Mohamed O. Elsamani - Academia.edu (original) (raw)

Papers by Mohamed O. Elsamani

International Journal Of Pharmaceutical Research And Allied Sciences, 2021

Breast cancer screening programs may lead to a reduction of cancer mortality rates among women. I... more Breast cancer screening programs may lead to a reduction of cancer mortality rates among women. In this study, knowledge, and attitude towards mammography and ultrasound (U/S) were evaluated among females living in the Taif region, Saudi Arabia. This examination was carried out using a well-structured electronic questionnaire from April to August 2020. A total number of 218 female applicants, aged in the range from 18 to 65 years old, participated in this investigation. The obtained data led to the following conclusions: 183 (83.95%) applicants had appropriate knowledge about mammography and U/S breast cancer screening tools and 86 (40.3%) advanced their knowledge levels through the use of social media. There was a significant correlation between good knowledge and the educational level of the participants (p=0.003). Regarding attitude and practices, 73.39% of the respondents have not had mammography or U/S experiences. Despite their good knowledge level, they justified their lack of experience through the following reasons: 59.5% did not have lump or pain, 14.19% were afraid of the results, and 11.49% were ashamed or afraid to perform it. This study implied the insufficient attitude of women about mammography and ultrasound. Accordingly, relevant educational programs are required to improve the practices of women towards breast cancer.

Journal of Diseases and Medicinal Plants, 2016

The stem bark of Eribroma oblongum (malvaceae) is used in traditional Cameroonian medicine to tre... more The stem bark of Eribroma oblongum (malvaceae) is used in traditional Cameroonian medicine to treat various metabolic illnesses including the management of hypertension but there is no scientific evidence to how relief is brought about. The present study was to evaluate the effect of the ethyl acetate extract of the dried stem bark of E. oblongum on arterial blood pressure and heart rate in normotensive rat (NTR) and their mechanisms of EAEO. The effects of ethyl acetate extract of Eribroma oblongum (EAEO; 10, 20, 30 mg/kg; i.v) was tested on systolic blood pressure (SBP) and heart rate (HR) of normotensive rat. The mechanism of EAEO (20mg/kg) was studied in the presence of atropine, yohimbine, propranolol, L-NAME or reserpine. At the end of the experiment, SBP and HR were recorded. EAEO (10-20 mg/kg) induced a significant hypotensive effect of SBP. The hypotensive effects of EAEO (20 mg/kg) were inhibited by pre-treatment of rats with atropine, reserpine, yohimbine and L-NAME. At the end of this study the result demonstrates that the hypotensive as well as the antihypertensive effects of the ethyl acetate extract of the stem bark of Eribroma oblongum. Our data validate the use of the extract in traditional medicine against hypertension. The effect on blood pressure is, at least in part, due to a modulation of the orthosympathetic nervous system and to the improvement of the antioxidant status. Further studies are from now needed to study the toxicity of Eribroma oblongum.

Pharmaceuticals

A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their ... more A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their anticancer activities against three human cancer cell lines such as human breast carcinoma (MCF-7), human lung adenocarcinoma (A-549), and human ovarian carcinoma (SKOV3) by employing MTT assay. The synthesized compounds were characterized by NMR and elemental analysis. Results revealed that all the synthesized compounds displayed significant inhibition towards the tested cell lines. Among them, 2g and 2f, which differ only by the presence of an ester group at the C-3 position and small EDG (methyl) at the C-5 position of the phenyl ring (2g), were the most active derivatives in attenuating the growth of the three cells in a dose-dependent manner. The IC50 for 2g were 17.7 ± 1 µM (MCF-7), 12.1 ± 1.1 µM (A-549), and 13.9 ± 0.7 µM (SKOV3), and for 2f were 9.7 ± 1.3µM (MCF-7), 9.7 ± 0.7µM (A-549), and 6.5 ± 0.9µM (SKOV3), respectively, which were comparable to the standard drug, doxorubicin...

MDPI, 2023

A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their ... more A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their anticancer activities against three human cancer cell lines such as human breast carcinoma (MCF-7), human lung adenocarcinoma (A-549), and human ovarian carcinoma (SKOV3) by employing MTT assay. The synthesized compounds were characterized by NMR and elemental analysis. Results revealed that all the synthesized compounds displayed significant inhibition towards the tested cell lines. Among them, 2g and 2f, which differ only by the presence of an ester group at the C-3 position and small EDG (methyl) at the C-5 position of the phenyl ring (2g), were the most active derivatives in attenuating the growth of the three cells in a dose-dependent manner. The IC50 for 2g were 17.7 ± 1 µM (MCF-7), 12.1 ± 1.1 µM (A-549), and 13.9 ± 0.7 µM (SKOV3), and for 2f were 9.7 ± 1.3µM (MCF-7), 9.7 ± 0.7µM (A-549), and 6.5 ± 0.9µM (SKOV3), respectively, which were comparable to the standard drug, doxorubicin. The enzymatic inhibition of 2f and 2g against EGFR afforded good inhibitory activity with IC50 of 0.298 ± 0.007 μM and 0.484 ± 0.01 µM, respectively, close to the positive control, Afatinib. Compound 2f arrested the cell cycle in the S phase in MCF-7 and SKOV3 cells, and in the G2/M phase in the A549 cell; however, 2g induced G0/G1 phase cell cycle arrest, and inhibited the progression of the three cancer cells, together with significant apoptotic effects. The docking study of compounds 2f and 2g into EGFR ATP-active site revealed that it fits nicely with good binding affinity. The pharmacokinetic and drug-likeness scores revealed notable lead-like properties. At 100 ns, the dynamic simulation investigation revealed high conformational stability in the EGFR binding cavity.

