M. Brueton - Profile on Academia.edu (original) (raw)
Papers by M. Brueton
Energy and nutrient intakes in cystic fibrosis
Archives of Disease in Childhood, 1989
The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with ... more The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with simultaneous measurement of energy losses in stools. Median energy intakes were in excess of the WHO estimated daily requirements (118.2%) when expressed as MJ/kg/24 hours, the excess almost accounted for by energy losses in the stools. When expressed as MJ/24 hours, however, median energy
Hepatic dysfunction in association with pancreatic insufficiency and cyclical neutropenia. Shwachman-Diamond syndrome
Archives of Disease in Childhood, 1977
A patient with pancreatic insufficiency and cyclical neutropenia is described who also has eviden... more A patient with pancreatic insufficiency and cyclical neutropenia is described who also has evidence of hepatic dysfunction. He and 3 other patients whose findings are given emphasize the wide range of abnormalities seen in this syndrome.
An Afghan child with deep vein thrombosis
Journal of the Royal Society of Medicine, 2003
International journal of pancreatology : official journal of the International Association of Pancreatology, 2001
We report a case of a child with portal vein thrombosis presenting with protein losing enteropath... more We report a case of a child with portal vein thrombosis presenting with protein losing enteropathy. He later developed exocrine and endocrine pancreatic failure. This association has not been reported before.
Increased resting energy expenditure in cystic fibrosis
Journal of applied physiology (Bethesda, Md. : 1985), 1988
To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting e... more To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting energy expenditure was measured by indirect calorimetry in 23 subjects with cystic fibrosis in a stable clinical state and in 42 normal control subjects. Resting energy expenditure was found to be elevated by an average of 0.45 MJ/24 h [95% confidence interval (CI) = 0.26-0.64, t = 4.91, P less than 0.001] (108 kcal/24 h), or 9.2% above expected values derived from the regression relating resting energy expenditure to whole body weight and sex in control subjects. When related to lean body mass, values were still elevated by 0.36 MJ/24 h (95% CI = 0.18-0.53, t = 4.15, P less than 0.001) (86 kcal/24 h), or 7.2%. The increased values were found to be independent of age, sex, or body size. There were significant correlations between increased values and poor pulmonary function as measured by the ratio of the forced expiratory volume in 1 s to forced vital capacity (r = -0.44, P less than 0.0...
The Effects Of Cisapride On Gastroesophageal Reflux In Children With And Without Neurological Disorders
... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J... more ... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J., Akkermans, LM A,, Wittebol, P. (1985) 'Effects of cisapride, a new gastro-intestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man.' Gut ...
A Study of Genetic Markers in a Family with Polyendocrine Disease
Tissue Antigens, 2008
Clinical Association of Helicobacter pylori Gastritis in Children
Southern Medical Journal, 1997
Pediatric Research, 1989
A G ~hmnas'. P ~a~lor'. V ~iller'. C M scrimgeour2 59 and M J ~ennie'
Kinetics of Uptake of L-Leucine and Glycylsarcosine into Normal and Protein Malnourished Young Rat Jejunum
Pediatric Research, 1984
The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate... more The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate postweaning period. At this time peptide uptake is quantitatively more important than amino acid uptake and the vulnerability of the infant to malnutrition is great. Everted rings of rat jejunum were used to investigate the uptake of the peptide glycylsarcosine (Gly-Sar) and the amino acid L-leucine. The animals had been weaned on to isocaloric diets containing 18% or 4% protein. The rats deprived of protein at this age showed a marked growth disturbance with considerable reduction in gut length in addition to poor weight gain. Mediated influx of Gly-Sar and leucine per centimeter of jejunum was reduced in the malnourished animals: Vmax, 77 +/- 7.1 (SEM) and 65 +/- 3.6 compared with 85 +/- 10.6 and 77 +/- 4.4 nmol . min-1 . cm-1., respectively. But, when expressed in relation to body weight, the maximal transport capacity showed a marked increase with malnutrition, values being 126 and 111 nmol-1 . cm-1 . 100 g-1 body weight compared with 39 and 35 nmol-1 . cm-1 . 100 g-1 body weight for Gly-Sar and leucine respectively.
