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Papers by MUHAMMAD HUSADA

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Anxiety disorder is the most prevalent comorbidity that may persist chronically in in... more BACKGROUND: Anxiety disorder is the most prevalent comorbidity that may persist chronically in individuals with epilepsy. Unfortunately, anxiety is commonly ignored and rarely reported by epileptic patient. Therefore, early intervention and proper treatment should be addressed in these people. Acknowledging risk factors related to anxiety among epileptic patients may be useful in tailoring more appropriate psychiatric support. AIM: The aim of our study is to investigate risk factors related to anxiety among epileptic patients. METHODS: This cross-sectional predictive analytical multivariate study was conducted through March to May 2021 in Haji Adam Malik General Hospital Medan involving 84 epileptic patients visiting Neurology outpatient clinic who fulfilled inclusion and exclusion criteria COVID-19 health protocols. Anxiety score was assessed using HADS-A self-reported questionnaire. RESULTS: We found that most of our patients are female who have experienced epilepsy for around 3 y...

Frontiers in Psychiatry

BackgroundIn the first quarter of 2020, two cases of coronavirus disease (COVID-19) were reported... more BackgroundIn the first quarter of 2020, two cases of coronavirus disease (COVID-19) were reported in Indonesia, approximately 4 months after the first case was reported in China. The numbers continued to increase following the introduction of many variants of the virus. The pandemic may have an impact on the community's mental health, particularly on those with mental illnesses. Therefore, this study aimed to determine the correlation between schizophrenia and COVID-19 based on demographic characteristics.MethodsThis nominal-nominal and numerical-nominal correlative analytical study used a cross-sectional approach and was conducted at a psychiatric hospital in North Sumatra. The sample population consisted of 48 patients and 48 healthy controls, who were selected using a non-probability consecutive sampling method.ResultsThe analysis showed that there were correlations between schizophrenia and COVID-19 (r = 0.417, p < 0.001) and between the age of patients with schizophrenia...

Open Access Macedonian Journal of Medical Sciences, 2021

Background: Mental health conditions that can occur immediately after a traumatic event is called... more Background: Mental health conditions that can occur immediately after a traumatic event is called acute stress reaction; in this case, happens after hypnosis. This can cause a variety of psychological symptoms without attention or treatment, causesost-traumatic stress disorder. The psychological symptoms can negatively affect the quality of life, especially the reactions arise after a traumatic event that after being hypnotized. Hypnosis works by changing the activity in brain regions associated with attention or alertness. At the time hypnotised, we saw a very high level of concentration, so that suggestions given to him will be more easily accepted. Case Report: The case presented is the hypnotic impact of acute stress reactions. A woman named Mrs. J 63 years old. The Karo tribe who experienced anxiety, fear, and difficulty sleeping after experiencing hypnosis four days ago. This experienced it after being hypnotized at home. Conclusion: Hypnosis plays a role in all parts of life ...

BACKGROUND: Schizophrenia affects approximately 1% of the population and in Indonesia, the preval... more BACKGROUND: Schizophrenia affects approximately 1% of the population and in Indonesia, the prevalence is about 400.000 people or as many as 1.7/10,000 individuals of the population. Schizophrenia is characterized by positive symptoms, negative symptoms, and also cognitive, aggressive, and affective symptoms, where negative symptoms reflect loss of function. One important factor that plays a role in the pathophysiology of schizophrenia is the excessive production of free radical substances and the failure of the anti-oxidant defense process. AIM: The aim of this study is to see how levels of superoxide dismutase change after N-acetylcystein augmentation in schizophrenic patients treated with risperidone. METHODS: This study is a pre-post experimental test design, where schizophrenic patients meet inclusion and exclusion criteria. At baseline and after 8 weeks of N-acetyl cysteine (NAC) administration, patients were assessed at each of the time points using Positive and Negative Syndr...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Drug abuse occurs widely in various parts of the world. The drugs that are misused ar... more BACKGROUND: Drug abuse occurs widely in various parts of the world. The drugs that are misused are not only cocaine, or heroin, but also drugs that are commonly prescribed. If you want to get drunk, usually use dextromethorphan (DMP) pills, but now switch to mixing herbal cough medicines with energy drinks. Herbal cough medicine is usually used as a cough reliever, but in teens today, herbal cough medicine is starting to be abused. Mixing energy drinks using herbal cough medicine are motivated by a lack of positive activities or activities, influenced by peers or the environment where the subject lives, lack of application of religious and school education, lack of the role of parents in supervising their children, easy access to herbal cough medicines and drinks energy in large quantities, and the price is cheap. The crime that occurred is not only limited to theft but also drugs and drinking. The only difference, they are not drunk with liquor, but mixed energy drinks with some he...

