Lurys Bourdett-stanziola - Academia.edu (original) (raw)

Papers by Lurys Bourdett-stanziola

Asian Journal of Research in Animal and Veterinary Sciences, Dec 9, 2021

Rotavirus infections are the most common causes of infectious diarrhea in young children and anim... more Rotavirus infections are the most common causes of infectious diarrhea in young children and animals worldwide. We performed a genotyping of rotavirus strains by RT-PCR for G (VP7) and P (VP4), in diarrhea samples from calves, in several locations in Costa Rica. Combinations of genotypes G (VP7) and P (VP4) were identified in cattle: 4 (26%) corresponding to G8 P [11], 4 (24%) to G6P [11], 3 (19%) to G8P [7], 2 (13%) to G10P [1], 3 (19%) to G10P [11], and 1 (6%) to G8P [1] and mixed infections. This research represents the first report of bovine rotavirus strains (calves) in Costa Rica and in the Central American region.

American Journal of Tropical Medicine and Hygiene, Dec 1, 2008

In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from different... more In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from different hospitals in Panama, Costa Rica, and the Dominican Republic during the period comprised between December 2002 and July 2003. One hundred samples per country from the positives to the enzyme-linked immunosorbent assay (ELISA) kit were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) to determine the G and P genotypes: in Panama, Costa Rica, and Dominican Republic the combinations G and P have a great diversity and unusual genotypes. These results highlight an unexpected diversity among rotavirus strains in these countries and emphasize the need for further serologic and genetic surveys on more rotavirus strains in Central America and the Caribbean. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused by unusual genotypes. These results represent the second report of rotavirus genotypes in Costa Rica and first-time reports of rotavirus genotypes in Panama and the Dominican Republic.

International Journal of Pathogen Research, Aug 8, 2022

The epidemiology of animal rotaviruses infection and their association with illnesses in humans r... more The epidemiology of animal rotaviruses infection and their association with illnesses in humans remains unknown in Central America and the world. In this study, we performed a genotyping of rotavirus strains by RT-PCR for-G (VP7) and P (VP4), in samples of diarrhea in calves and piglets, in Honduras and Panama. Mixed infections and combinations of genotypes G (VP7) and P (VP4) were identified in calves in Honduras: 3 (4%) G2P [6], 2 (2%) G2P [4], in piglets: 4 (5%) G4P [6], and in calves in Panama: 63 (72%) G10 P [2], 12 (13%) G8 P [11], 9 (10%) G6 P [11] and 3 (3%) G10 P [1].This investigation represents the first report of bovine and porcine rotavirus strains in Honduras and Panama.

Microbiology research journal international, May 9, 2022

Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered re... more Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered reservoirs of many viruses with zoonotic impact worldwide. Rotaviruses have been detected in bats and many of those strains that have been identified globally share high homology with rotavirus strains identified in animals and humans, demonstrating that roles are being created in interspecies transmission and genetic rearrangement in a large number of occasions, which is producing rotavirus genetic diversity. The current effort to characterize strains of rotavirus in bats would help expand knowledge about the great genetic diversity of rotaviruses and could also suggest a bat origin for several unusual rotavirus strains detected in humans and animals. This is a review of the different strains of rotavirus that have been detected in bats globally, where bats have been identified as a possible zoonotic potential in the transmission of rotavirus to animals and humans; and possible anthropozoonosis events are revealed.

International Journal of TROPICAL DISEASE & Health

Rotavirus is considered a major public health problem worldwide because many children, adults, an... more Rotavirus is considered a major public health problem worldwide because many children, adults, and animals die from gastroenteritis due to rotavirus; rotavirus contamination follows the fecal/oral route, and it is well supported that infection can also be achieved by consuming food and water that is contaminated with rotavirus. Research has shown that, in Latin American countries, unusual emerging strains of rotavirus are occurring in children and adults with gastroenteritis; which contain in their sequence genes from rotavirus genotypes detected in animals; Therefore, researchers consider it a virus with zoonotic potential. In this review, I propose that rotavirus transmission occurs from wild animals, who use an intermediate host before contaminating humans, by means of the fecal/oral route, food, and water. Rotavirus produces genetic rearrangements generating new emerging strains, which are excreted into the environment. Generally, during the dry season in our Latin American coun...

