M. Brioschi - Academia.edu (original) (raw)

Papers by M. Brioschi

Revista do Colégio Brasileiro de Cirurgiões, 2009

OBJETIVO: Determinar se a termografia infravermelha é capaz de detectar com precisão a perda de p... more OBJETIVO: Determinar se a termografia infravermelha é capaz de detectar com precisão a perda de perfusão tecidual em áreas de parênquima esplênico. MÉTODOS: Cinco porcos Landrace pesando entre 12 a 15 kg, após medicação pré-anestésica intramuscular e anestesia por infusão endovenosa, foram submetidos a quatro etapas de ligaduras sequenciais, dos vasos arteriais para o pólo inferior do baço: 1-vasos do ligamento esplênico; 2-ramo da artéria esplênica para o pólo inferior; 3-ramo arterial para o pólo inferior na face visceral do órgão; 4-parênquima esplênico dividindo o órgão. As imagens foram captadas por câmera Therma CAM SC500 instalada a 50 centímetros da superfície do órgão. As temperaturas foram medidas na região proximal (vascularizada) e na região distal (isquêmica), em três áreas circulares distintas de cada região através do software SAT Report, antes e após cada etapa de ligaduras, constituindo cinco grupos de medidas: tempo 0 = antes da etapa 1; tempo 1 = após etapa 1; tem...

European Respiratory Journal, 2010

Surfactant derived protein B (SPB) and plasma receptor for advanced glycation end products (RAGE)... more Surfactant derived protein B (SPB) and plasma receptor for advanced glycation end products (RAGE) have been proposed as markers of lung injury. The former is produced specifically by pneumocytes while RAGE production is present in several body tissues. Cardiopulmonary bypass (CPB) generates a transient lung injury. We measured SPB and RAGE in plasma before surgery and after CPB, as well as 24 h and 48 h later. We analysed plasma samples from 20 subjects scheduled for elective coronary artery bypass grafting. We performed a quantitative analysis of plasma levels of RAGE and SPB mature form (8 kDa) by ELISA and a semi-quantitative analysis of SPB immature form (,40 kDa) by Western blotting. Surgery procedures were uneventful. After CPB RAGE median (75th-25th interquartile difference) increased from 633 (539) pg?mL-1 to 1,362 (557) pg?mL-1 (p,0.01), while mature SPB increased from 5,587 (3,089) ng?mL-1 to 20,307 (19,873) ng?mL-1 (p,0.01). RAGE and mature SPB returned to normal values within 48 h. This behaviour was confirmed when RAGE and SPB were normalised for protein content. Parallel changes were observed for immature SPB. Plasma RAGE and SPBs are sensitive and rapid markers of lung distress.

ABSTRACT Digital Thermal Monitoring (DTM) is a non-invasive provocative assessment of vascular re... more ABSTRACT Digital Thermal Monitoring (DTM) is a non-invasive provocative assessment of vascular reactivity, as a potential indicator of endothelial dysfunction and cardiovascular disease risk. This test is based on temperature changes of the fingertips, after brachial artery decompression. In this work we studied the thermal response employing infrared (IR) thermography images of the upper extremities. For this it was applied brachial pneumatic compression and decompression. Two subjects, with and without high cardiovascular risk, were studied. Initially, they remained seated for two minutes and the IR images of the fingertips started to be registered. Then, the right arm brachial artery was compressed by inflating the blood pressure device for five minutes. Next, the brachial artery was decompressed and thermal images were acquired for more five minutes. Thermal pattern curves responses were obtained during compression and decompression periods.

