Luc Van Hijfte - Academia.edu (original) (raw)
Papers by Luc Van Hijfte
Journal of Photochemistry, 1985
... CYCLOBUTENE: A VERSATILE ENTRY TO THE STEREOCONTROLLED TOTAL SYNTHESIS OF VARIOUS SESQUITERPE... more ... CYCLOBUTENE: A VERSATILE ENTRY TO THE STEREOCONTROLLED TOTAL SYNTHESIS OF VARIOUS SESQUITERPENES AND DITERPENESt DENIS DE KEUKELEIRE ... 6 M. Vandewalle, P. De Clercq, M. Dernuynck, P. Kok, G. Rozing and F. Scott, in W. Bartinann and E ...
ChemInform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, 1993
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ACS chemical biology, Jan 19, 2014
ChemInform, 2009
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, 2006
ABSTRACT Alcohols are solvents of choice to react boronates, aldehydes and either primary or seco... more ABSTRACT Alcohols are solvents of choice to react boronates, aldehydes and either primary or secondary amines. Thus, while the reaction proceeds sluggishly, or not at all, in aprotic solvents, the desired aminoacids are in most cases obtained in high yields when conducted in methanol or hexafluoro-iso-propanol. In the case of secondary amines, microwave activation is shown to strongly accelerate the process without altering the yields.
Tetrahedron Letters, 2003
A Brassard diene analogue was grafted on a modified Merrifield resin and used in a hetero Diels-A... more A Brassard diene analogue was grafted on a modified Merrifield resin and used in a hetero Diels-Alder reaction with various aldehydes or ketones. The reaction gave access to 6-substituted 5,6-dihydropyrones (5a-u). This new immobilized electron-rich diene is more stable than the corresponding native diene, and is a versatile supported reagent.
Tetrahedron Letters, 2003
![Research paper thumbnail of Studies on pyrrolidinones. Oxidations and rearrangements in the hexahydrobenz[f]indolizine-3,10-dione series](https://attachments.academia-assets.com/41934056/thumbnails/1.jpg)
](Tetrahedron, 2006
Air oxidation of hexahydrobenz[f]indolizine-3,10-diones in MeOH/MeONa yields alcohols, which are ... more Air oxidation of hexahydrobenz[f]indolizine-3,10-diones in MeOH/MeONa yields alcohols, which are easily and selectively transformed, in very good yields, to succinimides, isoquinoline propanoic acids or dehydrated to ene lactams. q
Tetrahedron, 2012
The synthesis of some condensed indolizinediones derived from pyroglutamic acid is described. Tre... more The synthesis of some condensed indolizinediones derived from pyroglutamic acid is described. Treatment of these ketones in HCl, HBr or MeONa/MeOH furnished aryl propionic acid derivatives. During the ketone transformations, two sequential processes could take place in competitive manner to provide heterocyclic systems bearing carboxylic acid or hydroxycarboxylic acid function. Easy synthesis of amides indicates that potential DNA-intercalating heterocyclic systems fused on g-carboline and isoquinoline nucleus could be obtained from these series.
Tetrahedron, 2012
ABSTRACT The synthesis of new condensed indolizinediones derived from pyroglutamic acid is descri... more ABSTRACT The synthesis of new condensed indolizinediones derived from pyroglutamic acid is described. The Semmler–Wolff transposition of the oxime of these ketones leads to fused dihydro-1,5-naphthyridinones. Easy introduction of side amino chains indicates that potential DNA-intercalating heterocyclic systems fused on 1,5-naphthyridine nucleus could be obtained in these series.
Organic Letters, 2012
A series of new silylated heterocycles has been efficiently prepared using an intramolecular sili... more A series of new silylated heterocycles has been efficiently prepared using an intramolecular silicon version of the Matteson rearrangement, providing two isomers of binuclear heterocycles. This method applies to a large variety of substrates, a direct relationship between the Hammett constants of the aromatic substituents and the isomer ratio being observed. Complementary experiments suggest that a common pentaorganosilicate species is involved.
Organic Letters, 2009
A diastereodivergent addition of allenylzincs to aryl glyoxylates was observed depending on the m... more A diastereodivergent addition of allenylzincs to aryl glyoxylates was observed depending on the method used for the preparation of the allenylzinc reagent. The allenylzincs were prepared from propargylic benzoates in the presence of a palladium catalyst or by metalation of alkynes.
European Journal of Organic Chemistry, 2010
The α-ketol rearrangement of tertiary α-hydroxy esters induced by LiAlH 4 /acid treatment provide... more The α-ketol rearrangement of tertiary α-hydroxy esters induced by LiAlH 4 /acid treatment provides α-hydroxy ketones in good yields and high diastereoselectivity. A mechanism is Eur.
