Mohammad Hovaidi Ardestani - Academia.edu (original) (raw)
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Papers by Mohammad Hovaidi Ardestani
selbständig verfasst, nur die angegebenen Quellen und Hilfsmittel benutzt und wörtlich oder inhal... more selbständig verfasst, nur die angegebenen Quellen und Hilfsmittel benutzt und wörtlich oder inhaltlichübernommene Stellen als solche gekennzeichnet habe. Ich versichere an Eides statt, dass diese Angaben wahr sind und dass ich nichts verschwiegen habe. Mir ist bekannt, dass die falsche Abgabe einer Versicherung an Eides statt mit Freiheitsstrafe bis zu drei Jahren oder mit Geldstrafe bestraft wird.
And to my wife Behnaz, who has given me her unequivocal support for which my mere expression of t... more And to my wife Behnaz, who has given me her unequivocal support for which my mere expression of thanks likewise does not suffice.
Journal of Neuroscience Research, 2011
In the present work, the Ca(2+) dependence of mitochondrial H(2) O(2) elimination was investigate... more In the present work, the Ca(2+) dependence of mitochondrial H(2) O(2) elimination was investigated. Mitochondria isolated from guinea pig brain were energized by glutamate and malate and incubated with micromolar concentrations of Ca(2+) in the presence of ADP, preventing permeability transition pore formation. After the completion of Ca(2+) uptake, mitochondria were challenged with H(2) O(2) (5 μM), then at various time points residual H(2) O(2) was determined using the Amplex red method and compared with that in mitochondria incubated with H(2) O(2) without Ca(2+) addition. Dose-dependent inhibition of H(2) O(2) elimination by Ca(2+) was detected, which was prevented by the Ca(2+) -uptake inhibitor Ru 360. Stimulation of Ca(2+) release from Ca(2+) -loaded mitochondria by a combined addition of Ru 360 and Na(+) decreased the Ca(2+) -evoked inhibition of H(2) O(2) removal. After Ca(2+) uptake (50 μM), mitochondrial aconitase activity was found to be decreased, which was partially attributable to the impaired elimination of endogenously produced reactive oxygen species. We found that the effects of Ca(2+) and H(2) O(2) on the activity of aconitase were additive. These results confirm that Ca(2+) inhibits elimination of H(2) O(2) in mitochondria and demonstrate that this effect is concentration dependent and reversible. The phenomenon described here can play a role in the modulation of ROS handling under conditions involving excessive cellular Ca(2+) load.
1 Bronchioloalveolar carcinoma is a form of adenocarcinoma. Its clinical presentation spans the e... more 1 Bronchioloalveolar carcinoma is a form of adenocarcinoma. Its clinical presentation spans the entire spectrum from asymptomatic solitary pulmonary nodule to full presentation with cough, hemoptysis and dyspnea. Clinical symptoms usually are in correlation with the extent of disease. The case we present here is a patient in late stage of disease with few symptoms regarding to the extent of disease involvement. This was a case report of a 53‑year‑old woman who admitted in Al‑Zahra Hospital due to chest X‑ray abnormality founded during evaluation of weight loss and headache [Figure 1]. There was no history of dyspnea, chills or fever. She just mentioned productive cough since about 6 months ago. History taking revealed neither inhalation exposure nor hemoptysis. Weight loss was about 15 kg during recent 3 months. Headache was in frontal region almost every day lasting about 30 min without any accompanying symptom. It has begun about 6 months ago. At admission time vital sign was as b...
selbständig verfasst, nur die angegebenen Quellen und Hilfsmittel benutzt und wörtlich oder inhal... more selbständig verfasst, nur die angegebenen Quellen und Hilfsmittel benutzt und wörtlich oder inhaltlichübernommene Stellen als solche gekennzeichnet habe. Ich versichere an Eides statt, dass diese Angaben wahr sind und dass ich nichts verschwiegen habe. Mir ist bekannt, dass die falsche Abgabe einer Versicherung an Eides statt mit Freiheitsstrafe bis zu drei Jahren oder mit Geldstrafe bestraft wird.
And to my wife Behnaz, who has given me her unequivocal support for which my mere expression of t... more And to my wife Behnaz, who has given me her unequivocal support for which my mere expression of thanks likewise does not suffice.
Journal of Neuroscience Research, 2011
In the present work, the Ca(2+) dependence of mitochondrial H(2) O(2) elimination was investigate... more In the present work, the Ca(2+) dependence of mitochondrial H(2) O(2) elimination was investigated. Mitochondria isolated from guinea pig brain were energized by glutamate and malate and incubated with micromolar concentrations of Ca(2+) in the presence of ADP, preventing permeability transition pore formation. After the completion of Ca(2+) uptake, mitochondria were challenged with H(2) O(2) (5 μM), then at various time points residual H(2) O(2) was determined using the Amplex red method and compared with that in mitochondria incubated with H(2) O(2) without Ca(2+) addition. Dose-dependent inhibition of H(2) O(2) elimination by Ca(2+) was detected, which was prevented by the Ca(2+) -uptake inhibitor Ru 360. Stimulation of Ca(2+) release from Ca(2+) -loaded mitochondria by a combined addition of Ru 360 and Na(+) decreased the Ca(2+) -evoked inhibition of H(2) O(2) removal. After Ca(2+) uptake (50 μM), mitochondrial aconitase activity was found to be decreased, which was partially attributable to the impaired elimination of endogenously produced reactive oxygen species. We found that the effects of Ca(2+) and H(2) O(2) on the activity of aconitase were additive. These results confirm that Ca(2+) inhibits elimination of H(2) O(2) in mitochondria and demonstrate that this effect is concentration dependent and reversible. The phenomenon described here can play a role in the modulation of ROS handling under conditions involving excessive cellular Ca(2+) load.
1 Bronchioloalveolar carcinoma is a form of adenocarcinoma. Its clinical presentation spans the e... more 1 Bronchioloalveolar carcinoma is a form of adenocarcinoma. Its clinical presentation spans the entire spectrum from asymptomatic solitary pulmonary nodule to full presentation with cough, hemoptysis and dyspnea. Clinical symptoms usually are in correlation with the extent of disease. The case we present here is a patient in late stage of disease with few symptoms regarding to the extent of disease involvement. This was a case report of a 53‑year‑old woman who admitted in Al‑Zahra Hospital due to chest X‑ray abnormality founded during evaluation of weight loss and headache [Figure 1]. There was no history of dyspnea, chills or fever. She just mentioned productive cough since about 6 months ago. History taking revealed neither inhalation exposure nor hemoptysis. Weight loss was about 15 kg during recent 3 months. Headache was in frontal region almost every day lasting about 30 min without any accompanying symptom. It has begun about 6 months ago. At admission time vital sign was as b...