M. Formigoni - Academia.edu (original) (raw)
Papers by M. Formigoni
Alcoholism Clinical and Experimental Research
Revista da Associação Médica Brasileira, 2004
The International Journal of Neuropsychopharmacology, 2010
Repeated ethanol administration may induce behavioural sensitization, defined as a progressive po... more Repeated ethanol administration may induce behavioural sensitization, defined as a progressive potentiation of locomotor stimulant effects. This process is associated with neuroadaptations in the mesolimbic pathway and the nucleus accumbens. The aim of the present study was to analyse dopamine D 1 receptor (D 1 R) participation in locomotor response to an agonist and an antagonist of the D 1 R in mice with different levels of sensitization to ethanol. In three separate experiments, mice received administrations of 2.2 g/kg ethanol or saline every other day for 10 d. According to their locomotor response on the last day, ethanol-treated animals were classified into two groups : sensitized or non-sensitized. After the treatment, mice were challenged with 4 or 8 mg/kg SKF-38393 (i.p.), a D 1 R agonist (expt 1) ; or with 0.01 or 0.1 mg/kg SCH-23390 (i.p.), a D 1 R antagonist, followed by 2.2 g/kg ethanol (i.p.) administration (expt 2). In expt 3, mice were challenged with intra-accumbens (intra-NAc) SKF-38393 (1 mg/side, in 0.2 ml), and with intra-NAc SCH-23390 (3 mg/side, in 0.2 ml) followed by 2.2 g/kg ethanol (i.p.). Although the i.p. administration of SKF-38393 did not affect the locomotion of mice, the intra-NAc administration of SKF-38393 significantly increased the locomotor activity in sensitized mice, suggesting that sensitized mice present functionally hyperresponsive D 1 Rs in the NAc. Both i.p. and intra-NAc administration of SCH-23390 blocked the expression of ethanol sensitization, suggesting that the activation of NAc D 1 Rs seems to be essential for the expression of ethanol sensitization.
Drug and Alcohol Dependence, 2003
Objectives: The main objectives of this study were to evaluate the effects of subject identificat... more Objectives: The main objectives of this study were to evaluate the effects of subject identification versus anonymity on adolescents' drug use assessment using the Drug Use Screening Inventory-R and to assess the usefulness of the "Lie Scale" of that instrument. Methods: Six hundred and fifty-five Brazilian students (5th to 11th graders) from a public school of São Paulo participated in the study. One third of them were instructed to put their names on the questionnaire, one third answered it anonymously and the remaining ones were partially identified according to a code list that was kept by one student who represented his classmates. The answers of the identified groups of students were compared with those from the anonymous group. According to their scores in the Lie Scale, the students were divided into two groups: low and high score groups. Results and conclusions: No significant differences were found among anonymous, identified and partially identified groups regarding alcohol or drug consumption report, or in the density of problems in all drug use screening inventory (DUSI) areas. Regarding the Lie Scale, the high score group reported lower alcohol or drug consumption and fewer alcohol or drug related problems in all DUSI areas when compared to the low score group. The results suggest that identification or anonymity does not affect the students' answers to the DUSI and point out the usefulness of the Lie Scale of DUSI-R.
Addictive Behaviors, 2000
The Brazilian translation of the Drug Use Screening Inventory (DUSI) was applied to 213 Brazilian... more The Brazilian translation of the Drug Use Screening Inventory (DUSI) was applied to 213 Brazilian teenagers who were classified according to their alcohol and/or drug dependence level (DSM-III-R) as: 71 nondrug users (Group 1), 71 with light/moderate dependence (Group 2) and 71 with severe dependence (Group 3). The DUSI was applied and the absolute density in each of 10 areas was calculated. The three groups presented statistically significant differences (p Ͻ .001) in the "substance use" area, with the following values (medians Ϯ interquartile range): Group 1: 0 Ϯ 7; Group 2: 20 Ϯ 33 and Group 3: 80 Ϯ 33. The groups also presented significant differences in behavior pattern, social competency, family system, work adjustment, peer relationships and leisure/recreation. Other differences detected among the groups indicated an important relationship between drug use and school delay. A good Spearman rank correlation (0.86, p Ͻ .0001) was observed between Composite International Diagnostic Interview (CIDI) diagnosis and DUSI, indicating that this instrument can be useful in the screening of substance use among Brazilian teenagers.
