Luca Golino - Academia.edu (original) (raw)
Papers by Luca Golino
Interventional Cardiology, 2020
A 54 years-old lady with NSTEMI underwent OCT-guided PCI. After a sirolimus-eluting bioresorbale ... more A 54 years-old lady with NSTEMI underwent OCT-guided PCI. After a sirolimus-eluting bioresorbale magnesium stent (BRS) implantation, a second BRS was lost in the coronary artery. OCT guidance allowed the successful management of such complication and showed a good result with almost complete reabsorption of the implanted BRSs at 9 months follow-up.
BETA-1 Adrenergic Receptor Blokade and Cardiac BETA-2 Overexpression Stimulates Angiogenesis in the Failing Heart
Exercise promotes angiogenesis and improves b-adrenergic receptor signalling in the post-ischaemic
{beta}-2 Adrenergic Receptors Overexpression Promotes Angiogenesis in the Failing Myocardium through Activation of Vascular Endothelial Growth Factor/Akt Transduction Pathway
Cardiac beta 1-adrenergic receptor blockade promotes angiogenesis in the post-ischemic failing heart via activation of VEGF- and Akt-dependent signalling pathway
AHA conference, 2009
Exercise promotes angiogenesis and improves b-adrenergic receptor signalling in the post-ischaemic
An active lifestyle improves outcome of primary angioplasty in elderly patients with acute myocardial infarction
American Heart Journal, 2007
Regular physical activity has been shown to improve outcome of acute myocardial infarction (AMI) ... more Regular physical activity has been shown to improve outcome of acute myocardial infarction (AMI) in the elderly population. The aim of this study was to evaluate whether the positive role of an active lifestyle on cardiac prognosis extends to elderly patients with AMI who undergo primary percutaneous transluminal coronary angioplasty (PTCA). We prospectively studied 180 patients with AMI aged > or = 70 years and treated with primary PTCA. In all patients, physical activity levels before AMI were quantified by a score derived from the Physical Activity Scale for the Elderly (PASE). Cardiac deaths and nonfatal cardiac events were evaluated within 30 days and 1-year from primary PTCA. A high PASE score was significantly associated with a strong reduction of 30-day cardiac deaths (from 23.1% to 4%; P for trend = .021) and overall nonfatal events (from 21.1% to 10%; P for trend = .01). Accordingly, at 1 year of follow-up, the incidence of cardiac mortality and nonfatal events significantly decreased with increasing PASE score (from 28.8% to 8% and from 55.7% to 14.5%, respectively). Logistic regression analysis indicated that physical activity before AMI was an independent predictor of increased survival in those patients that showed the highest PASE scores. In addition, at 6 months of follow-up, although low ejection fraction and recurrent angina strongly predicted 1-year mortality, high PASE scores still predicted a better outcome. Our data indicate that an active lifestyle may favorably affect early and late outcomes of primary PTCA in the elderly population.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2007
293:H1596-H1603, 2007. First published 8 June 2007; Am J Physiol Heart Circ Physiol Walter J. Koc... more 293:H1596-H1603, 2007. First published 8 June 2007; Am J Physiol Heart Circ Physiol Walter J. Koch and Franco Rengo Marchese, Giovanni Esposito, Antonio Rapacciuolo, Barbara Rinaldi, Nicola Ferrara, Lymperopoulos, Carmela Zincarelli, Francesca Fortunato, Luca Golino, Massimo Dario Leosco, Giuseppe Rengo, Guido Iaccarino, Amelia Filippelli, Anastasios adrenergic stimulation signaling and enhance cardiac responsiveness to -adrenergic receptor β age-dependent impairment of -blocker treatment ameliorate β Exercise training and
Abstract 1322: Exercise Stimulates Angiogenesis and Improves {beta}-Adrenergic Receptor Signaling in the Failing Heart
Circulation, 2006
ABSTRACT
Vantaggi del trattamento endoprotesico degli aneurismi aortici in categorie ad alto rischio chirurgico
Giornale di gerontologia, 2003
Abstract 630: Effects of Chronic Exercise on Restoring Age-impaired VEGF Upregulation and Angiogenetic Responses to Hindlimb Ischemia
[Epidemiology and risk factors for heart failure in the elderly]
Heart failure achieves particular relevance and different characteristics in the elderly populati... more Heart failure achieves particular relevance and different characteristics in the elderly population, especially for the clinical complexity related to the presence of comorbidity and chronicity, which are common conditions in these patients. Despite recent advances in clinical approach, diagnosis and therapeutic management of heart failure, the incidence and prevalence of this syndrome are still increasing, owing to the better control of the disease, and, largely, to the aging of the population. Epidemiologic data indicate that heart failure represents a crucial problem in the elderly population in terms of social, economic, and health burden. Despite their importance in the worsening of heart failure and prevention of the progression of this syndrome, the risks of hospital readmission and the causes of exacerbation have not been systematically evaluated in controlled trials. This explains why the precipitating factors of heart failure remain unknown in more than 40% of cases. For t...
