Lukas Staub - Academia.edu (original) (raw)

Papers by Lukas Staub

BMC health services research, 2005

The description of patient travel patterns and variations in health care utilization may guide a ... more The description of patient travel patterns and variations in health care utilization may guide a sound health care planning process. In order to accurately describe these differences across regions with homogeneous populations, small area analysis (SAA) has proved as a valuable tool to create appropriate area models. This paper presents the methodology to create and characterize population-based hospital service areas (HSAs) for Switzerland. We employed federal hospital discharge data to perform a patient origin study using small area analysis. Each of 605 residential regions was assigned to one of 215 hospital provider regions where the most frequent number of discharges took place. HSAs were characterized geographically, demographically, and through health utilization indices and rates that describe hospital use. We introduced novel planning variables extracted from the patient origin study and investigated relationships among health utilization indices and rates to understand pat...

Trials, 2009

Background: Bleeding is a frequent complication during surgery. The intraoperative administration... more Background: Bleeding is a frequent complication during surgery. The intraoperative administration of blood products, including packed red blood cells, platelets and fresh frozen plasma (FFP), is often live saving. Complications of blood transfusions contribute considerably to perioperative costs and blood product resources are limited. Consequently, strategies to optimize the decision to transfuse are needed.

Spine, 2010

Prospective multicenter observational case-series. The goal of the SWISSspine registry is to gene... more Prospective multicenter observational case-series. The goal of the SWISSspine registry is to generate evidence about the safety and efficiency of these Medtech innovations. The Swiss federal office of public health required a mandatory nationwide HTA-registry for cervical total disc arthroplasty (TDA), among other technologies, to decide about reimbursement of these interventions. Between March 2005 and June 2008, 808 interventions with implantation of 925 discs from 5 different suppliers were performed. Surgeon-administered outcome instruments were primary intervention, implant, and follow-up forms; patient self-reported measures were EQ-5D, COSS, and a comorbidity questionnaire. Data are recorded perioperative, at 3 months and 1 year postoperative, and annually thereafter. RESULTS. There was significant and clinically relevant reduction of neck (preoperative/postoperative 59.3/24.8 points) and arm pain (preoperative/postoperative 64.9/17.6) on visual analogue scale (VAS) and consequently decreased analgesics consumption. Similarly, quality of life (QoL) improved from preoperative 0.42 to postoperative 0.82 points on EQ-5D scale. There were 4 intraoperative complications and 23 revisions during the same hospitalization for 691 monosegmental TDAs, and 2 complications and 6 revisions for 117 2-level surgeries. A pharmacologically treated depression was identified as important risk factor for achieving a clinically relevant pain alleviation >20 points on VAS. Two-level surgery resulted in similar outcomes compared with the monosegmental interventions. Cervical TDA appeared as safe and efficacious in short-term pain alleviation, consequent reduction of pain killer consumption, and in improvement of QoL. A clinically relevant pain reduction of ≥20 points was most probable if patients had preoperative pain levels ≥40 points on VAS. A pharmacologically treated depression and 2-level surgery were identified as risk factors for less pronounced pain alleviation or QoL improvement.

The Journal of Foot and Ankle Surgery, 2008

The use of fibrin glue for repairing Achilles tendon ruptures was introduced in the 1980s. Althou... more The use of fibrin glue for repairing Achilles tendon ruptures was introduced in the 1980s. Although fibrin glue has been in regular use since that time, suturing remains the standard for surgical repair. Studies have indicated that, in the short term, fibrin glue is as effective as suturing. To date, there have been no long-term studies comparing the outcomes of these 2 techniques. This study compares the long-term results of surgical repair of Achilles tendon rupture with sutures versus fibrin glue. Forty-two patients who had undergone Achilles tendon repair with either suture or fibrin glue took part in a follow-up examination after an average of 12.1 years. The fibrin group consisted of 31 patients and the suture group consisted of 11 patients. Patients treated with fibrin glue reached a higher modified Thermann score (adapted from Weber), achieved equal results in an isokinetic force measurement, and showed fewer complications. The authors concluded that the use of fibrin glue for the repair of ruptured Achilles tendon is a suitable alternative to traditional sutures.

