MARIA JAN CORINNE MARIANO - Academia.edu (original) (raw)

Papers by MARIA JAN CORINNE MARIANO

Allergies, 2021

Purpose of the article: Acrylate and methacrylate (MA) use in the dental industry is widespread, ... more Purpose of the article: Acrylate and methacrylate (MA) use in the dental industry is widespread, being utilized in dental prostheses and composite resins, dentin bonding materials, and glass ionomers. However, occupational methacrylate allergy in dental personnel is a growing phenomenon. The aims of this retrospective observational study are to evaluate the risk of occupational contact dermatitis following exposure to methacrylates in dental personnel and to identify possible preventive measures. Materials and Methods: A total of 126 subjects exposed to acrylic and methacrylic resins in their professional context and who reported clinical manifestations were included from our outpatient department database. These were subdivided into two groups: 81 dental technicians and 45 dental hygienists. All the subjects had undergone patch testing with a “methacrylate series” (FIRMA) and readings were taken after 2 days (D2), 4 days (D4), and 7 days (D7). Results: A significantly higher incide...

International Journal of Dermatology, 2021

Morphea induced by SARS-CoV-2 infection: A case report Dear Editor, The widespread diffusion of s... more Morphea induced by SARS-CoV-2 infection: A case report Dear Editor, The widespread diffusion of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a member of the coronavirus family responsible for Coronavirus disease (COVID-19), is still in the headlines for the impressive health and economic burden worldwide. The immune response against this novel virus is still undergoing extensive research, and the possible long-term outcomes remain basically unknown. Immunity plays a key role in the defense against several microorganisms, and SARS-CoV-2 is no different. The infections can result in a hyperactive immune response with excessive inflammatory reactions. These are generally accompanied by the release of impressive amounts of proinflammatory cytokines, an event known as “cytokine storm,” that is correlated with lung damage, organ failure, and a negative prognosis. The possibility that these immunologic derangements could result in the induction and/or the exacerbation of other immune-mediated diseases, including cutaneous ones, has not been completely investigated. We report the case of a 61-year-old female patient referred to our dermatologic department for the development of asymptomatic bilateral sclerotic cutaneous lesions on the forearms which appeared 2 months before. The physical examination revealed the presence of several brownish and violaceous plaques with mild erythematous borders on forearms, with sclerotic appearance, partially tending to confluence. The lesions showed a symmetrical and bilateral distribution and were about 5–10 cm in diameter (Fig. 1a). The patient referred that the skin manifestations started about 1 month after the dismissal from hospitalization for COVID-19 pneumonia (confirmed through RT-PCR). Her familiar and personal history was negative for autoimmune and chronic inflammatory skin disorders. On suspicion of localized morphea, blood examination tests and skin biopsy were performed. Blood tests, including antinuclear antibodies (ANA), antibodies to single-stranded DNA (a-ssDNA), autoantibodies to extractable nuclear antigens (ENAs), and COVID-19 swab test, were negative excluding systemic involvement. Histological examination revealed the presence of thin epidermis with moderate dermal sclerosis and thickening of collagen fibers, confirming the diagnosis of morphea. A topical therapy with a high-potency steroid (clobetasol ointment) and vitamin E emollient was started, with a remarkable improvement after 8 weeks and a complete clinical resolution after 16 weeks of treatment (Fig. 1b). Morphea, also known as localized scleroderma, is an inflammatory skin condition that is characterized by the presentation of single or multiple inflammatory or sclerotic plaques. While the pathogenesis remains largely unknown, several factors can contribute to the emergence of autoimmune disease including the genetic predisposition, environmental triggers such as bacterial and viral infections, and intrinsic factors, such as hormonal and immunologic dysregulation. In this case, the negative personal anamnesis for autoimmune disorders and the development of cutaneous manifestations after COVID-19 infection suggested a possible link between autoimmune disease and SARS-CoV-2. Some authors proposed that SARS-CoV-2 could act as a trigger in the development of organ-specific autoimmune disorders, in genetic

Journal of the European Academy of Dermatology and Venereology, 2021

We present the case of a 60-year-old patient who reported the onset of pernio-like lesions on bot... more We present the case of a 60-year-old patient who reported the onset of pernio-like lesions on both hands, approximately 14 days after the administration of the second dose of the Pfizer-BioNTech vaccine. Local and systemic symptoms such as pain at the injection site, asthenia and headache of mild to moderate severity also appeared following the administration of the first and second doses, and resolved within 2 days. Physical examination showed erythematous-violaceous patches and swelling on the fingers, accompanied by itching and burning sensation (Figure 1). The occasional appearance of livedo reticularis-like manifestations on the lower limbs was also referred.

