Lucas Oliveira - Academia.edu (original) (raw)

Papers by Lucas Oliveira

Revista Eletrônica de Iniciação Científica em Computação

Este artigo apresenta uma ferramenta de gestão de atualizações para um ambiente de programação mu... more Este artigo apresenta uma ferramenta de gestão de atualizações para um ambiente de programação musical chamado Pure Date. A definição do sistema de gerenciamento inclui também a definição de pacote, um conjunto para distribuir novos plugins, e um repositório mínimo para armazenar os plugins. Neste artigo apresentamos as decisões de projeto para criar a ferramenta, tal como o nome padrão, a extensão do pacote, a estrutura, o descritor e afins. Apesar do fato de este artigo apresentar decisões de projeto a cerca do ambiente de desenvolvimento Pure Data, ele pode ser também usado para criar um ferramenta semelhante para qualquer outro software que aceite extensões.

Arquivos Brasileiros de Cirurgia Digestiva Express

Brasiliana- Journal for Brazilian Studies

Journal of the Brazilian Chemical Society

The removal of the beta-lactam antibiotics (ceftriaxone and cefadroxil) through zero-valent coppe... more The removal of the beta-lactam antibiotics (ceftriaxone and cefadroxil) through zero-valent copper nanoparticle (nZVC) was studied in this work. Excellent removal degrees (> 85%) were obtained for both analytes in only 20 min of reaction. Studies were performed in both oxic and anoxic conditions, and in the presence of t-butyl alcohol (TBA), an inhibitor of radicals. The results did not show significant changes. Therefore, the hydroxyl radicals are not the main species responsible for the removal. Total organic carbon cefadroxil analysis indicated a removal of 57% after 180 min of reaction. Studies involving Cu + indicated that probably these are the principal species responsible for the removal of antibiotics. Kinetic studies have shown that two-phase reaction occurred in the antibiotics removal process and both phases followed pseudo-first order kinetic model. The first mechanism is related to the antibiotics degradation by Cu + species and the second mechanism is related to the antibiotics adsorption by hydroxides/oxides of Cu 2+ species.

The neurologist, 2018

Parkinson disease (PD) is a neurodegenerative disorder affecting the basal nuclei, causing motor ... more Parkinson disease (PD) is a neurodegenerative disorder affecting the basal nuclei, causing motor and cognitive disorders. Bearing in mind that standard treatments are ineffective in delaying the disease progression, alternative treatments capable of eliminating symptoms and reversing the clinical condition have been sought. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSC). MSC are adult stem cells which have demonstrated remarkable therapeutic power in parkinsonian animals due to their differentiation competence, migratory capacity and the production of bioactive molecules. This review aims to analyze the main studies involving MSC and PD in more than a decade of studies, addressing their different methodologies and common characteristics, as well as suggesting perspectives on the application of MSC in PD. The results of MSC therapy in animal models and some clinical trials suggest that such cellular therapy may slow the p...

Annals of medicine and surgery (2012), 2018

Islets of Langerhans transplantation is a promising alternative for glycemic control in patients ... more Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of <250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with-student test. The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with...

PloS one, 2018

The 3-dimensional structure of the nucleocapsid (NC) of bacteriophage φ6 is described utilizing c... more The 3-dimensional structure of the nucleocapsid (NC) of bacteriophage φ6 is described utilizing component tree analysis, a topological and geometric image descriptor. The component trees are derived from density maps of cryo-electron microscopy single particle reconstructions. Analysis determines position and occupancy of structure elements responsible for RNA packaging and transcription. Occupancy of the hexameric nucleotide triphosphorylase (P4) and RNA polymerase (P2) are found to be essentially complete in the NC. The P8 protein lattice likely fixes P4 and P2 in place during maturation. We propose that the viral procapsid (PC) is a dynamic structural intermediate where the P4 and P2 can attach and detach until held in place in mature NCs. During packaging, the PC expands to accommodate the RNA, and P2 translates from its original site near the inner 3-fold axis (20 sites) to the inner 5-fold axis (12 sites) with excess P2 positioned inside the central region of the NC.