Intervirology, 2010

In this study, 574 stool samples from children with gastroenteritis were obtained from different ... more In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus (RV) by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P6, G2P8, G3P6, G9P4, and mixed infections. Recent studies have indicated that unusual human RV strains are emerging as global strains, which has important implications for effective vaccine development. In this context, the next generation of RV vaccines will need to provide adequate protection against diseases caused not only by mixed infections, but also by unusual G/P combinations.

Biology of Blood and Marrow Transplantation, 2016

supportive interventions for SCD have improved survival in children; yet disability and early dea... more supportive interventions for SCD have improved survival in children; yet disability and early death remain challenges in adulthood. Provider-related bias has been considered in the underutilization of disease-modifying therapies for SCD (e.g., Brandow and Panepinto 2010). Despite the availability of transplant in the US and France for over two decades, utilization remains heterogeneous across centers in both countries, despite similarities in patient population and health care access. Understanding these differences requires in-depth examination of institutional practices. Ethnographic research triangulated qualitative methods, including participantobservation, interviews and oral histories, and archival research. Fieldwork occurred over 30 months from 2012-15 and included two pediatric SCD centers in the US and two in France. Participant-observation and interviews were conducted in clinical settings and regional and international research and advocacy meetings. Interview participants included health care providers (25), adult patients (7), parents of children with SCD (19); additionally, 16 families were followed longitudinally over the course of their child's transplant. Fieldnotes and interviews were transcribed, coded, and analyzed using Atlas.ti data management software. Centers that were high utilizers of transplant employed multiple strategies to inform and refer families for treatment intensification. These practices were more uniform when a single provider managed a small clinic cohort, but were also observed in larger centers whose leadership worked to align provider clinical practice. Real time data collection and management of patient biometrics facilitated process control of treatment intensification in larger centers. The center whose providers were more atomized demonstrated greater heterogeneity in referral practices. Interviews and participant-observation revealed broad contingencies for provider comfort in initiating treatment intensification conversations with families. Responses from providers ranged from, "It's just information; why not tell them?" to refraining from discussions with patients altogether unless the case was discussed with other providers in the program. Of note, trusted non-physician members of the health care team provided significant support to families in centers that were high transplant utilizers. Biomedical ethical practice regularly outlines health care provider duties to inform patients of treatment options to facilitate autonomous decision-making. In this study, centers that regularly intensify treatment for SCD rarely provide "just information," but also incorporate multiple practice modalities to support families undergoing referral and evaluation for transplant.

Biology of Blood and Marrow Transplantation, 2015

Biology of Blood and Marrow Transplantation, 2015

International Journal of Pathogen Research

The epidemiology of animal rotaviruses infection and their association with illnesses in humans r... more The epidemiology of animal rotaviruses infection and their association with illnesses in humans remains unknown in Central America and the world. In this study, we performed a genotyping of rotavirus strains by RT-PCR for-G (VP7) and P (VP4), in samples of diarrhea in calves and piglets, in Honduras and Panama. Mixed infections and combinations of genotypes G (VP7) and P (VP4) were identified in calves in Honduras: 3 (4%) G2P [6], 2 (2%) G2P [4], in piglets: 4 (5%) G4P [6], and in calves in Panama: 63 (72%) G10 P [2], 12 (13%) G8 P [11], 9 (10%) G6 P [11] and 3 (3%) G10 P [1].This investigation represents the first report of bovine and porcine rotavirus strains in Honduras and Panama.

Journal of Advances in Microbiology

Rotavirus infections are the most common causes of infectious diarrhea in young children worldwid... more Rotavirus infections are the most common causes of infectious diarrhea in young children worldwide. We performed a genotyping of rotavirus strains by RT-PCR for G (VP7) and P (VP4), in Anadara tuberculosa, Lactuca sativa and feces samples of children with diarrhea collected in Panama. Combinations of genotypes G (VP7) and P (VP4) were identified in Anadara tuberculosa: 30 (15%) corresponding to G12P[8], 26 (13%) to G12P[6], 28 (14%) to G1P[8], 7 (3.5%) to G2P [6]. Lactuca sativa: 42 (18%) corresponding to G12P[8], 33 (14%) to G1P[8]. In feces of children with diarrhea: 39 (13%) corresponding to G12P[8], 14 (4.6%) to G9P[8], 12 (4%) to G12P[6], 2 (0.6%) to G2P[x], 1(0.3%) to G3P[8], 6(2%) to G2P[4] were identified. This research represents the first report of rotavirus strains identified in Anadara tuberculosa and Lactuca sativa in Panama and the Central American region.

