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Research paper thumbnail of Hirsutism: Diagnosis and Treatment

Journal of Metabolic Syndrome, 2012

Hirsutism, which is a common clinical problem in women of reproductive age, is characterized by e... more Hirsutism, which is a common clinical problem in women of reproductive age, is characterized by excessive growth of terminal hair in the androgen-sensitive skin regions. It is the result of either androgen excess or increased sensitivity of the hair follicles to normal levels of androgens. The therapeutic options of hirsutism can be divided into systemic, topical, and dermato-cosmetic therapies. Patients should be informed that the response to systemic agents is slow; occurring over 3-6 months after therapy has begun. In this review, the diagnosis and treatment of hirsutism were summarized with update literature.

Research paper thumbnail of Prevalence of metabolic syndrome in women with polycystic ovary syndrome

Clinical Endocrinology, 2013

Background: Polycystic Ovarian Syndrome (PCOS) is a multifactorial, polygenic and multisystem end... more Background: Polycystic Ovarian Syndrome (PCOS) is a multifactorial, polygenic and multisystem endocrine disorder affecting women in reproductive age. PCOS diagnosis is based on 2003 Rotterdam criteria It has been noted that hyperinsulinemia is a central factor in the pathogenesis of PCOS. Many studies show evidence of a critical link between PCOS and Metabolic Syndrome (MBS). Methods: It was a hospital-based observational study done over a period of one year with a sample size of 177.An observational study was done in patients satisfying the inclusion and exclusion criteria. After taking informed and written consent, history was obtained from the patient to know the age, socioeconomic status, present and past clinical history, menstrual and obstetric history, personal and family history and any other history as deemed necessary. Patient was clinically assessed to know the height, weight, body mass index. Results: The prevalence of MBS was 37.2%. The commonest age group was between 25-35 years.There is no statistical association between educational qualification, economic status and the prevalence of MBS and There no significant association between the presence of acne, androgenic aloepecia and the presence of PCOS.While the presence of increased waist circumference > 88cms, USG findings consistent with PCOS, high blood pressure > 130/85 mm of Hg, elevated FBS > 110 mg/dl, low HDL <50 mg/dl were statistically significant. Conclusions: The results can be used to formulate a screening policy for metabolic syndrome, particularly in the low resource settings of developing countries.

Research paper thumbnail of Prevenção do diabetes mellitus tipo 2

Arquivos Brasileiros de Endocrinologia & Metabologia, 2006

Diabetes mellitus do tipo 2 (DM2) é uma doença metabólica complexa, multifatorial e de presença g... more Diabetes mellitus do tipo 2 (DM2) é uma doença metabólica complexa, multifatorial e de presença global, que afeta a qualidade e o estilo de vida dos acometidos, podendo levar a uma redução pronunciada na expectativa de vida dessa população. Portadores de diabetes podem ter uma redução de 15 ou mais anos de vida, com a grande maioria morrendo em decorrência das complicações cardiovasculares. Faz-se necessário o estabelecimento de estratégias efetivas para a redução do impacto do DM2 para os próximos anos. Para isso, urge a necessidade de maior atenção no tocante às estratégias de prevenção, sobretudo para as populações de maior risco de desenvolvimento da doença. Nesse contexto, os portadores de tolerância diminuída à glicose (TDG) e glicemia de jejum alterada (GJA) devem, cada vez mais, ser alvos de estratégias de intervenção na busca de minimização de risco para o diabetes, devendo para isso terem direcionamento para a efetivação de mudanças comportamentais (fatores dietoterápicos ...

Research paper thumbnail of Hirsutism: diagnosis and treatment

Arquivos Brasileiros de Endocrinologia & Metabologia, 2014

Hirsutism is defined as excessive terminal hair growth in androgen-dependent areas of the body in... more Hirsutism is defined as excessive terminal hair growth in androgen-dependent areas of the body in women, which grows in a typical male distribution pattern. Hirsutism is a common clinical problem in women, and the treatment depends on the cause. The condition is often associated with a loss of self-esteem. Hirsutism reflects the interaction between circulating androgen concentrations, local androgen concentrations, and the sensitivity of the hair follicle to androgens. Polycystic ovary syndrome and idiopathic hirsutism are the most common causes of the condition. A woman&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s history and, physical examination are particularly important in evaluating excess hair growth. The vast majority of women with hirsutism have the idiopathic variety, and the diagnosis is made by exclusion. Serum testosterone level&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;200 ng/dL is highly suggestive of adrenal or ovarian tumor. Treatment of hirsutism should be based on the degree of excess hair growth presented by the patient and in the pathophysiology of the disorder. Treatment includes lifestyle therapies, androgen suppression, peripheral androgen blockage, and cosmetic treatments. The current review discusses definition, pathogenesis, physiopathology, differential diagnosis, diagnostic strategies, and treatment.

