MARYAM RASTI - Academia.edu (original) (raw)

MARYAM RASTI

Uploads

Papers by MARYAM RASTI

Research paper thumbnail of Sulfasalazine induces mitochondrial dysfunction and renal injury

Renal failure, 2017

Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory ... more Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days. Afterward, kidney mitochondria were isolated and assessed. Sulfasalazine-induced renal injury was biochemically evident by the increase in serum blood urea nitrogen (BUN), gamma-glutamyl transferase (γ-GT), and creatinine (Cr). Histopathological presentations of the kidney in sulfasalazine-treated animals revealed by interstitial inflammation, tubular atrophy, and tissue necrosis. Markers of oxidative stress including an increa...

Research paper thumbnail of Sulfasalazine-induced renal and hepatic injury in rats and the protective role of taurine

Research paper thumbnail of Hepatitis B Virus Infection Serology and the Associated Risk Factors Among Patients With HIV in Shiraz, Iran

Shiraz E-Medical Journal, 2015

Research paper thumbnail of Sulfasalazine induces mitochondrial dysfunction and renal injury

Renal failure, 2017

Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory ... more Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days. Afterward, kidney mitochondria were isolated and assessed. Sulfasalazine-induced renal injury was biochemically evident by the increase in serum blood urea nitrogen (BUN), gamma-glutamyl transferase (γ-GT), and creatinine (Cr). Histopathological presentations of the kidney in sulfasalazine-treated animals revealed by interstitial inflammation, tubular atrophy, and tissue necrosis. Markers of oxidative stress including an increa...

Research paper thumbnail of Sulfasalazine-induced renal and hepatic injury in rats and the protective role of taurine

Research paper thumbnail of Hepatitis B Virus Infection Serology and the Associated Risk Factors Among Patients With HIV in Shiraz, Iran

Shiraz E-Medical Journal, 2015

Log In