M. Tronko - Academia.edu (original) (raw)
Papers by M. Tronko
Žurnal Nacìonalʹnoï akademìï medičnih nauk Ukraïni, Jul 30, 2022
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ISEE Conference Abstracts, 2011
Background and aims – As a result of the accident at the Chernobyl Nuclear Power Plant, millions ... more Background and aims – As a result of the accident at the Chernobyl Nuclear Power Plant, millions of residents of Belarus, Russia and Ukraine were exposed to significant doses of radioactive iodine ...
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Cytology and Genetics, 2021
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Data are analyzed for Kyiv and Sewastopol City and 25 oblasts (regions) in Ukraine, and for Minsk... more Data are analyzed for Kyiv and Sewastopol City and 25 oblasts (regions) in Ukraine, and for Minsk and Gomel City and 6 oblasts in Belarus. Average thyroid doses due to the Chernobyl accident were assessed for every birth year in the period 1968-85. Census data were used to derive the population in 1986. Case data were thyroid cancers operated in the period 19862001 allocated to the place of residence at the time of the accident. The 35 oblasts/cities were subdivided in an upper, middle and lower group of baseline thyroid cancer incidence. Poisson regressions were performed to estimate baseline incidence rates in the three groups. Compared to 1986-89, the baseline rate is increased by about a factor of 4 for females in the upper group for the whole period 1990-2001, and in the lower group for the period 19982001. The increase is less expressed in the other cases and for males in general. The baseline cases is assessed to contribute about 65% to the thyroid cancer incidence in Ukraine...
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Data are analysed for 684 settlements in Ukraine and 458 settlements in Belarus. In each of the s... more Data are analysed for 684 settlements in Ukraine and 458 settlements in Belarus. In each of the settlements more than 10 measurements of the I content in human thyroids had been performed in the period May/June 1986. Based on the measurement data, average thyroid doses due to the Chernobyl accident were assessed for every birth year in the birth-year cohort 1968-85. Census data from 1979 and 1989, and mortality rates in the period 1986-89 were used to derive the population structure in 1986. Case data were numbers of operations of pathologically confirmed thyroid cancers in the period 1986-2001 taken from registries that include the place of residence at the time of the accident. The excess absolute risk (EAR) per thyroid dose in all 1142 settlements is estimated for females to 3.1 (95% CI: 2.6; 3.6) cases per 10 PY-Gy, and for males to 2.4 (95% CI: 2.0; 2.8) cases per 10 PY-Gy. The excess relative risk (ERR) per dose is for females 7.2 (95% CI: 5.3; 9.1) Gy, and for males 42 (95% C...
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The Lancet Oncology, 2018
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Ukrainskiĭ biokhimicheskiĭ zhurnal
A comparative analysis of the expression of both, RET/PTC1 and RET/PTC3 oncogenes in papillary th... more A comparative analysis of the expression of both, RET/PTC1 and RET/PTC3 oncogenes in papillary thyroid carcinomas (PTC) of patients from different age groups was carried out. Those were the following groups: children (mean age - 13 years, mean latency period - 13 years), young adults (mean age - 24 years, mean latency period - 14 years), adults (mean age - 38 years, mean latency period - 22 years). The presence of RET/PTC oncogenes was detected using polymerase chain reaction. In all cases the samples of both tumor and normal thyroid tissue were studied. It was established that induction of both, RET/PTC1 and RET/PTC3 rearrangements was present only in carcinoma samples. In PTCs the percentage of RET/PTC-positive tumors with increasing the age of patients has been decreasing. It should be noted that the part of carcinomas with induction of RET/PTC1 did not change with increasing the age of patients. At the same time the frequency of RET/PTC3 rearrangements with the increasing both t...
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Experimental oncology, 2009
To study the changes of cell cycle, mitochondrial membrane potential and caspase activation in re... more To study the changes of cell cycle, mitochondrial membrane potential and caspase activation in response to an antitumour drug Taxol in ARO and KTC-2 cell lines of anaplastic thyroid carcinoma. Experiments were done on thyroid anaplastic cancer cell lines ARO and KTC-2 using Western blotting, flow cytometry, light and fluorescent microscopy. Taxol significantly activated caspases in ARO cells starting from drug concentration of 5 nM. Maximum activation was observed at 25 nM and further increase of Taxol concentration to 100 nM resulted in a reduction of caspase activation. Concomitant to caspase activation, a loss of mitochondrial membrane potential was observed. At Taxol concentration of 100 nM, most cells lost their mitochondrial membrane potential. Low Taxol concentrations (10 nM) caused changes in the cell cycle that are typical for apoptosis without cell cycle arrest. Higher drug doses starting from 50 nM arrested cell cycle in G2/M phase. In KTC-2 cell line Taxol concentration ...
