Lutfi Ozkan - Academia.edu (original) (raw)
Papers by Lutfi Ozkan
Tumori Journal, 2006
Aims and Background The status of the axillary lymph nodes at the time of diagnosis has been acce... more Aims and Background The status of the axillary lymph nodes at the time of diagnosis has been accepted as one of the most important prognostic factors for the overall and disease-free survival of patients with breast cancer. The aim of our study was to determine which factors influence axillary node involvement in invasive breast cancer. Methods The data presented here were obtained from 344 patients who were treated for invasive breast cancer at the Department of Radiation Oncology, Uludag University Medical College, Bursa, Turkey. Possible prognostic factors were categorized as patient related and tumor related. The Mann-Whitney U test was used for univariate analysis and logistic regression was used for multivariate analysis. Results In univariate analysis, a familial cancer history (P = 0.0042), age <40 years (P = 0.0276), higher T stage (P <0.0000), nipple involvement (P = 0.0345), skin involvement (P = 0.0270), perineural invasion (P = 0.0231), and lymphatic vessel invasi...
European Journal of Cancer, 2001
European Journal of Cancer, 1997
European Journal of Cancer, 2001
The patients with pain had worse QL outcomes in comparison to the patients without (the results i... more The patients with pain had worse QL outcomes in comparison to the patients without (the results in terms of subscales scores are described in the table).
International Journal of Radiation Oncology*Biology*Physics, 2001
Materials and Methods: 575 patients from 36 community hospitals underwent full dose I-125 implant... more Materials and Methods: 575 patients from 36 community hospitals underwent full dose I-125 implantation by the real-time technique, of which 505 had adequate data for evaluation, including mCi implanted and prostate size. All underwent peripheral implantation with needles and seeds placed according to a set of rules developed specifically for this technique, in which seed strength and total implant radioactivity were obtained from look-up tables relating mCi to prostate volume (PV). CT-based dosimetry was performed 1 month post implant by one individual. Dose volume histogram parameters were analyzed for volume-related effects, including dose to 90% of the prostate (D90), 10% and 30% of the rectal wall (R10, R30), and 30% of the urethra (U30). Volume was defined as small (Ͻ25 cc), medium (25-39 cc) or large (Ͼ40 cc). Significance was assessed by Student's t-test and chi square test. Results: Median prostate volume was 32.7 cc (range 9 to 79 cc). Median D90 was 164 Gy (range 90 to 230 Gy). 455 patients (90%) achieved D90 Ͼ 140 Gy. Median D90 was significantly lower in the Ͻ25 cc group (pϽ0.001) and higher in Ͼ 40 cc group (pϽ0.001). D90 Ͻ140 Gy occurred in 19.8% of small versus 9% of medium and 3.5% of large prostates (pϭ 0.003). D90 Ͼ180 Gy occurred in 6.5% of small and 9% of medium vs. 25% of large glands (pϽ0.001). R10, R30, and U30 values also showed volume-related differences, although urethral dose did not increase in the large glands (R30 not shown).
Tumori (Milano)
To evaluate the efficacy and tolerability of a new treatment approach including induction chemoth... more To evaluate the efficacy and tolerability of a new treatment approach including induction chemotherapy (CT) and concurrent chemoradiotherapy (CRT) in unresectable, locally advanced pancreatic cancer (LAPC). Twenty-four patients with LAPC were enrolled in the study. They first received induction CT consisting of 5-fluorouracil (5FU) (500 mg/m2) and gemcitabine (1000 mg/m2), which were given weekly for 3 weeks of every 4. Patients showing a response or disease stabilization after 2 cycles of induction CT received CRT consisting of external beam radiotherapy (50.4-54 Gy in fractions of 1.8 Gy/day) and gemcitabine (350 mg/m2, weekly for 6 weeks). Patients without disease progression received 2 additional cycles of CT consisting of 5FU plus gemcitabine with the same doses and schedule as given in the induction CT. After the end of the study, 2 (8%) and 5 (21%) patients showed complete and partial responses, respectively. Five patients (21%) had disease stabilization. The grade 3 and 4 to...