Revista Brasileira de Ortopedia (English Edition)

The aim of this study was to evaluate the reconstruction of the medial patellofemoral ligament as... more The aim of this study was to evaluate the reconstruction of the medial patellofemoral ligament associated with the medial patellotibial ligament in skeletally immature patients. Method: This is a case series study in patients with patellar instability with open physis. In total, seven patients were evaluated: four males and three females were operated using the proposed technique. Patients with open physis who had more than two episodes of recurring patellar dislocation were included. No patients underwent additional procedures. The distance from the anterior tibial tuberosity to the trochlea grove (TT-TG) was measured in all patients. On physical examination, the inverted J-sign, the apprehension sign, and the knee range of motion parameters were used in the pre-and post-operative period. In addition, the Kujala and Lysholm scores were applied before and 12 months after surgery. The results were analyzed with the Wilcoxon test. Results: The mean age of the patients was 11.28 in both genders. Comparing the data of the pre-and post-operative period, the inverted J-sign was present in six patients (85.7%) vs. absent in one (14.3%). The apprehension sign was absent in cases in the postoperative period; the range of motion was 117.85 ± 8.09 vs. 148.57 ± 3.77. The Kujala score was 42.57 ± 8.9 vs. 88.57 ± 5.09 and the Lysholm scores were classified as excellent or good in 28.6% and 71.4%, respectively. Conclusion: The combined reconstruction of the medial patellofemoral ligament combined with the medial patellotibial ligament in skeletally immature patients with predisposing factors, presents satisfactory results without episodes of recurrence or residual subluxation; according to these preliminary results, it should be considered as a treatment option.

Clinics (Sao Paulo, Brazil), 2017

Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invas... more Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The i...

BMC surgery, Jan 5, 2017

Subxiphoid incisional hernia occurs as a complication following median sternotomy and are difficu... more Subxiphoid incisional hernia occurs as a complication following median sternotomy and are difficult to repair. We present recent data of a standardized technique for correction of subxiphoid incisional hernias, and discuss possible anatomical and surgical factors related to recurrence of the hernia. A retrospective study with medical records analysis of patients submitted to surgical correction of subxiphoid incisional hernias through standardized treatment between July 2014 and September 2016. All procedures were carried out using the same standardized technique, surgical materials (threads and meshes) and pre- and post-operative care. All of the surgical procedures carried out were elective. The hernia defect varied between 5 cm and 16 cm (mean of 7.4 cm); the procedure lasted between 32 and 75 min; the mean time of hospital stay was 2.2 days (range from 1 to 5 days). In five patients the correction of subxiphoid incisional hernia was carried out concurrently with another procedur...

Surgical endoscopy, Oct 24, 2017

Inguinal hernia repair is one of the most frequently conducted surgical procedures worldwide. Tot... more Inguinal hernia repair is one of the most frequently conducted surgical procedures worldwide. Totally extraperitoneal (TEP) hernioplasty has shown many advantages over traditional open surgery. However, because of increased surgical complexity, it requires more practice to achieve optimal results. The aim of this study is to evaluate the learning curve for TEP hernioplasty, analysing parameters related to the mean operating time. The secondary objective is to assess the complications and early discharge rates related to this procedure. A prospective study of 238 consecutive patients undergoing TEP hernioplasty from the same practitioner between May 2009 and May 2014, in a specialised centre for abdominal hernias in Sao Paulo, Brazil, was conducted. All data were obtained through medical records. The study included 137 patients undergoing a total of 157 TEP hernia repairs. Bilaterality and complications can influence the operating time and so were excluded. Patients with unilateral s...