64 Oral Redhyration Solutions – Experimental Studies of Net Water an Electrolyte Absorption
Pediatric Research, 1988
Protein Turnover Increases in Parenterally Fed Premature Infants - a Study With [13C]LEUCINE
Pediatric Research, 1990
Concurrent Congenital Human Immunodeficiency Virus Infection and Toxoplasmosis
The Pediatric Infectious Disease Journal, 1991
Aspergillus allergy and allergic bronchopulmonary aspergillosis in cystic fibrosis
Pediatric Allergy and Immunology, 1991
Epidermal growth factor in necrotising enteritis
The Lancet, 1991
Polydipsia in infant with oesophagitis
The Lancet, 1996
Hyperphenylalanaemia in Parenterally Fed Newborn Infants
The Lancet, 1988
An Afghan child with deep vein thrombosis
JRSM, 2003
Evaluation of the Effects of Varying Solute Content on the Efficacy of Oral Rehydration Solutions in a Rat Model of Secretory Diarrhoea
Journal of Pediatric Gastroenterology and Nutrition, 1994
A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intesti... more A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intestine were carried out to investigate net water, sodium, and potassium absorption and water influx and efflux from a range of oral rehydration solutions (ORSs) in which the glucose content had been partially replaced by amino acids or food supplements and the sodium content had been reduced to 60 mM. The reference solution used was the World Health Organization formula. There was a significant correlation between the osmolality of the ORS and the net water absorption (r = -0.911; p < 0.02). The greatest net water absorption occurred using comminuted chicken- and tapioca-supplemented ORS.
Concurrent Pancreatic and Growth Hormone Insufficiency in Johanson-Blizzard Syndrome
Journal of Pediatric Gastroenterology and Nutrition, 1989
Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard synd... more Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard syndrome; other features include hypothyroidism, sensorineural deafness, aplastic alae nasi, developmental delay, and growth retardation. Twenty-one cases of the syndrome have been described to date. The child reported here was diagnosed in the neonatal period, but despite early pancreatic and thyroid replacement therapy his growth remained poor. Anterior pituitary function studies demonstrated growth hormone deficiency, subsequent administration of growth hormone has resulted in an improvement in his growth velocity. This feature has not been well documented and should be considered as a factor contributing to the growth retardation which is a constant feature of this syndrome.
Energy and nutrient intakes in cystic fibrosis
Archives of Disease in Childhood, 1989
The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with ... more The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with simultaneous measurement of energy losses in stools. Median energy intakes were in excess of the WHO estimated daily requirements (118.2%) when expressed as MJ/kg/24 hours, the excess almost accounted for by energy losses in the stools. When expressed as MJ/24 hours, however, median energy
Hepatic dysfunction in association with pancreatic insufficiency and cyclical neutropenia. Shwachman-Diamond syndrome
Archives of Disease in Childhood, 1977
A patient with pancreatic insufficiency and cyclical neutropenia is described who also has eviden... more A patient with pancreatic insufficiency and cyclical neutropenia is described who also has evidence of hepatic dysfunction. He and 3 other patients whose findings are given emphasize the wide range of abnormalities seen in this syndrome.
An Afghan child with deep vein thrombosis
Journal of the Royal Society of Medicine, 2003
International journal of pancreatology : official journal of the International Association of Pancreatology, 2001
We report a case of a child with portal vein thrombosis presenting with protein losing enteropath... more We report a case of a child with portal vein thrombosis presenting with protein losing enteropathy. He later developed exocrine and endocrine pancreatic failure. This association has not been reported before.
Increased resting energy expenditure in cystic fibrosis
Journal of applied physiology (Bethesda, Md. : 1985), 1988
To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting e... more To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting energy expenditure was measured by indirect calorimetry in 23 subjects with cystic fibrosis in a stable clinical state and in 42 normal control subjects. Resting energy expenditure was found to be elevated by an average of 0.45 MJ/24 h [95% confidence interval (CI) = 0.26-0.64, t = 4.91, P less than 0.001] (108 kcal/24 h), or 9.2% above expected values derived from the regression relating resting energy expenditure to whole body weight and sex in control subjects. When related to lean body mass, values were still elevated by 0.36 MJ/24 h (95% CI = 0.18-0.53, t = 4.15, P less than 0.001) (86 kcal/24 h), or 7.2%. The increased values were found to be independent of age, sex, or body size. There were significant correlations between increased values and poor pulmonary function as measured by the ratio of the forced expiratory volume in 1 s to forced vital capacity (r = -0.44, P less than 0.0...