Hepato-Gastroenterology
To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes s... more To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes starting just within 5 minutes after the completion of radiotherapy thrice weekly. Thirty-eight patients with locally advanced rectal cancer were enrolled in the study. Ranges of total radiation doses were between 50.4 Gy and 61.2 Gy with a median of 59.4 Gy with fraction size of 1.8 Gy five times weekly. 5-fluorouracil was administered thrice weekly with the dose of 250-300mg/m2/day concomitantly with radiation therapy. Median follow-up time was 30 months. Administration of chemotherapy concomitant with radiotherapy (p=0.089), AJCC stage III (p=0.079), Duke's stage C (p=0.079), presence of lymph node involvement (p=0.079) and presence of local recurrence (p=0.066) appeared to be effecting distant metastasis although differences did not reach statistically significance. Mean overall survival was 46 months in patients without any distant metastasis (SD: 3.28; 95% CI: 39.46 and 52.31) w...
Hepato-Gastroenterology
5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant... more 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer. Capecitabine represents a valuable alternative to 5-Fluorouracil in this situation. Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery. The data concerning the toxicity and the efficacy of the treatments were compared in patients treated with 5-Fluorouracil- and capecitabine-based chemoradiotherapy. Forty-three patients received 5-Fluorouracil, and 24 patients received capecitabine during adjuvant radiotherapy. Although there were no differences between the groups in terms of toxicity rates, distant metastasis-free survival, disease-free ...
Hepato-gastroenterology, 2005
BACKGROUND/AIMS To determine the percentage of responders and the resectability rate for patients... more BACKGROUND/AIMS To determine the percentage of responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by infusional 5-fluorouracil chemotherapy and pelvic radiation. METHODOLOGY Twenty-four patients with a diagnosis of locally advanced unresectable rectal cancer received preoperative 5-fluorouracil by intravenous infusion at the dose of 250-300mg/m2/day concurrent with pelvic radiation (median 50.4 Gy/28 fractions). Surgery was performed with a mean delay of 15 days after completion of irradiation and included 11 abdominoperineal resections and five anal sphincter-preserving procedures. RESULTS The median follow-up was 22 months. Complete histological response occurred in 6%, and tumor down-staging in 58% of cases. There was a significant difference in the rate of local control based on the distance of the tumor from the anal verge (>5.4cm; p=0.046). Our results have suggested the importance of the total dose on the local control ...
Saudi medical journal, 2006
S ignet cell carcinoma is a variant of adenocarcinoma commonly seen in the gastrointestinal syste... more S ignet cell carcinoma is a variant of adenocarcinoma commonly seen in the gastrointestinal system. Dominance of a signet cell carcinoma component in adenocarcinoma is generally considered as a sign of poor prognosis. Primary signet cell carcinoma of the breast is not seen as a distinct histological type in the World Health Organization classification, and is generally accepted as a sub-type of mucinous and lobular carcinoma. It appears to originate from the lobular epithelium, and an intracytoplasmic mucin collection is present histologically in most of the neoplastic cells. 4 divided signet cell carcinomas into 2 groups according to distribution of mucinous content within the cytoplasm, intracytoplasmic lumina type and non-intracytoplasmic lumina type. There is no agreement on the treatment and prognosis of breast carcinomas with signet cell dominance. It was suggested that the metastatic rate was higher in these tumors, and treatment should be shaped keeping in mind this importan...
BACKGROUND/AIMS To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil ... more BACKGROUND/AIMS To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes starting just within 5 minutes after the completion of radiotherapy thrice weekly. METHODOLOGY Thirty-eight patients with locally advanced rectal cancer were enrolled in the study. Ranges of total radiation doses were between 50.4 Gy and 61.2 Gy with a median of 59.4 Gy with fraction size of 1.8 Gy five times weekly. 5-fluorouracil was administered thrice weekly with the dose of 250-300mg/m2/day concomitantly with radiation therapy. RESULTS Median follow-up time was 30 months. Administration of chemotherapy concomitant with radiotherapy (p=0.089), AJCC stage III (p=0.079), Duke's stage C (p=0.079), presence of lymph node involvement (p=0.079) and presence of local recurrence (p=0.066) appeared to be effecting distant metastasis although differences did not reach statistically significance. Mean overall survival was 46 months in patients without any distant metastasis (...
