Luis Quintero - Academia.edu (original) (raw)
Papers by Luis Quintero
Psychiatry Research, 2007
Psychosocial research on schizophrenia would benefit from reliable and valid measures of knowledg... more Psychosocial research on schizophrenia would benefit from reliable and valid measures of knowledge about schizophrenia. Although a variety of instruments have been developed to assess the effects of specific family psychoeducational programs, little research has been conducted on the psychometric properties of scales measuring knowledge about schizophrenia. This study assessed reliability and validity of a brief, easily administered, multiple-choice knowledge test completed by 441 participants from several samples: 144 lay community members, 77 family members of inpatients with schizophrenia, 170 police officers involved in a training program on mental illnesses, and 50 mental health professionals. After item analysis, good internal consistency reliability and construct validity were demonstrated for an 18-item version of this test. The findings demonstrate that knowledge about schizophreniaa construct with potentially broad applicability in psychosocially oriented schizophrenia researchcan be assessed with brief, self-administered, multiple-choice knowledge tests.
Schizophrenia Research, 2006
Olfactory identification deficits and verbal memory impairments may represent trait markers for s... more Olfactory identification deficits and verbal memory impairments may represent trait markers for schizophrenia. The aims of this study were to: (1) assess olfactory identification in patients, first-degree relatives, and non-psychiatric controls, (2) determine differences in verbal memory functioning in these three groups, and (3) study correlations between olfactory identification and three specific verbal memory domains.A total of 106 participants–41 patients with schizophrenia or related disorders, 27 relatives, and 38 controls–were assessed with the University of Pennsylvania Smell Identification Test (UPSIT) and the Wechsler Memory Scale-Third Edition. Linear mixed models, accounting for clustering within families and relevant covariates, were used to compare scores across groups and to examine associations between olfactory identification ability and the three verbal memory domains.A group effect was apparent for all four measures, and relatives scored midway between patients and controls on all three memory domains. UPSIT scores were significantly correlated with all three forms of verbal memory. Age, verbal working memory, and auditory recognition delayed memory were independently predictive of UPSIT scores.Impairments in olfactory identification and verbal memory appear to represent two correlated risk markers for schizophrenia, and frontal–temporal deficits likely account for both impairments.
Human Genetics, 1981
A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly ... more A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly malformed 4-year-old female patient. Although no chromosomal loss was demonstrated at 1p the patient's phenotype is discussed on the basis of a possible minimal 1p deletion.
Human Genetics, 1981
Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromos... more Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromosome 15. Several banding methods showed the r(15) chromosome not to have any apparent deletion of the long arm. The silver staining technique for nucleolar organizer regions showed an NOR positive region (band p12). In only a few cells was a chromosome 15 missing. The size of the r(15) was found to be constant. Comparison with 11 previous reported cases in the literature shows that the clinical manifestations in the different patients with ring chromosome 15 are constant although not clinically identifiable and it appears likely to attribute them to a significantly retarded intrauterine and postnatal growth instead of presumed deficiency in the long arm and mosaic configurations.
Clinical Genetics, 2008
Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Claus... more Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Clausen (DMC) syndrome are described. The ages of the affected males varied from 13 to 50 years and they presented with typical clinical and radiological manifestations of the syndrome. The association of normal intelligence and a clear X-linked recessive inheritance in this family is evidence of heterogeneity in the Dyggve-Melchior-Clausen syndrome. In agreement with previous reports for DMC dwarfism, this new form has normal mucopolysaccharide excretion.
Human Genetics, 1981
A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly ... more A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly malformed 4-year-old female patient. Although no chromosomal loss was demonstrated at 1p the patient's phenotype is discussed on the basis of a possible minimal 1p deletion.
Human Genetics, 1981
Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromos... more Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromosome 15. Several banding methods showed the r(15) chromosome not to have any apparent deletion of the long arm. The silver staining technique for nucleolar organizer regions showed an NOR positive region (band p12). In only a few cells was a chromosome 15 missing. The size of the r(15) was found to be constant. Comparison with 11 previous reported cases in the literature shows that the clinical manifestations in the different patients with ring chromosome 15 are constant although not clinically identifiable and it appears likely to attribute them to a significantly retarded intrauterine and postnatal growth instead of presumed deficiency in the long arm and mosaic configurations.
Clinical Genetics, 2008
Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Claus... more Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Clausen (DMC) syndrome are described. The ages of the affected males varied from 13 to 50 years and they presented with typical clinical and radiological manifestations of the syndrome. The association of normal intelligence and a clear X-linked recessive inheritance in this family is evidence of heterogeneity in the Dyggve-Melchior-Clausen syndrome. In agreement with previous reports for DMC dwarfism, this new form has normal mucopolysaccharide excretion.