Dermatologic Therapy, 2020

Rosacea is a very common chronic facial dermatosis characterized by a multiphase evolution. Infla... more Rosacea is a very common chronic facial dermatosis characterized by a multiphase evolution. Inflammation is an important reaction in rosacea not only due to inflammatory reactions to cutaneous microorganisms, such as Demodex follicolorum, but also to ultraviolet damage that generates reactive oxygen species. This study evaluated the efficacy and tolerability of a nonsteroidal anti‐inflammatory 18‐beta glycyrrhetinic acid cream for the treatment of mild rosacea by means of noninvasive methods. A total of 24 subjects suffering from erythemato‐telangiectatic or mild papulo‐pustular rosacea were recruited in the trial. Twelve patients applied an anti‐inflammatory cream with 18‐beta glycyrrhetinic acid twice daily for 20 days and 12 patients, recruited as control, applied the same formulation without 18‐beta glycyrrhetinic acid. After 10 days of treatment, a significant reduction of erythema was recorded in the patient sample who applied the 18‐beta glycyrrhetinic acid cream, the mean change from baseline showed an increase in hydration level of the skin surface but it was not statistically significant. The use of 18‐beta glycyrrhetinic acid cream can be helpful in managing symptoms and condition of rosacea skin, especially in the management of erythema.

Blood, 1991

In search of a possible involvement of the human herpesvirus type 6 (HHV-6) in human…

Blood, 1988

By using a cDNA clone of the myeloperoxidase (MPO) gene, we have studied, by Northern blot analys... more By using a cDNA clone of the myeloperoxidase (MPO) gene, we have studied, by Northern blot analysis, the level of MPO mRNA in eight cases of acute lymphoblastic leukemia (ALL). The blast cell populations studied were characterized by morphologic, cytochemical, immunochemical, and molecular criteria. With all the methods used the populations were found to be highly homogeneous and showed a typical lymphoid phenotype. In particular, the Ig heavy-chain gene rearrangement was largely prevalent, and the germ line configuration was almost absent. However, in three of eight cases, high levels of MPO mRNA were detected. The remarkable homogeneity of the cell populations examined suggests that the MPO mRNA observed was present in cellular elements certainly identified as lymphoid. The absence of contamination by myeloid cells was confirmed by the results of Western blot analysis of the proteins of the cell population studied: no MPO protein was detectable. The levels of mRNA observed were hi...

Dermatitis, 2010

Musicians are a risk group for various skin diseases because intense contact between the instrume... more Musicians are a risk group for various skin diseases because intense contact between the instrument and the skin is usually needed during playing. Clinical presentation and localization are related to the specific instrument. Cheilitis in woodwind players (eg, saxophonists, flautists, and clarinetists) and brass instrumentalists (eg, trumpeters) is frequently observed. It is mostly an irritant dermatitis, but allergic contact sensitization (eg, to colophony, nickel, and exotic woods) has been described. A 26-year-old saxophonist was first referred to us with a 6-month history of a patch of erythema, desquamation, hyperkeratosis, and peripheric vesiculation of the median area of the lower lip (Fig 1). The disease developed about 2 months after he replaced the plastic reed on his saxophone with a wood reed. The result of patch tests with the Società Italiana di Dermatologia Allergologica Professionale e Ambientale standard series was negative. The result of patch testing with fragments of the wood reed wetted with water was positive (++). The same test was performed in 10 volunteers, including another saxophonist, and showed negative results. The patient returned to playing with plastic reeds, and the cheilitis subsided after a few weeks.