Addiction, 2004
Aims In the last few years, epidemiological studies in Brazil have detected significant increases... more Aims In the last few years, epidemiological studies in Brazil have detected significant increases in the use and abuse of psychoactive drugs by adolescents; however, there is a paucity of data on the factors associated with this use. Objectives To assess the prevalence of drug use by students from public schools in a Brazilian city and to evaluate the influence of age, school achievement, family, psychosocial, health, demographic and behavioural characteristics on regular drug use. Design This cross-sectional study was conducted using a representative sample of 6417 students attending public schools in the city of Barueri, Brazil and included adolescents from the 5th grade of elementary school to the 3rd year of high school. The Brazilian version of the Drug Use Screening Inventory
Revista da Associação Médica Brasileira, 2004
INTERVENÇÃO BREVE EM ADOLESCENTES RESUMO-OBJETIVOS. O principal objetivo deste estudo foi avaliar... more INTERVENÇÃO BREVE EM ADOLESCENTES RESUMO-OBJETIVOS. O principal objetivo deste estudo foi avaliar a efetividade de uma intervenção breve e de uma orientação preventiva do uso de álcool e/ou outras drogas, dirigidas a adolescentes. MÉTODOS. Noventa e nove adolescentes que buscaram atendimento médico em um serviço ambulatorial especializado no atendimento de adolescentes foram divididos de acordo com seus níveis de consumo de substâncias em usuários no último mês (UM) e não usuários no último mês (NUM). Cada um destes grupos foi dividido em dois: um grupo controle de usuários no último mês (COUM), um grupo controle de não usuários no último mês (CONUM), um grupo que receberia Intervenção Breve no caso de serem usuários no mês (UM-IB) e um grupo que receberia Orientação Preventiva no caso de serem não usuários no mês (NUM-OP), totalizando quatro grupos. A orientação preventiva teve duração de 2 a 3 minutos e intervenção breve de 20 minutos, sendo realizada segundo roteiro pré-estruturado. Todos os participantes foram novamente avaliados após seis meses. RESULTADOS. No seguimento realizado ao final de seis meses, observou-se um aumento significativo na prevalência de consumo de maconha, álcool e tabaco bem como na intensidade de problemas e comportamentos de risco no grupo CONUM. No grupo NUM-OP, INTRODUÇÃO De acordo com o IV Levantamento Nacional realizado pelo Centro Brasileiro de Informações sobre Drogas Psicotrópicas-CEBRID (Galduróz, Noto Carlini, 1997), realizado com 15.503 estudantes de escolas de 1º e 2º graus de dez capitais brasileiras, as drogas mais consumidas entre os estudantes foram o álcool, responsável por 20% das faltas escolares, e os solventes. Em relação às drogas ilícitas, observou-se um aumento significativo de uso na vida desde o III Levantamento Nacional realizado em 1993, passando de 22% para 25% (Galduróz, D'Almeida, Carvalho & Carlini, 1994; Galduróz et al., 1997). Dados do 1º Levantamento Domiciliar sobre o uso de drogas psicotrópicas no Brasil (Carlini, Galduróz, Noto & Nappo, 2002), considerando as 107 cidades brasileiras com mais de 200 mil habitantes, mostraram que, em relação ao uso na vida de substâncias psicoativas, 48.3% dos entrevistados na faixa de 12 a 17 anos de idade mencionaram ter consumido bebidas alcoólicas, 15,7% tabaco, 3,4% solventes e 3,5% maconha. Considerando a prevalência de dependência nesta mesma faixa etária (12 a 17 anos), observa-se que 5,2% dos jovens foram considerados dependentes de álcool, 2,2% de tabaco e 0,6% de maconha.
Nordic Studies on Alcohol and Drugs
Arch Clin Psychiatry, Feb 1, 1999
... Maria Lucia O. Souza Formigoni 1 , Saulo Castel 2. ... autores: essa lista pode não estar atu... more ... Maria Lucia O. Souza Formigoni 1 , Saulo Castel 2. ... autores: essa lista pode não estar atualizada, sendo provável que existam outras traduções dos instrumentos citados. ... Endereço para correspondência: Rua Botucatu, 862 1o andar São Paulo, SP CEP 04023-062 Telfax ...
Psicologia Teoria E Pratica, 2006
J Bras Psiquiatr, Jun 1, 1995
Pesquisa : 311146 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1... more Pesquisa : 311146 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 311146. Autor: Silva, Eroy Aparecida da; Ferri, Cleusa Pinheiro; Formigoni, Maria Lucia OS ...