The Journal of pharmacy and pharmacology, Jan 17, 2016

Geopropolis (GEO) in combination with doxorubicin (DOX) reduced HEp-2 cells viability compared to... more Geopropolis (GEO) in combination with doxorubicin (DOX) reduced HEp-2 cells viability compared to GEO and DOX alone. A possible effect of this combination on the innate immunity could take place, and its effects were analysed on THP-1 cell - a human leukaemia monocytic cell line used as a model to study monocyte activity and macrophage activity, assessing cell viability, expression of cell markers and cytokine production. THP-1 cells were incubated with GEO, DOX and their combination. Cell viability was assessed by MTT assay, cell markers expression by flow cytometry and cytokine production by ELISA. GEO + DOX did not affect cell viability. GEO alone or in combination increased TLR-4 and CD80 but not HLA-DR and TLR-2 expression. GEO stimulated TNF-α production while DOX alone or in combination did not affect it. GEO alone or in combination inhibited IL-6 production. GEO exerted a pro-inflammatory profile by increasing TLR-4 and CD80 expression and TNF-α production, favouring the act...

Trends in psychiatry and psychotherapy, 2016

Objective To describe the case of a patient with schizophrenia on clozapine treatment who had an ... more Objective To describe the case of a patient with schizophrenia on clozapine treatment who had an episode of heat stroke. Case description During a heat wave in January and February 2014, a patient with schizophrenia who was on treatment with clozapine was initially referred for differential diagnose between systemic infection and neuroleptic malignant syndrome, but was finally diagnosed with heat stroke and treated with control of body temperature and hydration. Comments This report aims to alert clinicians take this condition into consideration among other differential diagnoses, especially nowadays with the rise in global temperatures, and to highlight the need for accurate diagnosis of clinical events during pharmacological intervention, in order to improve treatment decisions and outcomes.

Indicadores Economicos Fee, 1990

Studies in health technology and informatics, 2015

Advances in image quality produced by computed tomography (CT) and the growth in the number of im... more Advances in image quality produced by computed tomography (CT) and the growth in the number of image studies currently performed has made the management of incidental pulmonary nodules (IPNs) a challenging task. This research aims to identify IPNs in radiology reports of chest and abdominal CT by Natural Language Processing techiniques to recognize IPN in sentences of radiology reports. Our preliminary analysis indicates vastly different pulmonary incidental findings rates for two different patient groups.

Studies in health technology and informatics, 2015

The management of follow-up recommendations is fundamental for the appropriate care of patients w... more The management of follow-up recommendations is fundamental for the appropriate care of patients with incidental pulmonary findings. The lack of communication of these important findings can result in important actionable information being lost in healthcare provider electronic documents. This study aims to analyze follow-up recommendations in radiology reports containing pulmonary incidental findings by using Natural Language Processing and Regular Expressions. Our evaluation highlights the different follow-up recommendation rates for oncology and non-oncology patient cohorts. The results reveal the need for a context-sensitive approach to tracking different patient cohorts in an enterprise-wide assessment.

Resumo Este trabalho apresenta um relato dos projetos de pesquisa e extensão Web Rádio e Totem Di... more Resumo Este trabalho apresenta um relato dos projetos de pesquisa e extensão Web Rádio e Totem Digital vinculados ao grupo de pesquisa Mídia e Conhecimento. O Web Rádio é um ambiente radiofônico de caráter educativo que contempla a capacitação de estudantes e professores para produção de conteúdos que resgatem e divulguem a cultura local. E, o Totem Digital é uma aplicação multimídia interativa dentro do contexto de quiosque de informações a ser utilizado como um dispositivo de museu virtual para o Museu Histórico de Araranguá. Ambos os projetos estão em desenvolvimento e já apresentam resultados parciais. Na conclusão destes projetos será possível obter uma melhor integração entre as tecnologias digitais e atividades culturais para a comunidade do Vale do Araranguá no sul de Santa Catarina. Introdução Na área de Educação, Cultura Digital e Multimídia Interativa os seguintes projetos estão em desenvolvimento no Grupo de Pesquisa Mídia e Conhecimento: Web Rádio e Totem Digital. Ambos...

Studies in health technology and informatics, 2015

The emerging penetration of Health IT in Latin America (especially in Brazil) has exacerbated the... more The emerging penetration of Health IT in Latin America (especially in Brazil) has exacerbated the ever-increasing amount of Electronic Health Record (EHR) clinical free text documents.This imposes a workflow efficiency challenge on clinicians who need to synthesize such documents during the typically time-constrained patient care. We propose an ontology-driven semantic search framework that effectively supports clinicians' information synthesis at the point of care.