Abstract. In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from... more Abstract. In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from different hospitals in Panama, Costa Rica, and the Dominican Republic during the period comprised between December 2002 and July 2003. One hundred samples per country from the positives to the enzyme-linked immunosorbent assay (ELISA) kit were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) to determine the G and P genotypes: in Panama, Costa Rica, and Dominican Republic the combinations G and P have a great diversity and unusual genotypes. These results highlight an unexpected diversity among rotavirus strains in these countries and emphasize the need for further serologic and genetic surveys on more rotavirus strains in Central America and the Caribbean. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused by unusual genotypes. These results represent the second report of rotavirus genotypes in...

Microbiology Research Journal International

Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered re... more Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered reservoirs of many viruses with zoonotic impact worldwide. Rotaviruses have been detected in bats and many of those strains that have been identified globally share high homology with rotavirus strains identified in animals and humans, demonstrating that roles are being created in interspecies transmission and genetic rearrangement in a large number of occasions, which is producing rotavirus genetic diversity. The current effort to characterize strains of rotavirus in bats would help expand knowledge about the great genetic diversity of rotaviruses and could also suggest a bat origin for several unusual rotavirus strains detected in humans and animals. This is a review of the different strains of rotavirus that have been detected in bats globally, where bats have been identified as a possible zoonotic potential in the transmission of rotavirus to animals and humans; and possible anthropozo...

Intervirology, 2011

In this study, 574 stool samples from children with gastroenteritis were obtained from different ... more In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P6, G2P8, G3P6, G9P4 and mixed infections. Recent studies have indicated that unusual human rotavirus strains are emerging as global strains, which has important implications for effective vaccine development. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused not only by mixed infections, but also by unusual G/P combinations.

South Asian Journal of Research in Microbiology

Rotavirus infections are the most common causes of infectious diarrhea in young children and anim... more Rotavirus infections are the most common causes of infectious diarrhea in young children and animal worldwide. In some countries in Latin American specifically in Central American and Caribbean countries, rotavirus infections are not subject to specific surveillance. This review is about the unusually strains detected and potential zoonotic of rotavirus in Latin American. Although, interspecies transmission has not been documented to occur directly, an increase of the number of reports of atypical rotavirus genotypes; apparently derived from transmission between animal of farm, domestic and wild with humans, has been reported in some Latin American countries and the world. We consider that the rapid increase in the detection of new unusual strains with genetic heterogeneity, raises interesting questions about the evolution of rotavirus in The Latin American region. The emergence of novel strains derived from interspecies transmission has implications for the design and implementatio...

Asian Journal of Research in Infectious Diseases

Interspecies transmission is an important aspect of rotavirus evolution and is enhanced by the cl... more Interspecies transmission is an important aspect of rotavirus evolution and is enhanced by the close contact between humans and animals. The role of bats as a reservoir or intermediary host for viruses associated with human gastroenteritis is poorly understood, but there are reports of rotaviruses detected in humans that contain genes from bat rotavirus. In this study, a total of 15 rotavirus positive samples from children hospitalized for gastroenteritis in 2007 in the Dominican Republic were investigated by sequencing of the capsid VP4, VP7 and VP6 genes to identify genetic variants. The most common genotypes were G1-P[8]-I1, G3-P[6]-I2 and G12-P[8]-I1. Interestingly, 3 of the 15 sequenced strains had VP7 encoding genes highly similar (≥97%) to those of bat rotaviruses of the G3 genotype detected in Bulgaria in 2008. These VP7 sequences were more distantly related (≤92%) to other G3 rotavirus found in bat, human, rabbit, pigs, rat and monkeys. Only 1 VP4 sequence was available fr...