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Thyroid, 2004
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The Journal of Clinical Endocrinology & Metabolism, 2009
Background: Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid... more Background: Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid cancer risk in exposed children. Data on exposure to the embryonic/fetal thyroid are rare, raising questions about use of iodine 131 (I-131) in pregnant women. We present here estimated risks of thyroid disease from exposure in utero to I-131 fallout from the Chernobyl nuclear accident. Methods: We conducted a cross-sectional thyroid screening study (palpation, ultrasound, thyroid hormones, and, if indicated, fine needle aspiration) from 2003 to 2006. Participants were 2582 mother-child pairs from Ukraine in which the mother had been pregnant at the time of the accident on April 26, 1986, or 2 months after the time during which I-131 fallout was still present (1494 from contaminated areas, 1088 in the comparison group). Individual cumulative in utero thyroid dose estimates were derived from estimated I-131 activity in the mother’s thyroid (mean 72 mGy; range 0–3230 mGy). Results: There ...
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Journal of radiological protection : official journal of the Society for Radiological Protection, 2012
As a result of the accident at the Chernobyl Nuclear Power Plant, millions of residents of Belaru... more As a result of the accident at the Chernobyl Nuclear Power Plant, millions of residents of Belarus, Russia, and Ukraine were exposed to large doses of radioactive iodine isotopes, mainly I-131. The purpose of the Ukraine-American (UkrAm) and Belarus-American (BelAm) projects are to quantify the risks of thyroid cancer in the framework of a classical cohort study, comprising subjects who were aged under 18 years at the time of the accident, had direct measurements of thyroid I-131 radioactivity taken within two months after the accident, and were residents of three heavily contaminated northern regions of Ukraine (Zhitomir, Kiev, and Chernigov regions). Four two-year screening examination cycles were implemented from 1998 until 2007 to study the risks associated with thyroid cancer due to the iodine exposure caused during the Chernobyl accident. A standardised procedure of clinical examinations included: thyroid palpation, ultrasound examination, blood collection followed by a determ...
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Environmental Health Perspectives, 2011
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Cytology and Genetics, 2021
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World journal of …, 2000
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The Ukrainian Biochemical Journal
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Experimental Oncology
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British Journal of Cancer, 2015
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Žurnal Nacìonalʹnoï akademìï medičnih nauk Ukraïni, Jul 30, 2022
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ISEE Conference Abstracts, 2011
Background and aims – As a result of the accident at the Chernobyl Nuclear Power Plant, millions ... more Background and aims – As a result of the accident at the Chernobyl Nuclear Power Plant, millions of residents of Belarus, Russia and Ukraine were exposed to significant doses of radioactive iodine ...
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Cytology and Genetics, 2021
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Bookmarks Related papers MentionsView impact
Data are analyzed for Kyiv and Sewastopol City and 25 oblasts (regions) in Ukraine, and for Minsk... more Data are analyzed for Kyiv and Sewastopol City and 25 oblasts (regions) in Ukraine, and for Minsk and Gomel City and 6 oblasts in Belarus. Average thyroid doses due to the Chernobyl accident were assessed for every birth year in the period 1968-85. Census data were used to derive the population in 1986. Case data were thyroid cancers operated in the period 19862001 allocated to the place of residence at the time of the accident. The 35 oblasts/cities were subdivided in an upper, middle and lower group of baseline thyroid cancer incidence. Poisson regressions were performed to estimate baseline incidence rates in the three groups. Compared to 1986-89, the baseline rate is increased by about a factor of 4 for females in the upper group for the whole period 1990-2001, and in the lower group for the period 19982001. The increase is less expressed in the other cases and for males in general. The baseline cases is assessed to contribute about 65% to the thyroid cancer incidence in Ukraine...
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Data are analysed for 684 settlements in Ukraine and 458 settlements in Belarus. In each of the s... more Data are analysed for 684 settlements in Ukraine and 458 settlements in Belarus. In each of the settlements more than 10 measurements of the I content in human thyroids had been performed in the period May/June 1986. Based on the measurement data, average thyroid doses due to the Chernobyl accident were assessed for every birth year in the birth-year cohort 1968-85. Census data from 1979 and 1989, and mortality rates in the period 1986-89 were used to derive the population structure in 1986. Case data were numbers of operations of pathologically confirmed thyroid cancers in the period 1986-2001 taken from registries that include the place of residence at the time of the accident. The excess absolute risk (EAR) per thyroid dose in all 1142 settlements is estimated for females to 3.1 (95% CI: 2.6; 3.6) cases per 10 PY-Gy, and for males to 2.4 (95% CI: 2.0; 2.8) cases per 10 PY-Gy. The excess relative risk (ERR) per dose is for females 7.2 (95% CI: 5.3; 9.1) Gy, and for males 42 (95% C...
