Maria Schinoni - Academia.edu (original) (raw)
Papers by Maria Schinoni
Journal of medical virology, Jan 13, 2017
The Brazilian public health system (SUS) has provided antiviral drugs for chronic hepatitis B tre... more The Brazilian public health system (SUS) has provided antiviral drugs for chronic hepatitis B treatment for over 10 years, but a system for monitoring for drug-related resistance mutations is not available. Determine the presence of HBV mutations associated with resistance to nucleos(t)ide analogs among 81 patients with chronic HBV infection in Salvador - BA - Brazil. HBV-DNA was PCR amplified with primers deduced from the rt domain at the HBV P gene, the sequence extended 1032 bp (from amino acid 1 to 344 - rt domain). Those sequences were submitted to the HBV drug resistance database to retrieve each mutation according to the genotype. HBV genotype A1 (85.2%) was the most prevalent, followed by genotype A2 (4.9%), F (6.2%), and C1, D2 and D4 (1.2% each). Six patients (7%) exhibited resistance mutations to LAM, ETV and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T. All of these mutations were pr...
Rev Cienc Med Biol, Apr 1, 2009
Revista De Ciencias Medicas E Biologicas, Nov 21, 2012
Acta Gastroenterologica Latinoamericana, 2013
Gazeta Medica Da Bahia, Jul 8, 2009
A hepatite crônica por vírus C (HVC) é uma doença de endemicidade mundial atingindo 200 milhões d... more A hepatite crônica por vírus C (HVC) é uma doença de endemicidade mundial atingindo 200 milhões de pessoas em todo o mundo e pode manifestar-se num estágio avançado de cirrose e em 20% como hepatocarcinoma. Vários trabalhos têm documentado uma associação entre hepatite C e diabetes tipo 2. Atualmente é conhecido a ação do vírus C sobre o metabolismo da glicose assim como o papel fibrosante do hiperinsulinismo . A prevalência aumentada do diabetes tipo 2 na hepatite por vírus C, não foi relatada exclusivamente em pacientes com cirrose (4) . A resistência à insulina assim como uma captação reduzida de glicose pelo fígado, seriam os responsáveis pela progressão para diabetes mellitus em pacientes com cirrose avançada . A insulina é o principal hormônio regulatório da homeostase da glicose. Quando se liga a seu receptor induz a fosforilação do receptor do substrato na célula do músculo e do tecido adiposo, estimulando a trans-ativação dos transportadores GLUT 4 favorecendo, assim, a captação de glicose por estas células para armazenar como glicogênio e com isso a se inibe a produção de glicose pelo fígado. A secreção de insulina cresce quando a sensibilidade das células a insulina diminui até um ponto que este aumento de insulina não consegue induzir uma melhora na sensibilidade à mesma manifestandose assim o diabetes. A resistência à insulina é o principal mecanismo fisiopatológico da síndrome metabólica e depende da secreção de insulina e da sensibilidade dos tecidos a mesma sendo o hiperinsulinismo a alteração bioquímica deste processo. O padrão ouro in vivo para medir resistência à insulina (RI) é a técnica do "clamp" euglicémico hiperinsulinemico sendo substituído por praticidade pelo método de HOMA-RI (Homeostasis Model Assesment of Insulin Resistance), sendo sua fórmula: insulina em jejum U/ mL x glicose plasmática em jejum (mmol/L).
Acta gastroenterologica Latinoamericana
Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associa... more Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associated with an increased progression to severe liver fibrosis, such as alcohol intake higher than 30 g/day, older age at infection and co-infection. Nevertheless, different research centers have found conflicting data concerning the liver iron overload fibrogenic role. To assess the association between hepatic iron overload and fibrosis stage grades in hepatitis C Virus carriers, hepatic steatosis and demographic variables. In this descriptive study we recruited 290 positive anti-HCV and qualitative HCV-RNA, treatment naive chronic hepatitis C outpatients registered fom 2007 to 2009 at the Federal University of Bahia's Hospital. The variables studied in the liver biopsy results were: 1) fibrosis stage according to META VIR score (F0-F4), 2) iron overload presence or absence according to Perls staining, and 3) presence or absence of steatosis. Fibrosis stages were categorized as mild/mod...