Open Access Macedonian Journal of Medical Sciences, 2021

Background: COVID-19 is a newly emerging infectious disease which is found to be caused by SARS-2... more Background: COVID-19 is a newly emerging infectious disease which is found to be caused by SARS-2. COVID-19 pandemic has spread worldwide causing a rapidly increasing number of mental disorders cases, primarily anxiety disorder. Since majority of panic disorder patients are present with great anxiety in response to their physical or respiratory symptoms, support and encouragement from psychiatrist or therapist are fundamental to alleviate the severity of the symptoms. Case Report: We reported a case of COVID-19 induced panic disorder in a woman, 52 years old, batak tribe who started to experience multiple panic attacks since one of her family members was confirmed to be Covid-10 positive. Conclusion: In general, panic disorder is a common diagnosis, but this case appeared to be interesting as it is induced by COVID-19 pandemic. As in this case, the individual who experienced multiple panic attack is not even a COVID-19 patient but has one of her family member affected by the virus. ...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Schizophrenia according to the world health organization is one of the top ten causes... more BACKGROUND: Schizophrenia according to the world health organization is one of the top ten causes of disability in developed countries around the world. Because of the severity, chronicity, and prevalence of schizophrenia, it has a very large economic burden. Magnesium is a micronutrient needed by the body which can affect mental health. Erythrocyte magnesium levels are considered more sensitive than serum magnesium levels to reflect intracellular magnesium status. AIM: The objective of the study was to determine the differences in erythrocyte magnesium levels between men with schizophrenia who received risperidone and haloperidol treatment at Prof. Dr. M Ildrem Psychiatric Hospital, Medan. METHODS: This study is an intention to treat and is an experimental pre-test and post-test that compares two groups, namely the intervention group and the control group. The sampling method is non-probability sampling with a consecutive sampling type. The research was conducted at Prof. Dr. M. Il...

AIM: The objectives of the study were to compare total cholesterol levels in men with schizophren... more AIM: The objectives of the study were to compare total cholesterol levels in men with schizophrenia receiving risperidone and haloperidol treatment. METHODS: We conducted on treatment analysis experiment study involving 30 subjects who received risperidone and 30 subjects who received haloperidol. Total cholesterol levels were examined at week 0 and week 8. RESULTS: There were no statistically significant differences in baseline characteristics. At week 8, mean of total cholesterol level in the risperidone group was 207.23 ± 21.49 compared to 188.17 ± 17.00 in the haloperidol group. A difference of 19.06 ± 5.00 (95% CI 9.05–29.08) was observed, which is statistically significant (p < 0.001). CONCLUSIONS: There was a statistically significant increase in total cholesterol levels in men with schizophrenia receiving risperidone compared to haloperidol. Edited by: Branislav Filipović Citation: Agusmita A, Loebis B, Husada MS, Effendy E. Total Cholesterol Levels in Men with Schizophre...

Open Access Macedonian Journal of Medical Sciences, 2020

BACKGROUND: The availability of psychotic medications in primary health care in Indonesia is in a... more BACKGROUND: The availability of psychotic medications in primary health care in Indonesia is in a limited number. The center of psychiatric health-care provides varied types of medications. However, the quantities are limited, in which the second generation of psychotic drugs is relatively expensive. Common available drug medications are haloperidol and diazepam. AIM: This study aims to investigate the difference scores of Positive and Negative Syndrome Scale (PANSS-EC) in psychotic agitation patients of haloperidol prescription and those who have been prescribed with haloperidol and diazepam injections at Prof. Dr. M. Ildrem Mental Hospital, Medan North Sumatera, Indonesia. METHODS: This study involved 64 psychotic agitation patients who were divided into two groups. The first group was 32 patients who have been prescribed by 5 mg of haloperidol injections and the second group was 32 patients who have been injected by 5 mg of haloperidol and 10 mg of diazepam. The PANSS-EC score as...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies... more BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies indicate that schizophrenia pathogenesis can be related to changes at the cellular level. The studies show homocysteine in people with schizophrenia was significantly increased, abnormal homocysteine metabolism can lead to DNA methylation. AIM: This study aimed to establish the correlation between the Indonesian Montreal Cognitive Assessment Version (MoCA-Ina) scores and homocysteine levels in males with Bataknese schizophrenia. METHODS: This study is a numerical correlative analytic study with an approach to cross-sectional study; by evaluating the correlation between the MoCA-Ina scores and the level of homocysteine in males with Bataknese schizophrenia. RESULTS: The median of the MoCA-Ina score in the study subjects was 22, with a minimum score of 18 and a maximum score of 26. There was a significant correlation between the MoCA-Ina scores and Homocysteine levels (p = 0.001). CONCLUS...

