Lynn Bradley - Academia.edu (original) (raw)
Uploads
Papers by Lynn Bradley
Journal of Pharmacy and Pharmacology, 1985
The ability of cocaine (10 microM) to potentiate the contractile responses of the epididymal half... more The ability of cocaine (10 microM) to potentiate the contractile responses of the epididymal half of the rat vas deferens to methacholine was reversed by prazosin. Prazosin also partially reversed the ability of cocaine to increase the spontaneous overflow of 3H following loading of the tissue with [3H]noradrenaline. We suggest that cocaine potentiated the responses to methacholine by stimulating, directly or indirectly, alpha 1-adrenoceptors.
Journal of Autonomic Pharmacology, 1983
1 The effects of prazosin, phentolamine and yohimbine on the accumulation of radioactivity from [... more 1 The effects of prazosin, phentolamine and yohimbine on the accumulation of radioactivity from [ 3H]noradrenaline, and on the subsequent spontaneous and field stimulation-evoked outflow of radioactivity have been investigated in the rat right ventricle in uitro. In addition the effects of these agents on contractions produced by exogenous amines or by field stimulation are reported.
Journal of Autonomic Pharmacology, 1983
1 The effects of amitriptyline, desipramine and mianserin on the accumulation of radioactivity fr... more 1 The effects of amitriptyline, desipramine and mianserin on the accumulation of radioactivity from [ 'HI-nuradrenaline, and on the subsequent spontaneous and field stimulation-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition the effect of these agents on contractions produced by isoprenaline or by field stimulation are reported. 2 Amitriptyline, desipramine (both at b 10-'M) and mianserin at 2 lO-'M inhibited the accumulation of radioactivity from ['HI-noradrenaline. 3 The decline in the spontaneous outflow of radioactivity, following loading of the tissue with ['HInoradrenaline, was not altered by amitriptyline, desipramine or mianserin. 4 Rauwolscine, amitriptyline, desipramine and mianserin (all at lO-'M) reduce? or reversed the decline in outflow of radioactivity evoked by field stimulation at 5 Hz. Desipramine had no additional effects in the presence of cocaine (10-'M) and amitriptyline and mianserin had no further effect in the presence of cocaine and rauwolscine. The effect of desipramine probably represents inhibition of neuronal uptake and that of amitriptiyline and mianserin blockade of neuronal uptake and prejunctional 01,adrenoreceptors. 5 The rate of beating in the presence of isoprenaline (lo-") was reduced by amitriptyline (lO-'M), desipramine (lo-") and mianserin (lo-'-lo-"). Higher concentrations of the antidepressants greatly reduced or abolished the rate and force of beating in the presence of isoprenaline.
Journal of Pharmacy and Pharmacology, 1985
The ability of cocaine (10 microM) to potentiate the contractile responses of the epididymal half... more The ability of cocaine (10 microM) to potentiate the contractile responses of the epididymal half of the rat vas deferens to methacholine was reversed by prazosin. Prazosin also partially reversed the ability of cocaine to increase the spontaneous overflow of 3H following loading of the tissue with [3H]noradrenaline. We suggest that cocaine potentiated the responses to methacholine by stimulating, directly or indirectly, alpha 1-adrenoceptors.
Journal of Autonomic Pharmacology, 1983
1 The effects of prazosin, phentolamine and yohimbine on the accumulation of radioactivity from [... more 1 The effects of prazosin, phentolamine and yohimbine on the accumulation of radioactivity from [ 3H]noradrenaline, and on the subsequent spontaneous and field stimulation-evoked outflow of radioactivity have been investigated in the rat right ventricle in uitro. In addition the effects of these agents on contractions produced by exogenous amines or by field stimulation are reported.
Journal of Autonomic Pharmacology, 1983
1 The effects of amitriptyline, desipramine and mianserin on the accumulation of radioactivity fr... more 1 The effects of amitriptyline, desipramine and mianserin on the accumulation of radioactivity from [ 'HI-nuradrenaline, and on the subsequent spontaneous and field stimulation-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition the effect of these agents on contractions produced by isoprenaline or by field stimulation are reported. 2 Amitriptyline, desipramine (both at b 10-'M) and mianserin at 2 lO-'M inhibited the accumulation of radioactivity from ['HI-noradrenaline. 3 The decline in the spontaneous outflow of radioactivity, following loading of the tissue with ['HInoradrenaline, was not altered by amitriptyline, desipramine or mianserin. 4 Rauwolscine, amitriptyline, desipramine and mianserin (all at lO-'M) reduce? or reversed the decline in outflow of radioactivity evoked by field stimulation at 5 Hz. Desipramine had no additional effects in the presence of cocaine (10-'M) and amitriptyline and mianserin had no further effect in the presence of cocaine and rauwolscine. The effect of desipramine probably represents inhibition of neuronal uptake and that of amitriptiyline and mianserin blockade of neuronal uptake and prejunctional 01,adrenoreceptors. 5 The rate of beating in the presence of isoprenaline (lo-") was reduced by amitriptyline (lO-'M), desipramine (lo-") and mianserin (lo-'-lo-"). Higher concentrations of the antidepressants greatly reduced or abolished the rate and force of beating in the presence of isoprenaline.