International Journal of Nutrition and Food Sciences, 2016

The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetabl... more The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetable (lupine and peanuts) milk, and to evaluate its probiotics, organoleptic and physicochemical characteristics. Ice cream samples were produced from blends of vegetable milk and skimmed milk powder together with the added Probiotics bacteria of Lactobacillusacidophilus and Bifidobacterium. lactis. The changes of Bio-ice cream qualities and survival of added microbes were evaluated at 0, 1, and 30 days. The viable of L. acidophilus decreased by 1.62 and 2.05 log cycles in lupine and peanuts milk ice creams throughout 30 days storage respectively. The counts of B. lactis reduced by 1.32 and 2.22 log cycles in lupine and peanuts ice creams respectively. Regardless of ice cream color, incorporation of vegetable milk ice cream significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of ice cream. The highest total solids and protein were found in ice creams containing peanuts milk and lowest fat and total acceptability were found in ice creams containing lupine milk. The produce of ice cream with vegetable milks developed the growth and viability of B. lactis and L. acidophilus.

The Journal of Microbiology, Biotechnology and Food Sciences, Aug 1, 2014

Guidelines book is your guide to: building skills and knowledge needed for control diabetes, find... more Guidelines book is your guide to: building skills and knowledge needed for control diabetes, finding a diet may be used to avoid complication of diabetes, finding tips for adolescence with diabetes,learning what makes your blood glucose too high or too low and make healthy food choices. This book is the outgrowth of experiences gained from our published scientific articles and teaching experiences in the Faculty of Applied Medical Sciences at Al Baha & Al Taif Universities, Saudi Arabia. In this book, we emphasized the educational training control of children with type1 diabetes, effectiveness of diabetic education program on the HbA1c levels among type1 diabetic children in Omdurman Paediatric Hospital, dietary guidelines, nutritional care, and meal planning for children with type1 diabetes. Hopefully, this book will serve to stimulate further scientific study on the children with type1 diabetes. The feedback contributed effectively to knowledge of diabetic children and their carer...

Advances in Applied Sciences, 2017

Education of patients with diabetes is considered a fundamental aspect of diabetes care and aimed... more Education of patients with diabetes is considered a fundamental aspect of diabetes care and aimed to evaluate the effectiveness of diabetic education, using a guiding style, for children with Type 1 diabetes in Omdurman pediatric hospital. The aim of this study was to achieving a near normal glycosylated hemoglobin, and preventing acute complications (hypoglycemia, hyperglycemia) on the children patients with type1 diabetic in Khartoum state. The sampling size was (101) according to the attendance to Diabetic clinic during data collection period (February-August 2013) in this study, the Control of diabetes through HA1C monitoring was measured prior to the intervention and over seven months after post-test. The result of present study showed that: the effective method of diabetes education for children with type1 diabetes has improved such as HA1C was significantly reduced from 11.6% to a mean of 9.1%.glycaemic control. Innovative education programme for Diabetic children with type 1 diabetes. It is effective in reducing the diabetes complications among diabetic children such as hyperglycaemia and hypoglycaemia. This educational programme for diabetic children is effective in reducing HA1c after seven months intervention. Diabetic educational program administered to type1 diabetes mellitus patients seen at a Diabetic clinic improved the knowledge and distress associated with the disease. The results also suggest the prevention of an increase in HbA1c.

Turkish Journal of Agriculture - Food Science and Technology, 2014

The aim of this study was to assess the effect of heat treatment and salt concentrations (0, 5, a... more The aim of this study was to assess the effect of heat treatment and salt concentrations (0, 5, and 10%) on the free amino acids (FAA) composition of Sudanese braided cheese (BC) ripened for up to 3 months at 5±2°C. Heat and salt concentration significantly affected the FAA of braided cheese. The free amino acids concentrations of BC ripened in 0%, 5%, and 10% salted whey (SW) were significantly fluctuated. Under ripening conditions tested (salt level + time), braided cheese made from pasteurized milk (BCPM) had consistently lower values of FAA than braided cheese made from raw milk (BCRM). In fresh cheese, the major FAA in BCRM were Glu (36.12 nmol/ml), Leu (26.77nmol/ml) and Lys (14.51 nmol/ml) while the major ones in BCPM were Lys (2.94 nmol/ml) and Ala (2.45 nmol/ml). BCPM stored in 10% SW had shorter quality life compared to that stored in 5% salted whey.

