Majid Mohammadhosseini - Academia.edu (original) (raw)

Papers by Majid Mohammadhosseini

Research paper thumbnail of Journal of Chemical Health Risks

A surface molecularly imprinted dispersive solid phase extraction coupled with liquid chromatogra... more A surface molecularly imprinted dispersive solid phase extraction coupled with liquid chromatography-ultraviolet detection is proposed as a selective and fast clean-up technique for the determination of sertraline in biological sample. Surface sertraline-molecular imprinted polymer was grafted and synthesized on the SiO 2 /graphene oxide surface. Firstly SiO 2 was coated on synthesized graphene oxide sheet using sol-gel technique. Prior to polymerization, the vinyl group was incorporated on to the surface of SiO 2 /graphene oxide to direct selective polymerization on the surface. Methacrylic acid, ethylene glycol dimethacrylate and ethanol were used as monomer, cross-linker and progen, respectively. Non-imprinted polymer was also prepared for comparing purposes. The properties of the molecular imprinted polymer were characterized using field emission-scanning electron microscopy and Fourier transform infrared spectroscopy methods. The surface molecular imprinted polymer was utilized as an adsorbent of dispersive solid phase extraction for separation and preconcentration of sertraline. The effects of the different parameters influencing the extraction efficiency, such as sample pH were investigated and optimized. The specificity of the molecular imprinted polymer over the non-imprinted polymer was examined in absence and presence of competitive drugs. Sertraline calibration curve showed linearity in the ranges 1-500 µg L-1. The limits of detection and quantification under optimized conditions were obtained 0.2 and 0.5 µg L-1. The within-day and between-day relative standard deviations (n=3) were 4.3 and 7.1%, respectively. Furthermore, the relative recoveries for spiked biological samples were above 92%.

Research paper thumbnail of Solid Phase Extraction of Trace Copper in Aqueous Samples Using C18 Membrane Disks Modified by Benzildithiosemicarbazone Prior to Flame Atomic Absorption Spectrometric (FAAS) Determination

DOAJ (DOAJ: Directory of Open Access Journals), Jun 1, 2013

A highly convenient, selective and sensitive procedure for pre-concentration, separation and dete... more A highly convenient, selective and sensitive procedure for pre-concentration, separation and determination of sub-ppm levels of Cu 2+ in aqueous samples based on modification of octadecyl silica bonded phase membrane (OSBPM) disks is described using benzildithiosemicarbazone (BDSC) as a powerful modifier. It was revealed that each loaded OSBPM disk with 6.0 mg of BDSC serves as excellent bead for trapping, enrichment and isolation of trace copper. The analyte was trapped during introduction the aqueous solutions through the surface of each modified membrane, quantitatively, while other interfering ions passed through the disk to drain. The adsorbed Cu 2+ ions were then stripped by appropriate eluting agents followed by monitoring of the eluates by FAAS. The effects of sample pH, amount of the modifier, stripping agent types and sample flowrates were also investigated. The described method permitted a pre-concentration factor of about 200. The detection limit of the procedure was predicted to be about 0.013 ng L-1. The method was successfully employed for recovery and quantification of trace copper in different water samples.

Research paper thumbnail of Ruta Essential Oils: Composition and Bioactivities

Molecules, 2021

Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different sp... more Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oils, which predominantly contain aliphatic ketones, e.g., 2-undecanone and 2-nonanone, but lack any significant amounts of terpenes. Three Ruta species, Ruta chalepensis L., Ruta graveolens L., and Ruta montana L., have been extensively studied for the composition of their essential oils and several bioactivities, revealing their potential medicinal and agrochemical applications. This review provides a systematic evaluation and critical appraisal of publications available in the literature on the composition and bioactivities of the essential oils obtained from Ruta species and includes a brief outlook of the potential applications of nanote...

Research paper thumbnail of The Genus Haplophyllum Juss.: Phytochemistry and Bioactivities—A Review

Molecules, 2021

Herein, a comprehensive review is given focusing on the chemical profiles of the essential oils (... more Herein, a comprehensive review is given focusing on the chemical profiles of the essential oils (EOs), non-volatile compounds, ethnobotany, and biological activities of different Haplophyllum (Rutaceae family) species. To gather the relevant data, all the scientific databases, including Scopus, ISI-WOS (Institute of Scientific Information-Web of Science), and PubMed and highly esteemed publishers such as Elsevier, Springer, Taylor and Francis, etc., were systematically retrieved and reviewed. A wide array of valuable groups of natural compounds, e.g., terpenoids, coumarins, alkaloids, lignans, flavonoids, and organic acids have been isolated and subsequently characterized in different organic extracts of a number of Haplophyllum species. In addition, some remarkable antimicrobial, antifungal, anti-inflammatory, anticancer, cytotoxic, antileishmanial, and antialgal effects as well as promising remedial therapeutic properties have been well-documented for some species of the genus Hap...