Journal of cosmetic dermatology, 2018

Atopic dermatitis is a chronic, pruritic inflammatory skin disease that adversely affects quality... more Atopic dermatitis is a chronic, pruritic inflammatory skin disease that adversely affects quality of life. The current study evaluates the efficacy of a shower cream and a lotion, each with skin-identical lipids and emollients, in the treatment of atopic dry skin of subjects with a history of atopic condition. In all, 40 healthy females with clinically dry skin on the lower legs were enrolled in the study and underwent 4 weeks of daily use of the shower cream and 2 additional weeks of both the shower cream and the body lotion. Subjects were evaluated at day 0, week 4, and week 6. Skin barrier function was assessed by Tewameter , skin hydration by Corneometer , smoothness and desquamation by Visioscan , and stratum corneum architecture by reflectance confocal microscopy (RCM). The investigator assessed the degree of dryness, roughness, redness, cracks, tingling and itch, and subjective self-assessment evaluated the perception of skin soothing, smoothness, and softness. Skin barrier f...

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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, Jan 28, 2017

Apheresis therapies play an important role in the treatment of many pathologies, both as first-li... more Apheresis therapies play an important role in the treatment of many pathologies, both as first-line and rescue therapies after drug failure or drug toxicity and, furthermore, when it is important to reach a therapeutic goal in a short time. Apheresis devices have evolved at an astounding rate over the last decades. Therapeutic apheresis are usually part of a treatment plan, so, a patient-centered approach to select the most appropriate treatment for each patient, balancing personal preferences, medication interferences and technological availability can significantly influence the choice of the protocol to be used. But, if the wide diversity of apheresis treatments may offer a tailored-patient approach, it can also create concerns on the right decision about the most appropriate protocol. Therapeutic apheresis - whose purpose is to cure diseases due to abnormality of blood cells or to toxicity of plasma substances - and, productive apheresis - whose purpose is to produce autologous ...

Journal of Cosmetic Dermatology, 2017

Objective: To instrumentally evaluate the efficacy and the safety of a new ternary system chemo e... more Objective: To instrumentally evaluate the efficacy and the safety of a new ternary system chemo exfoliating formulation (water-dimethyl isosorbide-acid) vs traditional binary systems (water and acid) where the acid is maintained in both the systems at the same concentration. Methods: Different peelings (binary system pyruvic acid and trichloroacetic acid-TCA, and ternary system pyruvic acid and TCA) were tested on the volar forearm of 20 volunteers of both sexes between 28 and 50 years old. The outcomes were evaluated at the baseline, 10 minutes, 24 hours, and 1 week after the peeling by means of noninvasive skin diagnosis techniques. In vivo reflectance confocal microscopy was used for stratum corneum evaluation, transepidermal waterloss, and Corneometry for skin barrier and hydration, Laser Doppler velocimetry in association with colorimetry for irritation and erythema analysis. Results: The instrumental data obtained showed that the efficacy and safety of the new ternary system peel compounds were significantly higher compared with the binary system formulations tested. The new formulation peels improved chemexfoliation and reduced complications such as irritation, redness, and postinflammatory pigmentation compared to the traditional aqueous solutions. Conclusion: The study showed that ternary system chemexfoliation, using a controlled delivery technology, was able to provide the same clinical effects in term of stratum corneum reduction with a significantly reduced barrier alteration, water loss, and irritation/erythema compared to traditional binary system peels.

Revista Recien - Revista Científica de Enfermagem, 2015

Objetivou-se avaliar a incidência de complicações gastrointestinais em pacientes submetidos a sup... more Objetivou-se avaliar a incidência de complicações gastrointestinais em pacientes submetidos a suporte nutricional exclusivo por via enteral em Unidade de Terapia Intensiva (UTI). Estudo descritivo, retrospectivo com abordagem quantitativa por meio de avaliação de 250 prontuários de pacientes internados no ano de 2010 e 2011. Dos prontuários estudados, 166 (66%) apresentaram registro de alguma complicação gastrointestinal após o início da terapia nutricional, sendo a diarreia presente em 94 (57%), vômitos em 40 (24%) e constipação em 32 (19%). Constatou-se que a diarreia e vômito foram as principais complicações apresentadas pelos pacientes em uso de terapia nutricional enteral, mostrando que sua utilização apesar de benéfica em muitas situações, não é livre de complicações. Ressalta-se a necessidade do envolvimento e avaliação contínuos do paciente pela equipe multiprofissional com o intuito de minimizar complicações decorrentes deste tratamento.Descritores: Enfermagem, Nutrição Ent...