Annals of hepatology
Fatigue is an important clinical finding in the hepatitis virus chronic infection. However, the a... more Fatigue is an important clinical finding in the hepatitis virus chronic infection. However, the absence of scales to measure fatigue, translated and validated for Brazilian Portuguese, prevents access to information essential in clarifying specific clinical conditions in this population. The aim of this study was to determine the psychometric properties of the fatigue impact scale for daily use (D-FIS), in Brazilian Portuguese, for patients with the hepatitis C virus (HCV) and hepatitis B virus (HBV) chronic infection. In this cross-sectional study, the authors evaluated the D-FIS in 101 outpatients, followed at the reference hospital. The Mini International Neuropsychiatric Interview Brazilian (MINI PLUS) was used to identify psychiatric disorders, and the Short Form Health Survey 36-item (SF-36) to evaluate the self-reported quality of life. We also examined the impact of fatigue on the quality of life of this group of patients. Relevant psychometric D-FIS results were: floor effe...
Annals of hepatology
Drug-induced liver injury (DILI) remains a major problem for drug development and represents a ch... more Drug-induced liver injury (DILI) remains a major problem for drug development and represents a challenging diagnosis for clinicians. The absence of specific biomarkers for diagnosing DILI precludes the availability of reliable data on the epidemiology of the disease. In this study we aimed to describe the features of idiosyncratic hepatotoxicity reports in Latin American countries. A literature search was performed using the online version of MEDLINE, EMBASE, Scopus, Google Scholar and specific data bases from Latin America (LA) (Scielo, Lilacs) to identify any case report or case series of published DILI from 1996 to 2012. From 1996 to 2012, a total of 176 patients with DILI were published in LA, involving 53 suspicious drugs. The median age in the adult population of these patients was 55 years (17-82) with prevalence of women (67%). Among main therapeutic classes, the rank order was led by non-steroidal anti-inflammatory (61 cases) and systemic antibacterial drugs (37 cases). Nim...
Clinical Neuropharmacology, 2006
Assess the effect of amantadine on depressive symptoms during interferon alfa therapy for hepatit... more Assess the effect of amantadine on depressive symptoms during interferon alfa therapy for hepatitis C virus infection. We performed a randomized, controlled trial with 14 hepatitis C virus-infected patients, treated with pegylated interferon alfa-2a 180 microg/wk plus ribavirin 1.200 mg/d. Eight patients were randomized to receive amantadine 200 mg/d, and 6 other individuals were randomized to control group without amantadine. Severity of depression and anxiety was measured using the Hospital Anxiety and Depression Scale, before starting re-treatment, and 4, 12, and 24 weeks after immunotherapy with pegylated interferon alfa-2a. Evaluations were performed by psychiatrists blinded in reference to the state of amantadine treatment. Friedman chi(2) test for repeated measures and Mann-Whitney test for nonparametric data were used to assess significant differences. From baseline to follow-up, no significant increase in mean Hospital Anxiety and Depression Scale scores of depressive symptoms were seen in amantadine group (P = 0.142), meanwhile there was a statistical increase of depression scores in the control group (P = 0.001). Our randomized pilot study, though small, clearly indicates that interferon alfa-induced depressive symptoms can be prevented by the use of amantadine. However, double-blind placebo-controlled trials with a higher sample size are required to confirm these preliminary findings.
Annals of hepatology
Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepato... more Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepatoportal sclerosis (HPS) is a disease of uncertain etiology. However, various pathophysiological mechanisms has been postulated, including chronic or recurrent infections and exposure to drugs or toxins. In this context, it appears to be of multifactorial etiology or resulting from a portal vascular endothelium aggression. It is important to consider whether the use of dietary supplements and herbs can trigger or contribute to the occurance of HPS. We report a possible association of HPS with the consumption of herbals and / or dietary supplements. We describe two cases of HPS in patients without known etiology causes associated with this disease. Both patients were females who were diagnosed with HPS following the consumption of Herbalife® products and putative anorexigenic agents in the form herbals infusions. Image-based analysis and the assessment of the histopathological alterations f...