Research paper thumbnail of Journal of Chemical Health Risks (): -, ISSN: - Chemical Composition of the Essential Oil from the Aerial Parts of Satureja hortensis As a Potent Medical Plant Using Traditional Hydrodistillation

ABSTRACT: The water-distilled essential oils, which were obtained from the fresh aerial parts of ... more ABSTRACT: The water-distilled essential oils, which were obtained from the fresh aerial parts of Satureja hortensis were analyzed by means of GC and CC/MS instruments. The plant was collected during the flowering stage from Foroomad Mountains, Semnan Province, and heart of Iran. Twenty compounds were identified in the different samples analyzed, representing of the total oil contents. In terms of general categories, monoterpene hydrocarbons dominated the chemical profile of the oils with γ-terpinene ( ), carvacrol ( ), p-cymene ( ), α-terpinene ( ), α-pinene ( ) and myrcene ( ) as the main constituent components. The other constituents were found to be α-thujene ( ), β-pinene ( ), sylvestrene ( ), α-phellandrene (. ) and (-)-terpinen--ol ( ).

Research paper thumbnail of Novel QSPR Study on the Melting Points of a Broad Set of Drug-Like Compounds Using the Genetic Algorithm Feature Selection Approach Combined with Multiple Linear Regression and Support Vector Machine

Journal of Chemical Health Risks, 2016

A robust and reliable quantitative structure-property relationship (QSPR) study was established t... more A robust and reliable quantitative structure-property relationship (QSPR) study was established to forecast the melting points (MPs) of a diverse and long set including 250 drug-like compounds. Based on the calculated descriptors by Dragon software package, to detect homogeneities and to split the whole dataset into training and test sets, a principal component analysis (PCA) approach was used. Accordingly, there was no outlier in the constructed cluster. Afterwards, the genetic algorithm (GA) feature selection strategy was used to select the most impressive descriptors resulting in the best-fitted models. In addition, multiple linear regression (MLR) and support vector machine (SVM) were used to develop linear and non-linear models correlating the molecular descriptors and the melting points. The validation of the obtained models was confirmed applying cross validation, chance correlation along with statistical features associated with external test set. Our computational study ex...

Research paper thumbnail of Assessment of the Trace Levels of Lead (II) Using Solid Phase Extraction and Flame Atomic Absorption Spectrometry

Material Science Research India, 2006

An efficient procedure for pre-concentration, separation and determination of the trace amounts o... more An efficient procedure for pre-concentration, separation and determination of the trace amounts of lead (II) ions in water samples has been established. The analyte is adsorbed on the surface of C18 silica membrane disk modified with APDC, quantitatively, while other interfering ions pass through the disk to drain. The sorbed Pb2+ ions are then stripped by appropriate eluting agents followed by monitoring of the eluates by flame atomic absorption spectrometry (FAAS). The effects of sample pH, amount of the modifier, stripping agent types, sample flow-rates, and potential interfering ions were also investigated. The described method involves a pre-concentration factor of about 200. The detection limit of the procedure is 0.93 ng.mL-1. The method was employed for isolation and determination of lead in different water samples.

Research paper thumbnail of The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Industrial Crops and Products, 2019

This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional c... more This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional culinary uses of Ferula species, related products and extracts in different countries together with the description of recently isolated new components and the related bioactivities. The phytochemical composition of the essential oils (EOs), oleo-gum-resin (OGR) and the non-volatile fractions obtained from several endemic and indigenous Ferula species is also reported. A special emphasis is placed on their unusual components, i.e. sulfur-containing volatiles from the EOs and the new phytochemicals with mixed biogenetic origins. More than 180 chemical constituents (excluding common essential oils components), including sulfur-containing metabolites, terpenoids, coumarins, sesquiterpene coumarins, etc., as both aglycones and glycosides, are reported, along with their occurrence and biological activities when available. A large number of new secondary metabolites, belonging to different classes of natural products possessing interesting biological activities, from the antiproliferative to the anti-inflammatory to the neuroprotective ones, among the others, have been recently found in the Ferula genus. Several of these phytochemicals are exclusive to this genus; therefore may be considered chemotaxonomic markers. All these aspects are extensively discussed in this review.

Research paper thumbnail of An update on applications of nanostructured drug delivery systems in cancer therapy: a review

Artificial cells, nanomedicine, and biotechnology, 2017

Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell... more Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell growth, with the potential to assault or spread to other parts of the body. Recently, remarkable efforts have been devoted to develop nanotechnology to improve the delivery of anticancer drug to tumor tissue as minimizing its distribution and toxicity in healthy tissue. Nanotechnology has been extensively used in the advance of new strategies for drug delivery and cancer therapy. Compared to customary drug delivery systems, nano-based drug delivery method has greater potential in different areas, like multiple targeting functionalization, in vivo imaging, extended circulation time, systemic control release, and combined drug delivery. Nanofibers are used for different medical applications such as drug delivery systems.

Research paper thumbnail of Quantitative monitoring of the volatiles from the aerial parts of Satureja hortensis by the use of HS-SPME-GC-MS approach

Oriental Journal of Chemistry, 2016

The volatile fractions isolated from the ground aerial parts of Satureja hortensis were trapped u... more The volatile fractions isolated from the ground aerial parts of Satureja hortensis were trapped using the headspace solid phase microextraction (HS-SPME) strategy and subsequently monitored using gas chromatography in combination with mass spectrometry (GC-MS) instrumentation. Eleven constituents were totally recognized in the analyzed volatile parts, representing entire of the corresponding profile. Among the natural groups present in the chemical profile, monoterpene hydrocarbons (99.5%) were found as the major constituents with the dominant compounds being γ-terpinene (46.0%), p-cymene (11.8%), α-terpinene (11.1%), α-pinene (10.4%) and α-thujene (6.8%). However, lower contents of some natural compounds including myrcene (5.2%), β-pinene (3.9%), o-cymene (2.6%), α-phellandrene (1.1%), camphene (0.6%) and thymol (0.5%) were identified. Accordingly, only 0.5% of the profile included oxygenated monoterpenes.