Chemistry - A European Journal, 2011
European Journal of Medicinal Chemistry, 2005
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone dea... more A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
Journal of Photochemistry, 1985
... CYCLOBUTENE: A VERSATILE ENTRY TO THE STEREOCONTROLLED TOTAL SYNTHESIS OF VARIOUS SESQUITERPE... more ... CYCLOBUTENE: A VERSATILE ENTRY TO THE STEREOCONTROLLED TOTAL SYNTHESIS OF VARIOUS SESQUITERPENES AND DITERPENESt DENIS DE KEUKELEIRE ... 6 M. Vandewalle, P. De Clercq, M. Dernuynck, P. Kok, G. Rozing and F. Scott, in W. Bartinann and E ...
ChemInform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, 1993
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ACS chemical biology, Jan 19, 2014
ChemInform, 2009
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform, 2006
ABSTRACT Alcohols are solvents of choice to react boronates, aldehydes and either primary or seco... more ABSTRACT Alcohols are solvents of choice to react boronates, aldehydes and either primary or secondary amines. Thus, while the reaction proceeds sluggishly, or not at all, in aprotic solvents, the desired aminoacids are in most cases obtained in high yields when conducted in methanol or hexafluoro-iso-propanol. In the case of secondary amines, microwave activation is shown to strongly accelerate the process without altering the yields.
Tetrahedron Letters, 2003
A Brassard diene analogue was grafted on a modified Merrifield resin and used in a hetero Diels-A... more A Brassard diene analogue was grafted on a modified Merrifield resin and used in a hetero Diels-Alder reaction with various aldehydes or ketones. The reaction gave access to 6-substituted 5,6-dihydropyrones (5a-u). This new immobilized electron-rich diene is more stable than the corresponding native diene, and is a versatile supported reagent.
Tetrahedron Letters, 2003
Tetrahedron, 2006
Air oxidation of hexahydrobenz[f]indolizine-3,10-diones in MeOH/MeONa yields alcohols, which are ... more Air oxidation of hexahydrobenz[f]indolizine-3,10-diones in MeOH/MeONa yields alcohols, which are easily and selectively transformed, in very good yields, to succinimides, isoquinoline propanoic acids or dehydrated to ene lactams. q
Tetrahedron, 2012
The synthesis of some condensed indolizinediones derived from pyroglutamic acid is described. Tre... more The synthesis of some condensed indolizinediones derived from pyroglutamic acid is described. Treatment of these ketones in HCl, HBr or MeONa/MeOH furnished aryl propionic acid derivatives. During the ketone transformations, two sequential processes could take place in competitive manner to provide heterocyclic systems bearing carboxylic acid or hydroxycarboxylic acid function. Easy synthesis of amides indicates that potential DNA-intercalating heterocyclic systems fused on g-carboline and isoquinoline nucleus could be obtained from these series.
Tetrahedron, 2012
ABSTRACT The synthesis of new condensed indolizinediones derived from pyroglutamic acid is descri... more ABSTRACT The synthesis of new condensed indolizinediones derived from pyroglutamic acid is described. The Semmler–Wolff transposition of the oxime of these ketones leads to fused dihydro-1,5-naphthyridinones. Easy introduction of side amino chains indicates that potential DNA-intercalating heterocyclic systems fused on 1,5-naphthyridine nucleus could be obtained in these series.
Organic Letters, 2012
A series of new silylated heterocycles has been efficiently prepared using an intramolecular sili... more A series of new silylated heterocycles has been efficiently prepared using an intramolecular silicon version of the Matteson rearrangement, providing two isomers of binuclear heterocycles. This method applies to a large variety of substrates, a direct relationship between the Hammett constants of the aromatic substituents and the isomer ratio being observed. Complementary experiments suggest that a common pentaorganosilicate species is involved.
Organic Letters, 2009
A diastereodivergent addition of allenylzincs to aryl glyoxylates was observed depending on the m... more A diastereodivergent addition of allenylzincs to aryl glyoxylates was observed depending on the method used for the preparation of the allenylzinc reagent. The allenylzincs were prepared from propargylic benzoates in the presence of a palladium catalyst or by metalation of alkynes.
European Journal of Organic Chemistry, 2010
The α-ketol rearrangement of tertiary α-hydroxy esters induced by LiAlH 4 /acid treatment provide... more The α-ketol rearrangement of tertiary α-hydroxy esters induced by LiAlH 4 /acid treatment provides α-hydroxy ketones in good yields and high diastereoselectivity. A mechanism is Eur.
Chemistry - A European Journal, 2011
European Journal of Medicinal Chemistry, 2005
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone dea... more A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.