Psicologia Teoria E Pratica, 2006
Revista De Psiquiatria Clinica, 1999
Psicologia Teoria E Pratica, Jun 1, 2008
The Faseb Journal, Apr 1, 2010
Http Dx Doi Org 10 1080 02791072 2007 10400618, Sep 8, 2011
Death by overdose is loaded with social/moral stigmas, in addition to strong feelings of anger, h... more Death by overdose is loaded with social/moral stigmas, in addition to strong feelings of anger, helplessness, guilt and shame in the families. The objective of this study was to analyze the impact of these feelings on families facing death by overdose. Qualitative methodology was used to study six families with a history of death by overdose of one of their members. The interview was open, and guided by the question "What did you feel with the death of your family member by overdose and what was the impact of this death on your family as a whole?" The families were grouped into two categories: families who knew about the drug use of their family member, and families who were not aware of it. The reports show that secrecy regarding drug use followed by death by overdose arouses feelings of anger, guilt, helplessness, and deprives the family members of information that could allow them to take action. As regards families that were aware of the drug use, there seems to be a "veiled preparation" for a possible death by overdose, bringing about ambivalent situations of grief and relief. The report stresses how disturbing it is to lose a family member by overdose, and points to the need for psychological support for those families.
Revista da Associação Médica Brasileira (1992)
An increase in crack use epidemiological research and police data. Currently, in Brazil, no data ... more An increase in crack use epidemiological research and police data. Currently, in Brazil, no data are available linking the route of administration and attendance to treatment for cocaine dependence. The purpose of this paper was to analyze the changes in cocaine routes of administration in a cocaine dependent population treatment in two outpatient public services (PROAD and UDED). Standardized interview data, collected at admission to treatment were compared from 1990 to 1993. The prevalence rates of smoked ("crack"), injected and snorted cocaine were compared. The percentage of patients who reported "crack" cocaine use increased from 17% in 1990 to 64% in 1993 (p < 0.01) The prevalence of snorted cocaine remained stable in the period of time analyzed, being the most frequent route reported. The intravenous route tended to decrease from 40% in 1990 to 28% in 1993. The implications of the increase of "crack" cocaine users who sought treatment are disc...
Alcoholism Clinical and Experimental Research
Revista da Associação Médica Brasileira, 2004
The International Journal of Neuropsychopharmacology, 2010
Repeated ethanol administration may induce behavioural sensitization, defined as a progressive po... more Repeated ethanol administration may induce behavioural sensitization, defined as a progressive potentiation of locomotor stimulant effects. This process is associated with neuroadaptations in the mesolimbic pathway and the nucleus accumbens. The aim of the present study was to analyse dopamine D 1 receptor (D 1 R) participation in locomotor response to an agonist and an antagonist of the D 1 R in mice with different levels of sensitization to ethanol. In three separate experiments, mice received administrations of 2.2 g/kg ethanol or saline every other day for 10 d. According to their locomotor response on the last day, ethanol-treated animals were classified into two groups : sensitized or non-sensitized. After the treatment, mice were challenged with 4 or 8 mg/kg SKF-38393 (i.p.), a D 1 R agonist (expt 1) ; or with 0.01 or 0.1 mg/kg SCH-23390 (i.p.), a D 1 R antagonist, followed by 2.2 g/kg ethanol (i.p.) administration (expt 2). In expt 3, mice were challenged with intra-accumbens (intra-NAc) SKF-38393 (1 mg/side, in 0.2 ml), and with intra-NAc SCH-23390 (3 mg/side, in 0.2 ml) followed by 2.2 g/kg ethanol (i.p.). Although the i.p. administration of SKF-38393 did not affect the locomotion of mice, the intra-NAc administration of SKF-38393 significantly increased the locomotor activity in sensitized mice, suggesting that sensitized mice present functionally hyperresponsive D 1 Rs in the NAc. Both i.p. and intra-NAc administration of SCH-23390 blocked the expression of ethanol sensitization, suggesting that the activation of NAc D 1 Rs seems to be essential for the expression of ethanol sensitization.