Abstract 5570: {beta}-2 Adrenergic Receptors Overexpression Promotes Angiogenesis in the Failing Myocardium through Activation of Vascular Endothelial Growth Factor/Akt Transduction Pathway
Abstract 1574: Lymphocyte GRK2 as a Novel Biological Marker of Alzheimer's Disease
Il trattamento farmacologico della cardiopatia nell'anziano fragile: La pratica clinica alla luce dei trial clinici
Abstract 5118: Cardiac β1-Adrenergic Receptor Blockade Promotes Angiogenesis in the Post-Ischemic Failing Heart via Activation of VEGF- and Akt-dependent Signalling Pathways
Circulation, 2009
Impaired angiogenesis in the post-myocardial infarction (MI) heart, contributes to the progressio... more Impaired angiogenesis in the post-myocardial infarction (MI) heart, contributes to the progression to heart failure (HF). The inhibition of vascular endothelial growth factor (VEGF) signaling has been shown to induce the transition from compensatory hypertrophy to failure. In the present study, we investigated whether treatment with β 1- adrenergic receptor ( β -AR) blockade Bisoprolol (B) may reactivate VEGF-dependent angiogenesis and counteract maladaptive remodeling in HF. 4 weeks from surgically-induced MI, 40 male Sprague Dawley rats, were randomized to receive B (10 mg/Kg/d, for 10 weeks) or vehicle. 10 sham-operated rats were also included in the study. Echocardiography revealed reduced cardiac LV diameters in B-treated compared to vehicle-treated rats. Moreover, B treatment was associated with increased LV capillary and arteriolar density, and with increased in vivo coronary perfusion and reserve. Importantly, 10 days after B treatment was started, increased cardiac VEGF exp...
REabsorbable vs. DUrable Polymer Drug-Eluting Stents in All-Comer PatiEnts: the REDUCE registry
Coronary Artery Disease
BACKGROUND While the superiority of reabsorbable-polymer drug-eluting stents (RP-DES) over bare-m... more BACKGROUND While the superiority of reabsorbable-polymer drug-eluting stents (RP-DES) over bare-metal stents and first-generation durable-polymer (DP)-DES has been largely established, their advantage compared with new-generation DP-DES is still controversial. This study aimed was to compare clinical outcomes of all-comer patients undergoing percutaneous coronary intervention (PCI) with new generation DP-DES or RP-DES implantation. METHODS We prospectively enrolled 679 consecutive patients treated with PCI with RP-DES or DP-DES. The primary endpoint was the 1-year incidence of major adverse clinical events (MACE), a composite of death, myocardial infarction (MI), and target vessel revascularization (TVR). Target lesion revascularization (TLR) and definite stent thrombosis were also recorded. RESULTS A total of 439 (64.6%) received RP-DES and 240 (36.4%) received DP-DES. No significant difference in the incidence of MACE (5.9 vs. 4.9%; hazard ratio, 1.23; 95% confidence interval (CI), 0.61-2.49; P = 0.569), death (1.8 vs. 1.7%; hazard ratio, 1.09; 95% CI, 0.33-3.64; P = 0.882), MI (2.3 vs. 2.1%; hazard ratio, 1.05; 95% CI, 0.36-3.08; P = 0.927), TVR (2.3 vs. 1.3%; hazard ratio, 1.70; 95% CI, 0.47-6.20; P = 0.418), TLR (1.4 vs. 0.4%; hazard ratio, 3.06; 95% CI, 0.37-25.40; P = 0.301), and definite stent thrombosis (0.5 vs. 0.4%; hazard ratio, 1.09; 95% CI, 0.10-12.10; P = 0.942) was observed between RP-DES and DP-DES patients at 1-year follow-up. These results were confirmed in a propensity score-matched cohort (n = 134 per group). CONCLUSION In our registry including a real-world population of all-comer patients undergoing PCI, RP-DES, or durable polymer-DES showed similar efficacy and safety at a 1-year follow-up.
