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Papers by Luciano Cardinale
Poster: "ECR 2008 / C-282 / Lung ultrasound in the follow-up of patients with decompensated ... more Poster: "ECR 2008 / C-282 / Lung ultrasound in the follow-up of patients with decompensated heart failure" by: "M. Busso, L. Cardinale, A. De Pascale, G. Garofalo, A. Ramanzin, G. Volpicelli, C. Fava; Orbassano/IT"
Cancer dissemination pathways, 2020
Jbr-btr, Sep 15, 2015
A 29-year-old Caucasian woman on post-partum was affected by fever, right lower quadrant abdomina... more A 29-year-old Caucasian woman on post-partum was affected by fever, right lower quadrant abdominal pain, irregular alvus and lung micronodules at chest X-ray. Thoracic and abdominal MDCT imaging investigations accompanied by microbiological tests of bronchial aspirate, histology on the surgical bowel specimen resulted positive for pulmonary and intestinal tuberculosis (TB). Volumetric high-resolution computed tomography (HRCT) demonstrated a very interesting pattern about nodules distribution called "Sarcoid cluster sign" (Fig. A). Coronal (Fig. B) and sagittal (Fig. C) Maximum Intensity Projection (MIP) images (18-mm-thick slab) demonstrate the micronodules clusters distribution prevalent in the upper lobes.
Journal of radiological review, May 1, 2019
The Ultrasound Journal
The clinical use of lung ultrasound (LUS) has made more efficient many diagnostic processes at be... more The clinical use of lung ultrasound (LUS) has made more efficient many diagnostic processes at bedside. The great power of LUS is a superior diagnostic sensitivity in many applications, when compared to chest radiography (CXR). The implementation of LUS in emergency is contributing to reveal a growing number of radio-occult pulmonary conditions. In some diseases, the superior sensitivity of LUS is a great advantage, like for pneumothorax and pulmonary edema. Diagnosing at bedside pneumothoraxes, pulmonary congestions, and COVID-19 pneumonia that are visible by LUS but undetected by CXR may be decisive for appropriate management, and even for saving lives. However, in other conditions, like bacterial pneumonia and small peripheral infarctions due to subsegmental pulmonary embolism, the high sensitivity of LUS does not always lead to advantages. Indeed, we doubt that it is always necessary to treat by antibiotics patients suspected of lower respiratory tract infection, who show radio-...
Poster: "ECR 2015 / C-2202 / Lung Cancer: one issue, many faces " by: "E. Piacibel... more Poster: "ECR 2015 / C-2202 / Lung Cancer: one issue, many faces " by: "E. Piacibello1, V. Angelino1, F. Moretti1, M. Busso 2, L. Cardinale1, A. Veltri1; 1Orbassano /IT, 2Orbassano/IT"
Journal of Clinical Oncology, 2006
7206 Background: In 2001 a feasibility study testing low-dose sCT as an early diagnosis tool in a... more 7206 Background: In 2001 a feasibility study testing low-dose sCT as an early diagnosis tool in asymptomatic volunteers at high risk for lung cancer was planned and initiated at our institution with an evaluation at baseline and then annually for 5 years. Subjects & Methods: We enrolled 520 asymptomatic volunteers, 73% males, aged 55 years or older (median age 60 yrs), with at least 20 pack-years of cigarette smoking and no previous cancer. Results: At baseline, one hundred forty-four extra-pulmonary findings (28%) were detected. The more common findings were: radiologically-detected adrenal enlargements (19%); thyroid struma (8%); hepatic abnormalities, like angiomas, cysts, calcifications, steatosis (29%); renal alterations, like cysts, lithiasis, vascular calcifications and one case of stage I renal carcinoma (21%); spleen abnormalities, like cysts, calcifications, accessory spleen (5%); cholelithiasis (4%); pancreatic alterations (1%); thymic nodules (1%); axillary adenopathy (5...