Revista Eletrônica de Iniciação Científica em Computação

Este artigo apresenta uma ferramenta de gestão de atualizações para um ambiente de programação mu... more Este artigo apresenta uma ferramenta de gestão de atualizações para um ambiente de programação musical chamado Pure Date. A definição do sistema de gerenciamento inclui também a definição de pacote, um conjunto para distribuir novos plugins, e um repositório mínimo para armazenar os plugins. Neste artigo apresentamos as decisões de projeto para criar a ferramenta, tal como o nome padrão, a extensão do pacote, a estrutura, o descritor e afins. Apesar do fato de este artigo apresentar decisões de projeto a cerca do ambiente de desenvolvimento Pure Data, ele pode ser também usado para criar um ferramenta semelhante para qualquer outro software que aceite extensões.

Arquivos Brasileiros de Cirurgia Digestiva Express

Brasiliana- Journal for Brazilian Studies

Journal of the Brazilian Chemical Society

The removal of the beta-lactam antibiotics (ceftriaxone and cefadroxil) through zero-valent coppe... more The removal of the beta-lactam antibiotics (ceftriaxone and cefadroxil) through zero-valent copper nanoparticle (nZVC) was studied in this work. Excellent removal degrees (> 85%) were obtained for both analytes in only 20 min of reaction. Studies were performed in both oxic and anoxic conditions, and in the presence of t-butyl alcohol (TBA), an inhibitor of radicals. The results did not show significant changes. Therefore, the hydroxyl radicals are not the main species responsible for the removal. Total organic carbon cefadroxil analysis indicated a removal of 57% after 180 min of reaction. Studies involving Cu + indicated that probably these are the principal species responsible for the removal of antibiotics. Kinetic studies have shown that two-phase reaction occurred in the antibiotics removal process and both phases followed pseudo-first order kinetic model. The first mechanism is related to the antibiotics degradation by Cu + species and the second mechanism is related to the antibiotics adsorption by hydroxides/oxides of Cu 2+ species.

The neurologist, 2018

Parkinson disease (PD) is a neurodegenerative disorder affecting the basal nuclei, causing motor ... more Parkinson disease (PD) is a neurodegenerative disorder affecting the basal nuclei, causing motor and cognitive disorders. Bearing in mind that standard treatments are ineffective in delaying the disease progression, alternative treatments capable of eliminating symptoms and reversing the clinical condition have been sought. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSC). MSC are adult stem cells which have demonstrated remarkable therapeutic power in parkinsonian animals due to their differentiation competence, migratory capacity and the production of bioactive molecules. This review aims to analyze the main studies involving MSC and PD in more than a decade of studies, addressing their different methodologies and common characteristics, as well as suggesting perspectives on the application of MSC in PD. The results of MSC therapy in animal models and some clinical trials suggest that such cellular therapy may slow the p...

Annals of medicine and surgery (2012), 2018

Islets of Langerhans transplantation is a promising alternative for glycemic control in patients ... more Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of <250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with-student test. The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with...

PloS one, 2018

The 3-dimensional structure of the nucleocapsid (NC) of bacteriophage φ6 is described utilizing c... more The 3-dimensional structure of the nucleocapsid (NC) of bacteriophage φ6 is described utilizing component tree analysis, a topological and geometric image descriptor. The component trees are derived from density maps of cryo-electron microscopy single particle reconstructions. Analysis determines position and occupancy of structure elements responsible for RNA packaging and transcription. Occupancy of the hexameric nucleotide triphosphorylase (P4) and RNA polymerase (P2) are found to be essentially complete in the NC. The P8 protein lattice likely fixes P4 and P2 in place during maturation. We propose that the viral procapsid (PC) is a dynamic structural intermediate where the P4 and P2 can attach and detach until held in place in mature NCs. During packaging, the PC expands to accommodate the RNA, and P2 translates from its original site near the inner 3-fold axis (20 sites) to the inner 5-fold axis (12 sites) with excess P2 positioned inside the central region of the NC.

