M. Kuyumcu - Academia.edu (original) (raw)

Papers by M. Kuyumcu

European Geriatric Medicine, 2013

European review for medical and pharmacological sciences, 2013

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory diseases. Many seru... more Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory diseases. Many serum biomarkers have been studied for diagnosis and monitoring of disease activity in inflammatory bowel diseases (IBD). Platelets play an important role in inflammation. The aim of the present study is to determine whether platelet indices; mean platelet volume (MPV), platelet distribution width (PDW) and platelet-crit (PCT) would be useful, cheap, non-invasive biomarkers for following up and determining severity of IBD. The study group consisted of 175 patients with IBD (UC n: 103 and CD n: 72) and the control group included 40 healthy subjects. Disease activity was evaluated both by endoscope and clinically. Platelet indices and inflammatory parameters were measured for all study participants. Patients were checked in both active and remission phase of the diseases. In patients with active UC and CD, there was a statistically significant decrease in MPV, PDW levels and increase in PCT le...

European Journal of Clinical Nutrition, 2016

European Geriatric Medicine, 2016

European Geriatric Medicine, 2012

Introduction.-Though highly prevalent, the pathophysiology of orthostatic hypotension (OH), postp... more Introduction.-Though highly prevalent, the pathophysiology of orthostatic hypotension (OH), postprandial hypotension (PPH), and carotid sinus hypersensitivity (CSH) are rarely studied together. Therefore we conducted such a comprehensive study focusing on the common role of the cardiovascular autonomic system. We hypothesized that in geriatric patients, OH, PPH and CSH are manifestations of cardiovascular autonomic dysfunction, and investigated state of the art cardiovascular autonomic function indices in a group of geriatric falls or syncope patients. Methods.-In a retrospective cohort study of 242 consecutive eligible falls clinic patients, we compared heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) as potential autonomic function determinants of the three different hypotensive syndromes. Results.-OH, PPH and CSH were diagnosed in 129 of 239 (54%), 139 of 236 (59%) and 104 of 208 (50%) of patients, respectively. In a population relevant for geriatric practice, we found no differences in HRV, BPV and BRS between patients with and without OH, with and without PPH and with and without CSH, respectively, nor between patients with no versus one, two or three hypotensive syndromes. Conclusions.-In geriatric patients with hypotensive syndromes, cardiovascular autonomic function as measured by HRV, BPV, and BRS is comparable to patients without such syndromes. These findings argue against a single or dominant etiological factor, i.e. cardiac autonomic dysfunction and show that there is a need for a broader, multifactorial pathophysiological approach in understanding geriatric hypotensive syndromes. Disclosure.-No significant relationships.

European Geriatric Medicine, 2012

BACKGROUND: Zinc is one of the most important elements for human body. Zinc deficiency can occur ... more BACKGROUND: Zinc is one of the most important elements for human body. Zinc deficiency can occur in any age, if it is seen in elderly its clinical results can be more harmful due to already diminished functions. Some studies showed zinc deficiency has an important role in the pathogenesis of Alzheimer disease. In this study we measured the nail zinc levels and aimed to show its clinical implications in geriatric patients, especially Alzheimer disease. PATIENTS AND METHODS: 43 patients with Alzheimer disease and 89 patients with normal cognitive function were evaluated. The diagnosis of Alzheimer disease was made according to DSM-IV and NINCDS-ADRDA criteria after cognitive assessment and neuroimaging performed using magnetic resonance. Hand fingernail samples are obtained from the patients. RESULTS: Mean zinc level from fingernail samples was 117.99 ± 73.44 ppm in Alzheimer Disease patients, 123.86 ± 77.98 ppm in control group (p: 0.680). CONCLUSIONS: This is the first study measuring nail zinc levels in elderly patients with and without Alzheimer disease. Our data reveal no significant difference in nail zinc levels between two groups. However, fingernail zinc may be a useful biomarker in elderly population.

