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Papers by M. Lawson-smith

Research paper thumbnail of Cord compression secondary to intradural ossification

Journal of Clinical Neuroscience, 2006

The authors describe two patients presenting with a previous history of spinal trauma and a sever... more The authors describe two patients presenting with a previous history of spinal trauma and a several-year history of sensory changes secondary to spinal cord compression. Both patients underwent laminectomy and spinal decompression operations. In both cases intradural bone causing neural compression was removed at operation. Potential mechanisms to explain intradural ossification and the relevant literature are reviewed.

Research paper thumbnail of Biomechanisches Potential winkelstabiler Marknagelverriegelung bei distalen Tibiafrakturen

Research paper thumbnail of Do partial thickness, bursal side cuff tears affect outcome following arthroscopic subacromial decompression? A prospective comparative cohort study

Shoulder & Elbow, 2014

Background: The present study aimed to compare medium-term clinical outcomes of patients followin... more Background: The present study aimed to compare medium-term clinical outcomes of patients following arthroscopic subacromial decompression (ASAD): those with intact rotator cuff with two groups of increasing size of partial thickness bursal-side tears. Methods: Patients undergoing shoulder arthroscopy by a single surgeon had pre- and postoperative Constant scores prospectively recorded. Arthroscopic surgery included the assessment of any supraspinatus tears using the Ellman criteria, as well as ASAD and cuff debridement. Groups were created based on the status of rotator cuff and size of bursal tear. Outcome in these patient groups was then compared and analyzed Results: Seventy-four patients were suitable for inclusion in the study: 32 patients without a cuff tear; 21 patients with a cuff tear of 9 mm or less in length; and 21 patients with a cuff tear of 10 mm or more in length. Baseline characteristics of the three groups were similar. All three groups showed a significant improve...

Research paper thumbnail of Implant survivorship and clinical outcomes of the Bigliani-Flatow shoulder prosthesis at a mean of five years: A post-marketing surveillance study from three centres

Journal of Arthroscopy and Joint Surgery, 2015

ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generati... more ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generation shoulder prosthesis [Bigliani-Flatow (BF)], comparing BF total shoulder arthroplasty (TSA) versus hemiarthroplasty (HA); and cemented versus uncemented implantation.

Research paper thumbnail of Experimental skeletal muscle grafts as a model of regeneration

Australian and New Zealand Journal of Surgery, 1997

It is now well established that mature skeletal muscle has the ability to regenerate, and reports... more It is now well established that mature skeletal muscle has the ability to regenerate, and reports on this phenomenon have existed in the research literature for some 40 years. However, it is only relatively recently, largely due to the advances in microsurgery, that practising surgeons can make direct use of the regenerative ability of skeletal muscle. Most of the key data on skeletal muscle regeneration have come from experimental studies on muscle grafts in small animal models. One such model is the transplantation of the extensor digitorum muscle of the mouse or rat into the contralateral site, or the relocation of this muscle onto the surface of the tibialis anterior muscle. These and other models, together with the important cellular mechanisms involved in the regeneration of skeletal muscle, are reviewed briefly in this article. Skeletal muscle cells regenerate rapidly in muscle grafts, arising from satellite cells in the surviving peripheral fibres of the graft within 2 days ...

Research paper thumbnail of Lateral medullary syndrome caused by penetrating head injury

Journal of Clinical Neuroscience, 2006

Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low vel... more Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low velocity penetrating head injuries may be occult and are associated with a high incidence of vascular injury.

Research paper thumbnail of Lateral medullary syndrome caused by penetrating head injury

Journal of Clinical Neuroscience, Aug 31, 2006

Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low vel... more Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low velocity penetrating head injuries may be occult and are associated with a high incidence of vascular injury.