Acta Gastroenterologica Latinoamericana, Dec 1, 2012
Hepatitis C is the major cause of liver transplantation and hepatocellular carcinoma and shows a ... more Hepatitis C is the major cause of liver transplantation and hepatocellular carcinoma and shows a global prevalence of 3%. Hepatitis C virus (HCV) is associated with extrahepatic manifestations (e.g., cutaneous affections) and psoriasis has been reported as a comorbidity. However, there are few studies analyzing this association. 1) To evaluate anti-HCV prevalence (confirmed by the detection of HCV-RNA) in patients with psoriasis and its potential clinical implications; 2) to analyze the prevalence of other infections in this population: hepatitis B virus (HBV), human T lymphotropic virus, subtypes I and II (HTLVI/II), and human immunodeficiency virus, subtypes I and II (HIV I/II). This is cross sectional study that included patients older than 18 years-old with psoriasis from a Teaching Hospital in Salvador, Bahia. An epidemiological questionnaire was administered and serological tests were performed: surface HBV antigen (HBsAg), antibodies to HBsAg (anti-HBs), anti-HTL VI/II, anti-HIV I/II, and anti-HCV. Anti-HCV positive results were confirmed by HCV-RNA detection and viral genotype was determined. Skin lesions were evaluated using the Psoriasis Area and Severity Index (PASI). Liver biopsies were analyzed according to the METAVIR score. From the 140 patients included in the study, 7.1% were anti-HCV positive confirmed by the detection of HCV RNA. This prevalence was higher than that in the city of Salvador (1.5%). Other serological results were: HBsAg 0%, anti-HBs 25.8%, HTLV I/II (0,9%), and HIV I/II 0%. PASI score was higher in positive anti-HCV patients than in their negative counterparts (19.5 versus 13.4). Histopathological analysis showed 66.7% of patients with METAVIR F3/F4. Anti-HCV prevalence was higher in psoriasis patients than in the general population of the city. More severe skin lesions were found in HCV patients.
J Clin Virol, 2006
infection derive largely from Randomized Controlled Trials performed on selected patient populati... more infection derive largely from Randomized Controlled Trials performed on selected patient populations, excluding subjects with comorbid conditions. Objectives: To evaluate the feasibility, safety, and efficacy of antiviral treatment for HCV infection in real practice, including subgroups of patients with various co-morbidities.
Revista De Ciencias Medicas E Biologicas, 2009
In the course of a chronic infection with the hepatitis C virus, the fibrosis progression rate va... more In the course of a chronic infection with the hepatitis C virus, the fibrosis progression rate varies among individuals, and depends on the existence of certain co-factors. In this context, a growing interest has emerged and has focused on insulin resistance. In fact, the hepatitis C virus is now recognized as being responsible for a direct interference with the insulin signalling pathway. This insulin resistance of viral origin, in combination with an eventual insulin resistance associated with an existing metabolic syndrome, can therefore accelerate its evolution to a type II diabetes. Independently of its pathogenesis, insulin resistance occurring in chronic hepatitis C causes a fatty liver, contributes to the progression towards cirrhosis, and narrows the chances of a successful antiviral therapy. It is therefore crucial to recognize it in order to correct it.
Journal of medical virology, Jan 30, 2016
Hepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many... more Hepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences were present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/H...