Health & Place, 2009

The study systematically describes the frequency and geographic variability of major surgical int... more The study systematically describes the frequency and geographic variability of major surgical interventions for musculoskeletal disorders in Switzerland. Age-and sex-standardized rates for joint replacements, arthroscopies, spine surgery and hip fracture repair were calculated for hospital service regions. Various statistical analyses were used to measure the extent of variation. The authors argue that the surgery of hip fractures can be used as index surgery in the context of analyzing variations in orthopedic surgery. Temporal trends imply that patient demand and supply factors related to clinical ambiguity and non-medical incentives of providers are far more important components leading to increased use than the sole effect of an aging population.

European Spine Journal, 2008

With an official life time of over 5 years, Spine Tango can meanwhile be considered the first int... more With an official life time of over 5 years, Spine Tango can meanwhile be considered the first international spine registry. In this paper we present an overview of frequency statistics of Spine Tango for demonstrating the genesis of questionnaire development and the constantly increasing activity in the registry. Results from two exemplar studies serve for showing concepts of data analysis applied to a spine registry. Between 2002 and 2006, about 6,000 datasets were submitted by 25 centres. Descriptive analyses were performed for demographic, M. Melloh Á L. Staub (&) Á E. Aghayev Á T. Zweig Á M. Aebi Á C. Roeder

European Spine Journal, 2008

Lumbar spinal stenosis is a frequent indication for spinal surgery. The predictive quality of tre... more Lumbar spinal stenosis is a frequent indication for spinal surgery. The predictive quality of treadmill testing and MRI for diagnostic verification is not yet clearly defined. Aim of the current study was to assess correlations between treadmill testing and MRI findings in the lumbar spine. Twenty-five patients with lumbar spinal stenosis were prospectively examined. Treadmill tests were performed and the area of the dural sac and neuroforamina was examined with MRI for the narrowest spinal segment. VAS and ODI were used for clinical assessment. The median age of the patients was 67 years. In the narrowest spinal segment the median area of the dural sac was 91 mm 2 . The median ODI was 66 per cent. The median walking distance in the treadmill test was 70 m. The distance reached in the treadmill test correlated with the area of the dural sac (Spearman's q = 0.53) and ODI (q = -0.51), but not with the area of the neuroforamina and VAS. The distance reached in the treadmill test predicts the grade of stenosis in MRI but has a limited diagnostic importance for the level of clinical symptoms in lumbar spinal stenosis.

BMC health services research, 2005

The description of patient travel patterns and variations in health care utilization may guide a ... more The description of patient travel patterns and variations in health care utilization may guide a sound health care planning process. In order to accurately describe these differences across regions with homogeneous populations, small area analysis (SAA) has proved as a valuable tool to create appropriate area models. This paper presents the methodology to create and characterize population-based hospital service areas (HSAs) for Switzerland. We employed federal hospital discharge data to perform a patient origin study using small area analysis. Each of 605 residential regions was assigned to one of 215 hospital provider regions where the most frequent number of discharges took place. HSAs were characterized geographically, demographically, and through health utilization indices and rates that describe hospital use. We introduced novel planning variables extracted from the patient origin study and investigated relationships among health utilization indices and rates to understand pat...

Trials, 2009

Background: Bleeding is a frequent complication during surgery. The intraoperative administration... more Background: Bleeding is a frequent complication during surgery. The intraoperative administration of blood products, including packed red blood cells, platelets and fresh frozen plasma (FFP), is often live saving. Complications of blood transfusions contribute considerably to perioperative costs and blood product resources are limited. Consequently, strategies to optimize the decision to transfuse are needed.

Spine, 2010

Prospective multicenter observational case-series. The goal of the SWISSspine registry is to gene... more Prospective multicenter observational case-series. The goal of the SWISSspine registry is to generate evidence about the safety and efficiency of these Medtech innovations. The Swiss federal office of public health required a mandatory nationwide HTA-registry for cervical total disc arthroplasty (TDA), among other technologies, to decide about reimbursement of these interventions. Between March 2005 and June 2008, 808 interventions with implantation of 925 discs from 5 different suppliers were performed. Surgeon-administered outcome instruments were primary intervention, implant, and follow-up forms; patient self-reported measures were EQ-5D, COSS, and a comorbidity questionnaire. Data are recorded perioperative, at 3 months and 1 year postoperative, and annually thereafter. RESULTS. There was significant and clinically relevant reduction of neck (preoperative/postoperative 59.3/24.8 points) and arm pain (preoperative/postoperative 64.9/17.6) on visual analogue scale (VAS) and consequently decreased analgesics consumption. Similarly, quality of life (QoL) improved from preoperative 0.42 to postoperative 0.82 points on EQ-5D scale. There were 4 intraoperative complications and 23 revisions during the same hospitalization for 691 monosegmental TDAs, and 2 complications and 6 revisions for 117 2-level surgeries. A pharmacologically treated depression was identified as important risk factor for achieving a clinically relevant pain alleviation >20 points on VAS. Two-level surgery resulted in similar outcomes compared with the monosegmental interventions. Cervical TDA appeared as safe and efficacious in short-term pain alleviation, consequent reduction of pain killer consumption, and in improvement of QoL. A clinically relevant pain reduction of ≥20 points was most probable if patients had preoperative pain levels ≥40 points on VAS. A pharmacologically treated depression and 2-level surgery were identified as risk factors for less pronounced pain alleviation or QoL improvement.