Skin Appendage Disorders, 2016

Letter to the Editor ed in the past with topical corticosteroids, emollient creams, and mild dete... more Letter to the Editor ed in the past with topical corticosteroids, emollient creams, and mild detergents without any improvement. The histopathology of the lesion after incisional biopsy demonstrated irregularly dilated capillary vessels surrounded by lymphocytic perifollicular infiltrates in the upper dermis, dilated follicular infundibula with hyperplastic sebaceous glands, solar elastosis, and increase in fat tissue (Fig. 2). Given this clinical and histologic findings, she was diagnosed with gnatophyma. The patient was then treated with azelaic acid and applied daily sunscreens. At dental examination, poor oral health was revealed: bacterial plaque was present on every tooth, and a general inflammation of the marginal gingiva was noted. Dental care was started. At the 1-month follow-up visit, a significant clinical improvement of the skin lesion was detected. Case 2, a 50-year-old Caucasian female, presented with a history of an asymptomatic erythema and edema on her chin that had begun about 2 years earlier. There was nothing relevant in her clinical history. There were no dental abnormalities. Physical examination was remarkable for a not well-defined and erythematous patch (Fig. 3). A punch biopsy was taken from the lesion and demonstrated a follicular and capillary vessel dilatation and sebaceous gland hyperplasia as per gnatophyma (Fig. 4). Rosacea is a common skin disease. Its main clinical manifestations are redness, telangiectasia, papules, pustules, skin thickening, and phymas [1, 2]. Phyma is considered the last evolutionary stage of rosacea. Its most frequent localization is in the nose (rhinophyma), but more rarely, it can occur at chin level (gnatophyma), forehead (metophyma), ears (otophyma), and eyelids (blepharophy

Fruticultura Profesional, 1999

Revista Eletronica Faculdade Montes Belos, Sep 30, 2011

O tratamento dos pacientes acometidos com Dengue esta preconizado pela Organizacao Mundial de Sau... more O tratamento dos pacientes acometidos com Dengue esta preconizado pela Organizacao Mundial de Saude no Programa Nacional de Controle da Dengue (PNCD) desde 2002, o que colaborou drasticamente para a reducao da incidencia de casos. Este trabalho relata a construcao de propostas em acoes preventivas para a reducao da incidencia de Dengue e internacoes pela doenca, junto as equipes da Estrategia Saude da Familia e unidade hospitalar do Municipio de Sao Luis de Montes Belos. A tabela foi construida por concluintes e docentes do curso de Pos-Graduacao em Saude Publica Lato Sensu da Faculdade Montes Belos-GO. A construcao da tabela foi acompanhada e validada por profissionais e pesquisadores da area, a partir da coleta de dados no Nucleo de Vigilância Epidemiologico in locuo , do referencial teorico atualizado e orientacoes preconizadas pelo Ministerio da Saude nas seguintes palavras-chave: Dengue, Prevencao e Politicas Publicas. A realizacao da proposta em acoes preventivas foi possivel, a partir de dados coletados, considerando todos os recursos estruturais e de pessoas, disponiveis do municipio, de modo a viabilizar a implementacao das Politicas Publicas ja existentes para o controle da Dengue no Municipio.

Rev Paul Pediatr, Dec 1, 1993

Analytical Chemistry, 1970

Coloquio Do Museu Pedagogico Issn 2175 5493, Aug 14, 2014

Este artigo é parte da nossa tese de doutorado, ora em andamento intitulada " A História da Educa... more Este artigo é parte da nossa tese de doutorado, ora em andamento intitulada " A História da Educação em Valença: Memória de Professoras Negras". Nosso interesse é compreender porque uma grande parcela de mulheres negras valencianas exerce a docência nas séries iniciais do ensino fundamental na Rede Pública Municipal da cidade de Valença-Bahia. Pretendemos investigar se a opção dessas docentes pelo magistério, não é uma forma de "fuga" do determinismo social que as orientam para profissões menos privilegiadas e, também, uma maneira de ascender socialmente. A pesquisa atende aos pressupostos da pesquisa qualitativa. Utilizaremos como procedimento metodológico a História Oral.