Hepato Gastroenterology, 2008
5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant... more 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer. Capecitabine represents a valuable alternative to 5-Fluorouracil in this situation. Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery. The data concerning the toxicity and the efficacy of the treatments were compared in patients treated with 5-Fluorouracil- and capecitabine-based chemoradiotherapy. Forty-three patients received 5-Fluorouracil, and 24 patients received capecitabine during adjuvant radiotherapy. Although there were no differences between the groups in terms of toxicity rates, distant metastasis-free survival, disease-free survival, and overall survival rates; a trend for improved loco-regional recurrence-free survival rate was observed in the capecitabine arm (p = 0.063). Capecitabine is at least as effective as 5-Fluorouracil in the postoperative treatment of rectal adenocarcinoma. Considering the trend for improved loco-regional recurrence-free survival rate in the capecitabine arm, it seems that the drug exerts better synergy with radiotherapy in this situation.
... Sevilcan AYGÜN*, Meral KURT**, Sibel Kahraman ÇETİNTAŞ**, Eda Bengi YILMAZ**, Huriye ÖZTÜRK**... more ... Sevilcan AYGÜN*, Meral KURT**, Sibel Kahraman ÇETİNTAŞ**, Eda Bengi YILMAZ**, Huriye ÖZTÜRK**, Şenay KAPLAN**, Lütfi ÖZKAN ... muayene ve digital rektal muayene, akciğer grafisi, spiral abdominopelvik to-mografi, fleksible endoskopi, tam kan sayımı ve kara-ciğer ve ...
... Meral KURT*, Sibel ÇETİNTAŞ*, Ayşen ÖZTÜRK*, Neşe GÜNEŞ**, Çiğdem EDİNCİK*, Lütfi ÖZKAN*, Fey... more ... Meral KURT*, Sibel ÇETİNTAŞ*, Ayşen ÖZTÜRK*, Neşe GÜNEŞ**, Çiğdem EDİNCİK*, Lütfi ÖZKAN*, Feyzi TAMGAÇ** ... Hodgkin lenfomada (HL) başarılı tedavi yaklaşımının sağlanması, doğru evreleme ve etkin takip ile müm-kün olabilmektedir1. ...
Arch Gynecol Obstet, 2004
A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with t... more A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with three courses of methotrexate with folinic acid rescue and had been lost to follow up for 4 years was referred with the fractional curettage diagnosis of choriocarcinoma that had been performed for abnormal vaginal bleeding. Her serum beta human chorionic gonadotropin (betahCG) was 706000 mIU/mL and there were multiple pulmonary metastatic foci. The uterus was 12 weeks pregnant-size and a 6 x 6-cm tumor mass was seen within the anterior uterine wall at ultrasonography. Following total abdominal hysterectomy etoposide, methotrexate, actinomycin-D, vincristine and cyclophosphamide (EMA/CO) regimen was given. Whole brain radiation of 30 Gy in 3 weeks for brain metastasis, discovered in magnetic resonance imaging was given after the first course. Since serum betahCG levels plateaued after three courses of chemotherapy and multiple pulmonary metastases persisted, treatment was shifted to etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP) regimen. She was in remission after three courses of chemotherapy.
Asian Pacific journal of cancer prevention : APJCP, 2015
To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cyt... more To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cytokeratin 20 (CK20) and survinin gene expression on local control (LC) and overall survival (OS) in patients with locally advanced head and neck cancer (LAHNC) who were administered radiotherapy (RT). Twenty-six patients who were admitted to Uludag University Medical Faculty Department of Radiation Oncology with a diagnosis of LAHNC (GIII-GIV) were included in this study. Gene expression was evaluated in tumor tissues and peripheral blood. RNA isolation was performed on paraffinized tumor tissues and peripheral blood samples obtained before RT (BR). The densities of the obtained RNAs were analyzed at 260/280 nm. cDNA samples obtained from total RNA,EGFR, CK19, CK20 and survinin gene expression levels were assessed via the Sybr Green method and data were analyzed with the ΔΔCt method. The same process was repeated for peripheral blood samples taken after RT (AR). The female/male ratio was ...
