Luis Martín-López - Academia.edu (original) (raw)

Papers by Luis Martín-López

$Research paper thumbnail of Fracturas de cadera en pacientes tratados con fármacos antipsicóticos. Estudio de cohortes históricas en Cataluña Hip fractures in patients treated with antipsychotic drugs. Study of retrospective cohorts in Catalonia$

To evaluate the incidence of hip fracture in patients with antipsychotic treatment, comparing it ... more To evaluate the incidence of hip fracture in patients with antipsychotic treatment, comparing it with that of individuals who have not been treated with antipsychotics. Retrospective cohort study of patients treated with antipsychotic drugs (TAP) and patients without known treatment (non-TAP). The observation period was 2006-2014. SITE: All primary care teams in Catalonia of the Catalan Health Institute (ICS). Patients older than 44 years with TAP lasting at least 3 months. Control cohort: random selection of non-TAP patients matching for baseline comorbidities and other variables. A total of 22,010 are analyzed. Main measurements Incidence rate (1000× person-years: PY) of hip fracture in each group (TAP and non-TAP). Cox regression models to estimate adjusted risks (hazard ratio: HR). The hip fracture incidence rate was higher in TAP patients (5.83 vs 3.58 fractures per 1000 PY), and is higher in all strata according to sex, age and type of diagnosis. The risk of suffering a hip fracture was 60% higher (HR: 1.60 95% CI: 1.34-1.92) in the TAP group than in the non-TAP group. The risk was higher in the group with schizophrenia (HR: 3.57 95% CI: 1.75-7.30), followed by bipolar disorder (HR: 2.61; 95% CI: 1.39-4.92) and depression (HR: 1.51; 95% CI: 1.21-1.88). Patients with antipsychotic treatment have a higher risk of hip fracture than those who have not been treated with antipsychotics.

Journal of Clinical Medicine, Jun 15, 2023

Mindfulness, Nov 29, 2021

Cuadernos de Neuropsicologia, Oct 6, 2016

En las últimas tres décadas se ha incrementado el número de publicaciones que apuntan a una eleva... more En las últimas tres décadas se ha incrementado el número de publicaciones que apuntan a una elevada prevalencia de psicopatología entre las personas con el síndrome de hiperlaxitud articular (SHA). Aunque los trastornos de ansiedad son los más frecuentes, otros como la depresión y los trastornos de alimentación, así como el abuso de alcohol y tabaco también se han relacionado con el SHA. No cabe establecer un efecto causal directo pero en cambio, hay indicios de mecanismos comunes como la disfunción vegetativa, los déficits propioceptivos, las coincidencias genéticas y las hipersensibilidades exteroceptiva e interoceptiva. Para tratar adecuadamente a los pacientes que sufren SHA, es necesario combinar diversos enfoques psiquiátricos y psicológicos, ya que no se trata solamente Palabras clave: Síndrome de hiperlaxitud articular, Ehlers-Danlos hipermovil, psicopatología, ansiedad. Increasing number of papers pointing to a high prevalence of psychiatric conditions among individuals suffering from the Joint Hypermobility Syndrome or Ehlers Danlos III Hypermobility type, (JHS/EDS-HT) have been published for the past 3 decades. Anxiety disorders are the most common psychiatric disorders related to JHS, although other conditions such as depression, eating disorders, alcohol and tobacco misuse have also been found. Albeit a simple causal effect can not be found, genetic, autonomic, proprioceptive, exteroceptive and interoceptive mechanisms may underlie such strong association. In order to properly treat patients suffering from JHS/EDS-HT, psychiatric and psychological approaches must be considered, not only to relieve clinical conditions but also to improve abilities to cope through proper drug treatment, psychotherapy and

BMC Psychiatry, May 12, 2016

Value in Health, Nov 1, 2014

Community Mental Health Journal, Jun 6, 2013

The aim of this review is to systematically review randomized controlled trials on lifestyle inte... more The aim of this review is to systematically review randomized controlled trials on lifestyle interventions on PCa patients undergoing androgen deprivation therapy. Methods A literature search was conducted using the electronic databases Medline and PubMed. To be eligible, studies had to be randomized controlled trials (RCTs) that focused on side effects of ADT and lifestyle interventions to reduce side effects for men undergoing ADT with PCa. Lifestyle interventions were defined as interventions that included any dietary or behavioral components. Results Twenty-nine trials were included. Most of them focused on exercise interventions, while some investigated the effect of dietary or behavioral interventions. The effect of different lifestyle influencing modalities aimed to improve on the adverse effects of ADT varied greatly. Conclusions It is not possible to draw one conclusion on the effect of exercise-based interventions, but noted on several adverse effects of ADT improvement. Further studies are necessary to develop personalized lifestyle interventions in order to mitigate the adverse effects.

