Lucia Collado - Academia.edu (original) (raw)
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Papers by Lucia Collado
Cerebral Cortex, 2006
Two known germinal zones continue to generate new neurons and glia in the adult mammalian brain: ... more Two known germinal zones continue to generate new neurons and glia in the adult mammalian brain: the subventricular zone (SVZ), lining the lateral walls of the lateral ventricle, and the subgranular zone of the dentate gyrus. Here we describe a region we will refer to as the subcallosal zone (SCZ). The SCZ is a caudal extension of the SVZ that is no longer associated to an open ventricle. It lies between the hippocampus and the corpus callosum. Cells isolated from the SCZ and cultured as neurospheres behave as neural stem cells in vitro. Using electron and light microscopy, we describe the cell types present in this region and how their organization differs from that of the SVZ. Using retroviral labeling and homotypic-homochronic microtransplantation techniques, we show that the majority of cells born in the SCZ migrate into the corpus callosum to become oligodendrocytes in vivo. This study defines the organization and fate of cells born in a large germinal region of the adult forebrain.
Brain Research Bulletin, 2002
RESUMEN: Reflexión acerca de aspectos epistemológicos del cuidado y del confort como objetos de c... more RESUMEN: Reflexión acerca de aspectos epistemológicos del cuidado y del confort como objetos de conocimiento en Enfermería. Se destaca la importancia de la especificidad de los objetos de conocimiento referentes a la coherencia en el pensamiento epistemológico acerca del cuidado de enfermería y del conforto. Eses objetos se presentan en el espacio de exterioridad-a la orilla de-del pensamiento y del conocimiento científicos, a pesar de el cuidado ser objeto recientemente de otras áreas de conocimiento e inserido en los imaginarios coletivos, de las reglas del pensamiento lógico, de las formaciones discursivas, capaces de vincular valores y el saber con el pensamiento y la razón en la formación de enfermeros que cuidan y/o que investigan.
Brain Research Bulletin, 2002
Although evidence accumulated during the last decades has advanced our understanding of adult neu... more Although evidence accumulated during the last decades has advanced our understanding of adult neurogenesis in the vertebrate brain, many aspects of this intriguing phenomenon remain controversial. Here we review the organization and cellular composition of the ventricular wall of reptiles, birds, and mammals in an effort to identify differences and commonalities among these vertebrate classes. Three major cell types have been identified in the ventricular zone of reptiles and birds: migrating (Type A) cells, radial glial (Type B) cells, and ependymal (Type E) cells. Cells similar anatomically and functionally to Types A, B, and E have also been described in the ventricular wall of mammals, which contains an additional cell type (Type C) not found in reptiles or birds. The bulk of the evidence points to a role of Type B cells as primary neural precursors (stem cells) in the three classes of living amniotic vertebrates. This finding may have implications for the development of strategies for the possible treatment of human neurological disorders.
Cerebral Cortex, 2006
Two known germinal zones continue to generate new neurons and glia in the adult mammalian brain: ... more Two known germinal zones continue to generate new neurons and glia in the adult mammalian brain: the subventricular zone (SVZ), lining the lateral walls of the lateral ventricle, and the subgranular zone of the dentate gyrus. Here we describe a region we will refer to as the subcallosal zone (SCZ). The SCZ is a caudal extension of the SVZ that is no longer associated to an open ventricle. It lies between the hippocampus and the corpus callosum. Cells isolated from the SCZ and cultured as neurospheres behave as neural stem cells in vitro. Using electron and light microscopy, we describe the cell types present in this region and how their organization differs from that of the SVZ. Using retroviral labeling and homotypic-homochronic microtransplantation techniques, we show that the majority of cells born in the SCZ migrate into the corpus callosum to become oligodendrocytes in vivo. This study defines the organization and fate of cells born in a large germinal region of the adult forebrain.
Brain Research Bulletin, 2002
RESUMEN: Reflexión acerca de aspectos epistemológicos del cuidado y del confort como objetos de c... more RESUMEN: Reflexión acerca de aspectos epistemológicos del cuidado y del confort como objetos de conocimiento en Enfermería. Se destaca la importancia de la especificidad de los objetos de conocimiento referentes a la coherencia en el pensamiento epistemológico acerca del cuidado de enfermería y del conforto. Eses objetos se presentan en el espacio de exterioridad-a la orilla de-del pensamiento y del conocimiento científicos, a pesar de el cuidado ser objeto recientemente de otras áreas de conocimiento e inserido en los imaginarios coletivos, de las reglas del pensamiento lógico, de las formaciones discursivas, capaces de vincular valores y el saber con el pensamiento y la razón en la formación de enfermeros que cuidan y/o que investigan.
Brain Research Bulletin, 2002
Although evidence accumulated during the last decades has advanced our understanding of adult neu... more Although evidence accumulated during the last decades has advanced our understanding of adult neurogenesis in the vertebrate brain, many aspects of this intriguing phenomenon remain controversial. Here we review the organization and cellular composition of the ventricular wall of reptiles, birds, and mammals in an effort to identify differences and commonalities among these vertebrate classes. Three major cell types have been identified in the ventricular zone of reptiles and birds: migrating (Type A) cells, radial glial (Type B) cells, and ependymal (Type E) cells. Cells similar anatomically and functionally to Types A, B, and E have also been described in the ventricular wall of mammals, which contains an additional cell type (Type C) not found in reptiles or birds. The bulk of the evidence points to a role of Type B cells as primary neural precursors (stem cells) in the three classes of living amniotic vertebrates. This finding may have implications for the development of strategies for the possible treatment of human neurological disorders.