Research paper thumbnail of Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review

Journal of ethnopharmacology, Jan 5, 2017

The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which ha... more The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they heve been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines. They are also known as effective remedies that promote breast-feedings and regulate women menstruation. This review presents an overview on the ethnopharmacological knowledge of the Achillea genus and provides a deeper insight into medicinal and pharmaceutical applications of different Achillea species. Relevant data were obtained through ...

Research paper thumbnail of Magnetic nanoparticles in cancer diagnosis and treatment: a review

Artificial cells, nanomedicine, and biotechnology, Jan 25, 2016

Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. Howe... more Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. However, with the advancement in magnetic nanoparticle (MNP) technology, many challenges in the diagnosis and treatment of lung cancer are on the decline. The MNPs have led to many break-through in cancer therapy. This paper seeks to establish the role of MNPs in diagnosis and treatment of lung cancer. It proposes that the existing challenges in the diagnosis and treatment of lung cancer can be addressed through application of MNPs in the process.

Research paper thumbnail of Evaluation of two different extraction techniques on determination of Pb2+ contents of wastes of dye manufacturing industries

Extraction of trace amounts of toxic heavy metals from complicated environmental matrixes is a ch... more Extraction of trace amounts of toxic heavy metals from complicated environmental matrixes is a challenging task. The aim of this investigation is the comparison of the extraction efficiencies and other related experimental variables (chemicals, effect of pH, potential interfering ions) on the determination of inorganic lead (Pb+2) which is present in waste water of dye industries. Compared techniques are liquid liquid extraction followed by UV/Visible spectrophotometric determination (LLE-UVNIS) and solid phase extraction followed by flame atomic absorption determination (SPE-FAAS). The detection limits are 23 ng.m11 and 0.36 ng.m1-1 respectively. The effects of sample flow-rate and preconcentration factor are also investigated. The experimental results indicate that preconcentration factor of 300 could be achieved. The techniques are applied for determination of Pb+2 contents of wastes water of east Tehran regions.

Research paper thumbnail of Investigation and identification of types and amounts of heavy metals in soil of an industrial area

This study was mainly designed to investigate and identify the amounts and types of heavy metals ... more This study was mainly designed to investigate and identify the amounts and types of heavy metals in the soils of National Iranian Oil Refining & Distribution Company in Shahrood region and tried to establish a logical relation between the presence of heavy metals and their damage on vegetation. In addition, considering the power of drained soil and due to the proximity of ground water in Shahrood region, conducting this study provides a better insight into recognition of the possible contamination centers of drinking waters. The gridding and selective method was used for sampling step. Accordingly, five sub-samples were taken from each grid and finally after mixing all of the sub-samples, the final samples were obtained with an average weight of 400 grams prior to sending to the laboratory. To determine the total concentration of heavy metals in soil, extraction was done using concentrated solutions of HCl and HNO 3. The total concentration of the heavy metals of chromium, cobalt and nickel were measured using an ICP-MS instrument, and the rest of the elements using an XRF device. The results explicitly indicated that the quantities of nickel, lead, zinc and strontium in patient samples exceeded the standard, and the other elements were lower than their standard limits. More specifically, the contents of lead and strontium in both normal and patient samples were higher than their standard contents. Moreover, the majority of the vegetation loss across the affected areas was caused by heavy metal accumulation, particularly nickel, lead, zinc, and strontium.

Research paper thumbnail of Simultaneous Kinetic Determination of Phosphate and Silicate by Spectrophotometric H-Point Standard Addition Method

Journal of the Chinese Chemical Society, 2008

The H-point standard addition method (HPSAM), based on spectrophotometric measurements for simult... more The H-point standard addition method (HPSAM), based on spectrophotometric measurements for simultaneous determination of phosphate and silicate, has been established. The method is based on the difference between their reactions rates with molybdenum in the presence of ascorbic acid. The results revealed that phosphate and silicate could be determined simultaneously with the concentration ratios of phosphate to silicate varying from 1:10 to 12:1 in the binary mixtures. The effects of chelating agent nature, time, interferents and experimental variables are also investigated. Under working conditions, the proposed method was successfully applied to the simultaneous determination of phosphate and silicate in synthetic detergents.

Research paper thumbnail of Preconcentration and Determination of Chromium Species Using Octadecyl Silica Membrane Disks and Flame Atomic Absorption Spectrometry

Chinese Journal of Chemistry, 2007

A novel and selective method for the fast determination of trace amounts of chromium species in w... more A novel and selective method for the fast determination of trace amounts of chromium species in water samples has been developed. The procedure is based on the selective formation of chromium diethyldithiocarbamate complexes at different pH in the presence of Mn(II) as an enhancement agent of chromium signals followed by elution with organic eluents and determination by atomic absorption spectrometry. The maximum capacity of the employed disks was found to be 396 ± 3 µg and 376 ± 2 µg for Cr(III) and Cr(VI), respectively. The detection limit of the proposed method is 49 and 43 ng.L-1 for Cr(III) and Cr(VI), respectively. The proposed method was successfully applied for determination of Cr(III) and Cr(VI) in different water samples.