Archives of Gerontology and Geriatrics, 2015

This paper deals with the development of a control design model for a 1MW Solar Tower equipped wi... more This paper deals with the development of a control design model for a 1MW Solar Tower equipped with a heat storage facility. This model is precise enough to achieve a good prediction of the responses but is also simple enough to avoid computational burden. The paper presents the assumptions and equations used for the different components of the plant. The behavior of the model developed in Matlab/Simulink tm is qualitatively validated by closed loop simulations. The control used for these simulations is also given. It consists of two levels, the upper level being an automaton whose outputs are the set points of the lower level controllers.

European Geriatric Medicine, 2013

European Geriatric Medicine, 2012

European Geriatric Medicine, 2012

Metabolic bone disorders are very common in the elderly population. As fingernail clippings are e... more Metabolic bone disorders are very common in the elderly population. As fingernail clippings are easily available for analysis, this makes them an interesting screening instrument for stored mineral components in the body. Measurements of calcium concentrations in fingernail clippings are thought to give some insight into their value as an alternative screening test for metabolic bone disorders and our aim was to determine whether fingernail calcium concentrations could be used for this purpose. Patients and methods: This is a cross-sectional study, carried out in a Geriatric medicine outpatient clinic of a university hospital. A total of 159 patients with a mean age of 72.1 AE 5.8 years were involved. Fingernail calcium levels were analyzed with atomic absorption spectrophotometry. Results: There was no statistically significant difference in nail calcium levels between osteoporotic and non-osteoporotic patients and similarly between vitamin D deficient and normal patients. The correlation between nail calcium concentrations and femur neck t-score and serum 25-OH vitamin D levels was very weak and non-significant. Conclusion: We found no change in nail calcium concentrations in osteoporosis and vitamin D deficiency, and therefore nail calcium measurements do not seem to be a good alternative screening instrument for metabolic bone disorders in the elderly.

European Geriatric Medicine, 2014

Introduction: Among elderly patients vaccination rates are known to be very low. Elderly patients... more Introduction: Among elderly patients vaccination rates are known to be very low. Elderly patients are particularly vulnarable to influenza and pneumococcal infections. These infections may be associated with high morbidity and mortality. Vaccination is an affective method to prevent these diseases. The aim of this study was to assess vaccination knowledge, perception and coverage among geriatric population. Methods: Three hundred seventy-four elderly subjects were included. Comprehensive geriatric assessment were administered. Demographic charactereistics and chronic illnesses were noted. SPSS 15 version was used for statistical analysis. Results: Among these patients influenza coverage was 28.3% (106), pneumococcal coverage was 11% (41), tetanus coverage was 2.1% (8). Among males, the percentage of influenza vaccination was 29.3%, pneumococcal vaccination was 11.4%, tetanus vaccination was 0.7%; among females vaccination percentages were 27.8%, 10.7%, 3% respectively. The difference between gender was no statisticaly insignificant. There were significantly difference between vaccination proportions according to education levels of patients. Although there was no significant differance between subject with and without influenza vaccination according to comprehensive geriatric assessment tests, subjects with pneumococcal vaccination had significantly higher mini-mental state examination test and mini-nutritional assessment-short form test scores compared to subjects without pneumococcal vaccination. Conclusions: Inspite of increased education and knowledge, vaccination rates among elderly population are still to low. Efforts should be improved to increase vaccination rates to tackle preventable diseases.