A termografia e metodo diagnostico inocuo e sem radiacao ionica, capaz de quantificar objetivamen... more A termografia e metodo diagnostico inocuo e sem radiacao ionica, capaz de quantificar objetivamente, por imagem, as reacoes inflamatorias locais do sistema musculoesqueletico, sendo util no registro da atividade inflamatoria e na avaliacao terapeutica. Associacao Brasileira de Termologia Faculdade de Medicina da Universidade de Sao Paulo – Brasil Hospital Vila Franca de Xira Grupo de Estudo Medico Legal da SPOT

Archives of Orthopaedic and Trauma Surgery, 2019

Introduction Hip magnetic resonance arthrography (MRA) is the pre-operative imaging modality of c... more Introduction Hip magnetic resonance arthrography (MRA) is the pre-operative imaging modality of choice in patients with labral damage, with several classifications of labral tears having been reported based on MRA findings. Nevertheless, none of the available classification systems allows the surgeon to predict before surgery how a labral tear could be treated. Our purpose was to develop a new MRA-based scoring system of labral tears to predict before surgery the treatment option more suitable for labral tears. Materials and methods Forty-seven patients (29 males and 18 females; mean age: 35.9 ± 12.4) performed hip MRA for suspicious of femoroacetabular impingement and were afterwards subjected to arthroscopic treatment. Two musculoskeletal radiologists reviewed all pre-operative examinations and provided the Extension-Thickness-Damage score for each patient, based on Extension of tear, Thickness of labrum, and type of Damage. Chondral lesions grading was based on the arthroscopic findings according to Konan classification. For statistical purposes, patients were divided into two groups, depending on the type of treatment: labral repair or debridement. Mann-Whitney U, Chi-square, receiver operator curves, and Cohen kappa statistics were used. Results 35/47 underwent repair, while 12/47 were debrided. In both groups, the median chondral damage was grade III, with no significant differences (p = 0.439). The median Extension-Thickness-Damage score in the repair group (6) was significantly lower (p < 0.001) than that in the debridement group (8). The highest diagnostic performance (area under the curve) of Extension-Thickness-Damage was 0.819. The inter-observer agreement was substantial in the evaluation of Extension (k = 0.626) and Thickness (k = 0.771), and almost perfect for Damage (k = 0.827). Higher scores of Extension and Thickness were more frequently associated with debridement (p < 0.001; p = 0.0016, respectively), with no significant differences on the basis of Damage parameter (p = 0.284). Conclusions The MRA-based Extension-Thickness-Damage score could represent a helpful pre-operative tool, expressing the extent of the damage and its reparability before arthroscopy.

Osteoarthritis and Cartilage, 2019

Mobile Information Systems, 2006

Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto This art... more Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto This article is a review of the most common chromosomal mutations reported in cattle emphasizing their effects on the reproduction of the carrying animals and the transmission to their offspring.

The goal of the MAIS system is to provide support for flexible and adaptive execution of applicat... more The goal of the MAIS system is to provide support for flexible and adaptive execution of applications in a distributed, multichannel, mobile information system. In such a system, a fundamental requirement is an ability to describe the continuously evolving execution environment and user characteristics. Service requests are therefore satisfied by considering both the request itself and its provisioning environment.

Neuroscience, 2013

Medial prefrontal cortex (mPFC) has been implicated in the reward process and the development of ... more Medial prefrontal cortex (mPFC) has been implicated in the reward process and the development of cocaine addiction. In the current study, we used a proteomics-based approach, combining two-dimensional gel electrophoresis (2-DE) with mass spectrometry (MS), to analyze protein expression profiles of rat mPFC after repeated cocaine exposure. Conditioned place preference (CPP) assay was used here to evaluate cocaine-induced reward effect in rats. We detected about 3100 protein spots in rat mPFC. After repeated cocaine exposure, 125 spots were changed by more than 1.1-fold of control levels. Among them, 71 spots with 1.5-fold or greater changes in protein expression over control levels have been identified, including 50 spots that were up-regulated and 21 spots that were down-regulated by repeated cocaine exposure. These identified proteins that showed significant changes in expression in mPFC after repeated cocaine exposure may be useful biomarkers for assessing cocaine abuse and potential new targets for investigating the mechanism of cocaine abuse.