Research paper thumbnail of Hirsutism: Diagnosis and Treatment

Journal of Metabolic Syndrome, 2012

Hirsutism, which is a common clinical problem in women of reproductive age, is characterized by e... more Hirsutism, which is a common clinical problem in women of reproductive age, is characterized by excessive growth of terminal hair in the androgen-sensitive skin regions. It is the result of either androgen excess or increased sensitivity of the hair follicles to normal levels of androgens. The therapeutic options of hirsutism can be divided into systemic, topical, and dermato-cosmetic therapies. Patients should be informed that the response to systemic agents is slow; occurring over 3-6 months after therapy has begun. In this review, the diagnosis and treatment of hirsutism were summarized with update literature.

Research paper thumbnail of Prevalence of metabolic syndrome in women with polycystic ovary syndrome

Clinical Endocrinology, 2013

Background: Polycystic Ovarian Syndrome (PCOS) is a multifactorial, polygenic and multisystem end... more Background: Polycystic Ovarian Syndrome (PCOS) is a multifactorial, polygenic and multisystem endocrine disorder affecting women in reproductive age. PCOS diagnosis is based on 2003 Rotterdam criteria It has been noted that hyperinsulinemia is a central factor in the pathogenesis of PCOS. Many studies show evidence of a critical link between PCOS and Metabolic Syndrome (MBS). Methods: It was a hospital-based observational study done over a period of one year with a sample size of 177.An observational study was done in patients satisfying the inclusion and exclusion criteria. After taking informed and written consent, history was obtained from the patient to know the age, socioeconomic status, present and past clinical history, menstrual and obstetric history, personal and family history and any other history as deemed necessary. Patient was clinically assessed to know the height, weight, body mass index. Results: The prevalence of MBS was 37.2%. The commonest age group was between 25-35 years.There is no statistical association between educational qualification, economic status and the prevalence of MBS and There no significant association between the presence of acne, androgenic aloepecia and the presence of PCOS.While the presence of increased waist circumference > 88cms, USG findings consistent with PCOS, high blood pressure > 130/85 mm of Hg, elevated FBS > 110 mg/dl, low HDL <50 mg/dl were statistically significant. Conclusions: The results can be used to formulate a screening policy for metabolic syndrome, particularly in the low resource settings of developing countries.

Research paper thumbnail of Prevenção do diabetes mellitus tipo 2

Arquivos Brasileiros de Endocrinologia & Metabologia, 2006

Diabetes mellitus do tipo 2 (DM2) é uma doença metabólica complexa, multifatorial e de presença g... more Diabetes mellitus do tipo 2 (DM2) é uma doença metabólica complexa, multifatorial e de presença global, que afeta a qualidade e o estilo de vida dos acometidos, podendo levar a uma redução pronunciada na expectativa de vida dessa população. Portadores de diabetes podem ter uma redução de 15 ou mais anos de vida, com a grande maioria morrendo em decorrência das complicações cardiovasculares. Faz-se necessário o estabelecimento de estratégias efetivas para a redução do impacto do DM2 para os próximos anos. Para isso, urge a necessidade de maior atenção no tocante às estratégias de prevenção, sobretudo para as populações de maior risco de desenvolvimento da doença. Nesse contexto, os portadores de tolerância diminuída à glicose (TDG) e glicemia de jejum alterada (GJA) devem, cada vez mais, ser alvos de estratégias de intervenção na busca de minimização de risco para o diabetes, devendo para isso terem direcionamento para a efetivação de mudanças comportamentais (fatores dietoterápicos ...

Research paper thumbnail of Hirsutism: diagnosis and treatment

Arquivos Brasileiros de Endocrinologia & Metabologia, 2014

Hirsutism is defined as excessive terminal hair growth in androgen-dependent areas of the body in... more Hirsutism is defined as excessive terminal hair growth in androgen-dependent areas of the body in women, which grows in a typical male distribution pattern. Hirsutism is a common clinical problem in women, and the treatment depends on the cause. The condition is often associated with a loss of self-esteem. Hirsutism reflects the interaction between circulating androgen concentrations, local androgen concentrations, and the sensitivity of the hair follicle to androgens. Polycystic ovary syndrome and idiopathic hirsutism are the most common causes of the condition. A woman&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s history and, physical examination are particularly important in evaluating excess hair growth. The vast majority of women with hirsutism have the idiopathic variety, and the diagnosis is made by exclusion. Serum testosterone level&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;200 ng/dL is highly suggestive of adrenal or ovarian tumor. Treatment of hirsutism should be based on the degree of excess hair growth presented by the patient and in the pathophysiology of the disorder. Treatment includes lifestyle therapies, androgen suppression, peripheral androgen blockage, and cosmetic treatments. The current review discusses definition, pathogenesis, physiopathology, differential diagnosis, diagnostic strategies, and treatment.