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: The increase of smartphone user among Indonesian junior high school students, particu... more BACKGROUND: The increase of smartphone user among Indonesian junior high school students, particularly for teenagers, indicates the addiction factor of the smartphone. AIM: This research is designed to adapt the Smartphone Addiction Scale-Short Version (SASS-SV) to Indonesian version based on cultural adaptation of the rating scale. METHODS: This study involves 300 participants consisted of 151 of male children and 149 female children with an average age is 13.27 years-of-old. The validity of concurrent was used to obtain the validity, while the internal consistency and Receiver Operating Characteristic (ROC) were conducted to confirm the reliability of the rating scale. RESULTS: In purpose to measure internal consistency, the Cronbach alpha has been applied. The Cronbach alpha value was 0.740, and Concurrent validity was checked to NMP the Nomophobia Questionnaire (NMP-Q) based on Indonesian version. The analysis of ROC showed that the value of Area under the Curve (AUC) was 0.997 ...

International Journal of Life-Sciences Scientific Research, 2018

Background: Schizophrenia is a common psychotic disorder, with a risk of about 1%, the etiology o... more Background: Schizophrenia is a common psychotic disorder, with a risk of about 1%, the etiology of schizophrenia unknown, one of which includes immunological disorders. Although, there are conflicting results, most studies focusing on plasma levels or the production of mitogen-stimulated cytokines. Furthermore, this study compared serum levels of TNF-α in male chronic schizophrenic patients and healthy control. Methods: This cross-sectional study was conducted on 40 male patients diagnosed with chronic schizophrenic and 40 healthy control. Severity of illness was assessed with PANSS. Serum levels of TNF-α were measured by Quantikine HS Human TNF-α Immunoassay. Results: TNF-α levels were significantly higher in chronic schizophrenic (25.12±1.76) to healthy control subjects (5.49±1.69), p=0.001; p<0.05. Conclusion: This study suggested that TNF-α play a role in the immunopathogenesis of schizophrenia and behavioral changes. The relationship between schizophrenia and inflammation was supported by the production of abnormal cytokines.

Open Access Macedonian Journal of Medical Sciences, 2019

INTRODUCTION: Prohibited substances issue and their abuse have become a scourge for people in Ind... more INTRODUCTION: Prohibited substances issue and their abuse have become a scourge for people in Indonesia. This situation creates concern for every level of society since this is very influential to damage and can even eliminate generations at a later time. AIM: This study aims to determine the characteristics of age, education, psychological and social problems related to substance dependence experienced by individuals with substance disorders who undergo rehabilitation in Medan, Indonesia. METHODS: This study is a cross-sectional analytic, in which the sample of this study was individuals who underwent rehabilitation in the Rehabilitation Center in Medan City who fulfilled the inclusion and exclusion criteria. A structured interview was carried out with the MINI ICD-10 on part M. disorders related to psychoactive substances. Furthermore, to see the level of dependence, WHO ASSIST questionnaire (The Alcohol, Smoking and Substance Involvement Screening Test) was used. RESULTS: This st...

Current Nutrition & Food Science, 2018

Background: Schizophrenia is a chronic mental disorder that affects approximately 1% of the world... more Background: Schizophrenia is a chronic mental disorder that affects approximately 1% of the world’s population. Particularly, negative symptoms are frequently resistant and are the main contributors to the disability on schizophrenia patients. Folic acid and vitamin B12 supplementation is the safe and affordable approach, which can significantly improve the outcome on the patients with residual symptoms. Objectives: We aimed to understand the difference of negative subscale of Positive and Negative Syndrome Scale (PANSS) Score on patients with schizophrenia who receive risperidone with the addition folic acid and Vitamin B12 and patients who receive only risperidone after 6 weeks. Methods: This study is a quasi experimental pre-test and post-test designs that are divided into two groups, they are group receiving risperidone with the addition of folic acid and vitamin B12 and the group receiving only risperidone. Diagnosis of schizophrenia according to the International Classificatio...

IOP Conference Series: Earth and Environmental Science, 2018

Caring for schizophrenic patients can lead to emotional distress. It remains unclear about the le... more Caring for schizophrenic patients can lead to emotional distress. It remains unclear about the level of depressive syndromes among female caregivers of schizophrenic patients. To determine the level of depression among female caregivers of schizophrenic patients. This is a descriptive study with a cross-sectional approach to describe the level of depression of female caregivers in Prof. dr. M. Ildrem Mental Hospital Medan, using HADS instruments. Most age group of caregivers is from age 51-60 years that is 48.15%, caregiver's work status mostly not works (62.96%), marital status of caregiver mostly is married (59.26%), kinship with most patients are a biological mother (57.41%). Most patient age group is from age below 30 years (50%), work status of most patients is not working (81.48%), marital status of most caregiver is married (83.33%). Mostly of the depressive syndrome is mild depression (42.59%). Mostly of the depressive syndrome is from mild depression.