Research paper thumbnail of Hydrodistilled Volatile Oil from Stems of Eryngium creticum Lam. in the Marginal Brackish Regions of Semnan Province by Using Gas Chromatography Combined with Mass Spectrometry

Asian Journal of Chemistry, 2013

The present report deals with chemical composition of the volatile oil from stems of Eryngium cre... more The present report deals with chemical composition of the volatile oil from stems of Eryngium creticum Lam. a growing wild plant in Iran. All the samples were collected from different brackish and hill slope locations during the flowering stage in Semnan province, Iran. The oil was obtained by using a modified Clevenger-type apparatus and the respective analyses were performed by means of GC and GC-MS instrumentations. It was obtained as a clear yellowish colour liquid involving 0.18 w.w-1 (%). Seventeen components were identified constituting 91.4 % of the oil composition. The major components of the oil were found to be bornyl acetate (28.4 %), camphor (17.8 %), α-pinene (12.1 %), germacrene D (9.4 %), borneol (8.6 %) and α-thujene (4.2 %). Based upon the chemical profile, the essential oil was mainly characterized by the presence of higher amounts of oxygenated monoterpenes.

Research paper thumbnail of Chemical composition of the essential oils from the hulls of Pistacia vera L. by using magnetic nanoparticle-assisted microwave (MW) distillation: comparison with routine MW and conventional hydrodistillation

Anal. Methods, 2014

In this paper, classical hydrodistillation and microwave assisted hydrodistillation were used for... more In this paper, classical hydrodistillation and microwave assisted hydrodistillation were used for extraction ofPistachiohull essential oil.

Research paper thumbnail of Homogeneous liquid–liquid microextraction via flotation assistance for rapid and efficient determination of polycyclic aromatic hydrocarbons in water samples

Analytica Chimica Acta, 2013

In the present study, facile and competent homogeneous liquid-liquid microextraction via flotatio... more In the present study, facile and competent homogeneous liquid-liquid microextraction via flotation assistance (HLLME-FA) method combined with flow injection flame atomic absorption spectrometry (FI-FAAS) was proposed for simultaneous separation/ preconcentration and determination of trace amounts of cadmium and copper in water samples. The efficient 2-(3,4-dihydroxyphenyl)-1,3-dithiolane (DHPDTO) with thiol groups was used as chelating reagent. The predominant parameters influencing the HLLME-FA, such as solution pH, concentration of DHPDTO, extraction and homogeneous solvent types and volumes, ionic strength, and extraction time were studied. Applying all the optimum conditions in the process, the detection limits of 0.008 and 0.01 μg L −1 , linear ranges of 0.08-40 and 0.1-45 μg L −1 , and the precision (RSD%, n=7) of 3.4 and 3.9 % were obtained, respectively, for cadmium and copper. The proposed procedure showed satisfactory results for analysis of tap water, river water, well water, and seawater.

Research paper thumbnail of First Report on Screening of the Profiles of the Essential Oils and Volatiles from the Aerial Parts of Marrubium persicum Using Classical and Advanced Methods Prior to Gas Chromatographic Mass Spectrometric Determination

DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 2016

The Lamiaceae family consists of a broad spectrum of medicinal plants involving Marrubium L. genu... more The Lamiaceae family consists of a broad spectrum of medicinal plants involving Marrubium L. genus. Regarding the diverse pharmaceutical uses of the plants belonging to this genus, they can be considered as proper alternatives for chemical drugs having harmful effects. The present work aims to identify and characterize chemical compositions of the essential oils and volatiles from the aerial parts of Marrubium persicum C. A. Mey. as an herbal plant in Iran using classical hydrodistillation. To establish a comprehensive comparison between the traditional techniques and advanced ones, microwave-based extraction techniques namely MAHD as well as SFME have also been utilized. In another part of this project, the profiles related to the volatile fractions from the aerial parts of Marrubium persicum C. A. Mey.have been assessed and compared with the other categories. The main components in the hydrodistillation (HD) method were α-pinene (21.5%), spathulenol (19.5%), α-thujene (17.4%), while the headspace solid-phase microextraction (HS-SPME) profile mainly consisted of β-caryophyllene (14%), eugenol (11.2%) and methyl eugenol (10.2%). On the other hand, using the SFME approach spathulenol (25.4%), α-pinene (17.4%) and germacrene D (9.5%) were found as the most abundant constituents. Moreover, in the MAHD profile caryophyllene oxide (13.1%), δ-elemene (12.4%), camphene (8.5%) were respectively the predominant natural compounds. According to gas chromatographicmass spectrometric determinations, a total of 40 compounds were recognized in the corresponding profiles totally covering 94.6-99.7% of the whole chemical compositions. Sesquiterpene hydrocarbons were recognized as the most frequent groups of natural compounds in the profiles of the advanced approaches, whereas in the traditional one monoterpene hydrocarbons were found to be the dominant constituting group.