European Geriatric Medicine, 2012

European Geriatric Medicine, 2014

European Geriatric Medicine, 2013

Nephro-Urology Monthly, 2014

Background: Chronic kidney disease can lead to sarcopenia; however, no study has described sarcop... more Background: Chronic kidney disease can lead to sarcopenia; however, no study has described sarcopenia in the patients undergoing renal transplantation. Objectives: The aim of the present study was to assess the prevalence of sarcopenia in renal transplant recipients (RTR) and to evaluate the demographic and metabolic risk factors associated with sarcopenia in these patients. Patients and Methods: Sarcopenia was diagnosed by measuring handgrip strength in 166 RTR (68 females and 98 males; mean age, 37.9 ± 11.9 years). Basal metabolic rate, fat mass, free-fat mass, total body water, body mass index, and calf circumference were determined, along with blood biochemistry, vitamin D levels, and glomerular filtration rate. Results: Among 166 patients, sarcopenia was present in 34 (20.5%). Handgrip, basal metabolic rate, free fat mass, and total body water were significantly lower in patients with sarcopenia in comparison with those without sarcopenia. There were no differences between patients with and without sarcopenia in terms of mean time since transplantation, the presence of diabetes mellitus, hypertension, coronary artery disease, hyperlipidemia, glomerular filtration rate, and body mass index. Univariate analysis revealed significant differences between patients with and without sarcopenia with respect to age (mean of 43.70 ± 13.97 and 36.37 ± 10.82 years, respectively; P = 0.007) and 25-OH vitamin D levels (median (IQR) of 12 (2-39) and 17.70 (3-68) μg/L, respectively; P = 0.024). There was a statistically significant positive correlation between vitamin D levels and handgrip strength (r = 0.334; P < 0.001). Multivariate regression analysis determined that age was an independent predictive variable of sarcopenia in RTR (β = 1.060; 95% CI, 1.017-1.105; and P = 0.006). Conclusions: Chronic renal disease contributes to sarcopenia, which may develop at an earlier age in RTR.

European Geriatric Medicine, 2013

P604 Effect of cholinesterase inhibitors on the long-term course of cognition in patients with Al... more P604 Effect of cholinesterase inhibitors on the long-term course of cognition in patients with Alzheimer’s disease treated in a ‘real-life’ clinical setting: Results from The Frisian Alzheimer’s Disease Cohort Study E. Droogsma , M. Diekhuis , N. Veeger , P. van Walderveen , E. Huinink , C. van der Hooft , D. van Asselt Department of Geriatric Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands

European Geriatric Medicine, 2013

all included patients and subgroups. Determination of predictors was done by multivariable binary... more all included patients and subgroups. Determination of predictors was done by multivariable binary logistic regression. Results.– Four hundred and forty-two people aged 75 years or older were included in the study, 73.5% (n=325) were admitted to the hospital, of which 35.1% (n=114) were admitted to an acute geriatric ward. Of the patients being discharged from the ED, 26.5% (31/117) had an unplanned ED revisit within 3 months. Nursing care at home (OR 4.63, 95% CI 1.45–14.77) and depression (OR 3.91, 95% CI 1.16–13.19) were found to be independent predictors for unplanned ED readmission in the multivariable analysis. A significant trend was found for falls in the last year (OR 2.99, 95% CI 0.95–9.37). Conclusion.–This study confirms thehigh readmission rates of older persons being discharged from the ED and suggests the potential value ofmultidisciplinary, psychosocial and functional assessment, interventions and follow-up to avoid early-unplanned ED readmissions.

European Journal of Clinical Nutrition, 2014

BACKGROUND/OBJECTIVES: Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to ... more BACKGROUND/OBJECTIVES: Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to physical disability, poor quality of life and death. The aim of this study was to investigate the prevalence of sarcopenia and SO in nursing homes in Turkey and to define local disparities for diagnosing sarcopenia and SO. SUBJECTS/METHODS: This cross-sectional multicenter study was performed in 711 patients in 14 nursing homes. Comprehensive geriatric assessment tests, handgrip strength and calf circumference (CC) measurements were carried out. Sarcopenia was both defined by handgrip strength and CC criteria. RESULTS: According to handgrip strength measurement, 483 (68%) of patients were sarcopenic (male: 72%, female: 63.8%), 228 were non-sarcopenic. The prevalence of SO was 22% (13.7% in men, 30.2% in women). Patients (82.5%) who were diagnosed as sarcopenic by the handgrip strength test were not sarcopenic according to CC sarcopenia criteria. Therefore, we tried to determine the optimal CC value for diagnosing sarcopenia in our population. CONCLUSIONS: Both sarcopenia and SO were prevalent among Turkish nursing home elderly residents. Most of the patients with sarcopenia were obese or overweight. We showed that diagnosing sarcopenia with CC measurement underestimated the sarcopenia prevalence assessed by handgrip strength. So we concluded that, although different assessment methods are recommended for the diagnosis of sarcopenia local disparities should be considered.