OCT-guided complication management during sirolimus-eluting bioresorbable magnesium stent im-plantation with 9-months OCT follow-up
Journal of Interventional Cardiology
Background. Sirolimus-coated balloons (SCBs) represent a novel therapeutic option for both in-ste... more Background. Sirolimus-coated balloons (SCBs) represent a novel therapeutic option for both in-stent restenosis (ISR) and de novo coronary lesions treatment, especially in small vessels. Our registry sought to evaluate the procedural and clinical outcomes of such devices in a complex acute coronary syndrome (ACS) clinical setting. Methods and Results. We treated 74 consecutive patients with percutaneous coronary intervention (PCI) with at least 1 SCB used for ISR and/or de novo coronary lesion in small vessels at our institution. Sixty-two patients presented with ACS, and their data were included in our analysis. The mean age was 67 ± 10 years, and patients presenting with ST-elevated myocardial infarction (STEMI) were 14 (23%). De novo lesions were 52%, whereas ISR was 48%. Procedural success occurred in 100% of the cases. At the 11 ± 7 months follow-up, major adverse cardiovascular events (MACEs) were 3 (4.8%). Cardiovascular death (CD) occurred in 1 (1.6%) patient and myocardial i...
Interventional Cardiology, 2020
A 54 years-old lady with NSTEMI underwent OCT-guided PCI. After a sirolimus-eluting bioresorbale ... more A 54 years-old lady with NSTEMI underwent OCT-guided PCI. After a sirolimus-eluting bioresorbale magnesium stent (BRS) implantation, a second BRS was lost in the coronary artery. OCT guidance allowed the successful management of such complication and showed a good result with almost complete reabsorption of the implanted BRSs at 9 months follow-up.
BETA-1 Adrenergic Receptor Blokade and Cardiac BETA-2 Overexpression Stimulates Angiogenesis in the Failing Heart
Exercise promotes angiogenesis and improves b-adrenergic receptor signalling in the post-ischaemic
{beta}-2 Adrenergic Receptors Overexpression Promotes Angiogenesis in the Failing Myocardium through Activation of Vascular Endothelial Growth Factor/Akt Transduction Pathway
Cardiac beta 1-adrenergic receptor blockade promotes angiogenesis in the post-ischemic failing heart via activation of VEGF- and Akt-dependent signalling pathway
AHA conference, 2009
Exercise promotes angiogenesis and improves b-adrenergic receptor signalling in the post-ischaemic
An active lifestyle improves outcome of primary angioplasty in elderly patients with acute myocardial infarction
American Heart Journal, 2007
Regular physical activity has been shown to improve outcome of acute myocardial infarction (AMI) ... more Regular physical activity has been shown to improve outcome of acute myocardial infarction (AMI) in the elderly population. The aim of this study was to evaluate whether the positive role of an active lifestyle on cardiac prognosis extends to elderly patients with AMI who undergo primary percutaneous transluminal coronary angioplasty (PTCA). We prospectively studied 180 patients with AMI aged > or = 70 years and treated with primary PTCA. In all patients, physical activity levels before AMI were quantified by a score derived from the Physical Activity Scale for the Elderly (PASE). Cardiac deaths and nonfatal cardiac events were evaluated within 30 days and 1-year from primary PTCA. A high PASE score was significantly associated with a strong reduction of 30-day cardiac deaths (from 23.1% to 4%; P for trend = .021) and overall nonfatal events (from 21.1% to 10%; P for trend = .01). Accordingly, at 1 year of follow-up, the incidence of cardiac mortality and nonfatal events significantly decreased with increasing PASE score (from 28.8% to 8% and from 55.7% to 14.5%, respectively). Logistic regression analysis indicated that physical activity before AMI was an independent predictor of increased survival in those patients that showed the highest PASE scores. In addition, at 6 months of follow-up, although low ejection fraction and recurrent angina strongly predicted 1-year mortality, high PASE scores still predicted a better outcome. Our data indicate that an active lifestyle may favorably affect early and late outcomes of primary PTCA in the elderly population.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2007