Revista Brasileira de Ortopedia (English Edition)

The aim of this study was to evaluate the reconstruction of the medial patellofemoral ligament as... more The aim of this study was to evaluate the reconstruction of the medial patellofemoral ligament associated with the medial patellotibial ligament in skeletally immature patients. Method: This is a case series study in patients with patellar instability with open physis. In total, seven patients were evaluated: four males and three females were operated using the proposed technique. Patients with open physis who had more than two episodes of recurring patellar dislocation were included. No patients underwent additional procedures. The distance from the anterior tibial tuberosity to the trochlea grove (TT-TG) was measured in all patients. On physical examination, the inverted J-sign, the apprehension sign, and the knee range of motion parameters were used in the pre-and post-operative period. In addition, the Kujala and Lysholm scores were applied before and 12 months after surgery. The results were analyzed with the Wilcoxon test. Results: The mean age of the patients was 11.28 in both genders. Comparing the data of the pre-and post-operative period, the inverted J-sign was present in six patients (85.7%) vs. absent in one (14.3%). The apprehension sign was absent in cases in the postoperative period; the range of motion was 117.85 ± 8.09 vs. 148.57 ± 3.77. The Kujala score was 42.57 ± 8.9 vs. 88.57 ± 5.09 and the Lysholm scores were classified as excellent or good in 28.6% and 71.4%, respectively. Conclusion: The combined reconstruction of the medial patellofemoral ligament combined with the medial patellotibial ligament in skeletally immature patients with predisposing factors, presents satisfactory results without episodes of recurrence or residual subluxation; according to these preliminary results, it should be considered as a treatment option.

Clinics (Sao Paulo, Brazil), 2017

Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invas... more Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The i...

BMC surgery, Jan 5, 2017

Subxiphoid incisional hernia occurs as a complication following median sternotomy and are difficu... more Subxiphoid incisional hernia occurs as a complication following median sternotomy and are difficult to repair. We present recent data of a standardized technique for correction of subxiphoid incisional hernias, and discuss possible anatomical and surgical factors related to recurrence of the hernia. A retrospective study with medical records analysis of patients submitted to surgical correction of subxiphoid incisional hernias through standardized treatment between July 2014 and September 2016. All procedures were carried out using the same standardized technique, surgical materials (threads and meshes) and pre- and post-operative care. All of the surgical procedures carried out were elective. The hernia defect varied between 5 cm and 16 cm (mean of 7.4 cm); the procedure lasted between 32 and 75 min; the mean time of hospital stay was 2.2 days (range from 1 to 5 days). In five patients the correction of subxiphoid incisional hernia was carried out concurrently with another procedur...

Surgical endoscopy, Oct 24, 2017

Inguinal hernia repair is one of the most frequently conducted surgical procedures worldwide. Tot... more Inguinal hernia repair is one of the most frequently conducted surgical procedures worldwide. Totally extraperitoneal (TEP) hernioplasty has shown many advantages over traditional open surgery. However, because of increased surgical complexity, it requires more practice to achieve optimal results. The aim of this study is to evaluate the learning curve for TEP hernioplasty, analysing parameters related to the mean operating time. The secondary objective is to assess the complications and early discharge rates related to this procedure. A prospective study of 238 consecutive patients undergoing TEP hernioplasty from the same practitioner between May 2009 and May 2014, in a specialised centre for abdominal hernias in Sao Paulo, Brazil, was conducted. All data were obtained through medical records. The study included 137 patients undergoing a total of 157 TEP hernia repairs. Bilaterality and complications can influence the operating time and so were excluded. Patients with unilateral s...

The Journal of pharmacy and pharmacology, Jan 17, 2016

Geopropolis (GEO) in combination with doxorubicin (DOX) reduced HEp-2 cells viability compared to... more Geopropolis (GEO) in combination with doxorubicin (DOX) reduced HEp-2 cells viability compared to GEO and DOX alone. A possible effect of this combination on the innate immunity could take place, and its effects were analysed on THP-1 cell - a human leukaemia monocytic cell line used as a model to study monocyte activity and macrophage activity, assessing cell viability, expression of cell markers and cytokine production. THP-1 cells were incubated with GEO, DOX and their combination. Cell viability was assessed by MTT assay, cell markers expression by flow cytometry and cytokine production by ELISA. GEO + DOX did not affect cell viability. GEO alone or in combination increased TLR-4 and CD80 but not HLA-DR and TLR-2 expression. GEO stimulated TNF-α production while DOX alone or in combination did not affect it. GEO alone or in combination inhibited IL-6 production. GEO exerted a pro-inflammatory profile by increasing TLR-4 and CD80 expression and TNF-α production, favouring the act...