European Geriatric Medicine, 2013

European review for medical and pharmacological sciences, 2013

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory diseases. Many seru... more Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory diseases. Many serum biomarkers have been studied for diagnosis and monitoring of disease activity in inflammatory bowel diseases (IBD). Platelets play an important role in inflammation. The aim of the present study is to determine whether platelet indices; mean platelet volume (MPV), platelet distribution width (PDW) and platelet-crit (PCT) would be useful, cheap, non-invasive biomarkers for following up and determining severity of IBD. The study group consisted of 175 patients with IBD (UC n: 103 and CD n: 72) and the control group included 40 healthy subjects. Disease activity was evaluated both by endoscope and clinically. Platelet indices and inflammatory parameters were measured for all study participants. Patients were checked in both active and remission phase of the diseases. In patients with active UC and CD, there was a statistically significant decrease in MPV, PDW levels and increase in PCT le...

European Journal of Clinical Nutrition, 2016

European Geriatric Medicine, 2016

European Geriatric Medicine, 2012

Introduction.-Though highly prevalent, the pathophysiology of orthostatic hypotension (OH), postp... more Introduction.-Though highly prevalent, the pathophysiology of orthostatic hypotension (OH), postprandial hypotension (PPH), and carotid sinus hypersensitivity (CSH) are rarely studied together. Therefore we conducted such a comprehensive study focusing on the common role of the cardiovascular autonomic system. We hypothesized that in geriatric patients, OH, PPH and CSH are manifestations of cardiovascular autonomic dysfunction, and investigated state of the art cardiovascular autonomic function indices in a group of geriatric falls or syncope patients. Methods.-In a retrospective cohort study of 242 consecutive eligible falls clinic patients, we compared heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) as potential autonomic function determinants of the three different hypotensive syndromes. Results.-OH, PPH and CSH were diagnosed in 129 of 239 (54%), 139 of 236 (59%) and 104 of 208 (50%) of patients, respectively. In a population relevant for geriatric practice, we found no differences in HRV, BPV and BRS between patients with and without OH, with and without PPH and with and without CSH, respectively, nor between patients with no versus one, two or three hypotensive syndromes. Conclusions.-In geriatric patients with hypotensive syndromes, cardiovascular autonomic function as measured by HRV, BPV, and BRS is comparable to patients without such syndromes. These findings argue against a single or dominant etiological factor, i.e. cardiac autonomic dysfunction and show that there is a need for a broader, multifactorial pathophysiological approach in understanding geriatric hypotensive syndromes. Disclosure.-No significant relationships.

European Geriatric Medicine, 2012

BACKGROUND: Zinc is one of the most important elements for human body. Zinc deficiency can occur ... more BACKGROUND: Zinc is one of the most important elements for human body. Zinc deficiency can occur in any age, if it is seen in elderly its clinical results can be more harmful due to already diminished functions. Some studies showed zinc deficiency has an important role in the pathogenesis of Alzheimer disease. In this study we measured the nail zinc levels and aimed to show its clinical implications in geriatric patients, especially Alzheimer disease. PATIENTS AND METHODS: 43 patients with Alzheimer disease and 89 patients with normal cognitive function were evaluated. The diagnosis of Alzheimer disease was made according to DSM-IV and NINCDS-ADRDA criteria after cognitive assessment and neuroimaging performed using magnetic resonance. Hand fingernail samples are obtained from the patients. RESULTS: Mean zinc level from fingernail samples was 117.99 ± 73.44 ppm in Alzheimer Disease patients, 123.86 ± 77.98 ppm in control group (p: 0.680). CONCLUSIONS: This is the first study measuring nail zinc levels in elderly patients with and without Alzheimer disease. Our data reveal no significant difference in nail zinc levels between two groups. However, fingernail zinc may be a useful biomarker in elderly population.