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Caregiver plays an important role for a better outcome in people with schizophrenia, ... more BACKGROUND: Caregiver plays an important role for a better outcome in people with schizophrenia, although it usually causes emotional distress for the caregiver. Anxiety is one of the emotional distress. Gender of schizophrenic patients is associated with the emotional distress of caregiver. The differences in HADS-A scores between female caregivers of people with schizophrenia according to gender in Indonesia remain unclear. AIM: To determine whether HADS-A scores are higher in a male group compare with the female group. METHODS: This study was an analytical study with a cross-sectional approach to determine the comparison of HADS-A score between 27 female caregivers of male schizophrenic patients (male group) and 27 female caregivers of female schizophrenic patients (female group) in Prof. Dr M. Ildrem Mental Hospital Medan, using a HADS rating scale. RESULTS: There is no difference between the male and female group in caregivers: age, marital status, employment status, family inc...

Open Access Macedonian Journal of Medical Sciences, 2019

Introduction : Anxiety disorders can be comorbid with schizophrenia. There was 38.3% of subjects ... more Introduction : Anxiety disorders can be comorbid with schizophrenia. There was 38.3% of subjects with schizophrenia spectrum disorders suffer from at least one anxiety disorder. In the general population, it was found that higher levels of anxiety were experienced by women than men. Aims : to measure the difference between Hospital Anxiety and Depression Scale-Anxiety (HADS-A) scores in Batak male and female with schizophrenia. Materials and Methods : This preliminary study was a comparative analytical study with a cross sectional approach involving twenty participants, divided into two groups, Batak male and female in the stabilization phase who were outpatient in Prof.dr. M. Ildrem Mental Hospital Medan. Patient with schizophrenia was filled questionnaire of HADS-A to measure score of anxiety. Results : There were no statistically significant difference of HADS-A score from Batak male and female with schizophrenia with p value 0,129. Conclusion : From this preliminary s...

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Shared psychotic disorder was first introduced in the 19th century in France with the... more BACKGROUND: Shared psychotic disorder was first introduced in the 19th century in France with the name Folie à deux. Since then, the concept of Folie à deux has been developed and produces several subtypes in France. In DSM, this disorder is called Shared Psychotic Disorder, and in ICD-10, it is called Induced Delusional Disorder. However, some of the classic subtypes of Folie à deux are not included in the above categories. CASE REPORT: We found a case of shared psychotic disorder between a 38-year-old male inducer, a Batak tribe with two female recipients, 34 and 36 years from the Batak tribe. They were found to share the same delusions and hallucinations, and inducers could make recipients into trance conditions. These three individuals did not get along with the surrounding community and often carried out activities and perform rituals together. CONCLUSION: Overall, our case has some unique features of folie à deux. In this case, there is a trance condition that can be induced t...

IOP Conference Series: Earth and Environmental Science, 2018

The incidence of Lower Back Pain (LBP) in Indonesia is unclear. Various data in some developing c... more The incidence of Lower Back Pain (LBP) in Indonesia is unclear. Various data in some developing countries stated that the LBP incidence is approximately 15%-20% of the population. Because there is the unclear incidence of psychological symptoms such as depression on LBP, the researchers were interested in doing this research. A descriptive study was conducted to know the level of depression of patients with LBP in outpatient of neurology RS HAM Medan. Patients with LBP (n=78) in outpatient were examined BDI-II. The minimum depression was 47.44% (n=37), mild depression was 21.79% (n=17), moderate depression was 21.79% (n=17), severe depression was 8.98% (n=7). In conclusion, the level of depression in lower back pain patient at outpatient of neurology Haji Adam Malik Hospital Medan is higher at minimum depression.

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, p... more BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, perception and other aspects from the individual which interferences. This interference is normally started before age 25, and it can affect all social classes. AIM: To find out the difference in total positive and negative syndrome scale (PANSS) scores in schizophrenia between Bataknese and Javanese who have received treatment with risperidone. METHODS: This study is a prospective study. This study used numeric comparative analytic two unpaired groups to observe the differences of PANSS score of the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment. RESULTS: Our study found that the average score of PANSS for Bataknese was 49.76 ± 12.65 and Javanese was 42.43 ± 9.05. CONCLUSION: There was a difference score of PANSS for the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment for 6 weeks (p = 0.037).