Atencion Primaria, Feb 1, 2022

Mindfulness, May 21, 2019

Objectives Mindfulness-based cognitive therapy (MBCT), an intervention that integrates mindfulnes... more Objectives Mindfulness-based cognitive therapy (MBCT), an intervention that integrates mindfulness with cognitive-behavioral therapy, is an 8-week program originally developed to prevent relapses in patients with depression. Previous studies have demonstrated the efficacy of MBCT for preventing relapse, but few studies have evaluated MBCT in naturalistic conditions with real-world samples. Therefore, we sought to explore the characteristics and experiences of individuals receiving MBCT in primary care. Methods Mixed-methods approach combining descriptive and qualitative data. Quantitative data were obtained from 269 individuals from different socioeconomic backgrounds who participated in an MBCT program in our healthcare area during the years 2017 and 2018. Qualitative data were obtained from a subsample of participants who agree to participate in semi-structured individual interviews. An interpretative phenomenological analysis (IPA) approach was used to analyze the qualitative data. Results In the whole sample (n = 269), the most commonly diagnosed disorders were adjustment (41.6%), mood (22.7%), and anxiety (14.1%). Most participants (60%) were taking psychotropic medications (mainly antidepressants). Overall, mindfulness training improved depressive and anxiety symptoms, regardless of the specific diagnosis. A subsample of 14 individuals participated in the qualitative study. Four overarching themes emerged from the IPA analysis in this subsample: (1) effects of mindfulness practice, (2) learning process, (3) group experience, and (4) mindfulness in the healthcare system. Conclusions The findings of this naturalistic, mixed-methods study suggest that MBCT could be an effective approach to treating the symptoms of common mental disorders in the primary care setting.

Journal of Clinical Medicine

Research on the use of Acceptance and Commitment Therapy (ACT) for patients with degenerative lum... more Research on the use of Acceptance and Commitment Therapy (ACT) for patients with degenerative lumbar pathology awaiting surgery are limited. However, there is evidence to suggest that this psychological therapy may be effective in improving pain interference, anxiety, depression, and quality of life. This is the protocol for a randomized controlled trial (RCT) to evaluate the effectiveness of ACT compared to treatment as usual (TAU) for people with degenerative lumbar pathology who are candidates for surgery in the short term. A total of 102 patients with degenerative lumbar spine pathology will be randomly assigned to TAU (control group) or ACT + TAU (intervention group). Participants will be assessed after treatment and at 3-, 6-, and 12-month follow-ups. The primary outcome will be the mean change from baseline on the Brief Pain Inventory (pain interference). Secondary outcomes will include changes in pain intensity, anxiety, depression, pain catastrophizing, fear of movement, qu...

Mindfulness, 2021

Objectives Evidence suggests the efficacy of mindfulness-based cognitive therapy (MBCT) to preven... more Objectives Evidence suggests the efficacy of mindfulness-based cognitive therapy (MBCT) to prevent depression relapse and decrease depressive symptoms during the acute phase. However, the effectiveness of MBCT in real-world heterogeneous samples treated in clinical health settings, including primary care, has received little attention. This study had two aims: (1) to evaluate the effectiveness of MBCT delivered in primary care considering pre-treatment depression scores and (2) to explore the role of participants’ characteristics on symptom improvement. Methods Data were obtained from 433 individuals who received MBCT. Participants completed the Personality Inventory for ICD-11 (PiCD) pretreatment and the Beck Depression Inventory (BDI-II) pre- and post-treatment. Results Sixty percent presented moderate-to-severe depression according to scores on the BDI-II, 18.1% presented mild depression, and 21.7% were in the non-depressed range. The severity of pre-treatment depressive symptoms...

Quality assessment of the observational studies retained in the Review (STROBE). Quality assessme... more Quality assessment of the observational studies retained in the Review (STROBE). Quality assessment of the clinical trials studies retained in the Review (CONSORT). (DOC 97 kb)

International Journal of Environmental Research and Public Health, 2021

The association between physical illness and depression implies a poorer management of chronic di... more The association between physical illness and depression implies a poorer management of chronic disease and a lower response to antidepressant treatments. Our study evaluates the effectiveness of a psychoeducational group intervention led by Primary Care (PC) nurses, aimed at patients of this kind. It is a randomized, multicenter clinical trial with intervention (IG) and control groups (CG), blind response variables, and a one year follow-up. The study included 380 patients ≥50 years of age from 18 PC teams. The participants presented depression (BDI-II > 12) and a physical comorbidity: diabetes mellitus type 2, ischemic heart disease, chronic obstructive pulmonary disease, and/or asthma. The IG (n = 204) received the psychoeducational intervention (12 weekly sessions of 90 min), and the CG (n = 176) had standard care. The patients were evaluated at baseline, and at 4 and 12 months. The main outcome measures were clinical remission of depressive symptoms (BDI-II ≤ 13) and therapeu...

