Luis Antonio Alvarez-sala Walther - Academia.edu (original) (raw)

Papers by Luis Antonio Alvarez-sala Walther

Revista Clínica Española, 2012

Conclusiones: Más de la mitad de los pacientes con diabetes mellitus y/o arteriopatía coronaria i... more Conclusiones: Más de la mitad de los pacientes con diabetes mellitus y/o arteriopatía coronaria incluidos en el estudio CODIMET no alcanzan el objetivo de colesterol LDL recomendado para pacientes de alto riesgo cardiovascular.

To determine the effects of dietary fat saturation on plasma lipoproteins, we studied 2 1 free-li... more To determine the effects of dietary fat saturation on plasma lipoproteins, we studied 2 1 free-living normolipidemic women (I 3 pre-and 8 postmenopausal) on three consecutive diet periods. During the first 4 wk they consumed a saturated diet rich in palm oil and butter [19% saturated fatty acids (5), 14% monounsaturated fatty acids (M). and 3.5% polyunsaturated fatty acids (P)]. followed by 6 wk ofa monounsaturated diet rich in olive oil (1 1% 5, 22% M, and 3.6% P), and 6 wk of a polyunsaturated diet rich in sunflower oil (10.7% 5. 12.5% M, and 12.8% P). Compared with the diet rich in saturated fatty acids. both diets rich in unsaturated fatty acids had similar lowering effects on total and low-density-lipoprotein cholesterol. High-density lipoprotein cholesterol and apolipoprotein A-I were higher in the monounsaturated-nich period than in the polyunsaturated-rich (10.5% and 12.7% respectively, P < 0.001) and the saturated-rich period (5.3%, and 7.9%. respectively. P < 0.05). These effects were independent of menopause status. Our data show that at this level of fat intake (36% as calories), a monounsaturated-rich diet results in a less athenogenic lipid profile than either polyunsaturated-or saturated-rich diets.

Medicine - Programa de Formaci?n M?dica Continuada Acreditado, 2008

Los lípidos, como el colesterol y los triglicéridos (TG), son moléculas insolubles que circulan e... more Los lípidos, como el colesterol y los triglicéridos (TG), son moléculas insolubles que circulan en el plasma unidas a proteínas (apoproteínas) formando lipoproteínas. Así pueden ser transportados en el torrente circulatorio, desde el intestino y el hígado a otros tejidos como lipoproteínas hidrosolubles, para utilizarlos como fuente de energía, lugar de depósito y en la formación de hormonas esteroideas y ácidos biliares.

Revista Clinica Espanola, 2000

Medicine - Programa de Formaci?n M?dica Continuada Acreditado, 2008

This paper gathers the news concerning vascular risk in 2010. It summarizes five lectures, accord... more This paper gathers the news concerning vascular risk in 2010. It summarizes five lectures, according to the order of presentation, at the annual meeting of the vascular risk working group of the Spanish Society of Internal Medicine (SEMI, Valencia 5(th) and 6(th) May 2011): arterial hypertension, antithrombosis, lipid disorders, diabetes mellitus and vascular risk stratification. The authors have made a depth revision of the more relevant research been published in 2010 with some data of 2011.

Revista Española de Cardiología (English Edition), 2013

Revista Española de Cardiología, 2013

Clínica e Investigación en Arteriosclerosis, 2011

Las enfermedades cardiovasculares constituyen un problema de salud pública en todo el mundo, espe... more Las enfermedades cardiovasculares constituyen un problema de salud pública en todo el mundo, especialmente en los llamados países desarrollados, dada su elevada frecuencia, su gravedad y el impacto tan elevado que tienen tanto para el sistema sanitario como ...