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The Lancet Oncology, 2018
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Ukrainskiĭ biokhimicheskiĭ zhurnal
A comparative analysis of the expression of both, RET/PTC1 and RET/PTC3 oncogenes in papillary th... more A comparative analysis of the expression of both, RET/PTC1 and RET/PTC3 oncogenes in papillary thyroid carcinomas (PTC) of patients from different age groups was carried out. Those were the following groups: children (mean age - 13 years, mean latency period - 13 years), young adults (mean age - 24 years, mean latency period - 14 years), adults (mean age - 38 years, mean latency period - 22 years). The presence of RET/PTC oncogenes was detected using polymerase chain reaction. In all cases the samples of both tumor and normal thyroid tissue were studied. It was established that induction of both, RET/PTC1 and RET/PTC3 rearrangements was present only in carcinoma samples. In PTCs the percentage of RET/PTC-positive tumors with increasing the age of patients has been decreasing. It should be noted that the part of carcinomas with induction of RET/PTC1 did not change with increasing the age of patients. At the same time the frequency of RET/PTC3 rearrangements with the increasing both t...
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Experimental oncology, 2009
To study the changes of cell cycle, mitochondrial membrane potential and caspase activation in re... more To study the changes of cell cycle, mitochondrial membrane potential and caspase activation in response to an antitumour drug Taxol in ARO and KTC-2 cell lines of anaplastic thyroid carcinoma. Experiments were done on thyroid anaplastic cancer cell lines ARO and KTC-2 using Western blotting, flow cytometry, light and fluorescent microscopy. Taxol significantly activated caspases in ARO cells starting from drug concentration of 5 nM. Maximum activation was observed at 25 nM and further increase of Taxol concentration to 100 nM resulted in a reduction of caspase activation. Concomitant to caspase activation, a loss of mitochondrial membrane potential was observed. At Taxol concentration of 100 nM, most cells lost their mitochondrial membrane potential. Low Taxol concentrations (10 nM) caused changes in the cell cycle that are typical for apoptosis without cell cycle arrest. Higher drug doses starting from 50 nM arrested cell cycle in G2/M phase. In KTC-2 cell line Taxol concentration ...
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Thyroid, 2004
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The Journal of Clinical Endocrinology & Metabolism, 2009
Background: Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid... more Background: Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid cancer risk in exposed children. Data on exposure to the embryonic/fetal thyroid are rare, raising questions about use of iodine 131 (I-131) in pregnant women. We present here estimated risks of thyroid disease from exposure in utero to I-131 fallout from the Chernobyl nuclear accident. Methods: We conducted a cross-sectional thyroid screening study (palpation, ultrasound, thyroid hormones, and, if indicated, fine needle aspiration) from 2003 to 2006. Participants were 2582 mother-child pairs from Ukraine in which the mother had been pregnant at the time of the accident on April 26, 1986, or 2 months after the time during which I-131 fallout was still present (1494 from contaminated areas, 1088 in the comparison group). Individual cumulative in utero thyroid dose estimates were derived from estimated I-131 activity in the mother’s thyroid (mean 72 mGy; range 0–3230 mGy). Results: There ...
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Journal of radiological protection : official journal of the Society for Radiological Protection, 2012
As a result of the accident at the Chernobyl Nuclear Power Plant, millions of residents of Belaru... more As a result of the accident at the Chernobyl Nuclear Power Plant, millions of residents of Belarus, Russia, and Ukraine were exposed to large doses of radioactive iodine isotopes, mainly I-131. The purpose of the Ukraine-American (UkrAm) and Belarus-American (BelAm) projects are to quantify the risks of thyroid cancer in the framework of a classical cohort study, comprising subjects who were aged under 18 years at the time of the accident, had direct measurements of thyroid I-131 radioactivity taken within two months after the accident, and were residents of three heavily contaminated northern regions of Ukraine (Zhitomir, Kiev, and Chernigov regions). Four two-year screening examination cycles were implemented from 1998 until 2007 to study the risks associated with thyroid cancer due to the iodine exposure caused during the Chernobyl accident. A standardised procedure of clinical examinations included: thyroid palpation, ultrasound examination, blood collection followed by a determ...
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Environmental Health Perspectives, 2011
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Cytology and Genetics, 2021
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World journal of …, 2000
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The Ukrainian Biochemical Journal
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Experimental Oncology
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British Journal of Cancer, 2015
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