American Journal of Pediatrics, 2016

This an interventional study, pre and post study conducted in Khartoum State, from August 2011-20... more This an interventional study, pre and post study conducted in Khartoum State, from August 2011-2013, to assess the effect of the training of diabetic children in improving the control and management of diabetes. Convenience sampling technique was used to select 101 diabetic children from Khartoum State. The sample size was a according to the attendance to Omdurman pediatric hospital Diabetic clinic during data collection period. The data was collected by using a pre-tested questionnaire by the researcher. The data was then analyzed by using Statistical Package for Social Sciences (SPSS) version 20. The results of the study showed that; the training program me for diabetic children and their carers has increased the level of their knowledge about management of diabetes from 21.5% to 65.1%. It is also effective in enhancing a wide range of diabetic children and their carers 'knowledge about insulin from 28.40% to 82.32%. Innovative training programme for diabetic children and their carers is significantly effective in increasing their knowledge about checkup of diabetes from 8.2% to 90.80%. The study revealed that; the implementation of diabetes education for children with type1 diabetes has improved glycemic control. The study recommended that training programs about diabetic care for children and their carers should be emphasized at all pediatrics hospitals, Long term interventions are required for getting accurate diabetes control and more reduction of HA1c and Further researches with different design, different location to be conducted to assess the effectiveness of interventions on sustained glycemic control.

Improving the protein quality of foods by incorporating legumes or cereal protein isolates and/or... more Improving the protein quality of foods by incorporating legumes or cereal protein isolates and/or flour in blends is one of the main focuses of the international research community. The aim of this study was to produce peanut milk based yoghurt and to evaluate its physicochemical and organoleptic characteristics. Yoghurt samples were produced from blends of peanuts milk and skimmed milk powder together with the starter culture of Lactobacillus helveticus, Streptococcus thermophiles and Lactobacillus bulgaricus. The skimmed milk powder was added to peanuts milk at the concentration of 0% (sample A), 5% (sample B), 10 % (sample C), and 15% (sample D). The physicochemical and sensory characteristics of the products were subsequently analyzed at 0, 5, and 10 days. The results of chemical analysis showed protein contents of 11.55, 14.7, 18.55, and 20.65 % for the samples A, B, C, and D, respectively. Fat contents was varied and in the range of 3.35-4.55%, while total solid was ranged fro...

Journal of microbiology, biotechnology and food sciences, 2014

The aim of the present study was to search for milk clotting substitute from different parts (flo... more The aim of the present study was to search for milk clotting substitute from different parts (flowers, seeds, stem, leaves, ripe and unripe fruits) of Moringa oleifera. The samples were blended and extracted using different types of extracting solutions. The most reliable, quick and efficient enzyme extracting solution was found to be 5% NaCl in 100 mM sodium acetate buffer, pH 5.0, which was used throughout the study. The milk clotting activity was only observed in the seeds extract while the other parts were either deficient or has very low milk clotting activity. Thus, the moringa seeds were used as source of milk clotting enzyme. The extracted proteins were fractionated with ammonium sulfate at concentration of 20, 30, 40, 50 and 60 %. Highest milk clotting activity was observed in the 20 % fraction. This fraction was assumed to contain the clotting enzymes and characterized for its heating stability (30 – 90°C) and optimum temperature (30 – 90°C). The results demonstrated that ...

LWT - Food Science and Technology, 2014

The aim of the present study was to evaluate some physicochemical, microbiological and sensory pr... more The aim of the present study was to evaluate some physicochemical, microbiological and sensory properties of fresh and matured (75 days) soft cheeses made with mixtures of cow milk and 0, 25, 50 and 75 mL/100 mL of lupin milk. A remarkable increase in cheese yield was observed with increasing the level of lupin milk to the mixture. Compared to cow milk cheese, the protein content was significantly (P ≤ 0.05) increased while ash was decreased with the increase in the level of lupin milk for both fresh and matured cheese. However, fat content, total solids and acidity were increased only for fresh cheese and decreased for mature one compared to that of cow milk. The pH showed significant (P ≤ 0.05) reduction when the levels of lupin milk increased for fresh cheese while for matured cheese it slightly decreased. The total bacterial count is within the range that naturally exists in milk containing foods. The others microorganisms such as fungi, mould, E. coli, and Salmonella were not existed in both types of cheese. Regardless of cheese colour, incorporation of lupin milk at low concentration (25 mL/100 mL) significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of both fresh and mature cheese.

International Journal of Nutrition and Food Sciences, 2016

The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetabl... more The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetable (lupine and peanuts) milk, and to evaluate its probiotics, organoleptic and physicochemical characteristics. Ice cream samples were produced from blends of vegetable milk and skimmed milk powder together with the added Probiotics bacteria of Lactobacillusacidophilus and Bifidobacterium. lactis. The changes of Bio-ice cream qualities and survival of added microbes were evaluated at 0, 1, and 30 days. The viable of L. acidophilus decreased by 1.62 and 2.05 log cycles in lupine and peanuts milk ice creams throughout 30 days storage respectively. The counts of B. lactis reduced by 1.32 and 2.22 log cycles in lupine and peanuts ice creams respectively. Regardless of ice cream color, incorporation of vegetable milk ice cream significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of ice cream. The highest total solids and protein were found in ice creams containing peanuts milk and lowest fat and total acceptability were found in ice creams containing lupine milk. The produce of ice cream with vegetable milks developed the growth and viability of B. lactis and L. acidophilus.