Archives of Gerontology and Geriatrics, 2015

This paper deals with the development of a control design model for a 1MW Solar Tower equipped wi... more This paper deals with the development of a control design model for a 1MW Solar Tower equipped with a heat storage facility. This model is precise enough to achieve a good prediction of the responses but is also simple enough to avoid computational burden. The paper presents the assumptions and equations used for the different components of the plant. The behavior of the model developed in Matlab/Simulink tm is qualitatively validated by closed loop simulations. The control used for these simulations is also given. It consists of two levels, the upper level being an automaton whose outputs are the set points of the lower level controllers.

European Geriatric Medicine, 2013

European Geriatric Medicine, 2012

European Geriatric Medicine, 2012

Metabolic bone disorders are very common in the elderly population. As fingernail clippings are e... more Metabolic bone disorders are very common in the elderly population. As fingernail clippings are easily available for analysis, this makes them an interesting screening instrument for stored mineral components in the body. Measurements of calcium concentrations in fingernail clippings are thought to give some insight into their value as an alternative screening test for metabolic bone disorders and our aim was to determine whether fingernail calcium concentrations could be used for this purpose. Patients and methods: This is a cross-sectional study, carried out in a Geriatric medicine outpatient clinic of a university hospital. A total of 159 patients with a mean age of 72.1 AE 5.8 years were involved. Fingernail calcium levels were analyzed with atomic absorption spectrophotometry. Results: There was no statistically significant difference in nail calcium levels between osteoporotic and non-osteoporotic patients and similarly between vitamin D deficient and normal patients. The correlation between nail calcium concentrations and femur neck t-score and serum 25-OH vitamin D levels was very weak and non-significant. Conclusion: We found no change in nail calcium concentrations in osteoporosis and vitamin D deficiency, and therefore nail calcium measurements do not seem to be a good alternative screening instrument for metabolic bone disorders in the elderly.

European Geriatric Medicine, 2014

Introduction: Among elderly patients vaccination rates are known to be very low. Elderly patients... more Introduction: Among elderly patients vaccination rates are known to be very low. Elderly patients are particularly vulnarable to influenza and pneumococcal infections. These infections may be associated with high morbidity and mortality. Vaccination is an affective method to prevent these diseases. The aim of this study was to assess vaccination knowledge, perception and coverage among geriatric population. Methods: Three hundred seventy-four elderly subjects were included. Comprehensive geriatric assessment were administered. Demographic charactereistics and chronic illnesses were noted. SPSS 15 version was used for statistical analysis. Results: Among these patients influenza coverage was 28.3% (106), pneumococcal coverage was 11% (41), tetanus coverage was 2.1% (8). Among males, the percentage of influenza vaccination was 29.3%, pneumococcal vaccination was 11.4%, tetanus vaccination was 0.7%; among females vaccination percentages were 27.8%, 10.7%, 3% respectively. The difference between gender was no statisticaly insignificant. There were significantly difference between vaccination proportions according to education levels of patients. Although there was no significant differance between subject with and without influenza vaccination according to comprehensive geriatric assessment tests, subjects with pneumococcal vaccination had significantly higher mini-mental state examination test and mini-nutritional assessment-short form test scores compared to subjects without pneumococcal vaccination. Conclusions: Inspite of increased education and knowledge, vaccination rates among elderly population are still to low. Efforts should be improved to increase vaccination rates to tackle preventable diseases.