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Anxiety disorder is the most prevalent comorbidity that may persist chronically in in... more BACKGROUND: Anxiety disorder is the most prevalent comorbidity that may persist chronically in individuals with epilepsy. Unfortunately, anxiety is commonly ignored and rarely reported by epileptic patient. Therefore, early intervention and proper treatment should be addressed in these people. Acknowledging risk factors related to anxiety among epileptic patients may be useful in tailoring more appropriate psychiatric support. AIM: The aim of our study is to investigate risk factors related to anxiety among epileptic patients. METHODS: This cross-sectional predictive analytical multivariate study was conducted through March to May 2021 in Haji Adam Malik General Hospital Medan involving 84 epileptic patients visiting Neurology outpatient clinic who fulfilled inclusion and exclusion criteria COVID-19 health protocols. Anxiety score was assessed using HADS-A self-reported questionnaire. RESULTS: We found that most of our patients are female who have experienced epilepsy for around 3 y...

Frontiers in Psychiatry

BackgroundIn the first quarter of 2020, two cases of coronavirus disease (COVID-19) were reported... more BackgroundIn the first quarter of 2020, two cases of coronavirus disease (COVID-19) were reported in Indonesia, approximately 4 months after the first case was reported in China. The numbers continued to increase following the introduction of many variants of the virus. The pandemic may have an impact on the community's mental health, particularly on those with mental illnesses. Therefore, this study aimed to determine the correlation between schizophrenia and COVID-19 based on demographic characteristics.MethodsThis nominal-nominal and numerical-nominal correlative analytical study used a cross-sectional approach and was conducted at a psychiatric hospital in North Sumatra. The sample population consisted of 48 patients and 48 healthy controls, who were selected using a non-probability consecutive sampling method.ResultsThe analysis showed that there were correlations between schizophrenia and COVID-19 (r = 0.417, p < 0.001) and between the age of patients with schizophrenia...

Open Access Macedonian Journal of Medical Sciences, 2021

Background: Mental health conditions that can occur immediately after a traumatic event is called... more Background: Mental health conditions that can occur immediately after a traumatic event is called acute stress reaction; in this case, happens after hypnosis. This can cause a variety of psychological symptoms without attention or treatment, causesost-traumatic stress disorder. The psychological symptoms can negatively affect the quality of life, especially the reactions arise after a traumatic event that after being hypnotized. Hypnosis works by changing the activity in brain regions associated with attention or alertness. At the time hypnotised, we saw a very high level of concentration, so that suggestions given to him will be more easily accepted. Case Report: The case presented is the hypnotic impact of acute stress reactions. A woman named Mrs. J 63 years old. The Karo tribe who experienced anxiety, fear, and difficulty sleeping after experiencing hypnosis four days ago. This experienced it after being hypnotized at home. Conclusion: Hypnosis plays a role in all parts of life ...

BACKGROUND: Schizophrenia affects approximately 1% of the population and in Indonesia, the preval... more BACKGROUND: Schizophrenia affects approximately 1% of the population and in Indonesia, the prevalence is about 400.000 people or as many as 1.7/10,000 individuals of the population. Schizophrenia is characterized by positive symptoms, negative symptoms, and also cognitive, aggressive, and affective symptoms, where negative symptoms reflect loss of function. One important factor that plays a role in the pathophysiology of schizophrenia is the excessive production of free radical substances and the failure of the anti-oxidant defense process. AIM: The aim of this study is to see how levels of superoxide dismutase change after N-acetylcystein augmentation in schizophrenic patients treated with risperidone. METHODS: This study is a pre-post experimental test design, where schizophrenic patients meet inclusion and exclusion criteria. At baseline and after 8 weeks of N-acetyl cysteine (NAC) administration, patients were assessed at each of the time points using Positive and Negative Syndr...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Drug abuse occurs widely in various parts of the world. The drugs that are misused ar... more BACKGROUND: Drug abuse occurs widely in various parts of the world. The drugs that are misused are not only cocaine, or heroin, but also drugs that are commonly prescribed. If you want to get drunk, usually use dextromethorphan (DMP) pills, but now switch to mixing herbal cough medicines with energy drinks. Herbal cough medicine is usually used as a cough reliever, but in teens today, herbal cough medicine is starting to be abused. Mixing energy drinks using herbal cough medicine are motivated by a lack of positive activities or activities, influenced by peers or the environment where the subject lives, lack of application of religious and school education, lack of the role of parents in supervising their children, easy access to herbal cough medicines and drinks energy in large quantities, and the price is cheap. The crime that occurred is not only limited to theft but also drugs and drinking. The only difference, they are not drunk with liquor, but mixed energy drinks with some he...