Research paper thumbnail of Journal of Chemical Health Risks

A surface molecularly imprinted dispersive solid phase extraction coupled with liquid chromatogra... more A surface molecularly imprinted dispersive solid phase extraction coupled with liquid chromatography-ultraviolet detection is proposed as a selective and fast clean-up technique for the determination of sertraline in biological sample. Surface sertraline-molecular imprinted polymer was grafted and synthesized on the SiO 2 /graphene oxide surface. Firstly SiO 2 was coated on synthesized graphene oxide sheet using sol-gel technique. Prior to polymerization, the vinyl group was incorporated on to the surface of SiO 2 /graphene oxide to direct selective polymerization on the surface. Methacrylic acid, ethylene glycol dimethacrylate and ethanol were used as monomer, cross-linker and progen, respectively. Non-imprinted polymer was also prepared for comparing purposes. The properties of the molecular imprinted polymer were characterized using field emission-scanning electron microscopy and Fourier transform infrared spectroscopy methods. The surface molecular imprinted polymer was utilized as an adsorbent of dispersive solid phase extraction for separation and preconcentration of sertraline. The effects of the different parameters influencing the extraction efficiency, such as sample pH were investigated and optimized. The specificity of the molecular imprinted polymer over the non-imprinted polymer was examined in absence and presence of competitive drugs. Sertraline calibration curve showed linearity in the ranges 1-500 µg L-1. The limits of detection and quantification under optimized conditions were obtained 0.2 and 0.5 µg L-1. The within-day and between-day relative standard deviations (n=3) were 4.3 and 7.1%, respectively. Furthermore, the relative recoveries for spiked biological samples were above 92%.

Research paper thumbnail of Solid Phase Extraction of Trace Copper in Aqueous Samples Using C18 Membrane Disks Modified by Benzildithiosemicarbazone Prior to Flame Atomic Absorption Spectrometric (FAAS) Determination

DOAJ (DOAJ: Directory of Open Access Journals), Jun 1, 2013

A highly convenient, selective and sensitive procedure for pre-concentration, separation and dete... more A highly convenient, selective and sensitive procedure for pre-concentration, separation and determination of sub-ppm levels of Cu 2+ in aqueous samples based on modification of octadecyl silica bonded phase membrane (OSBPM) disks is described using benzildithiosemicarbazone (BDSC) as a powerful modifier. It was revealed that each loaded OSBPM disk with 6.0 mg of BDSC serves as excellent bead for trapping, enrichment and isolation of trace copper. The analyte was trapped during introduction the aqueous solutions through the surface of each modified membrane, quantitatively, while other interfering ions passed through the disk to drain. The adsorbed Cu 2+ ions were then stripped by appropriate eluting agents followed by monitoring of the eluates by FAAS. The effects of sample pH, amount of the modifier, stripping agent types and sample flowrates were also investigated. The described method permitted a pre-concentration factor of about 200. The detection limit of the procedure was predicted to be about 0.013 ng L-1. The method was successfully employed for recovery and quantification of trace copper in different water samples.

Research paper thumbnail of Ruta Essential Oils: Composition and Bioactivities

Molecules, 2021

Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different sp... more Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oils, which predominantly contain aliphatic ketones, e.g., 2-undecanone and 2-nonanone, but lack any significant amounts of terpenes. Three Ruta species, Ruta chalepensis L., Ruta graveolens L., and Ruta montana L., have been extensively studied for the composition of their essential oils and several bioactivities, revealing their potential medicinal and agrochemical applications. This review provides a systematic evaluation and critical appraisal of publications available in the literature on the composition and bioactivities of the essential oils obtained from Ruta species and includes a brief outlook of the potential applications of nanote...

Research paper thumbnail of The Genus Haplophyllum Juss.: Phytochemistry and Bioactivities—A Review

Molecules, 2021

Herein, a comprehensive review is given focusing on the chemical profiles of the essential oils (... more Herein, a comprehensive review is given focusing on the chemical profiles of the essential oils (EOs), non-volatile compounds, ethnobotany, and biological activities of different Haplophyllum (Rutaceae family) species. To gather the relevant data, all the scientific databases, including Scopus, ISI-WOS (Institute of Scientific Information-Web of Science), and PubMed and highly esteemed publishers such as Elsevier, Springer, Taylor and Francis, etc., were systematically retrieved and reviewed. A wide array of valuable groups of natural compounds, e.g., terpenoids, coumarins, alkaloids, lignans, flavonoids, and organic acids have been isolated and subsequently characterized in different organic extracts of a number of Haplophyllum species. In addition, some remarkable antimicrobial, antifungal, anti-inflammatory, anticancer, cytotoxic, antileishmanial, and antialgal effects as well as promising remedial therapeutic properties have been well-documented for some species of the genus Hap...