European Geriatric Medicine, 2012

European Geriatric Medicine, 2014

European Geriatric Medicine, 2013

Nephro-Urology Monthly, 2014

Background: Chronic kidney disease can lead to sarcopenia; however, no study has described sarcop... more Background: Chronic kidney disease can lead to sarcopenia; however, no study has described sarcopenia in the patients undergoing renal transplantation. Objectives: The aim of the present study was to assess the prevalence of sarcopenia in renal transplant recipients (RTR) and to evaluate the demographic and metabolic risk factors associated with sarcopenia in these patients. Patients and Methods: Sarcopenia was diagnosed by measuring handgrip strength in 166 RTR (68 females and 98 males; mean age, 37.9 ± 11.9 years). Basal metabolic rate, fat mass, free-fat mass, total body water, body mass index, and calf circumference were determined, along with blood biochemistry, vitamin D levels, and glomerular filtration rate. Results: Among 166 patients, sarcopenia was present in 34 (20.5%). Handgrip, basal metabolic rate, free fat mass, and total body water were significantly lower in patients with sarcopenia in comparison with those without sarcopenia. There were no differences between patients with and without sarcopenia in terms of mean time since transplantation, the presence of diabetes mellitus, hypertension, coronary artery disease, hyperlipidemia, glomerular filtration rate, and body mass index. Univariate analysis revealed significant differences between patients with and without sarcopenia with respect to age (mean of 43.70 ± 13.97 and 36.37 ± 10.82 years, respectively; P = 0.007) and 25-OH vitamin D levels (median (IQR) of 12 (2-39) and 17.70 (3-68) μg/L, respectively; P = 0.024). There was a statistically significant positive correlation between vitamin D levels and handgrip strength (r = 0.334; P < 0.001). Multivariate regression analysis determined that age was an independent predictive variable of sarcopenia in RTR (β = 1.060; 95% CI, 1.017-1.105; and P = 0.006). Conclusions: Chronic renal disease contributes to sarcopenia, which may develop at an earlier age in RTR.

European Geriatric Medicine, 2013

P604 Effect of cholinesterase inhibitors on the long-term course of cognition in patients with Al... more P604 Effect of cholinesterase inhibitors on the long-term course of cognition in patients with Alzheimer’s disease treated in a ‘real-life’ clinical setting: Results from The Frisian Alzheimer’s Disease Cohort Study E. Droogsma , M. Diekhuis , N. Veeger , P. van Walderveen , E. Huinink , C. van der Hooft , D. van Asselt Department of Geriatric Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands

European Geriatric Medicine, 2013

all included patients and subgroups. Determination of predictors was done by multivariable binary... more all included patients and subgroups. Determination of predictors was done by multivariable binary logistic regression. Results.– Four hundred and forty-two people aged 75 years or older were included in the study, 73.5% (n=325) were admitted to the hospital, of which 35.1% (n=114) were admitted to an acute geriatric ward. Of the patients being discharged from the ED, 26.5% (31/117) had an unplanned ED revisit within 3 months. Nursing care at home (OR 4.63, 95% CI 1.45–14.77) and depression (OR 3.91, 95% CI 1.16–13.19) were found to be independent predictors for unplanned ED readmission in the multivariable analysis. A significant trend was found for falls in the last year (OR 2.99, 95% CI 0.95–9.37). Conclusion.–This study confirms thehigh readmission rates of older persons being discharged from the ED and suggests the potential value ofmultidisciplinary, psychosocial and functional assessment, interventions and follow-up to avoid early-unplanned ED readmissions.

European Journal of Clinical Nutrition, 2014

BACKGROUND/OBJECTIVES: Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to ... more BACKGROUND/OBJECTIVES: Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to physical disability, poor quality of life and death. The aim of this study was to investigate the prevalence of sarcopenia and SO in nursing homes in Turkey and to define local disparities for diagnosing sarcopenia and SO. SUBJECTS/METHODS: This cross-sectional multicenter study was performed in 711 patients in 14 nursing homes. Comprehensive geriatric assessment tests, handgrip strength and calf circumference (CC) measurements were carried out. Sarcopenia was both defined by handgrip strength and CC criteria. RESULTS: According to handgrip strength measurement, 483 (68%) of patients were sarcopenic (male: 72%, female: 63.8%), 228 were non-sarcopenic. The prevalence of SO was 22% (13.7% in men, 30.2% in women). Patients (82.5%) who were diagnosed as sarcopenic by the handgrip strength test were not sarcopenic according to CC sarcopenia criteria. Therefore, we tried to determine the optimal CC value for diagnosing sarcopenia in our population. CONCLUSIONS: Both sarcopenia and SO were prevalent among Turkish nursing home elderly residents. Most of the patients with sarcopenia were obese or overweight. We showed that diagnosing sarcopenia with CC measurement underestimated the sarcopenia prevalence assessed by handgrip strength. So we concluded that, although different assessment methods are recommended for the diagnosis of sarcopenia local disparities should be considered.