The use of general descriptive names, registered names, trademarks, service marks, etc. in this p... more The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
Journal of Thoracic Oncology, Aug 1, 2007
Minerva Respiratory Medicine
Poster: "ECR 2011 / C-2017 / Thoracic Imaging: correlation of sonographic signs at Lung Ultr... more Poster: "ECR 2011 / C-2017 / Thoracic Imaging: correlation of sonographic signs at Lung Ultrasound with Chest Radiography and Computed Tomography Images" by: "T. Guarnieri1, A. Ramanzin1, F. Avogliero1, F. Boccuzzi1, G. Volpicelli1, G. Garofalo2, L. Cardinale1, A. Veltri2, C. Fava2; 1Orbassano (TO)/IT, 2Orbassano/IT"
A 50-year-old Caucasian man was presented to the emergency department with cough and progressive ... more A 50-year-old Caucasian man was presented to the emergency department with cough and progressive dyspnoea. Plain chest x-ray showed multiple pseudo-nodular paren-chymal opacities, partly confluent and calcified, prominent in the middle-basal lung fields (figure 1A). Volumetric high-resolution computed tomography (HRCT) confirmed multiple bilateral parenchymal nodules with lobu-lated margins and extensive calcifications due to diffuse bron-chiectasis with thickened and calcified walls (figure 1BeC). Airways involvement was evident, characterised by submucosal deposits and lumen distortion mainly in the trachea, without sparing of the posterior membranous portion, and main and segmental bronchi (figure 2). Biopsy specimen from bronchoscopy was striking for amyloid (figure 3), therefore the evidence pointed towards a diagnosis of
Emergency Radiology, 2022
Background The necessity to identify and isolate COVID-19 patients to avoid intrahospital cross i... more Background The necessity to identify and isolate COVID-19 patients to avoid intrahospital cross infections is particularly felt as a challenge. Clinically occult SARS-CoV-2 infection among patients admitted to the hospital is always considered a risk during the pandemic. The aim of our study is to describe the application of CT scan to reveal unexpected COVID-19 in patients needing hospital admission. Method In our emergency department, we prospectively enrolled adult patients needing hospital admission, without symptoms suspected of COVID-19, and showing negative reverse transcriptase-polymerase chain reaction (RT-PCR) swab test. CT scan was performed to diagnose clinically occult COVID-19 pneumonia. All the exams were read and discussed retrospectively by two expert radiologists and assigned to one of 4 exclusive diagnoses: typical (typCT), indeterminate (indCT), atypical (atyCT), negative (negCT). The clinical characteristics and final diagnoses were described and compared with the results of CT scans. Results From May 25 to August 18, 2020, we prospectively enrolled 197 patients. They showed 122 negCT, 52 atyCT, 22 indCT, and 1 typCT. Based on the CT imaging, the prevalence of suspected clinically occult COVID-19 pneumonia was 11.6% (23 patients). None had confirmation of SARS-CoV-2 infection after the hospital stay. Nineteen patients had negative serial RT-PCR while in 4 cases, the infection was excluded by clinical follow-up or appearance of positivity of RT-PCR after months. Conclusion Our descriptive analysis confirms that CT scan cannot be considered a valid tool to screen clinically occult COVID-19, when the asymptomatic patients need hospitalization for other conditions. Application of personnel protections and distancing among patients remains the best strategies to limit the possibility of intrahospital cross-infections.
Poster: "ECR 2008 / C-282 / Lung ultrasound in the follow-up of patients with decompensated ... more Poster: "ECR 2008 / C-282 / Lung ultrasound in the follow-up of patients with decompensated heart failure" by: "M. Busso, L. Cardinale, A. De Pascale, G. Garofalo, A. Ramanzin, G. Volpicelli, C. Fava; Orbassano/IT"
Cancer dissemination pathways, 2020
Jbr-btr, Sep 15, 2015
A 29-year-old Caucasian woman on post-partum was affected by fever, right lower quadrant abdomina... more A 29-year-old Caucasian woman on post-partum was affected by fever, right lower quadrant abdominal pain, irregular alvus and lung micronodules at chest X-ray. Thoracic and abdominal MDCT imaging investigations accompanied by microbiological tests of bronchial aspirate, histology on the surgical bowel specimen resulted positive for pulmonary and intestinal tuberculosis (TB). Volumetric high-resolution computed tomography (HRCT) demonstrated a very interesting pattern about nodules distribution called "Sarcoid cluster sign" (Fig. A). Coronal (Fig. B) and sagittal (Fig. C) Maximum Intensity Projection (MIP) images (18-mm-thick slab) demonstrate the micronodules clusters distribution prevalent in the upper lobes.
Journal of radiological review, May 1, 2019
The Ultrasound Journal
The clinical use of lung ultrasound (LUS) has made more efficient many diagnostic processes at be... more The clinical use of lung ultrasound (LUS) has made more efficient many diagnostic processes at bedside. The great power of LUS is a superior diagnostic sensitivity in many applications, when compared to chest radiography (CXR). The implementation of LUS in emergency is contributing to reveal a growing number of radio-occult pulmonary conditions. In some diseases, the superior sensitivity of LUS is a great advantage, like for pneumothorax and pulmonary edema. Diagnosing at bedside pneumothoraxes, pulmonary congestions, and COVID-19 pneumonia that are visible by LUS but undetected by CXR may be decisive for appropriate management, and even for saving lives. However, in other conditions, like bacterial pneumonia and small peripheral infarctions due to subsegmental pulmonary embolism, the high sensitivity of LUS does not always lead to advantages. Indeed, we doubt that it is always necessary to treat by antibiotics patients suspected of lower respiratory tract infection, who show radio-...