Annals of Hepatology Official Journal of the Mexican Association of Hepatology, May 1, 2012
BACKGROUND AND RATIONALE FOR THE STUDY: Hepatitis B (HB) is one of the most prevalent occupationa... more BACKGROUND AND RATIONALE FOR THE STUDY: Hepatitis B (HB) is one of the most prevalent occupational infections in health attendance environments. According to the Brazil Ministry of Health, health professionals must be vaccinated against the hepatitis B virus (HBV) and provide laboratory proof of immunization.AIMS: To evaluate the seroprevalence of HBV infection and to analyze the response to vaccine by measuring serum antibodies against HBV surface antigen (anti-HBs) levels in a sample of students and health professionals at the Federal University of Bahia.RESULTS: As part of this cross-sectional study, a campaign against occupational HB was launched in 2007 and vaccination and blood samples were collected for analysis of the following serological markers: HBV surface antigen (HBsAg) and anti-HBs (measured by enzyme-linked immunoassay) and total antibodies against HBV core antigen (anti-HBc). The study sample comprised 766 people. Global seropositivity for HBV was 1.7%: 0.5% in the students and 8.8% in the professionals. In a group of volunteers, a serological profile compatible with postvaccine immunity was shown by 95% of volunteers with proof of vaccination and by 81.8% of volunteers without proof of vaccination.CONCLUSIONS: In conclusion, this study shows that it is important to promote vaccination campaigns and improve knowledge and awareness about HB among health care workers and higher education students.
Microbial pathogenesis, Jan 21, 2015
Chronic infection with hepatitis C virus (HCV) causes a quantitative and functional alteration in... more Chronic infection with hepatitis C virus (HCV) causes a quantitative and functional alteration in innate and adaptative immunity. In the present work, we determined by flow-cytometry the profile of blood lymphocyte of untreated HCV patients and in subjects of this group that achieved or not an early virologic response at 12-weeks of treatment with interferon-α plus ribavirin. Twenty-six untreated HCV patients and 20 control healthy individuals were enrolled in the study. Untreated HCV patients had a higher proportion of B cell and a lower proportion of CD8(+) T cell and NK cells than healthy individuals did, but the proportions of CD4(+) T cells and Treg cells (CD4(+)CD25(+)Foxp3(+)) were similar in these patients and controls. Untreated HCV patients presenting cryoglobulinemia had a lower proportion of Treg cells and a lower Treg/NK cell ratio when compared with those without cryoglobulins. Nineteen out of 26 untreated HCV patients remained in the study and were treated with Interf...
Acta Gastroenterologica Latinoamericana, 2012
Journal of medical virology, Jan 13, 2017
The Brazilian public health system (SUS) has provided antiviral drugs for chronic hepatitis B tre... more The Brazilian public health system (SUS) has provided antiviral drugs for chronic hepatitis B treatment for over 10 years, but a system for monitoring for drug-related resistance mutations is not available. Determine the presence of HBV mutations associated with resistance to nucleos(t)ide analogs among 81 patients with chronic HBV infection in Salvador - BA - Brazil. HBV-DNA was PCR amplified with primers deduced from the rt domain at the HBV P gene, the sequence extended 1032 bp (from amino acid 1 to 344 - rt domain). Those sequences were submitted to the HBV drug resistance database to retrieve each mutation according to the genotype. HBV genotype A1 (85.2%) was the most prevalent, followed by genotype A2 (4.9%), F (6.2%), and C1, D2 and D4 (1.2% each). Six patients (7%) exhibited resistance mutations to LAM, ETV and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T. All of these mutations were pr...