Tumori
To evaluate the effect of bcl-2 expression on the local control and overall survival of patients ... more To evaluate the effect of bcl-2 expression on the local control and overall survival of patients with early stage laryngeal cancer treated with radiotherapy alone. We included 53 patients with stage Tis, T1, and T2 laryngeal cancer who were irradiated in our department. Paraffin blocks of all biopsy specimens were subjected to immunohistochemical analysis with a bcl-2 oncoprotein mouse clone 124 Scytek kit. The mean follow-up time was 61 months (range, 7-166). Local-regional recurrence was observed in 10 (19%) patients. Forty-three patients (81%) had negative bcl-2 staining, 5 patients (9%) had + staining, 3 patients (6%) ++ staining, and 2 patients (4%) +++ staining. No relationship was detected between bcl-2 expression and local control or overall survival. The emergence of a recurrence and a younger age (<50 years) were significantly related to poor overall survival (P = 0.000 and P = 0.021, respectively). Patients with hemoglobin levels in the middle of radiotherapy and at th...
Hepato-gastroenterology
5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant... more 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer. Capecitabine represents a valuable alternative to 5-Fluorouracil in this situation. Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery. The data concerning the toxicity and the efficacy of the treatments were compared in patients treated with 5-Fluorouracil- and capecitabine-based chemoradiotherapy. Forty-three patients received 5-Fluorouracil, and 24 patients received capecitabine during adjuvant radiotherapy. Although there were no differences between the groups in terms of toxicity rates, distant metastasis-free survival, disease-free ...
Tumori
To evaluate the efficacy and tolerability of a new treatment approach including induction chemoth... more To evaluate the efficacy and tolerability of a new treatment approach including induction chemotherapy (CT) and concurrent chemoradiotherapy (CRT) in unresectable, locally advanced pancreatic cancer (LAPC). Twenty-four patients with LAPC were enrolled in the study. They first received induction CT consisting of 5-fluorouracil (5FU) (500 mg/m2) and gemcitabine (1000 mg/m2), which were given weekly for 3 weeks of every 4. Patients showing a response or disease stabilization after 2 cycles of induction CT received CRT consisting of external beam radiotherapy (50.4-54 Gy in fractions of 1.8 Gy/day) and gemcitabine (350 mg/m2, weekly for 6 weeks). Patients without disease progression received 2 additional cycles of CT consisting of 5FU plus gemcitabine with the same doses and schedule as given in the induction CT. After the end of the study, 2 (8%) and 5 (21%) patients showed complete and partial responses, respectively. Five patients (21%) had disease stabilization. The grade 3 and 4 to...
Tumori Journal, 2006
Aims and Background The status of the axillary lymph nodes at the time of diagnosis has been acce... more Aims and Background The status of the axillary lymph nodes at the time of diagnosis has been accepted as one of the most important prognostic factors for the overall and disease-free survival of patients with breast cancer. The aim of our study was to determine which factors influence axillary node involvement in invasive breast cancer. Methods The data presented here were obtained from 344 patients who were treated for invasive breast cancer at the Department of Radiation Oncology, Uludag University Medical College, Bursa, Turkey. Possible prognostic factors were categorized as patient related and tumor related. The Mann-Whitney U test was used for univariate analysis and logistic regression was used for multivariate analysis. Results In univariate analysis, a familial cancer history (P = 0.0042), age <40 years (P = 0.0276), higher T stage (P <0.0000), nipple involvement (P = 0.0345), skin involvement (P = 0.0270), perineural invasion (P = 0.0231), and lymphatic vessel invasi...
European Journal of Cancer, 2001
European Journal of Cancer, 1997
European Journal of Cancer, 2001
The patients with pain had worse QL outcomes in comparison to the patients without (the results i... more The patients with pain had worse QL outcomes in comparison to the patients without (the results in terms of subscales scores are described in the table).
International Journal of Radiation Oncology*Biology*Physics, 2001
Materials and Methods: 575 patients from 36 community hospitals underwent full dose I-125 implant... more Materials and Methods: 575 patients from 36 community hospitals underwent full dose I-125 implantation by the real-time technique, of which 505 had adequate data for evaluation, including mCi implanted and prostate size. All underwent peripheral implantation with needles and seeds placed according to a set of rules developed specifically for this technique, in which seed strength and total implant radioactivity were obtained from look-up tables relating mCi to prostate volume (PV). CT-based dosimetry was performed 1 month post implant by one individual. Dose volume histogram parameters were analyzed for volume-related effects, including dose to 90% of the prostate (D90), 10% and 30% of the rectal wall (R10, R30), and 30% of the urethra (U30). Volume was defined as small (Ͻ25 cc), medium (25-39 cc) or large (Ͼ40 cc). Significance was assessed by Student's t-test and chi square test. Results: Median prostate volume was 32.7 cc (range 9 to 79 cc). Median D90 was 164 Gy (range 90 to 230 Gy). 455 patients (90%) achieved D90 Ͼ 140 Gy. Median D90 was significantly lower in the Ͻ25 cc group (pϽ0.001) and higher in Ͼ 40 cc group (pϽ0.001). D90 Ͻ140 Gy occurred in 19.8% of small versus 9% of medium and 3.5% of large prostates (pϭ 0.003). D90 Ͼ180 Gy occurred in 6.5% of small and 9% of medium vs. 25% of large glands (pϽ0.001). R10, R30, and U30 values also showed volume-related differences, although urethral dose did not increase in the large glands (R30 not shown).