Open Access Macedonian Journal of Medical Sciences, 2021

Background: COVID-19 is a newly emerging infectious disease which is found to be caused by SARS-2... more Background: COVID-19 is a newly emerging infectious disease which is found to be caused by SARS-2. COVID-19 pandemic has spread worldwide causing a rapidly increasing number of mental disorders cases, primarily anxiety disorder. Since majority of panic disorder patients are present with great anxiety in response to their physical or respiratory symptoms, support and encouragement from psychiatrist or therapist are fundamental to alleviate the severity of the symptoms. Case Report: We reported a case of COVID-19 induced panic disorder in a woman, 52 years old, batak tribe who started to experience multiple panic attacks since one of her family members was confirmed to be Covid-10 positive. Conclusion: In general, panic disorder is a common diagnosis, but this case appeared to be interesting as it is induced by COVID-19 pandemic. As in this case, the individual who experienced multiple panic attack is not even a COVID-19 patient but has one of her family member affected by the virus. ...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: Schizophrenia according to the world health organization is one of the top ten causes... more BACKGROUND: Schizophrenia according to the world health organization is one of the top ten causes of disability in developed countries around the world. Because of the severity, chronicity, and prevalence of schizophrenia, it has a very large economic burden. Magnesium is a micronutrient needed by the body which can affect mental health. Erythrocyte magnesium levels are considered more sensitive than serum magnesium levels to reflect intracellular magnesium status. AIM: The objective of the study was to determine the differences in erythrocyte magnesium levels between men with schizophrenia who received risperidone and haloperidol treatment at Prof. Dr. M Ildrem Psychiatric Hospital, Medan. METHODS: This study is an intention to treat and is an experimental pre-test and post-test that compares two groups, namely the intervention group and the control group. The sampling method is non-probability sampling with a consecutive sampling type. The research was conducted at Prof. Dr. M. Il...

AIM: The objectives of the study were to compare total cholesterol levels in men with schizophren... more AIM: The objectives of the study were to compare total cholesterol levels in men with schizophrenia receiving risperidone and haloperidol treatment. METHODS: We conducted on treatment analysis experiment study involving 30 subjects who received risperidone and 30 subjects who received haloperidol. Total cholesterol levels were examined at week 0 and week 8. RESULTS: There were no statistically significant differences in baseline characteristics. At week 8, mean of total cholesterol level in the risperidone group was 207.23 ± 21.49 compared to 188.17 ± 17.00 in the haloperidol group. A difference of 19.06 ± 5.00 (95% CI 9.05–29.08) was observed, which is statistically significant (p < 0.001). CONCLUSIONS: There was a statistically significant increase in total cholesterol levels in men with schizophrenia receiving risperidone compared to haloperidol. Edited by: Branislav Filipović Citation: Agusmita A, Loebis B, Husada MS, Effendy E. Total Cholesterol Levels in Men with Schizophre...

Open Access Macedonian Journal of Medical Sciences, 2020

BACKGROUND: The availability of psychotic medications in primary health care in Indonesia is in a... more BACKGROUND: The availability of psychotic medications in primary health care in Indonesia is in a limited number. The center of psychiatric health-care provides varied types of medications. However, the quantities are limited, in which the second generation of psychotic drugs is relatively expensive. Common available drug medications are haloperidol and diazepam. AIM: This study aims to investigate the difference scores of Positive and Negative Syndrome Scale (PANSS-EC) in psychotic agitation patients of haloperidol prescription and those who have been prescribed with haloperidol and diazepam injections at Prof. Dr. M. Ildrem Mental Hospital, Medan North Sumatera, Indonesia. METHODS: This study involved 64 psychotic agitation patients who were divided into two groups. The first group was 32 patients who have been prescribed by 5 mg of haloperidol injections and the second group was 32 patients who have been injected by 5 mg of haloperidol and 10 mg of diazepam. The PANSS-EC score as...

Open Access Macedonian Journal of Medical Sciences, 2021

BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies... more BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies indicate that schizophrenia pathogenesis can be related to changes at the cellular level. The studies show homocysteine in people with schizophrenia was significantly increased, abnormal homocysteine metabolism can lead to DNA methylation. AIM: This study aimed to establish the correlation between the Indonesian Montreal Cognitive Assessment Version (MoCA-Ina) scores and homocysteine levels in males with Bataknese schizophrenia. METHODS: This study is a numerical correlative analytic study with an approach to cross-sectional study; by evaluating the correlation between the MoCA-Ina scores and the level of homocysteine in males with Bataknese schizophrenia. RESULTS: The median of the MoCA-Ina score in the study subjects was 22, with a minimum score of 18 and a maximum score of 26. There was a significant correlation between the MoCA-Ina scores and Homocysteine levels (p = 0.001). CONCLUS...