293:H1596-H1603, 2007. First published 8 June 2007; Am J Physiol Heart Circ Physiol Walter J. Koc... more 293:H1596-H1603, 2007. First published 8 June 2007; Am J Physiol Heart Circ Physiol Walter J. Koch and Franco Rengo Marchese, Giovanni Esposito, Antonio Rapacciuolo, Barbara Rinaldi, Nicola Ferrara, Lymperopoulos, Carmela Zincarelli, Francesca Fortunato, Luca Golino, Massimo Dario Leosco, Giuseppe Rengo, Guido Iaccarino, Amelia Filippelli, Anastasios adrenergic stimulation signaling and enhance cardiac responsiveness to -adrenergic receptor β age-dependent impairment of -blocker treatment ameliorate β Exercise training and
Abstract 1322: Exercise Stimulates Angiogenesis and Improves {beta}-Adrenergic Receptor Signaling in the Failing Heart
Circulation, 2006
ABSTRACT
Vantaggi del trattamento endoprotesico degli aneurismi aortici in categorie ad alto rischio chirurgico
Giornale di gerontologia, 2003
Abstract 630: Effects of Chronic Exercise on Restoring Age-impaired VEGF Upregulation and Angiogenetic Responses to Hindlimb Ischemia
[Epidemiology and risk factors for heart failure in the elderly]
Heart failure achieves particular relevance and different characteristics in the elderly populati... more Heart failure achieves particular relevance and different characteristics in the elderly population, especially for the clinical complexity related to the presence of comorbidity and chronicity, which are common conditions in these patients. Despite recent advances in clinical approach, diagnosis and therapeutic management of heart failure, the incidence and prevalence of this syndrome are still increasing, owing to the better control of the disease, and, largely, to the aging of the population. Epidemiologic data indicate that heart failure represents a crucial problem in the elderly population in terms of social, economic, and health burden. Despite their importance in the worsening of heart failure and prevention of the progression of this syndrome, the risks of hospital readmission and the causes of exacerbation have not been systematically evaluated in controlled trials. This explains why the precipitating factors of heart failure remain unknown in more than 40% of cases. For t...
Abstract 5570: {beta}-2 Adrenergic Receptors Overexpression Promotes Angiogenesis in the Failing Myocardium through Activation of Vascular Endothelial Growth Factor/Akt Transduction Pathway
Abstract 1574: Lymphocyte GRK2 as a Novel Biological Marker of Alzheimer's Disease
Il trattamento farmacologico della cardiopatia nell'anziano fragile: La pratica clinica alla luce dei trial clinici
Abstract 5118: Cardiac β1-Adrenergic Receptor Blockade Promotes Angiogenesis in the Post-Ischemic Failing Heart via Activation of VEGF- and Akt-dependent Signalling Pathways
Circulation, 2009
Impaired angiogenesis in the post-myocardial infarction (MI) heart, contributes to the progressio... more Impaired angiogenesis in the post-myocardial infarction (MI) heart, contributes to the progression to heart failure (HF). The inhibition of vascular endothelial growth factor (VEGF) signaling has been shown to induce the transition from compensatory hypertrophy to failure. In the present study, we investigated whether treatment with β 1- adrenergic receptor ( β -AR) blockade Bisoprolol (B) may reactivate VEGF-dependent angiogenesis and counteract maladaptive remodeling in HF. 4 weeks from surgically-induced MI, 40 male Sprague Dawley rats, were randomized to receive B (10 mg/Kg/d, for 10 weeks) or vehicle. 10 sham-operated rats were also included in the study. Echocardiography revealed reduced cardiac LV diameters in B-treated compared to vehicle-treated rats. Moreover, B treatment was associated with increased LV capillary and arteriolar density, and with increased in vivo coronary perfusion and reserve. Importantly, 10 days after B treatment was started, increased cardiac VEGF exp...