Resultados Los pacientes con TEA presentaron puntuaciones más bajas y estadísticamente significat... more Resultados Los pacientes con TEA presentaron puntuaciones más bajas y estadísticamente significativas en la prueba de anillas, respecto a los pacientes con TDAH (T=2,658; p=0,014). La prueba de control inhibitorio, fue el único dominio en el cual el grupo de pacientes con TDAH presentó puntuaciones más bajas respecto al grupo de pacientes con TEA, pero no fueron estadísticamente significativas.

Frontiers in Psychiatry, 2020

Revista de Psiquiatría y Salud Mental, 2019

BACKGROUND Joint hypermobility syndrome (JHS) has been found to be associated with anxiety disord... more BACKGROUND Joint hypermobility syndrome (JHS) has been found to be associated with anxiety disorders in clinical and nonclinical populations, but to date no studies have evaluated this association in children. The main goal of this study is to evaluate JHS along with anxiety, somatic and behavioral measures in children to clarify if JHS is associated with any of these variables in this age range. METHODS A sample of 160 children (74 girls and 86 boys) ranging from 5 to 17 o were recruited from a Child-Adolescent Mental Health clinic to participate in the study. All children underwent a diagnostic interview using the Mini International Neuropsychiatric Interview for Children and Adolescents. Instruments used include the Child Behavior Checklist (CBCL), the Screening Questionnaire to detect Hypermobility (SQ-CH) and the Children Manifested Anxiety Scale (CMAS-R). RESULTS The prevalence of JHS in this sample was 22%, and this was significantly higher in girls (31%) than in boys (14%) (χ2=6.83; P=.001). The JHS group scored significantly higher in the CMAS-R total anxiety (F=4.51; P=.035), CMAS-R Physiological anxiety (F=7.19; P=.008) and the CBCL somatic complaints (F=8.46; 0.004) and regression analyses showed that these 3 variables were predictors of JHS (χ2=36.77; P<.001; r2=0.22). The JHS group also scored higher in some behavioral measures. CONCLUSION Children with JHS have higher frequency of anxiety disorders and higher intensity of physiological anxiety, somatic complaints, and therefore, JHS might be used as marker for this anxiety phenotype in youngsters.

Psychiatry Research, 2019

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service... more This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  The bipolar group had a shorter N2 stage than HC.  The bipolar group showed non-significantly higher scores on REM density (REMd) than HC.  The ADHD group had a lower REMd than HC.  The bipolar vs. ADHD groups differed in N2 duration (BD < ADHD), R1 duration and REMd (BD > ADHD).

Psychiatry research, Jan 23, 2018

Social withdrawal is a new mental health problem increasingly common, present in different cultur... more Social withdrawal is a new mental health problem increasingly common, present in different cultures, whose psychopathology and treatment is not yet established. This study aims to determine the socio-demographic and clinical features and possible clinical subtypes that predict the 12-month outcomes of cases with hikikomori syndrome, a severe form of social withdrawal. Socio-demographic and clinical data at baseline were analysed as well as data obtained for 12 months after at-home treatment in 190 cases. The inclusion criteria were: spending all time at home, avoiding social situations and relationships, significant deterioration due to social isolation, with a minimum duration of 6 months. Six major diagnostic groups were identified: affective, anxiety, psychotic, drug use, personality and other Axis I disorders. The anxiety-affective subgroup demonstrated lower clinical severity, but worse evolution. Less than half of the cases were available for medical follow-up at 12-months. Su...

International journal of geriatric psychiatry, Jan 23, 2017

Anxiety disorders (AD) are very prevalent in the elderly, tend to compromise quality of life, and... more Anxiety disorders (AD) are very prevalent in the elderly, tend to compromise quality of life, and generate substantial costs. Considering that the prevention and early detection of anxiety may be relevant to increase health gains in older adults, it would be of great interest to identify whether the joint hypermobility syndrome (JHS) is also related to anxiety disorders in this age range. Cross-sectional data was collected in a sample of 108 subjects in a rural town in Spain. Instruments included Spielberger STAI, a modified Wolpe Fear Survey Schedule, General health Questionnaire (GHQ)-28, and the anxiety and mood disorders section of the SCID, to assess past year prevalence of anxiety disorders. JHS was evaluated by trained examiners using the "Hospital del Mar criteria". Among the 108 subjects (55% women, 45% men) over 60 years old, 21.3% meet criteria for JHS. These subjects scored significantly higher in both State (F = 5.53; p = 0.02) and Trait (F = 4.68; p = 0.03) a...