Drug and Alcohol Dependence, 2003
Objectives: The main objectives of this study were to evaluate the effects of subject identificat... more Objectives: The main objectives of this study were to evaluate the effects of subject identification versus anonymity on adolescents' drug use assessment using the Drug Use Screening Inventory-R and to assess the usefulness of the "Lie Scale" of that instrument. Methods: Six hundred and fifty-five Brazilian students (5th to 11th graders) from a public school of São Paulo participated in the study. One third of them were instructed to put their names on the questionnaire, one third answered it anonymously and the remaining ones were partially identified according to a code list that was kept by one student who represented his classmates. The answers of the identified groups of students were compared with those from the anonymous group. According to their scores in the Lie Scale, the students were divided into two groups: low and high score groups. Results and conclusions: No significant differences were found among anonymous, identified and partially identified groups regarding alcohol or drug consumption report, or in the density of problems in all drug use screening inventory (DUSI) areas. Regarding the Lie Scale, the high score group reported lower alcohol or drug consumption and fewer alcohol or drug related problems in all DUSI areas when compared to the low score group. The results suggest that identification or anonymity does not affect the students' answers to the DUSI and point out the usefulness of the Lie Scale of DUSI-R.
Addictive Behaviors, 2000
The Brazilian translation of the Drug Use Screening Inventory (DUSI) was applied to 213 Brazilian... more The Brazilian translation of the Drug Use Screening Inventory (DUSI) was applied to 213 Brazilian teenagers who were classified according to their alcohol and/or drug dependence level (DSM-III-R) as: 71 nondrug users (Group 1), 71 with light/moderate dependence (Group 2) and 71 with severe dependence (Group 3). The DUSI was applied and the absolute density in each of 10 areas was calculated. The three groups presented statistically significant differences (p Ͻ .001) in the "substance use" area, with the following values (medians Ϯ interquartile range): Group 1: 0 Ϯ 7; Group 2: 20 Ϯ 33 and Group 3: 80 Ϯ 33. The groups also presented significant differences in behavior pattern, social competency, family system, work adjustment, peer relationships and leisure/recreation. Other differences detected among the groups indicated an important relationship between drug use and school delay. A good Spearman rank correlation (0.86, p Ͻ .0001) was observed between Composite International Diagnostic Interview (CIDI) diagnosis and DUSI, indicating that this instrument can be useful in the screening of substance use among Brazilian teenagers.
Addiction, 2004
Aims In the last few years, epidemiological studies in Brazil have detected significant increases... more Aims In the last few years, epidemiological studies in Brazil have detected significant increases in the use and abuse of psychoactive drugs by adolescents; however, there is a paucity of data on the factors associated with this use. Objectives To assess the prevalence of drug use by students from public schools in a Brazilian city and to evaluate the influence of age, school achievement, family, psychosocial, health, demographic and behavioural characteristics on regular drug use. Design This cross-sectional study was conducted using a representative sample of 6417 students attending public schools in the city of Barueri, Brazil and included adolescents from the 5th grade of elementary school to the 3rd year of high school. The Brazilian version of the Drug Use Screening Inventory
Revista da Associação Médica Brasileira, 2004
INTERVENÇÃO BREVE EM ADOLESCENTES RESUMO-OBJETIVOS. O principal objetivo deste estudo foi avaliar... more INTERVENÇÃO BREVE EM ADOLESCENTES RESUMO-OBJETIVOS. O principal objetivo deste estudo foi avaliar a efetividade de uma intervenção breve e de uma orientação preventiva do uso de álcool e/ou outras drogas, dirigidas a adolescentes. MÉTODOS. Noventa e nove adolescentes que buscaram atendimento médico em um serviço ambulatorial especializado no atendimento de adolescentes foram divididos de acordo com seus níveis de consumo de substâncias em usuários no último mês (UM) e não usuários no último mês (NUM). Cada um destes grupos foi dividido em dois: um grupo controle de usuários no último mês (COUM), um grupo controle de não usuários no último mês (CONUM), um grupo que receberia Intervenção Breve no caso de serem usuários no mês (UM-IB) e um grupo que receberia Orientação Preventiva no caso de serem não usuários no mês (NUM-OP), totalizando quatro grupos. A orientação preventiva teve duração de 2 a 3 minutos e intervenção breve de 20 minutos, sendo realizada segundo roteiro pré-estruturado. Todos os participantes foram novamente avaliados após seis meses. RESULTADOS. No seguimento realizado ao final de seis