Research paper thumbnail of Journal of Chemical Health Risks (): -, ISSN: - Chemical Composition of the Essential Oil from the Aerial Parts of Satureja hortensis As a Potent Medical Plant Using Traditional Hydrodistillation

ABSTRACT: The water-distilled essential oils, which were obtained from the fresh aerial parts of ... more ABSTRACT: The water-distilled essential oils, which were obtained from the fresh aerial parts of Satureja hortensis were analyzed by means of GC and CC/MS instruments. The plant was collected during the flowering stage from Foroomad Mountains, Semnan Province, and heart of Iran. Twenty compounds were identified in the different samples analyzed, representing of the total oil contents. In terms of general categories, monoterpene hydrocarbons dominated the chemical profile of the oils with γ-terpinene ( ), carvacrol ( ), p-cymene ( ), α-terpinene ( ), α-pinene ( ) and myrcene ( ) as the main constituent components. The other constituents were found to be α-thujene ( ), β-pinene ( ), sylvestrene ( ), α-phellandrene (. ) and (-)-terpinen--ol ( ).

Research paper thumbnail of Novel QSPR Study on the Melting Points of a Broad Set of Drug-Like Compounds Using the Genetic Algorithm Feature Selection Approach Combined with Multiple Linear Regression and Support Vector Machine

Journal of Chemical Health Risks, 2016

A robust and reliable quantitative structure-property relationship (QSPR) study was established t... more A robust and reliable quantitative structure-property relationship (QSPR) study was established to forecast the melting points (MPs) of a diverse and long set including 250 drug-like compounds. Based on the calculated descriptors by Dragon software package, to detect homogeneities and to split the whole dataset into training and test sets, a principal component analysis (PCA) approach was used. Accordingly, there was no outlier in the constructed cluster. Afterwards, the genetic algorithm (GA) feature selection strategy was used to select the most impressive descriptors resulting in the best-fitted models. In addition, multiple linear regression (MLR) and support vector machine (SVM) were used to develop linear and non-linear models correlating the molecular descriptors and the melting points. The validation of the obtained models was confirmed applying cross validation, chance correlation along with statistical features associated with external test set. Our computational study ex...

Research paper thumbnail of Assessment of the Trace Levels of Lead (II) Using Solid Phase Extraction and Flame Atomic Absorption Spectrometry

Material Science Research India, 2006

An efficient procedure for pre-concentration, separation and determination of the trace amounts o... more An efficient procedure for pre-concentration, separation and determination of the trace amounts of lead (II) ions in water samples has been established. The analyte is adsorbed on the surface of C18 silica membrane disk modified with APDC, quantitatively, while other interfering ions pass through the disk to drain. The sorbed Pb2+ ions are then stripped by appropriate eluting agents followed by monitoring of the eluates by flame atomic absorption spectrometry (FAAS). The effects of sample pH, amount of the modifier, stripping agent types, sample flow-rates, and potential interfering ions were also investigated. The described method involves a pre-concentration factor of about 200. The detection limit of the procedure is 0.93 ng.mL-1. The method was employed for isolation and determination of lead in different water samples.

Research paper thumbnail of The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Industrial Crops and Products, 2019

This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional c... more This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional culinary uses of Ferula species, related products and extracts in different countries together with the description of recently isolated new components and the related bioactivities. The phytochemical composition of the essential oils (EOs), oleo-gum-resin (OGR) and the non-volatile fractions obtained from several endemic and indigenous Ferula species is also reported. A special emphasis is placed on their unusual components, i.e. sulfur-containing volatiles from the EOs and the new phytochemicals with mixed biogenetic origins. More than 180 chemical constituents (excluding common essential oils components), including sulfur-containing metabolites, terpenoids, coumarins, sesquiterpene coumarins, etc., as both aglycones and glycosides, are reported, along with their occurrence and biological activities when available. A large number of new secondary metabolites, belonging to different classes of natural products possessing interesting biological activities, from the antiproliferative to the anti-inflammatory to the neuroprotective ones, among the others, have been recently found in the Ferula genus. Several of these phytochemicals are exclusive to this genus; therefore may be considered chemotaxonomic markers. All these aspects are extensively discussed in this review.

Research paper thumbnail of An update on applications of nanostructured drug delivery systems in cancer therapy: a review

Artificial cells, nanomedicine, and biotechnology, 2017

Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell... more Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell growth, with the potential to assault or spread to other parts of the body. Recently, remarkable efforts have been devoted to develop nanotechnology to improve the delivery of anticancer drug to tumor tissue as minimizing its distribution and toxicity in healthy tissue. Nanotechnology has been extensively used in the advance of new strategies for drug delivery and cancer therapy. Compared to customary drug delivery systems, nano-based drug delivery method has greater potential in different areas, like multiple targeting functionalization, in vivo imaging, extended circulation time, systemic control release, and combined drug delivery. Nanofibers are used for different medical applications such as drug delivery systems.

Research paper thumbnail of Quantitative monitoring of the volatiles from the aerial parts of Satureja hortensis by the use of HS-SPME-GC-MS approach

Oriental Journal of Chemistry, 2016

The volatile fractions isolated from the ground aerial parts of Satureja hortensis were trapped u... more The volatile fractions isolated from the ground aerial parts of Satureja hortensis were trapped using the headspace solid phase microextraction (HS-SPME) strategy and subsequently monitored using gas chromatography in combination with mass spectrometry (GC-MS) instrumentation. Eleven constituents were totally recognized in the analyzed volatile parts, representing entire of the corresponding profile. Among the natural groups present in the chemical profile, monoterpene hydrocarbons (99.5%) were found as the major constituents with the dominant compounds being γ-terpinene (46.0%), p-cymene (11.8%), α-terpinene (11.1%), α-pinene (10.4%) and α-thujene (6.8%). However, lower contents of some natural compounds including myrcene (5.2%), β-pinene (3.9%), o-cymene (2.6%), α-phellandrene (1.1%), camphene (0.6%) and thymol (0.5%) were identified. Accordingly, only 0.5% of the profile included oxygenated monoterpenes.