REabsorbable vs. DUrable Polymer Drug-Eluting Stents in All-Comer PatiEnts: the REDUCE registry
Coronary Artery Disease
BACKGROUND While the superiority of reabsorbable-polymer drug-eluting stents (RP-DES) over bare-m... more BACKGROUND While the superiority of reabsorbable-polymer drug-eluting stents (RP-DES) over bare-metal stents and first-generation durable-polymer (DP)-DES has been largely established, their advantage compared with new-generation DP-DES is still controversial. This study aimed was to compare clinical outcomes of all-comer patients undergoing percutaneous coronary intervention (PCI) with new generation DP-DES or RP-DES implantation. METHODS We prospectively enrolled 679 consecutive patients treated with PCI with RP-DES or DP-DES. The primary endpoint was the 1-year incidence of major adverse clinical events (MACE), a composite of death, myocardial infarction (MI), and target vessel revascularization (TVR). Target lesion revascularization (TLR) and definite stent thrombosis were also recorded. RESULTS A total of 439 (64.6%) received RP-DES and 240 (36.4%) received DP-DES. No significant difference in the incidence of MACE (5.9 vs. 4.9%; hazard ratio, 1.23; 95% confidence interval (CI), 0.61-2.49; P = 0.569), death (1.8 vs. 1.7%; hazard ratio, 1.09; 95% CI, 0.33-3.64; P = 0.882), MI (2.3 vs. 2.1%; hazard ratio, 1.05; 95% CI, 0.36-3.08; P = 0.927), TVR (2.3 vs. 1.3%; hazard ratio, 1.70; 95% CI, 0.47-6.20; P = 0.418), TLR (1.4 vs. 0.4%; hazard ratio, 3.06; 95% CI, 0.37-25.40; P = 0.301), and definite stent thrombosis (0.5 vs. 0.4%; hazard ratio, 1.09; 95% CI, 0.10-12.10; P = 0.942) was observed between RP-DES and DP-DES patients at 1-year follow-up. These results were confirmed in a propensity score-matched cohort (n = 134 per group). CONCLUSION In our registry including a real-world population of all-comer patients undergoing PCI, RP-DES, or durable polymer-DES showed similar efficacy and safety at a 1-year follow-up.
OCT-guided complication management during sirolimus-eluting bioresorbable magnesium stent im-plantation with 9-months OCT follow-up
Journal of Interventional Cardiology
Background. Sirolimus-coated balloons (SCBs) represent a novel therapeutic option for both in-ste... more Background. Sirolimus-coated balloons (SCBs) represent a novel therapeutic option for both in-stent restenosis (ISR) and de novo coronary lesions treatment, especially in small vessels. Our registry sought to evaluate the procedural and clinical outcomes of such devices in a complex acute coronary syndrome (ACS) clinical setting. Methods and Results. We treated 74 consecutive patients with percutaneous coronary intervention (PCI) with at least 1 SCB used for ISR and/or de novo coronary lesion in small vessels at our institution. Sixty-two patients presented with ACS, and their data were included in our analysis. The mean age was 67 ± 10 years, and patients presenting with ST-elevated myocardial infarction (STEMI) were 14 (23%). De novo lesions were 52%, whereas ISR was 48%. Procedural success occurred in 100% of the cases. At the 11 ± 7 months follow-up, major adverse cardiovascular events (MACEs) were 3 (4.8%). Cardiovascular death (CD) occurred in 1 (1.6%) patient and myocardial i...