Tumori (Milano)
To evaluate the efficacy and tolerability of a new treatment approach including induction chemoth... more To evaluate the efficacy and tolerability of a new treatment approach including induction chemotherapy (CT) and concurrent chemoradiotherapy (CRT) in unresectable, locally advanced pancreatic cancer (LAPC). Twenty-four patients with LAPC were enrolled in the study. They first received induction CT consisting of 5-fluorouracil (5FU) (500 mg/m2) and gemcitabine (1000 mg/m2), which were given weekly for 3 weeks of every 4. Patients showing a response or disease stabilization after 2 cycles of induction CT received CRT consisting of external beam radiotherapy (50.4-54 Gy in fractions of 1.8 Gy/day) and gemcitabine (350 mg/m2, weekly for 6 weeks). Patients without disease progression received 2 additional cycles of CT consisting of 5FU plus gemcitabine with the same doses and schedule as given in the induction CT. After the end of the study, 2 (8%) and 5 (21%) patients showed complete and partial responses, respectively. Five patients (21%) had disease stabilization. The grade 3 and 4 to...
Hepato-Gastroenterology
To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes s... more To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes starting just within 5 minutes after the completion of radiotherapy thrice weekly. Thirty-eight patients with locally advanced rectal cancer were enrolled in the study. Ranges of total radiation doses were between 50.4 Gy and 61.2 Gy with a median of 59.4 Gy with fraction size of 1.8 Gy five times weekly. 5-fluorouracil was administered thrice weekly with the dose of 250-300mg/m2/day concomitantly with radiation therapy. Median follow-up time was 30 months. Administration of chemotherapy concomitant with radiotherapy (p=0.089), AJCC stage III (p=0.079), Duke's stage C (p=0.079), presence of lymph node involvement (p=0.079) and presence of local recurrence (p=0.066) appeared to be effecting distant metastasis although differences did not reach statistically significance. Mean overall survival was 46 months in patients without any distant metastasis (SD: 3.28; 95% CI: 39.46 and 52.31) w...
Hepato-Gastroenterology
5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant... more 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer. Capecitabine represents a valuable alternative to 5-Fluorouracil in this situation. Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery. The data concerning the toxicity and the efficacy of the treatments were compared in patients treated with 5-Fluorouracil- and capecitabine-based chemoradiotherapy. Forty-three patients received 5-Fluorouracil, and 24 patients received capecitabine during adjuvant radiotherapy. Although there were no differences between the groups in terms of toxicity rates, distant metastasis-free survival, disease-free ...
Hepato-gastroenterology, 2005
BACKGROUND/AIMS To determine the percentage of responders and the resectability rate for patients... more BACKGROUND/AIMS To determine the percentage of responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by infusional 5-fluorouracil chemotherapy and pelvic radiation. METHODOLOGY Twenty-four patients with a diagnosis of locally advanced unresectable rectal cancer received preoperative 5-fluorouracil by intravenous infusion at the dose of 250-300mg/m2/day concurrent with pelvic radiation (median 50.4 Gy/28 fractions). Surgery was performed with a mean delay of 15 days after completion of irradiation and included 11 abdominoperineal resections and five anal sphincter-preserving procedures. RESULTS The median follow-up was 22 months. Complete histological response occurred in 6%, and tumor down-staging in 58% of cases. There was a significant difference in the rate of local control based on the distance of the tumor from the anal verge (>5.4cm; p=0.046). Our results have suggested the importance of the total dose on the local control ...