Rev Cienc Med Biol, Apr 1, 2009
Revista De Ciencias Medicas E Biologicas, Nov 21, 2012
Acta Gastroenterologica Latinoamericana, 2013
Gazeta Medica Da Bahia, Jul 8, 2009
A hepatite crônica por vírus C (HVC) é uma doença de endemicidade mundial atingindo 200 milhões d... more A hepatite crônica por vírus C (HVC) é uma doença de endemicidade mundial atingindo 200 milhões de pessoas em todo o mundo e pode manifestar-se num estágio avançado de cirrose e em 20% como hepatocarcinoma. Vários trabalhos têm documentado uma associação entre hepatite C e diabetes tipo 2. Atualmente é conhecido a ação do vírus C sobre o metabolismo da glicose assim como o papel fibrosante do hiperinsulinismo . A prevalência aumentada do diabetes tipo 2 na hepatite por vírus C, não foi relatada exclusivamente em pacientes com cirrose (4) . A resistência à insulina assim como uma captação reduzida de glicose pelo fígado, seriam os responsáveis pela progressão para diabetes mellitus em pacientes com cirrose avançada . A insulina é o principal hormônio regulatório da homeostase da glicose. Quando se liga a seu receptor induz a fosforilação do receptor do substrato na célula do músculo e do tecido adiposo, estimulando a trans-ativação dos transportadores GLUT 4 favorecendo, assim, a captação de glicose por estas células para armazenar como glicogênio e com isso a se inibe a produção de glicose pelo fígado. A secreção de insulina cresce quando a sensibilidade das células a insulina diminui até um ponto que este aumento de insulina não consegue induzir uma melhora na sensibilidade à mesma manifestandose assim o diabetes. A resistência à insulina é o principal mecanismo fisiopatológico da síndrome metabólica e depende da secreção de insulina e da sensibilidade dos tecidos a mesma sendo o hiperinsulinismo a alteração bioquímica deste processo. O padrão ouro in vivo para medir resistência à insulina (RI) é a técnica do "clamp" euglicémico hiperinsulinemico sendo substituído por praticidade pelo método de HOMA-RI (Homeostasis Model Assesment of Insulin Resistance), sendo sua fórmula: insulina em jejum U/ mL x glicose plasmática em jejum (mmol/L).
Acta gastroenterologica Latinoamericana
Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associa... more Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associated with an increased progression to severe liver fibrosis, such as alcohol intake higher than 30 g/day, older age at infection and co-infection. Nevertheless, different research centers have found conflicting data concerning the liver iron overload fibrogenic role. To assess the association between hepatic iron overload and fibrosis stage grades in hepatitis C Virus carriers, hepatic steatosis and demographic variables. In this descriptive study we recruited 290 positive anti-HCV and qualitative HCV-RNA, treatment naive chronic hepatitis C outpatients registered fom 2007 to 2009 at the Federal University of Bahia's Hospital. The variables studied in the liver biopsy results were: 1) fibrosis stage according to META VIR score (F0-F4), 2) iron overload presence or absence according to Perls staining, and 3) presence or absence of steatosis. Fibrosis stages were categorized as mild/mod...
Annals of hepatology
Fatigue is an important clinical finding in the hepatitis virus chronic infection. However, the a... more Fatigue is an important clinical finding in the hepatitis virus chronic infection. However, the absence of scales to measure fatigue, translated and validated for Brazilian Portuguese, prevents access to information essential in clarifying specific clinical conditions in this population. The aim of this study was to determine the psychometric properties of the fatigue impact scale for daily use (D-FIS), in Brazilian Portuguese, for patients with the hepatitis C virus (HCV) and hepatitis B virus (HBV) chronic infection. In this cross-sectional study, the authors evaluated the D-FIS in 101 outpatients, followed at the reference hospital. The Mini International Neuropsychiatric Interview Brazilian (MINI PLUS) was used to identify psychiatric disorders, and the Short Form Health Survey 36-item (SF-36) to evaluate the self-reported quality of life. We also examined the impact of fatigue on the quality of life of this group of patients. Relevant psychometric D-FIS results were: floor effe...
Annals of hepatology
Drug-induced liver injury (DILI) remains a major problem for drug development and represents a ch... more Drug-induced liver injury (DILI) remains a major problem for drug development and represents a challenging diagnosis for clinicians. The absence of specific biomarkers for diagnosing DILI precludes the availability of reliable data on the epidemiology of the disease. In this study we aimed to describe the features of idiosyncratic hepatotoxicity reports in Latin American countries. A literature search was performed using the online version of MEDLINE, EMBASE, Scopus, Google Scholar and specific data bases from Latin America (LA) (Scielo, Lilacs) to identify any case report or case series of published DILI from 1996 to 2012. From 1996 to 2012, a total of 176 patients with DILI were published in LA, involving 53 suspicious drugs. The median age in the adult population of these patients was 55 years (17-82) with prevalence of women (67%). Among main therapeutic classes, the rank order was led by non-steroidal anti-inflammatory (61 cases) and systemic antibacterial drugs (37 cases). Nim...