Journal of Neuroimmunology, 2012

Cerebrovascular Diseases, 2009

IntroductionPeriprosthetic joint infection (PJI) is considered one of the most feared causes of i... more IntroductionPeriprosthetic joint infection (PJI) is considered one of the most feared causes of implant failure, due to the difficulty in formulating a proper and timely diagnosis. In the diagnostic workup are often used test with a low specificity, such as the dosage of ESR and CRP, or sensitivity, such as cultures or the leukocyte count of the synovial fluid. Radiological investigations are expensive and unreliable to play a direct role in the diagnosis of PJI. The alpha-defensin is an antimicrobial peptide released by neutrophils in response to pathogens and it is an ideal biomarker for the diagnosis of PJI. It is now possible to verify the presence of alpha-defensin in periprosthetic synovial fluid with an ELISA (Synovasure® PJI, Zimmer) that provides results in 10 minutes, with a sensitivity of 97% and a specificity of 96%, without being affected by systemic inflammatory diseases or by the assumption of antibiotics. The purpose of this study is to assess the applicability and r...

Chronic paroxysmal hemicrania (CPH) is an unusual cause of headache, affecting predominantly wome... more Chronic paroxysmal hemicrania (CPH) is an unusual cause of headache, affecting predominantly women in the third to fourth decade. It is characterized by multiple attacks of unilateral pain, mostly located in fronto-orbito-temporal region, often associated with autonomic symptoms, such as lacrymation, conjunc-tival hyperaemia and nasal obstruction or rhinor-rhea. Each attack usually lasts from 2 to 45 min and as diagnostic criteria it should be absolutely respon-sive to indomethacin in varying doses (1). Since the first description and definition of diag-nostic criteria, few cases of CPH have been described in children. We report a 10 years-old girl with symp-toms beginning since early childhood. Case report

The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology, 2003

AIM This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scann... more AIM This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scanner, C-PET (ADAC-UGM), using a multi-ring 2D BGO PET scanner (multi-ring PET), as a reference. METHODS Thirty-seven oncological patients were studied in sequence with multi-ring PET and C-PET, within 30 days of a CT study. In order to assess the behaviour of C-PET in relation to acquisition count rate, patients were divided into 3 groups according to the count rate at the time of the C-PET scan acquisition. Group A (n=21): 3000-5000 kcounts/sec (recommended count rate range); Group B (n=8): <3000 Kcounts/sec and Group C (n=8): >5000 Kcounts/sec. RESULTS The number of lesions detected by multi-ring PET and C-PET, classified according to size, was compared. For Group A and Group B there was a good agreement between C-PET and multi-ring PET in terms of lesion detectability (relative sensitivity: 99.9% and 96.0%, respectively), while for Group C the relative sensitivity of C-PET was 61....

Elbow Arthroplasty

The engineering development and outcomes of distal humeral hemiarthroplasty (DHH) have gained inc... more The engineering development and outcomes of distal humeral hemiarthroplasty (DHH) have gained increasing interest for the utilization of these implants in a new large horizon of clinical scenario. This chapter will focus on the spectrum of the surgical indications and the expected results of DHH.

Pan American Journal of Medical Thermology, 2015

This guideline was prepared by members of the American Academy of Thermology (AAT) as a guide to ... more This guideline was prepared by members of the American Academy of Thermology (AAT) as a guide to aid the breast thermologist, and other interested parties, in the clinical application of infrared breast imaging. It implies a consensus from experts in the field of breast thermology and those substantially concerned with its scope and provisions. The AAT guideline may be revised or withdrawn at any time. The procedures of the AAT require that action be taken to reaffirm, revise, or withdraw this guideline no later than three years from the date of publication. Suggestions for improvement of this guideline are welcome and should be addressed to the president of the American Academy of Thermology. No part of this guideline may be reproduced in any form, in an electronic retrieval system or otherwise, without the prior written permission of the publisher.