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Papers by MUSA ADAMU
Journal of Animal Science and Veterinary Medicine, 2016
The study was designed to review the incidences and characteristics of Shiga toxin-producing Esch... more The study was designed to review the incidences and characteristics of Shiga toxin-producing Escherichia coli (STEC) from farm animals and humans in tropical Africa. Serotypes O157, O26, O103, O91, O45 and O111 are usually associated with public health risks, and these serotypes are most frequently isolated from food animals. The main virulent factors of STEC associated with human diseases are potent cytotoxins (shiga toxins [stx] stx1 and stx2), which are encoded by the stx1 and stx2 genes. Two additional markers also play a role in the pathogenesis of Hemorrhagic colitis (HC) and Hemolytic Uremic Syndrome (HUS): an outer membrane protein (intimin), encoded by the eae gene, and enterohaemolysin, encoded by the ehlyA gene. All age groups of animals and humans can be infected with STEC, but young animals and children, the elderly, and those with compromised immune systems are the most severely affected. Little is known about factors that determine susceptibility to STEC infection and...
Comparative Clinical Pathology, 2017
Prevalence and distribution of Shiga toxin-producing Escherichia coli (STEC) serogroups majorly l... more Prevalence and distribution of Shiga toxin-producing Escherichia coli (STEC) serogroups majorly linked with public health hazards in Maiduguri and the antimicrobial resistance pattern profile of the isolates were determined. Our results show that the prevalence of STEC isolated from human patients with gastroenteritis attending hospitals in Maiduguri was 1.2% of the 600 stool specimens examined. Two patients out of the seven STEC positive isolates had diarrhoea, and no significant statistical association (P < 0.05) was found between STEC positive samples and diarrheal disease. There was significant (P < 0.05) variation in the prevalence of STEC among the age groups. However, there were statistical differences (P < 0.05) between the detection rates of the four serogroups encountered. Five (71.4%) of the E. coli O157 strain showed resistance to at least one of the antimicrobials tested. The only STEC O157 isolate from humans showed resistance to gentamycin, ampicillin, streptomycin and cefotaxime. The results of the antimicrobial susceptibility study showed high resistance (71%) profile to the agents tested. However, all the seven isolates from humans were sensitive to ceftazidime, ceftriaxone and chloramphenicol. In conclusion, the study did not demonstrate significant influence of sex but it did document the presence of stx2 genes in 14.2% and stx1 in 85.7% of the isolates and other genes detected in this study were eae and ehlyA among the isolates. Therefore, ceftazidime, ceftriaxone and chloramphenicol may be drugs of choice for treating infections caused by STEC in Maiduguri.
Case Studies in Construction Materials
Construction and Building Materials, 2021
Journal of Animal Science and Veterinary Medicine, 2016
The study was designed to review the incidences and characteristics of Shiga toxin-producing Esch... more The study was designed to review the incidences and characteristics of Shiga toxin-producing Escherichia coli (STEC) from farm animals and humans in tropical Africa. Serotypes O157, O26, O103, O91, O45 and O111 are usually associated with public health risks, and these serotypes are most frequently isolated from food animals. The main virulent factors of STEC associated with human diseases are potent cytotoxins (shiga toxins [stx] stx1 and stx2), which are encoded by the stx1 and stx2 genes. Two additional markers also play a role in the pathogenesis of Hemorrhagic colitis (HC) and Hemolytic Uremic Syndrome (HUS): an outer membrane protein (intimin), encoded by the eae gene, and enterohaemolysin, encoded by the ehlyA gene. All age groups of animals and humans can be infected with STEC, but young animals and children, the elderly, and those with compromised immune systems are the most severely affected. Little is known about factors that determine susceptibility to STEC infection and...
Comparative Clinical Pathology, 2017
Prevalence and distribution of Shiga toxin-producing Escherichia coli (STEC) serogroups majorly l... more Prevalence and distribution of Shiga toxin-producing Escherichia coli (STEC) serogroups majorly linked with public health hazards in Maiduguri and the antimicrobial resistance pattern profile of the isolates were determined. Our results show that the prevalence of STEC isolated from human patients with gastroenteritis attending hospitals in Maiduguri was 1.2% of the 600 stool specimens examined. Two patients out of the seven STEC positive isolates had diarrhoea, and no significant statistical association (P < 0.05) was found between STEC positive samples and diarrheal disease. There was significant (P < 0.05) variation in the prevalence of STEC among the age groups. However, there were statistical differences (P < 0.05) between the detection rates of the four serogroups encountered. Five (71.4%) of the E. coli O157 strain showed resistance to at least one of the antimicrobials tested. The only STEC O157 isolate from humans showed resistance to gentamycin, ampicillin, streptomycin and cefotaxime. The results of the antimicrobial susceptibility study showed high resistance (71%) profile to the agents tested. However, all the seven isolates from humans were sensitive to ceftazidime, ceftriaxone and chloramphenicol. In conclusion, the study did not demonstrate significant influence of sex but it did document the presence of stx2 genes in 14.2% and stx1 in 85.7% of the isolates and other genes detected in this study were eae and ehlyA among the isolates. Therefore, ceftazidime, ceftriaxone and chloramphenicol may be drugs of choice for treating infections caused by STEC in Maiduguri.
Case Studies in Construction Materials
Construction and Building Materials, 2021