The Effects Of Cisapride On Gastroesophageal Reflux In Children With And Without Neurological Disorders
... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J... more ... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J., Akkermans, LM A,, Wittebol, P. (1985) 'Effects of cisapride, a new gastro-intestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man.' Gut ...
A Study of Genetic Markers in a Family with Polyendocrine Disease
Tissue Antigens, 2008
Clinical Association of Helicobacter pylori Gastritis in Children
Southern Medical Journal, 1997
Pediatric Research, 1989
A G ~hmnas'. P ~a~lor'. V ~iller'. C M scrimgeour2 59 and M J ~ennie'
Kinetics of Uptake of L-Leucine and Glycylsarcosine into Normal and Protein Malnourished Young Rat Jejunum
Pediatric Research, 1984
The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate... more The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate postweaning period. At this time peptide uptake is quantitatively more important than amino acid uptake and the vulnerability of the infant to malnutrition is great. Everted rings of rat jejunum were used to investigate the uptake of the peptide glycylsarcosine (Gly-Sar) and the amino acid L-leucine. The animals had been weaned on to isocaloric diets containing 18% or 4% protein. The rats deprived of protein at this age showed a marked growth disturbance with considerable reduction in gut length in addition to poor weight gain. Mediated influx of Gly-Sar and leucine per centimeter of jejunum was reduced in the malnourished animals: Vmax, 77 +/- 7.1 (SEM) and 65 +/- 3.6 compared with 85 +/- 10.6 and 77 +/- 4.4 nmol . min-1 . cm-1., respectively. But, when expressed in relation to body weight, the maximal transport capacity showed a marked increase with malnutrition, values being 126 and 111 nmol-1 . cm-1 . 100 g-1 body weight compared with 39 and 35 nmol-1 . cm-1 . 100 g-1 body weight for Gly-Sar and leucine respectively.
64 Oral Redhyration Solutions – Experimental Studies of Net Water an Electrolyte Absorption
Pediatric Research, 1988
Protein Turnover Increases in Parenterally Fed Premature Infants - a Study With [13C]LEUCINE
Pediatric Research, 1990
Concurrent Congenital Human Immunodeficiency Virus Infection and Toxoplasmosis
The Pediatric Infectious Disease Journal, 1991
Aspergillus allergy and allergic bronchopulmonary aspergillosis in cystic fibrosis
Pediatric Allergy and Immunology, 1991
Epidermal growth factor in necrotising enteritis
The Lancet, 1991
Polydipsia in infant with oesophagitis
The Lancet, 1996
Hyperphenylalanaemia in Parenterally Fed Newborn Infants
The Lancet, 1988
An Afghan child with deep vein thrombosis
JRSM, 2003
Evaluation of the Effects of Varying Solute Content on the Efficacy of Oral Rehydration Solutions in a Rat Model of Secretory Diarrhoea
Journal of Pediatric Gastroenterology and Nutrition, 1994
A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intesti... more A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intestine were carried out to investigate net water, sodium, and potassium absorption and water influx and efflux from a range of oral rehydration solutions (ORSs) in which the glucose content had been partially replaced by amino acids or food supplements and the sodium content had been reduced to 60 mM. The reference solution used was the World Health Organization formula. There was a significant correlation between the osmolality of the ORS and the net water absorption (r = -0.911; p < 0.02). The greatest net water absorption occurred using comminuted chicken- and tapioca-supplemented ORS.
Concurrent Pancreatic and Growth Hormone Insufficiency in Johanson-Blizzard Syndrome
Journal of Pediatric Gastroenterology and Nutrition, 1989
Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard synd... more Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard syndrome; other features include hypothyroidism, sensorineural deafness, aplastic alae nasi, developmental delay, and growth retardation. Twenty-one cases of the syndrome have been described to date. The child reported here was diagnosed in the neonatal period, but despite early pancreatic and thyroid replacement therapy his growth remained poor. Anterior pituitary function studies demonstrated growth hormone deficiency, subsequent administration of growth hormone has resulted in an improvement in his growth velocity. This feature has not been well documented and should be considered as a factor contributing to the growth retardation which is a constant feature of this syndrome.