M. Brueton - Academia.edu (original) (raw)
Papers by M. Brueton
Archives of Disease in Childhood, 1989
The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with ... more The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with simultaneous measurement of energy losses in stools. Median energy intakes were in excess of the WHO estimated daily requirements (118.2%) when expressed as MJ/kg/24 hours, the excess almost accounted for by energy losses in the stools. When expressed as MJ/24 hours, however, median energy
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Archives of Disease in Childhood, 1977
A patient with pancreatic insufficiency and cyclical neutropenia is described who also has eviden... more A patient with pancreatic insufficiency and cyclical neutropenia is described who also has evidence of hepatic dysfunction. He and 3 other patients whose findings are given emphasize the wide range of abnormalities seen in this syndrome.
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Journal of the Royal Society of Medicine, 2003
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International journal of pancreatology : official journal of the International Association of Pancreatology, 2001
We report a case of a child with portal vein thrombosis presenting with protein losing enteropath... more We report a case of a child with portal vein thrombosis presenting with protein losing enteropathy. He later developed exocrine and endocrine pancreatic failure. This association has not been reported before.
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Journal of applied physiology (Bethesda, Md. : 1985), 1988
To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting e... more To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting energy expenditure was measured by indirect calorimetry in 23 subjects with cystic fibrosis in a stable clinical state and in 42 normal control subjects. Resting energy expenditure was found to be elevated by an average of 0.45 MJ/24 h [95% confidence interval (CI) = 0.26-0.64, t = 4.91, P less than 0.001] (108 kcal/24 h), or 9.2% above expected values derived from the regression relating resting energy expenditure to whole body weight and sex in control subjects. When related to lean body mass, values were still elevated by 0.36 MJ/24 h (95% CI = 0.18-0.53, t = 4.15, P less than 0.001) (86 kcal/24 h), or 7.2%. The increased values were found to be independent of age, sex, or body size. There were significant correlations between increased values and poor pulmonary function as measured by the ratio of the forced expiratory volume in 1 s to forced vital capacity (r = -0.44, P less than 0.0...
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... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J... more ... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J., Akkermans, LM A,, Wittebol, P. (1985) 'Effects of cisapride, a new gastro-intestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man.' Gut ...
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Tissue Antigens, 2008
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Southern Medical Journal, 1997
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Pediatric Research, 1989
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Pediatric Research, 1984
The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate... more The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate postweaning period. At this time peptide uptake is quantitatively more important than amino acid uptake and the vulnerability of the infant to malnutrition is great. Everted rings of rat jejunum were used to investigate the uptake of the peptide glycylsarcosine (Gly-Sar) and the amino acid L-leucine. The animals had been weaned on to isocaloric diets containing 18% or 4% protein. The rats deprived of protein at this age showed a marked growth disturbance with considerable reduction in gut length in addition to poor weight gain. Mediated influx of Gly-Sar and leucine per centimeter of jejunum was reduced in the malnourished animals: Vmax, 77 +/- 7.1 (SEM) and 65 +/- 3.6 compared with 85 +/- 10.6 and 77 +/- 4.4 nmol . min-1 . cm-1., respectively. But, when expressed in relation to body weight, the maximal transport capacity showed a marked increase with malnutrition, values being 126 and 111 nmol-1 . cm-1 . 100 g-1 body weight compared with 39 and 35 nmol-1 . cm-1 . 100 g-1 body weight for Gly-Sar and leucine respectively.
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Pediatric Research, 1988
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Pediatric Research, 1990
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The Pediatric Infectious Disease Journal, 1991
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Pediatric Allergy and Immunology, 1991
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The Lancet, 1991
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The Lancet, 1996
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The Lancet, 1988
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JRSM, 2003
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Journal of Pediatric Gastroenterology and Nutrition, 1994
A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intesti... more A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intestine were carried out to investigate net water, sodium, and potassium absorption and water influx and efflux from a range of oral rehydration solutions (ORSs) in which the glucose content had been partially replaced by amino acids or food supplements and the sodium content had been reduced to 60 mM. The reference solution used was the World Health Organization formula. There was a significant correlation between the osmolality of the ORS and the net water absorption (r = -0.911; p < 0.02). The greatest net water absorption occurred using comminuted chicken- and tapioca-supplemented ORS.
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Journal of Pediatric Gastroenterology and Nutrition, 1989
Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard synd... more Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard syndrome; other features include hypothyroidism, sensorineural deafness, aplastic alae nasi, developmental delay, and growth retardation. Twenty-one cases of the syndrome have been described to date. The child reported here was diagnosed in the neonatal period, but despite early pancreatic and thyroid replacement therapy his growth remained poor. Anterior pituitary function studies demonstrated growth hormone deficiency, subsequent administration of growth hormone has resulted in an improvement in his growth velocity. This feature has not been well documented and should be considered as a factor contributing to the growth retardation which is a constant feature of this syndrome.
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Archives of Disease in Childhood, 1989
The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with ... more The diets of 20 children with cystic fibrosis were analysed for energy and nutrient content with simultaneous measurement of energy losses in stools. Median energy intakes were in excess of the WHO estimated daily requirements (118.2%) when expressed as MJ/kg/24 hours, the excess almost accounted for by energy losses in the stools. When expressed as MJ/24 hours, however, median energy
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Archives of Disease in Childhood, 1977
A patient with pancreatic insufficiency and cyclical neutropenia is described who also has eviden... more A patient with pancreatic insufficiency and cyclical neutropenia is described who also has evidence of hepatic dysfunction. He and 3 other patients whose findings are given emphasize the wide range of abnormalities seen in this syndrome.