Journal of Diseases and Medicinal Plants, 2016

The extraction of some medicinal plants (Plucheadioscorides aerial part, IPomoeacordofana whole p... more The extraction of some medicinal plants (Plucheadioscorides aerial part, IPomoeacordofana whole plant, Zaleya pantendra whole plant and Heliotrpium supinum aerial part), are commonly known to treat a variety of diseases in this study. Plants under study were investigated for their antibacterial activity against four standard bacterial strains Bacillus subtilis (NCTC8236), Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922), Pseudomonas aeruginosa (ATCC27853), and two standard fungal strains Aspergillius niger (ATCC9763) and Candida albicans (ATCC7596) in vitro. The plants extracts with diversely solvents with increasing in the polarity, petroleum ether, ethyl acetate and methanol at a concentration of 100mg/ml were applied using the agar plate well-diffusion method. All the extracts obtained from Zaleya pantendra were showed high activity against all tested bacterial strains, and while have no activity against fungal strains. The methanol extract showed high significantly activity against of all bacterial strains activity in particular at Gram-positive bacteria Staphylococcus aureus and less activity to Gram-negative bacteria was Escherichia coli. The least anti bacterially active plants was IPomoeacordofana. The crude extract from ethyl acetate of Heliotrpium supinum showed high activity against all tested fugal strains of all extracts, and have broader spectrum towards Aspergillius niger (IZ=30mm). The methanol extract of Zaleya pantendra is appropriate candidates for the development of modern antimicrobial compounds.

International Journal of Nutrition and Food Sciences, 2016

The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetabl... more The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetable (lupine and peanuts) milk, and to evaluate its probiotics, organoleptic and physicochemical characteristics. Ice cream samples were produced from blends of vegetable milk and skimmed milk powder together with the added Probiotics bacteria of Lactobacillusacidophilus and Bifidobacterium. lactis. The changes of Bio-ice cream qualities and survival of added microbes were evaluated at 0, 1, and 30 days. The viable of L. acidophilus decreased by 1.62 and 2.05 log cycles in lupine and peanuts milk ice creams throughout 30 days storage respectively. The counts of B. lactis reduced by 1.32 and 2.22 log cycles in lupine and peanuts ice creams respectively. Regardless of ice cream color, incorporation of vegetable milk ice cream significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of ice cream. The highest total solids and protein were found in ice creams containing peanuts milk and lowest fat and total acceptability were found in ice creams containing lupine milk. The produce of ice cream with vegetable milks developed the growth and viability of B. lactis and L. acidophilus.

Green Energy and Technology, 2012

To realize short-period high-magnetic-field undulator, we have proposed an undulator using bulk h... more To realize short-period high-magnetic-field undulator, we have proposed an undulator using bulk high temperature superconductor in a staggered array structure. To investigate the effect of the longitudinal solenoid field on the electron beam trajectory and find out the optimum value of the solenoid field, the magnetic field near the center of this undulator was modeled and the trajectory of the single electron was calculated. As a result, we found that the stronger solenoid field worked as a stronger convergence force. However, the optimum value was not able to be determined by the result of trajectory calculation because the stronger field changes the spectrum of the radiation from the beam.

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC), 2012

ABSTRACT Excitations in 235U were measured with LaBr3:Ce scintillation detectors using the nuclea... more ABSTRACT Excitations in 235U were measured with LaBr3:Ce scintillation detectors using the nuclear resonance fluorescence (NRF) technique. A NRF experiment was performed at the High Intensity y-ray Source (HIyS) facility using quasi-monochromatic circularly or linearly polarized y-ray beams. Photons scattered at 90· relative to the incident beam were detected with two different sizes of cylindrical LaBr3:Ce detectors. Clear NRF peaks at 1733 and 1815 keY corresponding to de-excitations to the ground state and/or low-lying levels in 235U were observed within 77 minutes of beam time even under the high background due to the selfactivity of LaBr3:Ce and the radioactive decay of 214Bi nuclei existing in the 235U target. The present study shows a possibility of using LaBr3:Ce detector to perform NRF experiments, promoting many options for inspection of special nuclear materials.

2013 1st International Conference on Communications, Signal Processing and Their Applications, ICCSPA 2013, 2013

This paper presents an L-shaped microphone array configuration for a robust 2-D localization of a... more This paper presents an L-shaped microphone array configuration for a robust 2-D localization of an impulsive acoustic source in an indoor environment. The localization technique relies on a recently proposed time delay estimation technique based on the orthogonal clustering algorithm (TDE-OC) which is designed to work under room reverberant conditions and at low sampling rates. The TDE-OC method finds the TDEs from the sparse room impulse response (RIR) signal. The TDE's obtained from RIR adds to the robustness of the TDE-OC method against room reverberations while the low sampling rates requirement reduces the hardware and computational complexity and relaxes the communication link between the microphones and the centralized location. Experimental results show the robustness of this method in a reverberant environment with low sampling rates, when compared with the generalized cross correlation method.