Research paper thumbnail of The identification of myogenic cells in skeletal muscle, with emphasis on the use of tritiated thymidine autoradiography and desmin antibodies

Journal of Anatomy, 1998

The identification of myogenic precursor cells (mpc) is a key factor in determining the early eve... more The identification of myogenic precursor cells (mpc) is a key factor in determining the early events in the myogenesis and regeneration of skeletal muscle. Although satellite cells have long been established as the providers of myoblastic cells, very little is really known (apart from their anatomical location in relation to muscle fibres and their ability to migrate) about the precise role of satellite cells in myogenesis. Numerous techniques for labelling mpc have been devised, but none of these has proven to be completely reliable in firmly establishing the origin of myogenic cells. The use of tritiated thymidine to label DNA in proliferating mpc (which are not specifically distinguishable at the time) and the subsequent location of their labelled progeny in myotube nuclei has revealed a great deal of data on the timing of myogenesis, but not about the nature of mpc themselves. DNA synthesis can also be detected by antibodies to the thymidine analogue, bromodeoxyuridine, and also by antibody staining for proliferating nuclear cell antigen. Like tritiated thymidine, these other markers are not specific for muscle but are general markers for DNA synthesis. In situ hybridisation of various muscle-specific genetic markers and their products has been informative, as has immunolabelling of myogenin, MyoD1 and desmin. Desmin labelling has been particularly instructive in identifying mpc because it is one of the first muscle-specific proteins to be produced in mpc. This review covers some of the techniques mentioned above and their usefulness in determining the early events in myogenesis.

Research paper thumbnail of Laparoscopic subtotal cholecystectomy without cystic duct ligation

British Journal of Surgery, 2007

Background Cholecystectomy is made hazardous by distortion of the anatomy of Calot's triangle... more Background Cholecystectomy is made hazardous by distortion of the anatomy of Calot's triangle by acute or chronic inflammation. Laparoscopic subtotal cholecystectomy (LSTC) without cystic duct ligation is an alternative to conversion to open surgery in difficult cases. Methods This prospective study included all cholecystectomies performed in a district general hospital upper gastrointestinal unit between 2003 and 2005, after the introduction of LSTC. Results Of 889 laparoscopic cholecystectomies, 28 LSTCs without cystic duct ligation were performed in 18 men and ten women of median age 68 years. Median operating time was 90 min and median duration of hospital stay was 3 days. Two temporary bile leaks resolved spontaneously on days 14 and 19. Three patients required endoscopic retrograde cholangiopancreatography, extraction of bile duct stones and stent insertion for persistent leaks. All five bile leaks were expected from peroperative findings. One patient had a myocardial infa...

Research paper thumbnail of Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history

British Journal of Neurosurgery, 2004

Research paper thumbnail of Implant survivorship and clinical outcomes of the Bigliani-Flatow shoulder prosthesis at a mean of five years: A post-marketing surveillance study from three centres

Journal of Arthroscopy and Joint Surgery, 2015

ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generati... more ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generation shoulder prosthesis [Bigliani-Flatow (BF)], comparing BF total shoulder arthroplasty (TSA) versus hemiarthroplasty (HA); and cemented versus uncemented implantation.

Research paper thumbnail of Combined fascia and mesh repair of incisional hernias

Hernia : the journal of hernias and abdominal wall surgery, 2006

Incisional hernia is a relatively common complication following abdominal operations. Due to high... more Incisional hernia is a relatively common complication following abdominal operations. Due to high recurrence rates following primary suture, a prosthetic mesh is now usually used to repair the hernia. Several different types of repair are described. A combined fascia and mesh technique avoids opening the peritoneal cavity and potential damage to bowel. This study describes results of this technique. Consecutive patients undergoing the operation were contacted to assess freedom from recurrence and satisfaction with results. Some 34 patients underwent 36 incisional repairs. Of the 34 patients 21 were men and 13 were women with a median age of 69 years (range 31-86 years). The causative incisions were midline (30), Kochers (2), Pfannesteil (2) and transverse (2). The median time spent in hospital was three nights (range 1-14 days). Two patients developed seromas, another complained of pain soon after operation, one patient developed a superficial wound infection another developed a ten...

Research paper thumbnail of Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history

British Journal of Neurosurgery, 2004

Research paper thumbnail of Do partial thickness, bursal side cuff tears affect outcome following arthroscopic subacromial decompression? A prospective comparative cohort study

Shoulder & Elbow, 2014

ABSTRACT Background: The present study aimed to compare medium-term clinical outcomes of patients... more ABSTRACT Background: The present study aimed to compare medium-term clinical outcomes of patients following arthroscopic subacromial decompression (ASAD): those with intact rotator cuff with two groups of increasing size of partial thickness bursal-side tears.