Acs Nano, 2009
Novel optical imaging methods, such as Raman microspectroscopy, have been gaining recognition in ... more Novel optical imaging methods, such as Raman microspectroscopy, have been gaining recognition in their ability to obtain noninvasively the distribution of biochemical components of a sample. Raman spectroscopy in combination with optical microscopy provides a label-free method to assess and image cellular processes, without the use of extrinsic fluorescent dyes. The submicrometer resolution of the confocal Raman instrumentation allows us to image cellular organelles on the scale of conventional microscopy. We used the technique to monitor subcellular degradation patterns of two biodegradable nanocarrier systemsOpoly-
Psychiatry Research, 2007
Psychosocial research on schizophrenia would benefit from reliable and valid measures of knowledg... more Psychosocial research on schizophrenia would benefit from reliable and valid measures of knowledge about schizophrenia. Although a variety of instruments have been developed to assess the effects of specific family psychoeducational programs, little research has been conducted on the psychometric properties of scales measuring knowledge about schizophrenia. This study assessed reliability and validity of a brief, easily administered, multiple-choice knowledge test completed by 441 participants from several samples: 144 lay community members, 77 family members of inpatients with schizophrenia, 170 police officers involved in a training program on mental illnesses, and 50 mental health professionals. After item analysis, good internal consistency reliability and construct validity were demonstrated for an 18-item version of this test. The findings demonstrate that knowledge about schizophreniaa construct with potentially broad applicability in psychosocially oriented schizophrenia researchcan be assessed with brief, self-administered, multiple-choice knowledge tests.
Schizophrenia Research, 2006
Olfactory identification deficits and verbal memory impairments may represent trait markers for s... more Olfactory identification deficits and verbal memory impairments may represent trait markers for schizophrenia. The aims of this study were to: (1) assess olfactory identification in patients, first-degree relatives, and non-psychiatric controls, (2) determine differences in verbal memory functioning in these three groups, and (3) study correlations between olfactory identification and three specific verbal memory domains.A total of 106 participants–41 patients with schizophrenia or related disorders, 27 relatives, and 38 controls–were assessed with the University of Pennsylvania Smell Identification Test (UPSIT) and the Wechsler Memory Scale-Third Edition. Linear mixed models, accounting for clustering within families and relevant covariates, were used to compare scores across groups and to examine associations between olfactory identification ability and the three verbal memory domains.A group effect was apparent for all four measures, and relatives scored midway between patients and controls on all three memory domains. UPSIT scores were significantly correlated with all three forms of verbal memory. Age, verbal working memory, and auditory recognition delayed memory were independently predictive of UPSIT scores.Impairments in olfactory identification and verbal memory appear to represent two correlated risk markers for schizophrenia, and frontal–temporal deficits likely account for both impairments.
Human Genetics, 1981
A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly ... more A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly malformed 4-year-old female patient. Although no chromosomal loss was demonstrated at 1p the patient's phenotype is discussed on the basis of a possible minimal 1p deletion.
Human Genetics, 1981
Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromos... more Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromosome 15. Several banding methods showed the r(15) chromosome not to have any apparent deletion of the long arm. The silver staining technique for nucleolar organizer regions showed an NOR positive region (band p12). In only a few cells was a chromosome 15 missing. The size of the r(15) was found to be constant. Comparison with 11 previous reported cases in the literature shows that the clinical manifestations in the different patients with ring chromosome 15 are constant although not clinically identifiable and it appears likely to attribute them to a significantly retarded intrauterine and postnatal growth instead of presumed deficiency in the long arm and mosaic configurations.
Clinical Genetics, 2008
Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Claus... more Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Clausen (DMC) syndrome are described. The ages of the affected males varied from 13 to 50 years and they presented with typical clinical and radiological manifestations of the syndrome. The association of normal intelligence and a clear X-linked recessive inheritance in this family is evidence of heterogeneity in the Dyggve-Melchior-Clausen syndrome. In agreement with previous reports for DMC dwarfism, this new form has normal mucopolysaccharide excretion.
Human Genetics, 1981
A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly ... more A unique case of terminal rearrangement (1p;21p) is described in a mentally retarded and grossly malformed 4-year-old female patient. Although no chromosomal loss was demonstrated at 1p the patient's phenotype is discussed on the basis of a possible minimal 1p deletion.
Human Genetics, 1981
Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromos... more Cytogenetic studies on lymphocytes from a girl aged 3 years and 10 months revealed a ring chromosome 15. Several banding methods showed the r(15) chromosome not to have any apparent deletion of the long arm. The silver staining technique for nucleolar organizer regions showed an NOR positive region (band p12). In only a few cells was a chromosome 15 missing. The size of the r(15) was found to be constant. Comparison with 11 previous reported cases in the literature shows that the clinical manifestations in the different patients with ring chromosome 15 are constant although not clinically identifiable and it appears likely to attribute them to a significantly retarded intrauterine and postnatal growth instead of presumed deficiency in the long arm and mosaic configurations.
Clinical Genetics, 2008
Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Claus... more Ten affected males studied from four generations of a Colombian family with Dyggve-Melchior-Clausen (DMC) syndrome are described. The ages of the affected males varied from 13 to 50 years and they presented with typical clinical and radiological manifestations of the syndrome. The association of normal intelligence and a clear X-linked recessive inheritance in this family is evidence of heterogeneity in the Dyggve-Melchior-Clausen syndrome. In agreement with previous reports for DMC dwarfism, this new form has normal mucopolysaccharide excretion.
Acs Nano, 2009
Novel optical imaging methods, such as Raman microspectroscopy, have been gaining recognition in ... more Novel optical imaging methods, such as Raman microspectroscopy, have been gaining recognition in their ability to obtain noninvasively the distribution of biochemical components of a sample. Raman spectroscopy in combination with optical microscopy provides a label-free method to assess and image cellular processes, without the use of extrinsic fluorescent dyes. The submicrometer resolution of the confocal Raman instrumentation allows us to image cellular organelles on the scale of conventional microscopy. We used the technique to monitor subcellular degradation patterns of two biodegradable nanocarrier systemsOpoly-