International Journal Of Pharmaceutical Research And Allied Sciences, 2021

Breast cancer screening programs may lead to a reduction of cancer mortality rates among women. I... more Breast cancer screening programs may lead to a reduction of cancer mortality rates among women. In this study, knowledge, and attitude towards mammography and ultrasound (U/S) were evaluated among females living in the Taif region, Saudi Arabia. This examination was carried out using a well-structured electronic questionnaire from April to August 2020. A total number of 218 female applicants, aged in the range from 18 to 65 years old, participated in this investigation. The obtained data led to the following conclusions: 183 (83.95%) applicants had appropriate knowledge about mammography and U/S breast cancer screening tools and 86 (40.3%) advanced their knowledge levels through the use of social media. There was a significant correlation between good knowledge and the educational level of the participants (p=0.003). Regarding attitude and practices, 73.39% of the respondents have not had mammography or U/S experiences. Despite their good knowledge level, they justified their lack of experience through the following reasons: 59.5% did not have lump or pain, 14.19% were afraid of the results, and 11.49% were ashamed or afraid to perform it. This study implied the insufficient attitude of women about mammography and ultrasound. Accordingly, relevant educational programs are required to improve the practices of women towards breast cancer.

Journal of Diseases and Medicinal Plants, 2016

The stem bark of Eribroma oblongum (malvaceae) is used in traditional Cameroonian medicine to tre... more The stem bark of Eribroma oblongum (malvaceae) is used in traditional Cameroonian medicine to treat various metabolic illnesses including the management of hypertension but there is no scientific evidence to how relief is brought about. The present study was to evaluate the effect of the ethyl acetate extract of the dried stem bark of E. oblongum on arterial blood pressure and heart rate in normotensive rat (NTR) and their mechanisms of EAEO. The effects of ethyl acetate extract of Eribroma oblongum (EAEO; 10, 20, 30 mg/kg; i.v) was tested on systolic blood pressure (SBP) and heart rate (HR) of normotensive rat. The mechanism of EAEO (20mg/kg) was studied in the presence of atropine, yohimbine, propranolol, L-NAME or reserpine. At the end of the experiment, SBP and HR were recorded. EAEO (10-20 mg/kg) induced a significant hypotensive effect of SBP. The hypotensive effects of EAEO (20 mg/kg) were inhibited by pre-treatment of rats with atropine, reserpine, yohimbine and L-NAME. At the end of this study the result demonstrates that the hypotensive as well as the antihypertensive effects of the ethyl acetate extract of the stem bark of Eribroma oblongum. Our data validate the use of the extract in traditional medicine against hypertension. The effect on blood pressure is, at least in part, due to a modulation of the orthosympathetic nervous system and to the improvement of the antioxidant status. Further studies are from now needed to study the toxicity of Eribroma oblongum.

Pharmaceuticals

A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their ... more A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their anticancer activities against three human cancer cell lines such as human breast carcinoma (MCF-7), human lung adenocarcinoma (A-549), and human ovarian carcinoma (SKOV3) by employing MTT assay. The synthesized compounds were characterized by NMR and elemental analysis. Results revealed that all the synthesized compounds displayed significant inhibition towards the tested cell lines. Among them, 2g and 2f, which differ only by the presence of an ester group at the C-3 position and small EDG (methyl) at the C-5 position of the phenyl ring (2g), were the most active derivatives in attenuating the growth of the three cells in a dose-dependent manner. The IC50 for 2g were 17.7 ± 1 µM (MCF-7), 12.1 ± 1.1 µM (A-549), and 13.9 ± 0.7 µM (SKOV3), and for 2f were 9.7 ± 1.3µM (MCF-7), 9.7 ± 0.7µM (A-549), and 6.5 ± 0.9µM (SKOV3), respectively, which were comparable to the standard drug, doxorubicin...

MDPI, 2023

A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their ... more A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their anticancer activities against three human cancer cell lines such as human breast carcinoma (MCF-7), human lung adenocarcinoma (A-549), and human ovarian carcinoma (SKOV3) by employing MTT assay. The synthesized compounds were characterized by NMR and elemental analysis. Results revealed that all the synthesized compounds displayed significant inhibition towards the tested cell lines. Among them, 2g and 2f, which differ only by the presence of an ester group at the C-3 position and small EDG (methyl) at the C-5 position of the phenyl ring (2g), were the most active derivatives in attenuating the growth of the three cells in a dose-dependent manner. The IC50 for 2g were 17.7 ± 1 µM (MCF-7), 12.1 ± 1.1 µM (A-549), and 13.9 ± 0.7 µM (SKOV3), and for 2f were 9.7 ± 1.3µM (MCF-7), 9.7 ± 0.7µM (A-549), and 6.5 ± 0.9µM (SKOV3), respectively, which were comparable to the standard drug, doxorubicin. The enzymatic inhibition of 2f and 2g against EGFR afforded good inhibitory activity with IC50 of 0.298 ± 0.007 μM and 0.484 ± 0.01 µM, respectively, close to the positive control, Afatinib. Compound 2f arrested the cell cycle in the S phase in MCF-7 and SKOV3 cells, and in the G2/M phase in the A549 cell; however, 2g induced G0/G1 phase cell cycle arrest, and inhibited the progression of the three cancer cells, together with significant apoptotic effects. The docking study of compounds 2f and 2g into EGFR ATP-active site revealed that it fits nicely with good binding affinity. The pharmacokinetic and drug-likeness scores revealed notable lead-like properties. At 100 ns, the dynamic simulation investigation revealed high conformational stability in the EGFR binding cavity.