Research paper thumbnail of Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review

Journal of ethnopharmacology, Jan 5, 2017

The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which ha... more The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they heve been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines. They are also known as effective remedies that promote breast-feedings and regulate women menstruation. This review presents an overview on the ethnopharmacological knowledge of the Achillea genus and provides a deeper insight into medicinal and pharmaceutical applications of different Achillea species. Relevant data were obtained through ...

Research paper thumbnail of Magnetic nanoparticles in cancer diagnosis and treatment: a review

Artificial cells, nanomedicine, and biotechnology, Jan 25, 2016

Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. Howe... more Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. However, with the advancement in magnetic nanoparticle (MNP) technology, many challenges in the diagnosis and treatment of lung cancer are on the decline. The MNPs have led to many break-through in cancer therapy. This paper seeks to establish the role of MNPs in diagnosis and treatment of lung cancer. It proposes that the existing challenges in the diagnosis and treatment of lung cancer can be addressed through application of MNPs in the process.

Research paper thumbnail of Evaluation of two different extraction techniques on determination of Pb2+ contents of wastes of dye manufacturing industries

Extraction of trace amounts of toxic heavy metals from complicated environmental matrixes is a ch... more Extraction of trace amounts of toxic heavy metals from complicated environmental matrixes is a challenging task. The aim of this investigation is the comparison of the extraction efficiencies and other related experimental variables (chemicals, effect of pH, potential interfering ions) on the determination of inorganic lead (Pb+2) which is present in waste water of dye industries. Compared techniques are liquid liquid extraction followed by UV/Visible spectrophotometric determination (LLE-UVNIS) and solid phase extraction followed by flame atomic absorption determination (SPE-FAAS). The detection limits are 23 ng.m11 and 0.36 ng.m1-1 respectively. The effects of sample flow-rate and preconcentration factor are also investigated. The experimental results indicate that preconcentration factor of 300 could be achieved. The techniques are applied for determination of Pb+2 contents of wastes water of east Tehran regions.

Research paper thumbnail of Investigation and identification of types and amounts of heavy metals in soil of an industrial area

This study was mainly designed to investigate and identify the amounts and types of heavy metals ... more This study was mainly designed to investigate and identify the amounts and types of heavy metals in the soils of National Iranian Oil Refining & Distribution Company in Shahrood region and tried to establish a logical relation between the presence of heavy metals and their damage on vegetation. In addition, considering the power of drained soil and due to the proximity of ground water in Shahrood region, conducting this study provides a better insight into recognition of the possible contamination centers of drinking waters. The gridding and selective method was used for sampling step. Accordingly, five sub-samples were taken from each grid and finally after mixing all of the sub-samples, the final samples were obtained with an average weight of 400 grams prior to sending to the laboratory. To determine the total concentration of heavy metals in soil, extraction was done using concentrated solutions of HCl and HNO 3. The total concentration of the heavy metals of chromium, cobalt and nickel were measured using an ICP-MS instrument, and the rest of the elements using an XRF device. The results explicitly indicated that the quantities of nickel, lead, zinc and strontium in patient samples exceeded the standard, and the other elements were lower than their standard limits. More specifically, the contents of lead and strontium in both normal and patient samples were higher than their standard contents. Moreover, the majority of the vegetation loss across the affected areas was caused by heavy metal accumulation, particularly nickel, lead, zinc, and strontium.

Research paper thumbnail of Simultaneous Kinetic Determination of Phosphate and Silicate by Spectrophotometric H-Point Standard Addition Method

Journal of the Chinese Chemical Society, 2008

The H-point standard addition method (HPSAM), based on spectrophotometric measurements for simult... more The H-point standard addition method (HPSAM), based on spectrophotometric measurements for simultaneous determination of phosphate and silicate, has been established. The method is based on the difference between their reactions rates with molybdenum in the presence of ascorbic acid. The results revealed that phosphate and silicate could be determined simultaneously with the concentration ratios of phosphate to silicate varying from 1:10 to 12:1 in the binary mixtures. The effects of chelating agent nature, time, interferents and experimental variables are also investigated. Under working conditions, the proposed method was successfully applied to the simultaneous determination of phosphate and silicate in synthetic detergents.

Research paper thumbnail of Preconcentration and Determination of Chromium Species Using Octadecyl Silica Membrane Disks and Flame Atomic Absorption Spectrometry

Chinese Journal of Chemistry, 2007

A novel and selective method for the fast determination of trace amounts of chromium species in w... more A novel and selective method for the fast determination of trace amounts of chromium species in water samples has been developed. The procedure is based on the selective formation of chromium diethyldithiocarbamate complexes at different pH in the presence of Mn(II) as an enhancement agent of chromium signals followed by elution with organic eluents and determination by atomic absorption spectrometry. The maximum capacity of the employed disks was found to be 396 ± 3 µg and 376 ± 2 µg for Cr(III) and Cr(VI), respectively. The detection limit of the proposed method is 49 and 43 ng.L-1 for Cr(III) and Cr(VI), respectively. The proposed method was successfully applied for determination of Cr(III) and Cr(VI) in different water samples.