Saudi medical journal, 2006
S ignet cell carcinoma is a variant of adenocarcinoma commonly seen in the gastrointestinal syste... more S ignet cell carcinoma is a variant of adenocarcinoma commonly seen in the gastrointestinal system. Dominance of a signet cell carcinoma component in adenocarcinoma is generally considered as a sign of poor prognosis. Primary signet cell carcinoma of the breast is not seen as a distinct histological type in the World Health Organization classification, and is generally accepted as a sub-type of mucinous and lobular carcinoma. It appears to originate from the lobular epithelium, and an intracytoplasmic mucin collection is present histologically in most of the neoplastic cells. 4 divided signet cell carcinomas into 2 groups according to distribution of mucinous content within the cytoplasm, intracytoplasmic lumina type and non-intracytoplasmic lumina type. There is no agreement on the treatment and prognosis of breast carcinomas with signet cell dominance. It was suggested that the metastatic rate was higher in these tumors, and treatment should be shaped keeping in mind this importan...
BACKGROUND/AIMS To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil ... more BACKGROUND/AIMS To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes starting just within 5 minutes after the completion of radiotherapy thrice weekly. METHODOLOGY Thirty-eight patients with locally advanced rectal cancer were enrolled in the study. Ranges of total radiation doses were between 50.4 Gy and 61.2 Gy with a median of 59.4 Gy with fraction size of 1.8 Gy five times weekly. 5-fluorouracil was administered thrice weekly with the dose of 250-300mg/m2/day concomitantly with radiation therapy. RESULTS Median follow-up time was 30 months. Administration of chemotherapy concomitant with radiotherapy (p=0.089), AJCC stage III (p=0.079), Duke's stage C (p=0.079), presence of lymph node involvement (p=0.079) and presence of local recurrence (p=0.066) appeared to be effecting distant metastasis although differences did not reach statistically significance. Mean overall survival was 46 months in patients without any distant metastasis (...
Hepato Gastroenterology, 2008
5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant... more 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer. Capecitabine represents a valuable alternative to 5-Fluorouracil in this situation. Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery. The data concerning the toxicity and the efficacy of the treatments were compared in patients treated with 5-Fluorouracil- and capecitabine-based chemoradiotherapy. Forty-three patients received 5-Fluorouracil, and 24 patients received capecitabine during adjuvant radiotherapy. Although there were no differences between the groups in terms of toxicity rates, distant metastasis-free survival, disease-free survival, and overall survival rates; a trend for improved loco-regional recurrence-free survival rate was observed in the capecitabine arm (p = 0.063). Capecitabine is at least as effective as 5-Fluorouracil in the postoperative treatment of rectal adenocarcinoma. Considering the trend for improved loco-regional recurrence-free survival rate in the capecitabine arm, it seems that the drug exerts better synergy with radiotherapy in this situation.
... Sevilcan AYGÜN*, Meral KURT**, Sibel Kahraman ÇETİNTAŞ**, Eda Bengi YILMAZ**, Huriye ÖZTÜRK**... more ... Sevilcan AYGÜN*, Meral KURT**, Sibel Kahraman ÇETİNTAŞ**, Eda Bengi YILMAZ**, Huriye ÖZTÜRK**, Şenay KAPLAN**, Lütfi ÖZKAN ... muayene ve digital rektal muayene, akciğer grafisi, spiral abdominopelvik to-mografi, fleksible endoskopi, tam kan sayımı ve kara-ciğer ve ...
... Meral KURT*, Sibel ÇETİNTAŞ*, Ayşen ÖZTÜRK*, Neşe GÜNEŞ**, Çiğdem EDİNCİK*, Lütfi ÖZKAN*, Fey... more ... Meral KURT*, Sibel ÇETİNTAŞ*, Ayşen ÖZTÜRK*, Neşe GÜNEŞ**, Çiğdem EDİNCİK*, Lütfi ÖZKAN*, Feyzi TAMGAÇ** ... Hodgkin lenfomada (HL) başarılı tedavi yaklaşımının sağlanması, doğru evreleme ve etkin takip ile müm-kün olabilmektedir1. ...