Poster: "ECR 2015 / C-2202 / Lung Cancer: one issue, many faces " by: "E. Piacibel... more Poster: "ECR 2015 / C-2202 / Lung Cancer: one issue, many faces " by: "E. Piacibello1, V. Angelino1, F. Moretti1, M. Busso 2, L. Cardinale1, A. Veltri1; 1Orbassano /IT, 2Orbassano/IT"
Journal of Clinical Oncology, 2006
7206 Background: In 2001 a feasibility study testing low-dose sCT as an early diagnosis tool in a... more 7206 Background: In 2001 a feasibility study testing low-dose sCT as an early diagnosis tool in asymptomatic volunteers at high risk for lung cancer was planned and initiated at our institution with an evaluation at baseline and then annually for 5 years. Subjects & Methods: We enrolled 520 asymptomatic volunteers, 73% males, aged 55 years or older (median age 60 yrs), with at least 20 pack-years of cigarette smoking and no previous cancer. Results: At baseline, one hundred forty-four extra-pulmonary findings (28%) were detected. The more common findings were: radiologically-detected adrenal enlargements (19%); thyroid struma (8%); hepatic abnormalities, like angiomas, cysts, calcifications, steatosis (29%); renal alterations, like cysts, lithiasis, vascular calcifications and one case of stage I renal carcinoma (21%); spleen abnormalities, like cysts, calcifications, accessory spleen (5%); cholelithiasis (4%); pancreatic alterations (1%); thymic nodules (1%); axillary adenopathy (5...
The use of general descriptive names, registered names, trademarks, service marks, etc. in this p... more The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
Journal of Thoracic Oncology, Aug 1, 2007
Minerva Respiratory Medicine
Poster: "ECR 2011 / C-2017 / Thoracic Imaging: correlation of sonographic signs at Lung Ultr... more Poster: "ECR 2011 / C-2017 / Thoracic Imaging: correlation of sonographic signs at Lung Ultrasound with Chest Radiography and Computed Tomography Images" by: "T. Guarnieri1, A. Ramanzin1, F. Avogliero1, F. Boccuzzi1, G. Volpicelli1, G. Garofalo2, L. Cardinale1, A. Veltri2, C. Fava2; 1Orbassano (TO)/IT, 2Orbassano/IT"
A 50-year-old Caucasian man was presented to the emergency department with cough and progressive ... more A 50-year-old Caucasian man was presented to the emergency department with cough and progressive dyspnoea. Plain chest x-ray showed multiple pseudo-nodular paren-chymal opacities, partly confluent and calcified, prominent in the middle-basal lung fields (figure 1A). Volumetric high-resolution computed tomography (HRCT) confirmed multiple bilateral parenchymal nodules with lobu-lated margins and extensive calcifications due to diffuse bron-chiectasis with thickened and calcified walls (figure 1BeC). Airways involvement was evident, characterised by submucosal deposits and lumen distortion mainly in the trachea, without sparing of the posterior membranous portion, and main and segmental bronchi (figure 2). Biopsy specimen from bronchoscopy was striking for amyloid (figure 3), therefore the evidence pointed towards a diagnosis of
Emergency Radiology, 2022
Background The necessity to identify and isolate COVID-19 patients to avoid intrahospital cross i... more Background The necessity to identify and isolate COVID-19 patients to avoid intrahospital cross infections is particularly felt as a challenge. Clinically occult SARS-CoV-2 infection among patients admitted to the hospital is always considered a risk during the pandemic. The aim of our study is to describe the application of CT scan to reveal unexpected COVID-19 in patients needing hospital admission. Method In our emergency department, we prospectively enrolled adult patients needing hospital admission, without symptoms suspected of COVID-19, and showing negative reverse transcriptase-polymerase chain reaction (RT-PCR) swab test. CT scan was performed to diagnose clinically occult COVID-19 pneumonia. All the exams were read and discussed retrospectively by two expert radiologists and assigned to one of 4 exclusive diagnoses: typical (typCT), indeterminate (indCT), atypical (atyCT), negative (negCT). The clinical characteristics and final diagnoses were described and compared with the results of CT scans. Results From May 25 to August 18, 2020, we prospectively enrolled 197 patients. They showed 122 negCT, 52 atyCT, 22 indCT, and 1 typCT. Based on the CT imaging, the prevalence of suspected clinically occult COVID-19 pneumonia was 11.6% (23 patients). None had confirmation of SARS-CoV-2 infection after the hospital stay. Nineteen patients had negative serial RT-PCR while in 4 cases, the infection was excluded by clinical follow-up or appearance of positivity of RT-PCR after months. Conclusion Our descriptive analysis confirms that CT scan cannot be considered a valid tool to screen clinically occult COVID-19, when the asymptomatic patients need hospitalization for other conditions. Application of personnel protections and distancing among patients remains the best strategies to limit the possibility of intrahospital cross-infections.