Asian Journal of Research in Animal and Veterinary Sciences, Dec 9, 2021

Rotavirus infections are the most common causes of infectious diarrhea in young children and anim... more Rotavirus infections are the most common causes of infectious diarrhea in young children and animals worldwide. We performed a genotyping of rotavirus strains by RT-PCR for G (VP7) and P (VP4), in diarrhea samples from calves, in several locations in Costa Rica. Combinations of genotypes G (VP7) and P (VP4) were identified in cattle: 4 (26%) corresponding to G8 P [11], 4 (24%) to G6P [11], 3 (19%) to G8P [7], 2 (13%) to G10P [1], 3 (19%) to G10P [11], and 1 (6%) to G8P [1] and mixed infections. This research represents the first report of bovine rotavirus strains (calves) in Costa Rica and in the Central American region.

American Journal of Tropical Medicine and Hygiene, Dec 1, 2008

In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from different... more In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from different hospitals in Panama, Costa Rica, and the Dominican Republic during the period comprised between December 2002 and July 2003. One hundred samples per country from the positives to the enzyme-linked immunosorbent assay (ELISA) kit were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) to determine the G and P genotypes: in Panama, Costa Rica, and Dominican Republic the combinations G and P have a great diversity and unusual genotypes. These results highlight an unexpected diversity among rotavirus strains in these countries and emphasize the need for further serologic and genetic surveys on more rotavirus strains in Central America and the Caribbean. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused by unusual genotypes. These results represent the second report of rotavirus genotypes in Costa Rica and first-time reports of rotavirus genotypes in Panama and the Dominican Republic.

International Journal of Pathogen Research, Aug 8, 2022

The epidemiology of animal rotaviruses infection and their association with illnesses in humans r... more The epidemiology of animal rotaviruses infection and their association with illnesses in humans remains unknown in Central America and the world. In this study, we performed a genotyping of rotavirus strains by RT-PCR for-G (VP7) and P (VP4), in samples of diarrhea in calves and piglets, in Honduras and Panama. Mixed infections and combinations of genotypes G (VP7) and P (VP4) were identified in calves in Honduras: 3 (4%) G2P [6], 2 (2%) G2P [4], in piglets: 4 (5%) G4P [6], and in calves in Panama: 63 (72%) G10 P [2], 12 (13%) G8 P [11], 9 (10%) G6 P [11] and 3 (3%) G10 P [1].This investigation represents the first report of bovine and porcine rotavirus strains in Honduras and Panama.

Microbiology research journal international, May 9, 2022

Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered re... more Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered reservoirs of many viruses with zoonotic impact worldwide. Rotaviruses have been detected in bats and many of those strains that have been identified globally share high homology with rotavirus strains identified in animals and humans, demonstrating that roles are being created in interspecies transmission and genetic rearrangement in a large number of occasions, which is producing rotavirus genetic diversity. The current effort to characterize strains of rotavirus in bats would help expand knowledge about the great genetic diversity of rotaviruses and could also suggest a bat origin for several unusual rotavirus strains detected in humans and animals. This is a review of the different strains of rotavirus that have been detected in bats globally, where bats have been identified as a possible zoonotic potential in the transmission of rotavirus to animals and humans; and possible anthropozoonosis events are revealed.

International Journal of TROPICAL DISEASE & Health

Rotavirus is considered a major public health problem worldwide because many children, adults, an... more Rotavirus is considered a major public health problem worldwide because many children, adults, and animals die from gastroenteritis due to rotavirus; rotavirus contamination follows the fecal/oral route, and it is well supported that infection can also be achieved by consuming food and water that is contaminated with rotavirus. Research has shown that, in Latin American countries, unusual emerging strains of rotavirus are occurring in children and adults with gastroenteritis; which contain in their sequence genes from rotavirus genotypes detected in animals; Therefore, researchers consider it a virus with zoonotic potential. In this review, I propose that rotavirus transmission occurs from wild animals, who use an intermediate host before contaminating humans, by means of the fecal/oral route, food, and water. Rotavirus produces genetic rearrangements generating new emerging strains, which are excreted into the environment. Generally, during the dry season in our Latin American coun...