meses, observou-se um aumento significativo na prevalência de consumo de maconha, álcool e tabaco bem como na intensidade de problemas e comportamentos de risco no grupo CONUM. No grupo NUM-OP, INTRODUÇÃO De acordo com o IV Levantamento Nacional realizado pelo Centro Brasileiro de Informações sobre Drogas Psicotrópicas-CEBRID (Galduróz, Noto Carlini, 1997), realizado com 15.503 estudantes de escolas de 1º e 2º graus de dez capitais brasileiras, as drogas mais consumidas entre os estudantes foram o álcool, responsável por 20% das faltas escolares, e os solventes. Em relação às drogas ilícitas, observou-se um aumento significativo de uso na vida desde o III Levantamento Nacional realizado em 1993, passando de 22% para 25% (Galduróz, D'Almeida, Carvalho & Carlini, 1994; Galduróz et al., 1997). Dados do 1º Levantamento Domiciliar sobre o uso de drogas psicotrópicas no Brasil (Carlini, Galduróz, Noto & Nappo, 2002), considerando as 107 cidades brasileiras com mais de 200 mil habitantes, mostraram que, em relação ao uso na vida de substâncias psicoativas, 48.3% dos entrevistados na faixa de 12 a 17 anos de idade mencionaram ter consumido bebidas alcoólicas, 15,7% tabaco, 3,4% solventes e 3,5% maconha. Considerando a prevalência de dependência nesta mesma faixa etária (12 a 17 anos), observa-se que 5,2% dos jovens foram considerados dependentes de álcool, 2,2% de tabaco e 0,6% de maconha.
Nordic Studies on Alcohol and Drugs
Arch Clin Psychiatry, Feb 1, 1999
... Maria Lucia O. Souza Formigoni 1 , Saulo Castel 2. ... autores: essa lista pode não estar atu... more ... Maria Lucia O. Souza Formigoni 1 , Saulo Castel 2. ... autores: essa lista pode não estar atualizada, sendo provável que existam outras traduções dos instrumentos citados. ... Endereço para correspondência: Rua Botucatu, 862 1o andar São Paulo, SP CEP 04023-062 Telfax ...
Psicologia Teoria E Pratica, 2006
J Bras Psiquiatr, Jun 1, 1995
Pesquisa : 311146 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1... more Pesquisa : 311146 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 311146. Autor: Silva, Eroy Aparecida da; Ferri, Cleusa Pinheiro; Formigoni, Maria Lucia OS ...
Psicologia Teoria E Pratica, 2006
Revista De Psiquiatria Clinica, 1999
Psicologia Teoria E Pratica, Jun 1, 2008
The Faseb Journal, Apr 1, 2010
Http Dx Doi Org 10 1080 02791072 2007 10400618, Sep 8, 2011
Death by overdose is loaded with social/moral stigmas, in addition to strong feelings of anger, h... more Death by overdose is loaded with social/moral stigmas, in addition to strong feelings of anger, helplessness, guilt and shame in the families. The objective of this study was to analyze the impact of these feelings on families facing death by overdose. Qualitative methodology was used to study six families with a history of death by overdose of one of their members. The interview was open, and guided by the question &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;What did you feel with the death of your family member by overdose and what was the impact of this death on your family as a whole?&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; The families were grouped into two categories: families who knew about the drug use of their family member, and families who were not aware of it. The reports show that secrecy regarding drug use followed by death by overdose arouses feelings of anger, guilt, helplessness, and deprives the family members of information that could allow them to take action. As regards families that were aware of the drug use, there seems to be a &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;veiled preparation&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; for a possible death by overdose, bringing about ambivalent situations of grief and relief. The report stresses how disturbing it is to lose a family member by overdose, and points to the need for psychological support for those families.
Revista da Associação Médica Brasileira (1992)
An increase in crack use epidemiological research and police data. Currently, in Brazil, no data ... more An increase in crack use epidemiological research and police data. Currently, in Brazil, no data are available linking the route of administration and attendance to treatment for cocaine dependence. The purpose of this paper was to analyze the changes in cocaine routes of administration in a cocaine dependent population treatment in two outpatient public services (PROAD and UDED). Standardized interview data, collected at admission to treatment were compared from 1990 to 1993. The prevalence rates of smoked ("crack"), injected and snorted cocaine were compared. The percentage of patients who reported "crack" cocaine use increased from 17% in 1990 to 64% in 1993 (p < 0.01) The prevalence of snorted cocaine remained stable in the period of time analyzed, being the most frequent route reported. The intravenous route tended to decrease from 40% in 1990 to 28% in 1993. The implications of the increase of "crack" cocaine users who sought treatment are disc...