Clinical Neuropharmacology, 2006
Assess the effect of amantadine on depressive symptoms during interferon alfa therapy for hepatit... more Assess the effect of amantadine on depressive symptoms during interferon alfa therapy for hepatitis C virus infection. We performed a randomized, controlled trial with 14 hepatitis C virus-infected patients, treated with pegylated interferon alfa-2a 180 microg/wk plus ribavirin 1.200 mg/d. Eight patients were randomized to receive amantadine 200 mg/d, and 6 other individuals were randomized to control group without amantadine. Severity of depression and anxiety was measured using the Hospital Anxiety and Depression Scale, before starting re-treatment, and 4, 12, and 24 weeks after immunotherapy with pegylated interferon alfa-2a. Evaluations were performed by psychiatrists blinded in reference to the state of amantadine treatment. Friedman chi(2) test for repeated measures and Mann-Whitney test for nonparametric data were used to assess significant differences. From baseline to follow-up, no significant increase in mean Hospital Anxiety and Depression Scale scores of depressive symptoms were seen in amantadine group (P = 0.142), meanwhile there was a statistical increase of depression scores in the control group (P = 0.001). Our randomized pilot study, though small, clearly indicates that interferon alfa-induced depressive symptoms can be prevented by the use of amantadine. However, double-blind placebo-controlled trials with a higher sample size are required to confirm these preliminary findings.
Annals of hepatology
Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepato... more Introduction and aim. Non-cirrhotic idiopathic portal hypertension (NCIPH), also known as hepatoportal sclerosis (HPS) is a disease of uncertain etiology. However, various pathophysiological mechanisms has been postulated, including chronic or recurrent infections and exposure to drugs or toxins. In this context, it appears to be of multifactorial etiology or resulting from a portal vascular endothelium aggression. It is important to consider whether the use of dietary supplements and herbs can trigger or contribute to the occurance of HPS. We report a possible association of HPS with the consumption of herbals and / or dietary supplements. We describe two cases of HPS in patients without known etiology causes associated with this disease. Both patients were females who were diagnosed with HPS following the consumption of Herbalife® products and putative anorexigenic agents in the form herbals infusions. Image-based analysis and the assessment of the histopathological alterations f...
Acta Gastroenterologica Latinoamericana, Dec 1, 2012
Hepatitis C is the major cause of liver transplantation and hepatocellular carcinoma and shows a ... more Hepatitis C is the major cause of liver transplantation and hepatocellular carcinoma and shows a global prevalence of 3%. Hepatitis C virus (HCV) is associated with extrahepatic manifestations (e.g., cutaneous affections) and psoriasis has been reported as a comorbidity. However, there are few studies analyzing this association. 1) To evaluate anti-HCV prevalence (confirmed by the detection of HCV-RNA) in patients with psoriasis and its potential clinical implications; 2) to analyze the prevalence of other infections in this population: hepatitis B virus (HBV), human T lymphotropic virus, subtypes I and II (HTLVI/II), and human immunodeficiency virus, subtypes I and II (HIV I/II). This is cross sectional study that included patients older than 18 years-old with psoriasis from a Teaching Hospital in Salvador, Bahia. An epidemiological questionnaire was administered and serological tests were performed: surface HBV antigen (HBsAg), antibodies to HBsAg (anti-HBs), anti-HTL VI/II, anti-HIV I/II, and anti-HCV. Anti-HCV positive results were confirmed by HCV-RNA detection and viral genotype was determined. Skin lesions were evaluated using the Psoriasis Area and Severity Index (PASI). Liver biopsies were analyzed according to the METAVIR score. From the 140 patients included in the study, 7.1% were anti-HCV positive confirmed by the detection of HCV RNA. This prevalence was higher than that in the city of Salvador (1.5%). Other serological results were: HBsAg 0%, anti-HBs 25.8%, HTLV I/II (0,9%), and HIV I/II 0%. PASI score was higher in positive anti-HCV patients than in their negative counterparts (19.5 versus 13.4). Histopathological analysis showed 66.7% of patients with METAVIR F3/F4. Anti-HCV prevalence was higher in psoriasis patients than in the general population of the city. More severe skin lesions were found in HCV patients.
