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Papers by Luis Enrique Lezcano Gort

Atherosclerosis, Dec 1, 2020

Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva, 2013

Cardiology research, 2020

Background: Low-density lipoprotein cholesterol (LDL-C) contributes decisively to the development... more Background: Low-density lipoprotein cholesterol (LDL-C) contributes decisively to the development of cardiovascular disease (CVD). In the LYNX registry we determined the rate of achievement of the target value of LDL-C, the use of lipid-lowering therapy (LLT) and the predictive factors of not reaching the target in patients with stable coronary heart disease (CHD). Methods: LYNX included consecutive patients with stable CHD treated at the University Hospital of Caceres, Extremadura (Spain) from September 2016 to September 2018, and those who must have an LDL-C target below 70 mg/dL according to the European Society of Cardiology (ESC) 2016 guidelines. The variables independently associated with the breach of the LDL-C objective were evaluated by multivariable logistic regression. Results: A total of 674 patients with stable CHD were included. The average LDL-C levels were 68.3 ± 24.5 mg/dL, with 56.7% showing a level below 70 mg/dL. LLT was used by 96.7% of patients, 71.7% were treated with high-powered statins and 30.1% with ezetimibe. The risk of not reaching the target value of LDL-C was higher in women, in active smokers, and in those who had multivessel CHD or had atrial fibrillation. Patients with diabetes mellitus, those who took potent statins or co-administration treatment with ezetimibe were more likely to reach the target level of LDL-C. Conclusions: The treatment of dyslipidemia in patients with chronic CHD remains suboptimal; however, an increasing number of very high-risk patients achieve the LDL-C objective, although there is still enormous potential to improve cardiovascular outcome through the use of more intensive LLT.

Netherlands Heart Journal, Apr 11, 2019

Revista Espanola De Cardiologia, Sep 1, 2016

Revista española de cardiología, Sep 1, 2016

Revista española de cardiología, Aug 1, 2016

Case Reports in Clinical Medicine

Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can b... more Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can be challenging and mortality remains high regardless of its management. A 50-year-old man admitted with cardiac arrest, whose physical examination and echocardioscopy suggested PVT confirmed with fluoroscopy. Intra-aortic fibrinolysis was the treatment chosen with successful results.

Revista Espanola de Enfermedades Digestivas, 2013

Pyogenic liver abscess (PLA) is a clinical entity usually related to hepatobiliary tract disease ... more Pyogenic liver abscess (PLA) is a clinical entity usually related to hepatobiliary tract disease or intra-abdominal infection (1). Recently, the association to non-metastatic colorectal cancer have been reported worldwide, mostly in eastern Asian countries (2,3). Staphylococcus aureus is an uncommon cause of liver abscess, but recovery of methicillin resistant Staphylococcus aureus (MRSA) is extremely rare (4,5). To our knowledge, we describe the first reported case of MRSA liver abscess associated to non-metastatic colorectal cancer in Europe. Case report A 76-year-old Caucasian man was admitted to the hospital for a 7-day history of fever, and several episodes of bloody diarrhea in the last month. His past medical history was relevant for hypertension and dyslipidemia, but he denied recent hospitalization, recent antibiotic use, intravenous or subcutaneous drug use, or recent travel. The physical examination showed an ill-appearing male with mucocutaneous pallor, and the abdomen was soft with no palpable masses. Significant laboratory data included neutrophilic leukocytosis (15.8 x 10 9 /L, neutrophils 85 %), and an

Annals of Emergency Medicine, 2020

Revista Española de Cardiología (English Edition), 2019

New mutation in the ACTA2 gene (p.Met84Val) in a family with nonsyndromic familial aortic aneurys... more New mutation in the ACTA2 gene (p.Met84Val) in a family with nonsyndromic familial aortic aneurysms Nueva mutación en el gen ACTA2 (p.Met84Val) en una familia con aneurismas de aorta familiares no sindrómicos

Revista Española de Cardiología, 2019

European Heart Journal, 2019

Introduction Myotonic dystrophy type 1 (DM 1), also known as Steinert's disease (SD), is the ... more Introduction Myotonic dystrophy type 1 (DM 1), also known as Steinert's disease (SD), is the most common muscular dystrophy in adults. It is characterized by multisystemic involvement and the cardiac affectation is the second leading cause of death after the respiratory one. Purpose The objective of our work was to study the cardiac involvement by transthoracic echocardiography (TTE) including systolic function, diastolic function and myocardial deformation with global longitudinal strain (GLS) by speckle tracking and trough biomarkers of myocardial damage with high-sensitive cardiac troponin T (hs-cTnT) and NT-proBNP. Methods 24 patients affected by SD were included. The TTE machine used has software to perform GLS with reference values: −20±2%. The normal values of hs-cTnT and NT-proBNP of our central laboratory are: <14 ng/L and 0–250 pg/ml, respectively. Results The mean age of patients was 52,08±12,14 years and the average age of diagnosis was 31,42 years. There was no g...

Clínica e Investigación en Arteriosclerosis, 2019

Resumen Introduccion y objetivo Determinar el cambio en las caracteristicas clinicas y pronostica... more Resumen Introduccion y objetivo Determinar el cambio en las caracteristicas clinicas y pronosticas de pacientes ingresados por sindrome coronario agudo (SCA) durante un periodo de los anos 2005 y 2015 en un hospital de referencia provincial. Material y metodo Estudio observacional transversal que compara las caracteristicas del SCA de los anos 2005 y 2015. Se analizaron factores de riesgo cardiovascular, tratamientos al alta, complicaciones y mortalidad. Resultados La incidencia de SCA en 2015 fue un 15,3% menor. La incidencia de hipertension arterial, diabetes y dislipemia fue similar, pero hubo mas fumadores en 2015 (25,9% vs 18,3%; p = 0,005). La reperfusion coronaria y la prescripcion de tratamientos de prevencion secundaria aumentaron respecto a 2005. La mortalidad hospitalaria fue similar. Conclusion La incidencia de SCA ha disminuido en la ultima decada en paralelo a una mejoria en el pronostico relacionado con un uso mas frecuente de los tratamientos recomendados en las guias.

Clínica e Investigación en Arteriosclerosis, 2018

Atención primaria; Coordinación asistencial; Formación continuada; Prevención cardiovascular Resu... more Atención primaria; Coordinación asistencial; Formación continuada; Prevención cardiovascular Resumen La existencia de una buena coordinación entre los distintos niveles asistenciales constituye un factor fundamental en el desarrollo de una asistencia sanitaria de calidad y eficiente. El médico de atención primaria es fundamental en la prevención secundaria de la enfermedad cardiovascular, y la estrecha colaboración entre atención primaria y cardiología constituye un factor clave en el control de la enfermedad cardiovascular. El proyecto CAPaCE-RES (Colaboración AP-Cardiología en Cáceres) pretende mejorar la coordinación entre atención primaria y cardiología desde la perspectiva del conocimiento mutuo y la mejora de la comunicación entre los profesionales que la desarrollan, y con ello a mejorar la calidad de la asistencia al paciente crónico con enfermedad cardiovascular.