Research paper thumbnail of Cord compression secondary to intradural ossification

Journal of Clinical Neuroscience, 2006

The authors describe two patients presenting with a previous history of spinal trauma and a sever... more The authors describe two patients presenting with a previous history of spinal trauma and a several-year history of sensory changes secondary to spinal cord compression. Both patients underwent laminectomy and spinal decompression operations. In both cases intradural bone causing neural compression was removed at operation. Potential mechanisms to explain intradural ossification and the relevant literature are reviewed.

Research paper thumbnail of Biomechanisches Potential winkelstabiler Marknagelverriegelung bei distalen Tibiafrakturen

Research paper thumbnail of Do partial thickness, bursal side cuff tears affect outcome following arthroscopic subacromial decompression? A prospective comparative cohort study

Shoulder & Elbow, 2014

Background: The present study aimed to compare medium-term clinical outcomes of patients followin... more Background: The present study aimed to compare medium-term clinical outcomes of patients following arthroscopic subacromial decompression (ASAD): those with intact rotator cuff with two groups of increasing size of partial thickness bursal-side tears. Methods: Patients undergoing shoulder arthroscopy by a single surgeon had pre- and postoperative Constant scores prospectively recorded. Arthroscopic surgery included the assessment of any supraspinatus tears using the Ellman criteria, as well as ASAD and cuff debridement. Groups were created based on the status of rotator cuff and size of bursal tear. Outcome in these patient groups was then compared and analyzed Results: Seventy-four patients were suitable for inclusion in the study: 32 patients without a cuff tear; 21 patients with a cuff tear of 9 mm or less in length; and 21 patients with a cuff tear of 10 mm or more in length. Baseline characteristics of the three groups were similar. All three groups showed a significant improve...

Research paper thumbnail of Implant survivorship and clinical outcomes of the Bigliani-Flatow shoulder prosthesis at a mean of five years: A post-marketing surveillance study from three centres

Journal of Arthroscopy and Joint Surgery, 2015

ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generati... more ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generation shoulder prosthesis [Bigliani-Flatow (BF)], comparing BF total shoulder arthroplasty (TSA) versus hemiarthroplasty (HA); and cemented versus uncemented implantation.

Research paper thumbnail of Experimental skeletal muscle grafts as a model of regeneration

Australian and New Zealand Journal of Surgery, 1997

It is now well established that mature skeletal muscle has the ability to regenerate, and reports... more It is now well established that mature skeletal muscle has the ability to regenerate, and reports on this phenomenon have existed in the research literature for some 40 years. However, it is only relatively recently, largely due to the advances in microsurgery, that practising surgeons can make direct use of the regenerative ability of skeletal muscle. Most of the key data on skeletal muscle regeneration have come from experimental studies on muscle grafts in small animal models. One such model is the transplantation of the extensor digitorum muscle of the mouse or rat into the contralateral site, or the relocation of this muscle onto the surface of the tibialis anterior muscle. These and other models, together with the important cellular mechanisms involved in the regeneration of skeletal muscle, are reviewed briefly in this article. Skeletal muscle cells regenerate rapidly in muscle grafts, arising from satellite cells in the surviving peripheral fibres of the graft within 2 days ...

Research paper thumbnail of Lateral medullary syndrome caused by penetrating head injury

Journal of Clinical Neuroscience, 2006

Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low vel... more Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low velocity penetrating head injuries may be occult and are associated with a high incidence of vascular injury.

Research paper thumbnail of Lateral medullary syndrome caused by penetrating head injury

Journal of Clinical Neuroscience, Aug 31, 2006

Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low vel... more Herein, we report a rare case of a patient surviving penetrating trauma to the brainstem. Low velocity penetrating head injuries may be occult and are associated with a high incidence of vascular injury.