The Journal of Foot and Ankle Surgery, 2008

The use of fibrin glue for repairing Achilles tendon ruptures was introduced in the 1980s. Althou... more The use of fibrin glue for repairing Achilles tendon ruptures was introduced in the 1980s. Although fibrin glue has been in regular use since that time, suturing remains the standard for surgical repair. Studies have indicated that, in the short term, fibrin glue is as effective as suturing. To date, there have been no long-term studies comparing the outcomes of these 2 techniques. This study compares the long-term results of surgical repair of Achilles tendon rupture with sutures versus fibrin glue. Forty-two patients who had undergone Achilles tendon repair with either suture or fibrin glue took part in a follow-up examination after an average of 12.1 years. The fibrin group consisted of 31 patients and the suture group consisted of 11 patients. Patients treated with fibrin glue reached a higher modified Thermann score (adapted from Weber), achieved equal results in an isokinetic force measurement, and showed fewer complications. The authors concluded that the use of fibrin glue for the repair of ruptured Achilles tendon is a suitable alternative to traditional sutures.

Health & Place, 2009

The study systematically describes the frequency and geographic variability of major surgical int... more The study systematically describes the frequency and geographic variability of major surgical interventions for musculoskeletal disorders in Switzerland. Age-and sex-standardized rates for joint replacements, arthroscopies, spine surgery and hip fracture repair were calculated for hospital service regions. Various statistical analyses were used to measure the extent of variation. The authors argue that the surgery of hip fractures can be used as index surgery in the context of analyzing variations in orthopedic surgery. Temporal trends imply that patient demand and supply factors related to clinical ambiguity and non-medical incentives of providers are far more important components leading to increased use than the sole effect of an aging population.

European Spine Journal, 2008

With an official life time of over 5 years, Spine Tango can meanwhile be considered the first int... more With an official life time of over 5 years, Spine Tango can meanwhile be considered the first international spine registry. In this paper we present an overview of frequency statistics of Spine Tango for demonstrating the genesis of questionnaire development and the constantly increasing activity in the registry. Results from two exemplar studies serve for showing concepts of data analysis applied to a spine registry. Between 2002 and 2006, about 6,000 datasets were submitted by 25 centres. Descriptive analyses were performed for demographic, M. Melloh Á L. Staub (&) Á E. Aghayev Á T. Zweig Á M. Aebi Á C. Roeder

European Spine Journal, 2008

Lumbar spinal stenosis is a frequent indication for spinal surgery. The predictive quality of tre... more Lumbar spinal stenosis is a frequent indication for spinal surgery. The predictive quality of treadmill testing and MRI for diagnostic verification is not yet clearly defined. Aim of the current study was to assess correlations between treadmill testing and MRI findings in the lumbar spine. Twenty-five patients with lumbar spinal stenosis were prospectively examined. Treadmill tests were performed and the area of the dural sac and neuroforamina was examined with MRI for the narrowest spinal segment. VAS and ODI were used for clinical assessment. The median age of the patients was 67 years. In the narrowest spinal segment the median area of the dural sac was 91 mm 2 . The median ODI was 66 per cent. The median walking distance in the treadmill test was 70 m. The distance reached in the treadmill test correlated with the area of the dural sac (Spearman's q = 0.53) and ODI (q = -0.51), but not with the area of the neuroforamina and VAS. The distance reached in the treadmill test predicts the grade of stenosis in MRI but has a limited diagnostic importance for the level of clinical symptoms in lumbar spinal stenosis.