International Journal of Nutrition and Food Sciences, 2016

The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetabl... more The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetable (lupine and peanuts) milk, and to evaluate its probiotics, organoleptic and physicochemical characteristics. Ice cream samples were produced from blends of vegetable milk and skimmed milk powder together with the added Probiotics bacteria of Lactobacillusacidophilus and Bifidobacterium. lactis. The changes of Bio-ice cream qualities and survival of added microbes were evaluated at 0, 1, and 30 days. The viable of L. acidophilus decreased by 1.62 and 2.05 log cycles in lupine and peanuts milk ice creams throughout 30 days storage respectively. The counts of B. lactis reduced by 1.32 and 2.22 log cycles in lupine and peanuts ice creams respectively. Regardless of ice cream color, incorporation of vegetable milk ice cream significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of ice cream. The highest total solids and protein were found in ice creams containing peanuts milk and lowest fat and total acceptability were found in ice creams containing lupine milk. The produce of ice cream with vegetable milks developed the growth and viability of B. lactis and L. acidophilus.

The Journal of Microbiology, Biotechnology and Food Sciences, Aug 1, 2014

Guidelines book is your guide to: building skills and knowledge needed for control diabetes, find... more Guidelines book is your guide to: building skills and knowledge needed for control diabetes, finding a diet may be used to avoid complication of diabetes, finding tips for adolescence with diabetes,learning what makes your blood glucose too high or too low and make healthy food choices. This book is the outgrowth of experiences gained from our published scientific articles and teaching experiences in the Faculty of Applied Medical Sciences at Al Baha & Al Taif Universities, Saudi Arabia. In this book, we emphasized the educational training control of children with type1 diabetes, effectiveness of diabetic education program on the HbA1c levels among type1 diabetic children in Omdurman Paediatric Hospital, dietary guidelines, nutritional care, and meal planning for children with type1 diabetes. Hopefully, this book will serve to stimulate further scientific study on the children with type1 diabetes. The feedback contributed effectively to knowledge of diabetic children and their carer...

Advances in Applied Sciences, 2017

Education of patients with diabetes is considered a fundamental aspect of diabetes care and aimed... more Education of patients with diabetes is considered a fundamental aspect of diabetes care and aimed to evaluate the effectiveness of diabetic education, using a guiding style, for children with Type 1 diabetes in Omdurman pediatric hospital. The aim of this study was to achieving a near normal glycosylated hemoglobin, and preventing acute complications (hypoglycemia, hyperglycemia) on the children patients with type1 diabetic in Khartoum state. The sampling size was (101) according to the attendance to Diabetic clinic during data collection period (February-August 2013) in this study, the Control of diabetes through HA1C monitoring was measured prior to the intervention and over seven months after post-test. The result of present study showed that: the effective method of diabetes education for children with type1 diabetes has improved such as HA1C was significantly reduced from 11.6% to a mean of 9.1%.glycaemic control. Innovative education programme for Diabetic children with type 1 diabetes. It is effective in reducing the diabetes complications among diabetic children such as hyperglycaemia and hypoglycaemia. This educational programme for diabetic children is effective in reducing HA1c after seven months intervention. Diabetic educational program administered to type1 diabetes mellitus patients seen at a Diabetic clinic improved the knowledge and distress associated with the disease. The results also suggest the prevention of an increase in HbA1c.

Turkish Journal of Agriculture - Food Science and Technology, 2014

The aim of this study was to assess the effect of heat treatment and salt concentrations (0, 5, a... more The aim of this study was to assess the effect of heat treatment and salt concentrations (0, 5, and 10%) on the free amino acids (FAA) composition of Sudanese braided cheese (BC) ripened for up to 3 months at 5±2°C. Heat and salt concentration significantly affected the FAA of braided cheese. The free amino acids concentrations of BC ripened in 0%, 5%, and 10% salted whey (SW) were significantly fluctuated. Under ripening conditions tested (salt level + time), braided cheese made from pasteurized milk (BCPM) had consistently lower values of FAA than braided cheese made from raw milk (BCRM). In fresh cheese, the major FAA in BCRM were Glu (36.12 nmol/ml), Leu (26.77nmol/ml) and Lys (14.51 nmol/ml) while the major ones in BCPM were Lys (2.94 nmol/ml) and Ala (2.45 nmol/ml). BCPM stored in 10% SW had shorter quality life compared to that stored in 5% salted whey.