Nutrients, 2013

Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle fact... more Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18-80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none; low, <10 g/day; moderate, 10-30 g/day; high, >30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve ( cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at

Lung, 2010

The aim of this study was to analyze the relationship between health-related quality of life (HRQ... more The aim of this study was to analyze the relationship between health-related quality of life (HRQOL) and tobacco consumption in adult individuals (over the age of 15). The study was based on individual data from the City of Madrid Health Survey (ESCM05). Subjects were divided into three groups according to tobacco consumption: smokers, nonsmokers, and ex-smokers. HRQOL was measured using the COOP/WONCA quality-of-life vignettes. A multivariate adjustment with multinomial logistic regression was made, including the following as covariables: sociodemographic characteristics, comorbidities, drug use, and lifestyles. A total of 7341 individuals were interviewed (53.7% women), with an average age of 46.7 (SD = 19.02) years. The percentage of smokers was 27%, that of ex-smokers was 16.5%, and that of nonsmokers was 56.5%. There were no significant differences between smokers, ex-smokers, and nonsmokers in the raw scores obtained as totals from the COOP/WONCA questionnaire. Multivariate analysis revealed that smokers consume more antidepressant drugs (OR = 1.54, 95% CI = 1.09-2.16) and tranquilizers (OR = 1.91, 95% CI = 1.45-2.51), drink more alcohol (OR = 2.55, 95% CI = 2.11-3.08), get less physical exercise (OR = 1.33, 95% CI = 1.11-1.60), and have a lower quality of life (OR = 1.02, 95% CI = 1.00-1.04) than nonsmokers. Following adjustment for a significant number of covariables, sociodemographic as well as health-related, smokers consume more antidepressant drugs and tranquilizers, drink more alcohol, get less physical exercise, and demonstrate a lower HRQOL than nonsmokers.

Gene, 2012

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.

European Journal of Internal Medicine, 2009

Current Therapeutic Research, 2003

Background:

Atherosclerosis, 2007

Different epidemiological studies have demonstrated that some ethanol containing beverages intake... more Different epidemiological studies have demonstrated that some ethanol containing beverages intake could be associated with a reduction of cardiovascular mortality, effect attributed in part to its antioxidant properties. Nuclear factor-kappa B (NF-kappaB) is a redox sensitive transcription factor implicated in the pathogenesis of atherosclerosis. We have examined the effect of four different ethanol containing beverages on the activation of NF-kappaB in peripheral blood mononuclear cells (PBMC) and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) in healthy volunteers receiving a fat-enriched diet. Sixteen volunteers received 16 g/m(2) of ethanol in form of red wine, spirits (vodka, rum, and brandy) or no ethanol intake along with a fat-enriched diet during 5 days and all of them took all alcohols at different periods. NF-kappaB activation (electrophoretic mobility shift assay) and circulating MCP-1 levels (ELISA) were examined in blood samples taken before and after 5 days of ethanol intake. Subjects receiving a fat-enriched diet had increased NF-kappaB activation in PBMC at day 5. Furthermore, MCP-1 levels were increased in plasma at day 5. Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. Consumption of moderate amounts of alcoholic drinks containing polyphenols decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a fat-enriched diet. Our results provide additional evidence of the anti-inflammatory effects of some ethanol containing beverages, further supporting the idea that its moderate consumption may help to reduce overall cardiovascular mortality.

Atención Primaria, 2004

... La decisión de iniciar el tratamiento farmacológico dependerá del riesgo cardiovascular y de ... more ... La decisión de iniciar el tratamiento farmacológico dependerá del riesgo cardiovascular y de posibles lesiones de órganos diana. ... Brotons C, Royo-Bordonada MA, Álvarez-Sala L, Armario P, Artigao R, Conthe P, de Álvaro F, de Santiago A, Gil A, Lobos JM, Maiques A ...

American Journal of Respiratory Cell and Molecular Biology, 2012

This study identifies mitochondrial complex III as the major source of reactive oxygen species re... more This study identifies mitochondrial complex III as the major source of reactive oxygen species released by mitochondria in skeletal muscle of chronic obstructive pulmonary disease and reports a significant association between complex III reactive oxygen species production and lipid peroxidation of the cell, a marker of local oxidative stress.

Medicina Clínica, 2005

Resumen: Fundamento y objetivo: Muchos estudios de factores de riesgo cardiovascular (FRCV) reali... more Resumen: Fundamento y objetivo: Muchos estudios de factores de riesgo cardiovascular (FRCV) realizados en nuestro medio se centran en sólo uno. El estudio PREVENCAT se diseñó para estimar el control de los principales FRCV en población asistida en atención ...