Intervirology, 2010

In this study, 574 stool samples from children with gastroenteritis were obtained from different ... more In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus (RV) by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P6, G2P8, G3P6, G9P4, and mixed infections. Recent studies have indicated that unusual human RV strains are emerging as global strains, which has important implications for effective vaccine development. In this context, the next generation of RV vaccines will need to provide adequate protection against diseases caused not only by mixed infections, but also by unusual G/P combinations.

Biology of Blood and Marrow Transplantation, 2016

supportive interventions for SCD have improved survival in children; yet disability and early dea... more supportive interventions for SCD have improved survival in children; yet disability and early death remain challenges in adulthood. Provider-related bias has been considered in the underutilization of disease-modifying therapies for SCD (e.g., Brandow and Panepinto 2010). Despite the availability of transplant in the US and France for over two decades, utilization remains heterogeneous across centers in both countries, despite similarities in patient population and health care access. Understanding these differences requires in-depth examination of institutional practices. Ethnographic research triangulated qualitative methods, including participantobservation, interviews and oral histories, and archival research. Fieldwork occurred over 30 months from 2012-15 and included two pediatric SCD centers in the US and two in France. Participant-observation and interviews were conducted in clinical settings and regional and international research and advocacy meetings. Interview participants included health care providers (25), adult patients (7), parents of children with SCD (19); additionally, 16 families were followed longitudinally over the course of their child's transplant. Fieldnotes and interviews were transcribed, coded, and analyzed using Atlas.ti data management software. Centers that were high utilizers of transplant employed multiple strategies to inform and refer families for treatment intensification. These practices were more uniform when a single provider managed a small clinic cohort, but were also observed in larger centers whose leadership worked to align provider clinical practice. Real time data collection and management of patient biometrics facilitated process control of treatment intensification in larger centers. The center whose providers were more atomized demonstrated greater heterogeneity in referral practices. Interviews and participant-observation revealed broad contingencies for provider comfort in initiating treatment intensification conversations with families. Responses from providers ranged from, "It's just information; why not tell them?" to refraining from discussions with patients altogether unless the case was discussed with other providers in the program. Of note, trusted non-physician members of the health care team provided significant support to families in centers that were high transplant utilizers. Biomedical ethical practice regularly outlines health care provider duties to inform patients of treatment options to facilitate autonomous decision-making. In this study, centers that regularly intensify treatment for SCD rarely provide "just information," but also incorporate multiple practice modalities to support families undergoing referral and evaluation for transplant.

Biology of Blood and Marrow Transplantation, 2015

Biology of Blood and Marrow Transplantation, 2015

International Journal of Pathogen Research

The epidemiology of animal rotaviruses infection and their association with illnesses in humans r... more The epidemiology of animal rotaviruses infection and their association with illnesses in humans remains unknown in Central America and the world. In this study, we performed a genotyping of rotavirus strains by RT-PCR for-G (VP7) and P (VP4), in samples of diarrhea in calves and piglets, in Honduras and Panama. Mixed infections and combinations of genotypes G (VP7) and P (VP4) were identified in calves in Honduras: 3 (4%) G2P [6], 2 (2%) G2P [4], in piglets: 4 (5%) G4P [6], and in calves in Panama: 63 (72%) G10 P [2], 12 (13%) G8 P [11], 9 (10%) G6 P [11] and 3 (3%) G10 P [1].This investigation represents the first report of bovine and porcine rotavirus strains in Honduras and Panama.

Journal of Advances in Microbiology

Rotavirus infections are the most common causes of infectious diarrhea in young children worldwid... more Rotavirus infections are the most common causes of infectious diarrhea in young children worldwide. We performed a genotyping of rotavirus strains by RT-PCR for G (VP7) and P (VP4), in Anadara tuberculosa, Lactuca sativa and feces samples of children with diarrhea collected in Panama. Combinations of genotypes G (VP7) and P (VP4) were identified in Anadara tuberculosa: 30 (15%) corresponding to G12P[8], 26 (13%) to G12P[6], 28 (14%) to G1P[8], 7 (3.5%) to G2P [6]. Lactuca sativa: 42 (18%) corresponding to G12P[8], 33 (14%) to G1P[8]. In feces of children with diarrhea: 39 (13%) corresponding to G12P[8], 14 (4.6%) to G9P[8], 12 (4%) to G12P[6], 2 (0.6%) to G2P[x], 1(0.3%) to G3P[8], 6(2%) to G2P[4] were identified. This research represents the first report of rotavirus strains identified in Anadara tuberculosa and Lactuca sativa in Panama and the Central American region.