American Journal of Pediatrics, 2016

This an interventional study, pre and post study conducted in Khartoum State, from August 2011-20... more This an interventional study, pre and post study conducted in Khartoum State, from August 2011-2013, to assess the effect of the training of diabetic children in improving the control and management of diabetes. Convenience sampling technique was used to select 101 diabetic children from Khartoum State. The sample size was a according to the attendance to Omdurman pediatric hospital Diabetic clinic during data collection period. The data was collected by using a pre-tested questionnaire by the researcher. The data was then analyzed by using Statistical Package for Social Sciences (SPSS) version 20. The results of the study showed that; the training program me for diabetic children and their carers has increased the level of their knowledge about management of diabetes from 21.5% to 65.1%. It is also effective in enhancing a wide range of diabetic children and their carers 'knowledge about insulin from 28.40% to 82.32%. Innovative training programme for diabetic children and their carers is significantly effective in increasing their knowledge about checkup of diabetes from 8.2% to 90.80%. The study revealed that; the implementation of diabetes education for children with type1 diabetes has improved glycemic control. The study recommended that training programs about diabetic care for children and their carers should be emphasized at all pediatrics hospitals, Long term interventions are required for getting accurate diabetes control and more reduction of HA1c and Further researches with different design, different location to be conducted to assess the effectiveness of interventions on sustained glycemic control.

Improving the protein quality of foods by incorporating legumes or cereal protein isolates and/or... more Improving the protein quality of foods by incorporating legumes or cereal protein isolates and/or flour in blends is one of the main focuses of the international research community. The aim of this study was to produce peanut milk based yoghurt and to evaluate its physicochemical and organoleptic characteristics. Yoghurt samples were produced from blends of peanuts milk and skimmed milk powder together with the starter culture of Lactobacillus helveticus, Streptococcus thermophiles and Lactobacillus bulgaricus. The skimmed milk powder was added to peanuts milk at the concentration of 0% (sample A), 5% (sample B), 10 % (sample C), and 15% (sample D). The physicochemical and sensory characteristics of the products were subsequently analyzed at 0, 5, and 10 days. The results of chemical analysis showed protein contents of 11.55, 14.7, 18.55, and 20.65 % for the samples A, B, C, and D, respectively. Fat contents was varied and in the range of 3.35-4.55%, while total solid was ranged fro...

Journal of microbiology, biotechnology and food sciences, 2014

The aim of the present study was to search for milk clotting substitute from different parts (flo... more The aim of the present study was to search for milk clotting substitute from different parts (flowers, seeds, stem, leaves, ripe and unripe fruits) of Moringa oleifera. The samples were blended and extracted using different types of extracting solutions. The most reliable, quick and efficient enzyme extracting solution was found to be 5% NaCl in 100 mM sodium acetate buffer, pH 5.0, which was used throughout the study. The milk clotting activity was only observed in the seeds extract while the other parts were either deficient or has very low milk clotting activity. Thus, the moringa seeds were used as source of milk clotting enzyme. The extracted proteins were fractionated with ammonium sulfate at concentration of 20, 30, 40, 50 and 60 %. Highest milk clotting activity was observed in the 20 % fraction. This fraction was assumed to contain the clotting enzymes and characterized for its heating stability (30 – 90°C) and optimum temperature (30 – 90°C). The results demonstrated that ...

LWT - Food Science and Technology, 2014

The aim of the present study was to evaluate some physicochemical, microbiological and sensory pr... more The aim of the present study was to evaluate some physicochemical, microbiological and sensory properties of fresh and matured (75 days) soft cheeses made with mixtures of cow milk and 0, 25, 50 and 75 mL/100 mL of lupin milk. A remarkable increase in cheese yield was observed with increasing the level of lupin milk to the mixture. Compared to cow milk cheese, the protein content was significantly (P ≤ 0.05) increased while ash was decreased with the increase in the level of lupin milk for both fresh and matured cheese. However, fat content, total solids and acidity were increased only for fresh cheese and decreased for mature one compared to that of cow milk. The pH showed significant (P ≤ 0.05) reduction when the levels of lupin milk increased for fresh cheese while for matured cheese it slightly decreased. The total bacterial count is within the range that naturally exists in milk containing foods. The others microorganisms such as fungi, mould, E. coli, and Salmonella were not existed in both types of cheese. Regardless of cheese colour, incorporation of lupin milk at low concentration (25 mL/100 mL) significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of both fresh and mature cheese.

International Journal of Nutrition and Food Sciences, 2016

The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetabl... more The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetable (lupine and peanuts) milk, and to evaluate its probiotics, organoleptic and physicochemical characteristics. Ice cream samples were produced from blends of vegetable milk and skimmed milk powder together with the added Probiotics bacteria of Lactobacillusacidophilus and Bifidobacterium. lactis. The changes of Bio-ice cream qualities and survival of added microbes were evaluated at 0, 1, and 30 days. The viable of L. acidophilus decreased by 1.62 and 2.05 log cycles in lupine and peanuts milk ice creams throughout 30 days storage respectively. The counts of B. lactis reduced by 1.32 and 2.22 log cycles in lupine and peanuts ice creams respectively. Regardless of ice cream color, incorporation of vegetable milk ice cream significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of ice cream. The highest total solids and protein were found in ice creams containing peanuts milk and lowest fat and total acceptability were found in ice creams containing lupine milk. The produce of ice cream with vegetable milks developed the growth and viability of B. lactis and L. acidophilus.