J Clin Virol, 2006
infection derive largely from Randomized Controlled Trials performed on selected patient populati... more infection derive largely from Randomized Controlled Trials performed on selected patient populations, excluding subjects with comorbid conditions. Objectives: To evaluate the feasibility, safety, and efficacy of antiviral treatment for HCV infection in real practice, including subgroups of patients with various co-morbidities.
Revista De Ciencias Medicas E Biologicas, 2009
In the course of a chronic infection with the hepatitis C virus, the fibrosis progression rate va... more In the course of a chronic infection with the hepatitis C virus, the fibrosis progression rate varies among individuals, and depends on the existence of certain co-factors. In this context, a growing interest has emerged and has focused on insulin resistance. In fact, the hepatitis C virus is now recognized as being responsible for a direct interference with the insulin signalling pathway. This insulin resistance of viral origin, in combination with an eventual insulin resistance associated with an existing metabolic syndrome, can therefore accelerate its evolution to a type II diabetes. Independently of its pathogenesis, insulin resistance occurring in chronic hepatitis C causes a fatty liver, contributes to the progression towards cirrhosis, and narrows the chances of a successful antiviral therapy. It is therefore crucial to recognize it in order to correct it.
Journal of medical virology, Jan 30, 2016
Hepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many... more Hepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences were present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/H...
Annals of Hepatology Official Journal of the Mexican Association of Hepatology, May 1, 2012
BACKGROUND AND RATIONALE FOR THE STUDY: Hepatitis B (HB) is one of the most prevalent occupationa... more BACKGROUND AND RATIONALE FOR THE STUDY: Hepatitis B (HB) is one of the most prevalent occupational infections in health attendance environments. According to the Brazil Ministry of Health, health professionals must be vaccinated against the hepatitis B virus (HBV) and provide laboratory proof of immunization.AIMS: To evaluate the seroprevalence of HBV infection and to analyze the response to vaccine by measuring serum antibodies against HBV surface antigen (anti-HBs) levels in a sample of students and health professionals at the Federal University of Bahia.RESULTS: As part of this cross-sectional study, a campaign against occupational HB was launched in 2007 and vaccination and blood samples were collected for analysis of the following serological markers: HBV surface antigen (HBsAg) and anti-HBs (measured by enzyme-linked immunoassay) and total antibodies against HBV core antigen (anti-HBc). The study sample comprised 766 people. Global seropositivity for HBV was 1.7%: 0.5% in the students and 8.8% in the professionals. In a group of volunteers, a serological profile compatible with postvaccine immunity was shown by 95% of volunteers with proof of vaccination and by 81.8% of volunteers without proof of vaccination.CONCLUSIONS: In conclusion, this study shows that it is important to promote vaccination campaigns and improve knowledge and awareness about HB among health care workers and higher education students.
Microbial pathogenesis, Jan 21, 2015
Chronic infection with hepatitis C virus (HCV) causes a quantitative and functional alteration in... more Chronic infection with hepatitis C virus (HCV) causes a quantitative and functional alteration in innate and adaptative immunity. In the present work, we determined by flow-cytometry the profile of blood lymphocyte of untreated HCV patients and in subjects of this group that achieved or not an early virologic response at 12-weeks of treatment with interferon-α plus ribavirin. Twenty-six untreated HCV patients and 20 control healthy individuals were enrolled in the study. Untreated HCV patients had a higher proportion of B cell and a lower proportion of CD8(+) T cell and NK cells than healthy individuals did, but the proportions of CD4(+) T cells and Treg cells (CD4(+)CD25(+)Foxp3(+)) were similar in these patients and controls. Untreated HCV patients presenting cryoglobulinemia had a lower proportion of Treg cells and a lower Treg/NK cell ratio when compared with those without cryoglobulins. Nineteen out of 26 untreated HCV patients remained in the study and were treated with Interf...
Acta Gastroenterologica Latinoamericana, 2012