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: The increase of smartphone user among Indonesian junior high school students, particu... more BACKGROUND: The increase of smartphone user among Indonesian junior high school students, particularly for teenagers, indicates the addiction factor of the smartphone. AIM: This research is designed to adapt the Smartphone Addiction Scale-Short Version (SASS-SV) to Indonesian version based on cultural adaptation of the rating scale. METHODS: This study involves 300 participants consisted of 151 of male children and 149 female children with an average age is 13.27 years-of-old. The validity of concurrent was used to obtain the validity, while the internal consistency and Receiver Operating Characteristic (ROC) were conducted to confirm the reliability of the rating scale. RESULTS: In purpose to measure internal consistency, the Cronbach alpha has been applied. The Cronbach alpha value was 0.740, and Concurrent validity was checked to NMP the Nomophobia Questionnaire (NMP-Q) based on Indonesian version. The analysis of ROC showed that the value of Area under the Curve (AUC) was 0.997 ...

International Journal of Life-Sciences Scientific Research, 2018

Background: Schizophrenia is a common psychotic disorder, with a risk of about 1%, the etiology o... more Background: Schizophrenia is a common psychotic disorder, with a risk of about 1%, the etiology of schizophrenia unknown, one of which includes immunological disorders. Although, there are conflicting results, most studies focusing on plasma levels or the production of mitogen-stimulated cytokines. Furthermore, this study compared serum levels of TNF-α in male chronic schizophrenic patients and healthy control. Methods: This cross-sectional study was conducted on 40 male patients diagnosed with chronic schizophrenic and 40 healthy control. Severity of illness was assessed with PANSS. Serum levels of TNF-α were measured by Quantikine HS Human TNF-α Immunoassay. Results: TNF-α levels were significantly higher in chronic schizophrenic (25.12±1.76) to healthy control subjects (5.49±1.69), p=0.001; p<0.05. Conclusion: This study suggested that TNF-α play a role in the immunopathogenesis of schizophrenia and behavioral changes. The relationship between schizophrenia and inflammation was supported by the production of abnormal cytokines.

Open Access Macedonian Journal of Medical Sciences, 2019

INTRODUCTION: Prohibited substances issue and their abuse have become a scourge for people in Ind... more INTRODUCTION: Prohibited substances issue and their abuse have become a scourge for people in Indonesia. This situation creates concern for every level of society since this is very influential to damage and can even eliminate generations at a later time. AIM: This study aims to determine the characteristics of age, education, psychological and social problems related to substance dependence experienced by individuals with substance disorders who undergo rehabilitation in Medan, Indonesia. METHODS: This study is a cross-sectional analytic, in which the sample of this study was individuals who underwent rehabilitation in the Rehabilitation Center in Medan City who fulfilled the inclusion and exclusion criteria. A structured interview was carried out with the MINI ICD-10 on part M. disorders related to psychoactive substances. Furthermore, to see the level of dependence, WHO ASSIST questionnaire (The Alcohol, Smoking and Substance Involvement Screening Test) was used. RESULTS: This st...

Current Nutrition & Food Science, 2018

Background: Schizophrenia is a chronic mental disorder that affects approximately 1% of the world... more Background: Schizophrenia is a chronic mental disorder that affects approximately 1% of the world’s population. Particularly, negative symptoms are frequently resistant and are the main contributors to the disability on schizophrenia patients. Folic acid and vitamin B12 supplementation is the safe and affordable approach, which can significantly improve the outcome on the patients with residual symptoms. Objectives: We aimed to understand the difference of negative subscale of Positive and Negative Syndrome Scale (PANSS) Score on patients with schizophrenia who receive risperidone with the addition folic acid and Vitamin B12 and patients who receive only risperidone after 6 weeks. Methods: This study is a quasi experimental pre-test and post-test designs that are divided into two groups, they are group receiving risperidone with the addition of folic acid and vitamin B12 and the group receiving only risperidone. Diagnosis of schizophrenia according to the International Classificatio...

IOP Conference Series: Earth and Environmental Science, 2018

Caring for schizophrenic patients can lead to emotional distress. It remains unclear about the le... more Caring for schizophrenic patients can lead to emotional distress. It remains unclear about the level of depressive syndromes among female caregivers of schizophrenic patients. To determine the level of depression among female caregivers of schizophrenic patients. This is a descriptive study with a cross-sectional approach to describe the level of depression of female caregivers in Prof. dr. M. Ildrem Mental Hospital Medan, using HADS instruments. Most age group of caregivers is from age 51-60 years that is 48.15%, caregiver's work status mostly not works (62.96%), marital status of caregiver mostly is married (59.26%), kinship with most patients are a biological mother (57.41%). Most patient age group is from age below 30 years (50%), work status of most patients is not working (81.48%), marital status of most caregiver is married (83.33%). Mostly of the depressive syndrome is mild depression (42.59%). Mostly of the depressive syndrome is from mild depression.