Revista Clínica Española, 2012

Conclusiones: Más de la mitad de los pacientes con diabetes mellitus y/o arteriopatía coronaria i... more Conclusiones: Más de la mitad de los pacientes con diabetes mellitus y/o arteriopatía coronaria incluidos en el estudio CODIMET no alcanzan el objetivo de colesterol LDL recomendado para pacientes de alto riesgo cardiovascular.

To determine the effects of dietary fat saturation on plasma lipoproteins, we studied 2 1 free-li... more To determine the effects of dietary fat saturation on plasma lipoproteins, we studied 2 1 free-living normolipidemic women (I 3 pre-and 8 postmenopausal) on three consecutive diet periods. During the first 4 wk they consumed a saturated diet rich in palm oil and butter [19% saturated fatty acids (5), 14% monounsaturated fatty acids (M). and 3.5% polyunsaturated fatty acids (P)]. followed by 6 wk ofa monounsaturated diet rich in olive oil (1 1% 5, 22% M, and 3.6% P), and 6 wk of a polyunsaturated diet rich in sunflower oil (10.7% 5. 12.5% M, and 12.8% P). Compared with the diet rich in saturated fatty acids. both diets rich in unsaturated fatty acids had similar lowering effects on total and low-density-lipoprotein cholesterol. High-density lipoprotein cholesterol and apolipoprotein A-I were higher in the monounsaturated-nich period than in the polyunsaturated-rich (10.5% and 12.7% respectively, P < 0.001) and the saturated-rich period (5.3%, and 7.9%. respectively. P < 0.05). These effects were independent of menopause status. Our data show that at this level of fat intake (36% as calories), a monounsaturated-rich diet results in a less athenogenic lipid profile than either polyunsaturated-or saturated-rich diets.

Medicine - Programa de Formaci?n M?dica Continuada Acreditado, 2008

Los lípidos, como el colesterol y los triglicéridos (TG), son moléculas insolubles que circulan e... more Los lípidos, como el colesterol y los triglicéridos (TG), son moléculas insolubles que circulan en el plasma unidas a proteínas (apoproteínas) formando lipoproteínas. Así pueden ser transportados en el torrente circulatorio, desde el intestino y el hígado a otros tejidos como lipoproteínas hidrosolubles, para utilizarlos como fuente de energía, lugar de depósito y en la formación de hormonas esteroideas y ácidos biliares.

Revista Clinica Espanola, 2000

Medicine - Programa de Formaci?n M?dica Continuada Acreditado, 2008

This paper gathers the news concerning vascular risk in 2010. It summarizes five lectures, accord... more This paper gathers the news concerning vascular risk in 2010. It summarizes five lectures, according to the order of presentation, at the annual meeting of the vascular risk working group of the Spanish Society of Internal Medicine (SEMI, Valencia 5(th) and 6(th) May 2011): arterial hypertension, antithrombosis, lipid disorders, diabetes mellitus and vascular risk stratification. The authors have made a depth revision of the more relevant research been published in 2010 with some data of 2011.

Revista Española de Cardiología (English Edition), 2013

Revista Española de Cardiología, 2013

Clínica e Investigación en Arteriosclerosis, 2011

Las enfermedades cardiovasculares constituyen un problema de salud pública en todo el mundo, espe... more Las enfermedades cardiovasculares constituyen un problema de salud pública en todo el mundo, especialmente en los llamados países desarrollados, dada su elevada frecuencia, su gravedad y el impacto tan elevado que tienen tanto para el sistema sanitario como ...