Research paper thumbnail of The identification of myogenic cells in skeletal muscle, with emphasis on the use of tritiated thymidine autoradiography and desmin antibodies

Journal of Anatomy, 1998

The identification of myogenic precursor cells (mpc) is a key factor in determining the early eve... more The identification of myogenic precursor cells (mpc) is a key factor in determining the early events in the myogenesis and regeneration of skeletal muscle. Although satellite cells have long been established as the providers of myoblastic cells, very little is really known (apart from their anatomical location in relation to muscle fibres and their ability to migrate) about the precise role of satellite cells in myogenesis. Numerous techniques for labelling mpc have been devised, but none of these has proven to be completely reliable in firmly establishing the origin of myogenic cells. The use of tritiated thymidine to label DNA in proliferating mpc (which are not specifically distinguishable at the time) and the subsequent location of their labelled progeny in myotube nuclei has revealed a great deal of data on the timing of myogenesis, but not about the nature of mpc themselves. DNA synthesis can also be detected by antibodies to the thymidine analogue, bromodeoxyuridine, and also by antibody staining for proliferating nuclear cell antigen. Like tritiated thymidine, these other markers are not specific for muscle but are general markers for DNA synthesis. In situ hybridisation of various muscle-specific genetic markers and their products has been informative, as has immunolabelling of myogenin, MyoD1 and desmin. Desmin labelling has been particularly instructive in identifying mpc because it is one of the first muscle-specific proteins to be produced in mpc. This review covers some of the techniques mentioned above and their usefulness in determining the early events in myogenesis.

Research paper thumbnail of Laparoscopic subtotal cholecystectomy without cystic duct ligation

British Journal of Surgery, 2007

Background Cholecystectomy is made hazardous by distortion of the anatomy of Calot's triangle... more Background Cholecystectomy is made hazardous by distortion of the anatomy of Calot's triangle by acute or chronic inflammation. Laparoscopic subtotal cholecystectomy (LSTC) without cystic duct ligation is an alternative to conversion to open surgery in difficult cases. Methods This prospective study included all cholecystectomies performed in a district general hospital upper gastrointestinal unit between 2003 and 2005, after the introduction of LSTC. Results Of 889 laparoscopic cholecystectomies, 28 LSTCs without cystic duct ligation were performed in 18 men and ten women of median age 68 years. Median operating time was 90 min and median duration of hospital stay was 3 days. Two temporary bile leaks resolved spontaneously on days 14 and 19. Three patients required endoscopic retrograde cholangiopancreatography, extraction of bile duct stones and stent insertion for persistent leaks. All five bile leaks were expected from peroperative findings. One patient had a myocardial infa...

Research paper thumbnail of Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history

British Journal of Neurosurgery, 2004

Research paper thumbnail of Implant survivorship and clinical outcomes of the Bigliani-Flatow shoulder prosthesis at a mean of five years: A post-marketing surveillance study from three centres

Journal of Arthroscopy and Joint Surgery, 2015

ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generati... more ABSTRACT This is the first study to report survivorship and clinical outcomes of a third generation shoulder prosthesis [Bigliani-Flatow (BF)], comparing BF total shoulder arthroplasty (TSA) versus hemiarthroplasty (HA); and cemented versus uncemented implantation.

Research paper thumbnail of Combined fascia and mesh repair of incisional hernias

Hernia : the journal of hernias and abdominal wall surgery, 2006

Incisional hernia is a relatively common complication following abdominal operations. Due to high... more Incisional hernia is a relatively common complication following abdominal operations. Due to high recurrence rates following primary suture, a prosthetic mesh is now usually used to repair the hernia. Several different types of repair are described. A combined fascia and mesh technique avoids opening the peritoneal cavity and potential damage to bowel. This study describes results of this technique. Consecutive patients undergoing the operation were contacted to assess freedom from recurrence and satisfaction with results. Some 34 patients underwent 36 incisional repairs. Of the 34 patients 21 were men and 13 were women with a median age of 69 years (range 31-86 years). The causative incisions were midline (30), Kochers (2), Pfannesteil (2) and transverse (2). The median time spent in hospital was three nights (range 1-14 days). Two patients developed seromas, another complained of pain soon after operation, one patient developed a superficial wound infection another developed a ten...

Research paper thumbnail of Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history

British Journal of Neurosurgery, 2004

Research paper thumbnail of Do partial thickness, bursal side cuff tears affect outcome following arthroscopic subacromial decompression? A prospective comparative cohort study

Shoulder & Elbow, 2014

ABSTRACT Background: The present study aimed to compare medium-term clinical outcomes of patients... more ABSTRACT Background: The present study aimed to compare medium-term clinical outcomes of patients following arthroscopic subacromial decompression (ASAD): those with intact rotator cuff with two groups of increasing size of partial thickness bursal-side tears.