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Journal of the Royal Society of Medicine, 2003
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International journal of pancreatology : official journal of the International Association of Pancreatology, 2001
We report a case of a child with portal vein thrombosis presenting with protein losing enteropath... more We report a case of a child with portal vein thrombosis presenting with protein losing enteropathy. He later developed exocrine and endocrine pancreatic failure. This association has not been reported before.
Bookmarks Related papers MentionsView impact
Journal of applied physiology (Bethesda, Md. : 1985), 1988
To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting e... more To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting energy expenditure was measured by indirect calorimetry in 23 subjects with cystic fibrosis in a stable clinical state and in 42 normal control subjects. Resting energy expenditure was found to be elevated by an average of 0.45 MJ/24 h [95% confidence interval (CI) = 0.26-0.64, t = 4.91, P less than 0.001] (108 kcal/24 h), or 9.2% above expected values derived from the regression relating resting energy expenditure to whole body weight and sex in control subjects. When related to lean body mass, values were still elevated by 0.36 MJ/24 h (95% CI = 0.18-0.53, t = 4.15, P less than 0.001) (86 kcal/24 h), or 7.2%. The increased values were found to be independent of age, sex, or body size. There were significant correlations between increased values and poor pulmonary function as measured by the ratio of the forced expiratory volume in 1 s to forced vital capacity (r = -0.44, P less than 0.0...
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... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J... more ... Michael's Hill, Bristol BS2 8BJ. ... Smout, AJPM, Bogaard, JW, Grade, AC, Ten Thije, 0. J., Akkermans, LM A,, Wittebol, P. (1985) 'Effects of cisapride, a new gastro-intestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man.' Gut ...
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Tissue Antigens, 2008
Bookmarks Related papers MentionsView impact
Southern Medical Journal, 1997
Bookmarks Related papers MentionsView impact
Pediatric Research, 1989
Bookmarks Related papers MentionsView impact
Pediatric Research, 1984
The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate... more The impact of malnutrition on peptide and amino acid absorption has been studied in the immediate postweaning period. At this time peptide uptake is quantitatively more important than amino acid uptake and the vulnerability of the infant to malnutrition is great. Everted rings of rat jejunum were used to investigate the uptake of the peptide glycylsarcosine (Gly-Sar) and the amino acid L-leucine. The animals had been weaned on to isocaloric diets containing 18% or 4% protein. The rats deprived of protein at this age showed a marked growth disturbance with considerable reduction in gut length in addition to poor weight gain. Mediated influx of Gly-Sar and leucine per centimeter of jejunum was reduced in the malnourished animals: Vmax, 77 +/- 7.1 (SEM) and 65 +/- 3.6 compared with 85 +/- 10.6 and 77 +/- 4.4 nmol . min-1 . cm-1., respectively. But, when expressed in relation to body weight, the maximal transport capacity showed a marked increase with malnutrition, values being 126 and 111 nmol-1 . cm-1 . 100 g-1 body weight compared with 39 and 35 nmol-1 . cm-1 . 100 g-1 body weight for Gly-Sar and leucine respectively.
Bookmarks Related papers MentionsView impact
Pediatric Research, 1988
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Pediatric Research, 1990
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The Pediatric Infectious Disease Journal, 1991
Bookmarks Related papers MentionsView impact
Pediatric Allergy and Immunology, 1991
Bookmarks Related papers MentionsView impact
The Lancet, 1991
Bookmarks Related papers MentionsView impact
The Lancet, 1996
Bookmarks Related papers MentionsView impact
The Lancet, 1988
Bookmarks Related papers MentionsView impact
JRSM, 2003
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Journal of Pediatric Gastroenterology and Nutrition, 1994
A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intesti... more A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intestine were carried out to investigate net water, sodium, and potassium absorption and water influx and efflux from a range of oral rehydration solutions (ORSs) in which the glucose content had been partially replaced by amino acids or food supplements and the sodium content had been reduced to 60 mM. The reference solution used was the World Health Organization formula. There was a significant correlation between the osmolality of the ORS and the net water absorption (r = -0.911; p < 0.02). The greatest net water absorption occurred using comminuted chicken- and tapioca-supplemented ORS.
Bookmarks Related papers MentionsView impact
Journal of Pediatric Gastroenterology and Nutrition, 1989
Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard synd... more Exocrine pancreatic insufficiency is one of the recognised features of the Johanson-Blizzard syndrome; other features include hypothyroidism, sensorineural deafness, aplastic alae nasi, developmental delay, and growth retardation. Twenty-one cases of the syndrome have been described to date. The child reported here was diagnosed in the neonatal period, but despite early pancreatic and thyroid replacement therapy his growth remained poor. Anterior pituitary function studies demonstrated growth hormone deficiency, subsequent administration of growth hormone has resulted in an improvement in his growth velocity. This feature has not been well documented and should be considered as a factor contributing to the growth retardation which is a constant feature of this syndrome.
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