Luciano Adorini - Academia.edu (original) (raw)

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Papers by Luciano Adorini

Journal of Immunology, Dec 1, 1998

Digestive and Liver Disease, Feb 1, 2020

15th International & 14th European Congress of Endocrinology, May 1, 2012

The Journal of Urology, Apr 1, 2006

Digestive and Liver Disease, Feb 1, 2016

Tumori Journal, Sep 1, 1976

Clinical Immunology, 2008

Memorias Do Instituto Oswaldo Cruz, 1987

Fresenius Journal of Analytical Chemistry, 1992

Immunologist, 1998

info:eu-repo/semantics/publishe

Publisher Summary This chapter discusses the need for the integration of two systems and the basi... more Publisher Summary This chapter discusses the need for the integration of two systems and the basic features of a possible comprehensive regulatory circuit. The lysozyme molecule can be operationally divided into carrier and hapten regions. B cells have idiotypic receptors with hapten specificity. There are at least two different helper T cells, one idiotype-specific bearing anti-idiotypes determinants and one bearing carrier-specific receptors. Suppressor T cells have receptors with the same hapten specificity and idiotype as the predominant population of B cells. With this minimal model, which explains a maximum number of cell interactions, the threads of the network can be traced. The long-term regulation of the system is sustained by the activity of the self-limiting idiotype network but at a new level reflecting the influence of antigen.

Journal of Immunological Methods, Apr 1, 1984

A sensitive and specific immunoenzyme assay (ELISA) for quantitation of total and cross-reactive ... more A sensitive and specific immunoenzyme assay (ELISA) for quantitation of total and cross-reactive idiotype-bearing (CRI) anti-ABA antibodies is described. Total anti-ABA antibodies are directly assessed in ABA-BGG coated polyvinyl wells with enzyme-labelled rabbit anti-mouse immunoglobulins. By interpolation on a standard curve absorbance values give the concentration of anti-ABA antibodies with a sensitivity of 30 ng/ml. CRI+ antibodies are quantitated by inhibition of enzyme-labelled monoclonal CRI+ antibody binding to solid-phase coated rabbit anti-CRI immunoglobulins. The concentration of CRI+ antibodies, evaluated by interpolation on a standard inhibition curve, can be measured at the level of 10 ng/ml. This highly sensitive, rapid, specific and reproducible assay is easily used, with minor modifications, to detect specific antibodies in any idiotype system.