Journal of Diseases and Medicinal Plants, 2016

The extraction of some medicinal plants (Plucheadioscorides aerial part, IPomoeacordofana whole p... more The extraction of some medicinal plants (Plucheadioscorides aerial part, IPomoeacordofana whole plant, Zaleya pantendra whole plant and Heliotrpium supinum aerial part), are commonly known to treat a variety of diseases in this study. Plants under study were investigated for their antibacterial activity against four standard bacterial strains Bacillus subtilis (NCTC8236), Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922), Pseudomonas aeruginosa (ATCC27853), and two standard fungal strains Aspergillius niger (ATCC9763) and Candida albicans (ATCC7596) in vitro. The plants extracts with diversely solvents with increasing in the polarity, petroleum ether, ethyl acetate and methanol at a concentration of 100mg/ml were applied using the agar plate well-diffusion method. All the extracts obtained from Zaleya pantendra were showed high activity against all tested bacterial strains, and while have no activity against fungal strains. The methanol extract showed high significantly activity against of all bacterial strains activity in particular at Gram-positive bacteria Staphylococcus aureus and less activity to Gram-negative bacteria was Escherichia coli. The least anti bacterially active plants was IPomoeacordofana. The crude extract from ethyl acetate of Heliotrpium supinum showed high activity against all tested fugal strains of all extracts, and have broader spectrum towards Aspergillius niger (IZ=30mm). The methanol extract of Zaleya pantendra is appropriate candidates for the development of modern antimicrobial compounds.

International Journal of Nutrition and Food Sciences, 2016

The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetabl... more The aim of the present study was to evaluate non fermented probiotic ice cream made from vegetable (lupine and peanuts) milk, and to evaluate its probiotics, organoleptic and physicochemical characteristics. Ice cream samples were produced from blends of vegetable milk and skimmed milk powder together with the added Probiotics bacteria of Lactobacillusacidophilus and Bifidobacterium. lactis. The changes of Bio-ice cream qualities and survival of added microbes were evaluated at 0, 1, and 30 days. The viable of L. acidophilus decreased by 1.62 and 2.05 log cycles in lupine and peanuts milk ice creams throughout 30 days storage respectively. The counts of B. lactis reduced by 1.32 and 2.22 log cycles in lupine and peanuts ice creams respectively. Regardless of ice cream color, incorporation of vegetable milk ice cream significantly (P ≤ 0.05) enhanced the taste, texture, flavor, and overall acceptability of ice cream. The highest total solids and protein were found in ice creams containing peanuts milk and lowest fat and total acceptability were found in ice creams containing lupine milk. The produce of ice cream with vegetable milks developed the growth and viability of B. lactis and L. acidophilus.

Green Energy and Technology, 2012

To realize short-period high-magnetic-field undulator, we have proposed an undulator using bulk h... more To realize short-period high-magnetic-field undulator, we have proposed an undulator using bulk high temperature superconductor in a staggered array structure. To investigate the effect of the longitudinal solenoid field on the electron beam trajectory and find out the optimum value of the solenoid field, the magnetic field near the center of this undulator was modeled and the trajectory of the single electron was calculated. As a result, we found that the stronger solenoid field worked as a stronger convergence force. However, the optimum value was not able to be determined by the result of trajectory calculation because the stronger field changes the spectrum of the radiation from the beam.

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC), 2012

ABSTRACT Excitations in 235U were measured with LaBr3:Ce scintillation detectors using the nuclea... more ABSTRACT Excitations in 235U were measured with LaBr3:Ce scintillation detectors using the nuclear resonance fluorescence (NRF) technique. A NRF experiment was performed at the High Intensity y-ray Source (HIyS) facility using quasi-monochromatic circularly or linearly polarized y-ray beams. Photons scattered at 90· relative to the incident beam were detected with two different sizes of cylindrical LaBr3:Ce detectors. Clear NRF peaks at 1733 and 1815 keY corresponding to de-excitations to the ground state and/or low-lying levels in 235U were observed within 77 minutes of beam time even under the high background due to the selfactivity of LaBr3:Ce and the radioactive decay of 214Bi nuclei existing in the 235U target. The present study shows a possibility of using LaBr3:Ce detector to perform NRF experiments, promoting many options for inspection of special nuclear materials.

2013 1st International Conference on Communications, Signal Processing and Their Applications, ICCSPA 2013, 2013

This paper presents an L-shaped microphone array configuration for a robust 2-D localization of a... more This paper presents an L-shaped microphone array configuration for a robust 2-D localization of an impulsive acoustic source in an indoor environment. The localization technique relies on a recently proposed time delay estimation technique based on the orthogonal clustering algorithm (TDE-OC) which is designed to work under room reverberant conditions and at low sampling rates. The TDE-OC method finds the TDEs from the sparse room impulse response (RIR) signal. The TDE's obtained from RIR adds to the robustness of the TDE-OC method against room reverberations while the low sampling rates requirement reduces the hardware and computational complexity and relaxes the communication link between the microphones and the centralized location. Experimental results show the robustness of this method in a reverberant environment with low sampling rates, when compared with the generalized cross correlation method.