Arch Gynecol Obstet, 2004
A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with t... more A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with three courses of methotrexate with folinic acid rescue and had been lost to follow up for 4 years was referred with the fractional curettage diagnosis of choriocarcinoma that had been performed for abnormal vaginal bleeding. Her serum beta human chorionic gonadotropin (betahCG) was 706000 mIU/mL and there were multiple pulmonary metastatic foci. The uterus was 12 weeks pregnant-size and a 6 x 6-cm tumor mass was seen within the anterior uterine wall at ultrasonography. Following total abdominal hysterectomy etoposide, methotrexate, actinomycin-D, vincristine and cyclophosphamide (EMA/CO) regimen was given. Whole brain radiation of 30 Gy in 3 weeks for brain metastasis, discovered in magnetic resonance imaging was given after the first course. Since serum betahCG levels plateaued after three courses of chemotherapy and multiple pulmonary metastases persisted, treatment was shifted to etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP) regimen. She was in remission after three courses of chemotherapy.
Asian Pacific journal of cancer prevention : APJCP, 2015
To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cyt... more To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cytokeratin 20 (CK20) and survinin gene expression on local control (LC) and overall survival (OS) in patients with locally advanced head and neck cancer (LAHNC) who were administered radiotherapy (RT). Twenty-six patients who were admitted to Uludag University Medical Faculty Department of Radiation Oncology with a diagnosis of LAHNC (GIII-GIV) were included in this study. Gene expression was evaluated in tumor tissues and peripheral blood. RNA isolation was performed on paraffinized tumor tissues and peripheral blood samples obtained before RT (BR). The densities of the obtained RNAs were analyzed at 260/280 nm. cDNA samples obtained from total RNA,EGFR, CK19, CK20 and survinin gene expression levels were assessed via the Sybr Green method and data were analyzed with the ΔΔCt method. The same process was repeated for peripheral blood samples taken after RT (AR). The female/male ratio was ...
Tumori
To evaluate the effect of bcl-2 expression on the local control and overall survival of patients ... more To evaluate the effect of bcl-2 expression on the local control and overall survival of patients with early stage laryngeal cancer treated with radiotherapy alone. We included 53 patients with stage Tis, T1, and T2 laryngeal cancer who were irradiated in our department. Paraffin blocks of all biopsy specimens were subjected to immunohistochemical analysis with a bcl-2 oncoprotein mouse clone 124 Scytek kit. The mean follow-up time was 61 months (range, 7-166). Local-regional recurrence was observed in 10 (19%) patients. Forty-three patients (81%) had negative bcl-2 staining, 5 patients (9%) had + staining, 3 patients (6%) ++ staining, and 2 patients (4%) +++ staining. No relationship was detected between bcl-2 expression and local control or overall survival. The emergence of a recurrence and a younger age (<50 years) were significantly related to poor overall survival (P = 0.000 and P = 0.021, respectively). Patients with hemoglobin levels in the middle of radiotherapy and at th...
Hepato-gastroenterology
5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant... more 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer. Capecitabine represents a valuable alternative to 5-Fluorouracil in this situation. Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery. The data concerning the toxicity and the efficacy of the treatments were compared in patients treated with 5-Fluorouracil- and capecitabine-based chemoradiotherapy. Forty-three patients received 5-Fluorouracil, and 24 patients received capecitabine during adjuvant radiotherapy. Although there were no differences between the groups in terms of toxicity rates, distant metastasis-free survival, disease-free ...
Tumori
To evaluate the efficacy and tolerability of a new treatment approach including induction chemoth... more To evaluate the efficacy and tolerability of a new treatment approach including induction chemotherapy (CT) and concurrent chemoradiotherapy (CRT) in unresectable, locally advanced pancreatic cancer (LAPC). Twenty-four patients with LAPC were enrolled in the study. They first received induction CT consisting of 5-fluorouracil (5FU) (500 mg/m2) and gemcitabine (1000 mg/m2), which were given weekly for 3 weeks of every 4. Patients showing a response or disease stabilization after 2 cycles of induction CT received CRT consisting of external beam radiotherapy (50.4-54 Gy in fractions of 1.8 Gy/day) and gemcitabine (350 mg/m2, weekly for 6 weeks). Patients without disease progression received 2 additional cycles of CT consisting of 5FU plus gemcitabine with the same doses and schedule as given in the induction CT. After the end of the study, 2 (8%) and 5 (21%) patients showed complete and partial responses, respectively. Five patients (21%) had disease stabilization. The grade 3 and 4 to...