Research paper thumbnail of Hydrodistilled Volatile Oil from Stems of Eryngium creticum Lam. in the Marginal Brackish Regions of Semnan Province by Using Gas Chromatography Combined with Mass Spectrometry

Asian Journal of Chemistry, 2013

The present report deals with chemical composition of the volatile oil from stems of Eryngium cre... more The present report deals with chemical composition of the volatile oil from stems of Eryngium creticum Lam. a growing wild plant in Iran. All the samples were collected from different brackish and hill slope locations during the flowering stage in Semnan province, Iran. The oil was obtained by using a modified Clevenger-type apparatus and the respective analyses were performed by means of GC and GC-MS instrumentations. It was obtained as a clear yellowish colour liquid involving 0.18 w.w-1 (%). Seventeen components were identified constituting 91.4 % of the oil composition. The major components of the oil were found to be bornyl acetate (28.4 %), camphor (17.8 %), α-pinene (12.1 %), germacrene D (9.4 %), borneol (8.6 %) and α-thujene (4.2 %). Based upon the chemical profile, the essential oil was mainly characterized by the presence of higher amounts of oxygenated monoterpenes.

Research paper thumbnail of Chemical composition of the essential oils from the hulls of Pistacia vera L. by using magnetic nanoparticle-assisted microwave (MW) distillation: comparison with routine MW and conventional hydrodistillation

Anal. Methods, 2014

In this paper, classical hydrodistillation and microwave assisted hydrodistillation were used for... more In this paper, classical hydrodistillation and microwave assisted hydrodistillation were used for extraction ofPistachiohull essential oil.

Research paper thumbnail of Homogeneous liquid–liquid microextraction via flotation assistance for rapid and efficient determination of polycyclic aromatic hydrocarbons in water samples

Analytica Chimica Acta, 2013

In the present study, facile and competent homogeneous liquid-liquid microextraction via flotatio... more In the present study, facile and competent homogeneous liquid-liquid microextraction via flotation assistance (HLLME-FA) method combined with flow injection flame atomic absorption spectrometry (FI-FAAS) was proposed for simultaneous separation/ preconcentration and determination of trace amounts of cadmium and copper in water samples. The efficient 2-(3,4-dihydroxyphenyl)-1,3-dithiolane (DHPDTO) with thiol groups was used as chelating reagent. The predominant parameters influencing the HLLME-FA, such as solution pH, concentration of DHPDTO, extraction and homogeneous solvent types and volumes, ionic strength, and extraction time were studied. Applying all the optimum conditions in the process, the detection limits of 0.008 and 0.01 μg L −1 , linear ranges of 0.08-40 and 0.1-45 μg L −1 , and the precision (RSD%, n=7) of 3.4 and 3.9 % were obtained, respectively, for cadmium and copper. The proposed procedure showed satisfactory results for analysis of tap water, river water, well water, and seawater.

Research paper thumbnail of First Report on Screening of the Profiles of the Essential Oils and Volatiles from the Aerial Parts of Marrubium persicum Using Classical and Advanced Methods Prior to Gas Chromatographic Mass Spectrometric Determination

DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 2016

The Lamiaceae family consists of a broad spectrum of medicinal plants involving Marrubium L. genu... more The Lamiaceae family consists of a broad spectrum of medicinal plants involving Marrubium L. genus. Regarding the diverse pharmaceutical uses of the plants belonging to this genus, they can be considered as proper alternatives for chemical drugs having harmful effects. The present work aims to identify and characterize chemical compositions of the essential oils and volatiles from the aerial parts of Marrubium persicum C. A. Mey. as an herbal plant in Iran using classical hydrodistillation. To establish a comprehensive comparison between the traditional techniques and advanced ones, microwave-based extraction techniques namely MAHD as well as SFME have also been utilized. In another part of this project, the profiles related to the volatile fractions from the aerial parts of Marrubium persicum C. A. Mey.have been assessed and compared with the other categories. The main components in the hydrodistillation (HD) method were α-pinene (21.5%), spathulenol (19.5%), α-thujene (17.4%), while the headspace solid-phase microextraction (HS-SPME) profile mainly consisted of β-caryophyllene (14%), eugenol (11.2%) and methyl eugenol (10.2%). On the other hand, using the SFME approach spathulenol (25.4%), α-pinene (17.4%) and germacrene D (9.5%) were found as the most abundant constituents. Moreover, in the MAHD profile caryophyllene oxide (13.1%), δ-elemene (12.4%), camphene (8.5%) were respectively the predominant natural compounds. According to gas chromatographicmass spectrometric determinations, a total of 40 compounds were recognized in the corresponding profiles totally covering 94.6-99.7% of the whole chemical compositions. Sesquiterpene hydrocarbons were recognized as the most frequent groups of natural compounds in the profiles of the advanced approaches, whereas in the traditional one monoterpene hydrocarbons were found to be the dominant constituting group.