Trends in psychiatry and psychotherapy, 2016

Objective To describe the case of a patient with schizophrenia on clozapine treatment who had an ... more Objective To describe the case of a patient with schizophrenia on clozapine treatment who had an episode of heat stroke. Case description During a heat wave in January and February 2014, a patient with schizophrenia who was on treatment with clozapine was initially referred for differential diagnose between systemic infection and neuroleptic malignant syndrome, but was finally diagnosed with heat stroke and treated with control of body temperature and hydration. Comments This report aims to alert clinicians take this condition into consideration among other differential diagnoses, especially nowadays with the rise in global temperatures, and to highlight the need for accurate diagnosis of clinical events during pharmacological intervention, in order to improve treatment decisions and outcomes.

Indicadores Economicos Fee, 1990

Studies in health technology and informatics, 2015

Advances in image quality produced by computed tomography (CT) and the growth in the number of im... more Advances in image quality produced by computed tomography (CT) and the growth in the number of image studies currently performed has made the management of incidental pulmonary nodules (IPNs) a challenging task. This research aims to identify IPNs in radiology reports of chest and abdominal CT by Natural Language Processing techiniques to recognize IPN in sentences of radiology reports. Our preliminary analysis indicates vastly different pulmonary incidental findings rates for two different patient groups.

Studies in health technology and informatics, 2015

The management of follow-up recommendations is fundamental for the appropriate care of patients w... more The management of follow-up recommendations is fundamental for the appropriate care of patients with incidental pulmonary findings. The lack of communication of these important findings can result in important actionable information being lost in healthcare provider electronic documents. This study aims to analyze follow-up recommendations in radiology reports containing pulmonary incidental findings by using Natural Language Processing and Regular Expressions. Our evaluation highlights the different follow-up recommendation rates for oncology and non-oncology patient cohorts. The results reveal the need for a context-sensitive approach to tracking different patient cohorts in an enterprise-wide assessment.

Resumo Este trabalho apresenta um relato dos projetos de pesquisa e extensão Web Rádio e Totem Di... more Resumo Este trabalho apresenta um relato dos projetos de pesquisa e extensão Web Rádio e Totem Digital vinculados ao grupo de pesquisa Mídia e Conhecimento. O Web Rádio é um ambiente radiofônico de caráter educativo que contempla a capacitação de estudantes e professores para produção de conteúdos que resgatem e divulguem a cultura local. E, o Totem Digital é uma aplicação multimídia interativa dentro do contexto de quiosque de informações a ser utilizado como um dispositivo de museu virtual para o Museu Histórico de Araranguá. Ambos os projetos estão em desenvolvimento e já apresentam resultados parciais. Na conclusão destes projetos será possível obter uma melhor integração entre as tecnologias digitais e atividades culturais para a comunidade do Vale do Araranguá no sul de Santa Catarina. Introdução Na área de Educação, Cultura Digital e Multimídia Interativa os seguintes projetos estão em desenvolvimento no Grupo de Pesquisa Mídia e Conhecimento: Web Rádio e Totem Digital. Ambos...

Studies in health technology and informatics, 2015

The emerging penetration of Health IT in Latin America (especially in Brazil) has exacerbated the... more The emerging penetration of Health IT in Latin America (especially in Brazil) has exacerbated the ever-increasing amount of Electronic Health Record (EHR) clinical free text documents.This imposes a workflow efficiency challenge on clinicians who need to synthesize such documents during the typically time-constrained patient care. We propose an ontology-driven semantic search framework that effectively supports clinicians' information synthesis at the point of care.