Nutrients, 2013

Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle fact... more Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18-80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none; low, <10 g/day; moderate, 10-30 g/day; high, >30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve ( cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at

Lung, 2010

The aim of this study was to analyze the relationship between health-related quality of life (HRQ... more The aim of this study was to analyze the relationship between health-related quality of life (HRQOL) and tobacco consumption in adult individuals (over the age of 15). The study was based on individual data from the City of Madrid Health Survey (ESCM05). Subjects were divided into three groups according to tobacco consumption: smokers, nonsmokers, and ex-smokers. HRQOL was measured using the COOP/WONCA quality-of-life vignettes. A multivariate adjustment with multinomial logistic regression was made, including the following as covariables: sociodemographic characteristics, comorbidities, drug use, and lifestyles. A total of 7341 individuals were interviewed (53.7% women), with an average age of 46.7 (SD = 19.02) years. The percentage of smokers was 27%, that of ex-smokers was 16.5%, and that of nonsmokers was 56.5%. There were no significant differences between smokers, ex-smokers, and nonsmokers in the raw scores obtained as totals from the COOP/WONCA questionnaire. Multivariate analysis revealed that smokers consume more antidepressant drugs (OR = 1.54, 95% CI = 1.09-2.16) and tranquilizers (OR = 1.91, 95% CI = 1.45-2.51), drink more alcohol (OR = 2.55, 95% CI = 2.11-3.08), get less physical exercise (OR = 1.33, 95% CI = 1.11-1.60), and have a lower quality of life (OR = 1.02, 95% CI = 1.00-1.04) than nonsmokers. Following adjustment for a significant number of covariables, sociodemographic as well as health-related, smokers consume more antidepressant drugs and tranquilizers, drink more alcohol, get less physical exercise, and demonstrate a lower HRQOL than nonsmokers.

Gene, 2012

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.

European Journal of Internal Medicine, 2009

Current Therapeutic Research, 2003

Background:

Atherosclerosis, 2007

Different epidemiological studies have demonstrated that some ethanol containing beverages intake... more Different epidemiological studies have demonstrated that some ethanol containing beverages intake could be associated with a reduction of cardiovascular mortality, effect attributed in part to its antioxidant properties. Nuclear factor-kappa B (NF-kappaB) is a redox sensitive transcription factor implicated in the pathogenesis of atherosclerosis. We have examined the effect of four different ethanol containing beverages on the activation of NF-kappaB in peripheral blood mononuclear cells (PBMC) and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) in healthy volunteers receiving a fat-enriched diet. Sixteen volunteers received 16 g/m(2) of ethanol in form of red wine, spirits (vodka, rum, and brandy) or no ethanol intake along with a fat-enriched diet during 5 days and all of them took all alcohols at different periods. NF-kappaB activation (electrophoretic mobility shift assay) and circulating MCP-1 levels (ELISA) were examined in blood samples taken before and after 5 days of ethanol intake. Subjects receiving a fat-enriched diet had increased NF-kappaB activation in PBMC at day 5. Furthermore, MCP-1 levels were increased in plasma at day 5. Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. Consumption of moderate amounts of alcoholic drinks containing polyphenols decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a fat-enriched diet. Our results provide additional evidence of the anti-inflammatory effects of some ethanol containing beverages, further supporting the idea that its moderate consumption may help to reduce overall cardiovascular mortality.

Atención Primaria, 2004

... La decisión de iniciar el tratamiento farmacológico dependerá del riesgo cardiovascular y de ... more ... La decisión de iniciar el tratamiento farmacológico dependerá del riesgo cardiovascular y de posibles lesiones de órganos diana. ... Brotons C, Royo-Bordonada MA, Álvarez-Sala L, Armario P, Artigao R, Conthe P, de Álvaro F, de Santiago A, Gil A, Lobos JM, Maiques A ...

American Journal of Respiratory Cell and Molecular Biology, 2012

This study identifies mitochondrial complex III as the major source of reactive oxygen species re... more This study identifies mitochondrial complex III as the major source of reactive oxygen species released by mitochondria in skeletal muscle of chronic obstructive pulmonary disease and reports a significant association between complex III reactive oxygen species production and lipid peroxidation of the cell, a marker of local oxidative stress.

Medicina Clínica, 2005

Resumen: Fundamento y objetivo: Muchos estudios de factores de riesgo cardiovascular (FRCV) reali... more Resumen: Fundamento y objetivo: Muchos estudios de factores de riesgo cardiovascular (FRCV) realizados en nuestro medio se centran en sólo uno. El estudio PREVENCAT se diseñó para estimar el control de los principales FRCV en población asistida en atención ...