Abstract. In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from... more Abstract. In this study 2,089 fecal samples from patients with gastroenteritis were analyzed from different hospitals in Panama, Costa Rica, and the Dominican Republic during the period comprised between December 2002 and July 2003. One hundred samples per country from the positives to the enzyme-linked immunosorbent assay (ELISA) kit were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) to determine the G and P genotypes: in Panama, Costa Rica, and Dominican Republic the combinations G and P have a great diversity and unusual genotypes. These results highlight an unexpected diversity among rotavirus strains in these countries and emphasize the need for further serologic and genetic surveys on more rotavirus strains in Central America and the Caribbean. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused by unusual genotypes. These results represent the second report of rotavirus genotypes in...

Microbiology Research Journal International

Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered re... more Rotaviruses are the most common cause of diarrhea in children and animals. Bats are considered reservoirs of many viruses with zoonotic impact worldwide. Rotaviruses have been detected in bats and many of those strains that have been identified globally share high homology with rotavirus strains identified in animals and humans, demonstrating that roles are being created in interspecies transmission and genetic rearrangement in a large number of occasions, which is producing rotavirus genetic diversity. The current effort to characterize strains of rotavirus in bats would help expand knowledge about the great genetic diversity of rotaviruses and could also suggest a bat origin for several unusual rotavirus strains detected in humans and animals. This is a review of the different strains of rotavirus that have been detected in bats globally, where bats have been identified as a possible zoonotic potential in the transmission of rotavirus to animals and humans; and possible anthropozo...

Intervirology, 2011

In this study, 574 stool samples from children with gastroenteritis were obtained from different ... more In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P6, G2P8, G3P6, G9P4 and mixed infections. Recent studies have indicated that unusual human rotavirus strains are emerging as global strains, which has important implications for effective vaccine development. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused not only by mixed infections, but also by unusual G/P combinations.

South Asian Journal of Research in Microbiology

Rotavirus infections are the most common causes of infectious diarrhea in young children and anim... more Rotavirus infections are the most common causes of infectious diarrhea in young children and animal worldwide. In some countries in Latin American specifically in Central American and Caribbean countries, rotavirus infections are not subject to specific surveillance. This review is about the unusually strains detected and potential zoonotic of rotavirus in Latin American. Although, interspecies transmission has not been documented to occur directly, an increase of the number of reports of atypical rotavirus genotypes; apparently derived from transmission between animal of farm, domestic and wild with humans, has been reported in some Latin American countries and the world. We consider that the rapid increase in the detection of new unusual strains with genetic heterogeneity, raises interesting questions about the evolution of rotavirus in The Latin American region. The emergence of novel strains derived from interspecies transmission has implications for the design and implementatio...

Asian Journal of Research in Infectious Diseases

Interspecies transmission is an important aspect of rotavirus evolution and is enhanced by the cl... more Interspecies transmission is an important aspect of rotavirus evolution and is enhanced by the close contact between humans and animals. The role of bats as a reservoir or intermediary host for viruses associated with human gastroenteritis is poorly understood, but there are reports of rotaviruses detected in humans that contain genes from bat rotavirus. In this study, a total of 15 rotavirus positive samples from children hospitalized for gastroenteritis in 2007 in the Dominican Republic were investigated by sequencing of the capsid VP4, VP7 and VP6 genes to identify genetic variants. The most common genotypes were G1-P[8]-I1, G3-P[6]-I2 and G12-P[8]-I1. Interestingly, 3 of the 15 sequenced strains had VP7 encoding genes highly similar (≥97%) to those of bat rotaviruses of the G3 genotype detected in Bulgaria in 2008. These VP7 sequences were more distantly related (≤92%) to other G3 rotavirus found in bat, human, rabbit, pigs, rat and monkeys. Only 1 VP4 sequence was available fr...