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Caregiver plays an important role for a better outcome in people with schizophrenia, ... more BACKGROUND: Caregiver plays an important role for a better outcome in people with schizophrenia, although it usually causes emotional distress for the caregiver. Anxiety is one of the emotional distress. Gender of schizophrenic patients is associated with the emotional distress of caregiver. The differences in HADS-A scores between female caregivers of people with schizophrenia according to gender in Indonesia remain unclear. AIM: To determine whether HADS-A scores are higher in a male group compare with the female group. METHODS: This study was an analytical study with a cross-sectional approach to determine the comparison of HADS-A score between 27 female caregivers of male schizophrenic patients (male group) and 27 female caregivers of female schizophrenic patients (female group) in Prof. Dr M. Ildrem Mental Hospital Medan, using a HADS rating scale. RESULTS: There is no difference between the male and female group in caregivers: age, marital status, employment status, family inc...

Open Access Macedonian Journal of Medical Sciences, 2019

Introduction : Anxiety disorders can be comorbid with schizophrenia. There was 38.3% of subjects ... more Introduction : Anxiety disorders can be comorbid with schizophrenia. There was 38.3% of subjects with schizophrenia spectrum disorders suffer from at least one anxiety disorder. In the general population, it was found that higher levels of anxiety were experienced by women than men. Aims : to measure the difference between Hospital Anxiety and Depression Scale-Anxiety (HADS-A) scores in Batak male and female with schizophrenia. Materials and Methods : This preliminary study was a comparative analytical study with a cross sectional approach involving twenty participants, divided into two groups, Batak male and female in the stabilization phase who were outpatient in Prof.dr. M. Ildrem Mental Hospital Medan. Patient with schizophrenia was filled questionnaire of HADS-A to measure score of anxiety. Results : There were no statistically significant difference of HADS-A score from Batak male and female with schizophrenia with p value 0,129. Conclusion : From this preliminary s...

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Shared psychotic disorder was first introduced in the 19th century in France with the... more BACKGROUND: Shared psychotic disorder was first introduced in the 19th century in France with the name Folie à deux. Since then, the concept of Folie à deux has been developed and produces several subtypes in France. In DSM, this disorder is called Shared Psychotic Disorder, and in ICD-10, it is called Induced Delusional Disorder. However, some of the classic subtypes of Folie à deux are not included in the above categories. CASE REPORT: We found a case of shared psychotic disorder between a 38-year-old male inducer, a Batak tribe with two female recipients, 34 and 36 years from the Batak tribe. They were found to share the same delusions and hallucinations, and inducers could make recipients into trance conditions. These three individuals did not get along with the surrounding community and often carried out activities and perform rituals together. CONCLUSION: Overall, our case has some unique features of folie à deux. In this case, there is a trance condition that can be induced t...

IOP Conference Series: Earth and Environmental Science, 2018

The incidence of Lower Back Pain (LBP) in Indonesia is unclear. Various data in some developing c... more The incidence of Lower Back Pain (LBP) in Indonesia is unclear. Various data in some developing countries stated that the LBP incidence is approximately 15%-20% of the population. Because there is the unclear incidence of psychological symptoms such as depression on LBP, the researchers were interested in doing this research. A descriptive study was conducted to know the level of depression of patients with LBP in outpatient of neurology RS HAM Medan. Patients with LBP (n=78) in outpatient were examined BDI-II. The minimum depression was 47.44% (n=37), mild depression was 21.79% (n=17), moderate depression was 21.79% (n=17), severe depression was 8.98% (n=7). In conclusion, the level of depression in lower back pain patient at outpatient of neurology Haji Adam Malik Hospital Medan is higher at minimum depression.

Open Access Macedonian Journal of Medical Sciences, 2019

BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, p... more BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, perception and other aspects from the individual which interferences. This interference is normally started before age 25, and it can affect all social classes. AIM: To find out the difference in total positive and negative syndrome scale (PANSS) scores in schizophrenia between Bataknese and Javanese who have received treatment with risperidone. METHODS: This study is a prospective study. This study used numeric comparative analytic two unpaired groups to observe the differences of PANSS score of the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment. RESULTS: Our study found that the average score of PANSS for Bataknese was 49.76 ± 12.65 and Javanese was 42.43 ± 9.05. CONCLUSION: There was a difference score of PANSS for the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment for 6 weeks (p = 0.037).