

Research paper thumbnail of Nonfibrous Mineralogical Analysis of Bronchoalveolar Lavage Fluid from Blast-Furnace Workers

Archives of Environmental Health, 1995

Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We ... more Steelworkers are exposed to many pollutants, and they are at risk for developing lung cancer. We demonstrated previously that steelworkers may be subject to an occult exposure to amphiboles in the plant environment. In the current study, we further analyzed bronchoalveolar lavage fluid of steelworkers by measuring intramacrophagic trace-metal content and nonfibrous mineral particles, using the particle-induced x-ray emission method and electron microscopy, respectively. Forty-seven blast-furnace workers and 45 healthy white-collar workers volunteered for this study. Significantly increased levels of iron, titanium, zinc, and bromine were found in the steelworkers, and levels of lead, chromium, arsenic, and strontium tended to increase in the macrophages and bronchoalveolar lavage fluid of the steelworkers. Nonfibrous particles, including illite, kaolinite, talc, chlorite, amorphous silica, quartz, iron (compounds), and titanium hydroxide, were found in both groups, but the particle number per ml bronchoalveolar lavage fluid (particularly iron hydroxides and silicates) was more pronounced in blast-furnace workers. These elements and particles may act synergistically with other occupational carcinogens and cigarette smoke, the result of which may be an increased incidence of lung cancer in the ironsteel industry.

Research paper thumbnail of S.22.05 Trauma-related disorders and suicide in the French WHO study “Santé Mentale en Population Générale

European Neuropsychopharmacology, 2008

Research paper thumbnail of Correlation of location of acute myocardial infarct after noncardiac vascular surgery with preoperative dobutamine echocardiographic findings

American Journal of Cardiology, 2001

T he aim of this study was to assess the usefulness of preoperative dobutamine stress echocardiog... more T he aim of this study was to assess the usefulness of preoperative dobutamine stress echocardiography (DSE) for the identification of culprit coronary lesions in patients who died within 30 days of major vascular surgery and underwent autopsy.

Research paper thumbnail of Role of Dobutamine Stress Echocardiography for Preoperative Cardiac Risk Assessment Before Major Vascular Surgery: A Diagnostic Tool Comes of Age

Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques, 2000

Background: Cardiac complications are a major cause for perioperative mortality and morbidity Als... more Background: Cardiac complications are a major cause for perioperative mortality and morbidity Also, the presence and severity of underlying coronary artery disease (CAD) determine long-ten prognosis after successful surgery. Aim: This overview evaluates the additional value ofdobutamir, stress echocardiography (DSE) to common clinical cardiac risk factors and other noninvasii cardiac imaging modalities for perioperative and late cardiac prognosis. Results: DSE provides tl attending physician with preoperative prognostic information for perioperative and long-ten prognosis for cardiac events. It also enables the selection of high risk patients for evaluation i cardiac risk reduction therapies. Conclusions: DSE is a useful tool for preoperative cardiac ris evaluation in addition to common clinical cardiac risk factors. (ECHOCARDIOGRAPHY, Vo ume 17, January 2000)

Research paper thumbnail of Why do patients with ischemic cardiomyopathy and a substantial amount of viable myocardium not always recover in function after revascularization

Journal of Thoracic and Cardiovascular Surgery, 2004

Why do patients with ischemic cardiomyopathy and a substantial amount of Objective: In patients w... more Why do patients with ischemic cardiomyopathy and a substantial amount of Objective: In patients with ischemic cardiomyopathy and a substantial amount of dysfunctional but viable myocardium, myocardial revascularization may improve left ventricular ejection fraction. The aim of this study was to evaluate why not all patients with a substantial amount of viable tissue recover in function after revascularization.

Research paper thumbnail of Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

Cancer Cell, 2007

Activation of NF-kB has been noted in many tumor types, however only rarely has this been linked ... more Activation of NF-kB has been noted in many tumor types, however only rarely has this been linked to an underlying genetic mutation. An integrated analysis of high-density oligonucleotide array CGH and gene expression profiling data from 155 multiple myeloma samples identified a promiscuous array of abnormalities contributing to the dysregulation of NF-kB in approximately 20% of patients. We report mutations in ten genes causing the inactivation of TRAF2, TRAF3, CYLD, cIAP1/cIAP2, and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK that result primarily in constitutive activation of the non-canonical NF-kB pathway, with the single most common abnormality being inactivation of TRAF3. These results highlight the critical importance of the NF-kB pathway in the pathogenesis of multiple myeloma.

Research paper thumbnail of Irish cardiac society

Irish Journal of Medical Science, 1992

Patients were eligible if they presented within 24 hours of suspected acute myocardial infarction... more Patients were eligible if they presented within 24 hours of suspected acute myocardial infarction with no clear indications for, or contraindications to, the study treatments (although planned use of a few days of intravenous or oral nitrates was permitted). About 40% were within 6 hours of pain onset. 75% had ST elevation, 25% were aged 70% 15% had heart failure, and 2% had systolic blood pressure < 100 ramHg Patients were randomly allocated in a 2 x 2 x 2 factorial design between one month of oral captopril (6.25 mg initial dose, 12.5 rag 2 hours later, 25 mg 10-12 hours later and then 50 mg twice daily) versus placebo, one month of oral controlled-release isosorbide mouonitrate (lmdur: 30 mg initial dose, 30 mg 10-12 hours later and then 60 nag each morning) versus placebo, and 24 hours of intravenous magnesium sulphate (8 raraol initial bolus over 15 minutes followed by 72 mmcl)'versus open control. About 75% received fibrinolytic and almost all antiplatelet therapy.

Research paper thumbnail of Towards an Integrated Model of Weathering, Climate, and Biospheric Processes

Reviews in Mineralogy & Geochemistry, 2009

Research paper thumbnail of Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction

American Journal of Cardiology, 2004

Contractile function in patients with ischemic left ventricular (LV) dysfunction may improve afte... more Contractile function in patients with ischemic left ventricular (LV) dysfunction may improve after myocardial revascularization. Currently, the incidence of contractile function recovery after revascularization in these patients is unclear. The aim of this study was to assess the incidence of function improvement after myocardial revascularization in patients with ischemic LV dysfunction. A total of 258 consecutive patients (aged 59 +/- 12 years) with severely depressed LV ejection fractions (EFs) due to chronic coronary artery disease and heart failure symptoms were studied. All patients underwent radionuclide ventriculography and 2-dimensional echocardiography at rest before and 3 to 6 months after revascularization. At baseline, 1,330 segments (32%) were normal and 2,775 segments (68%) were dysfunctional. Improvement after revascularization occurred in 736 of the 2,775 dysfunctional segments (27%). Overall, LVEF improved from 29 +/- 7 to 32 +/- 9 (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001). A clinically significant improvement of LVEF (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/=5% postrevascularization) was present in 101 patients (39%). Improvement of LVEF after revascularization was frequently observed in patients with a more severely impaired baseline LVEF. At least 3 segments with improvement of function were needed for an improvement of LVEF of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/=5%.